Search Results - "Dyer, Wayne"
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Preservation of functionality, immunophenotype, and recovery of HIV RNA from PBMCs cryopreserved for more than 20 years
Published in Frontiers in immunology (2024)“…Many research laboratories have long-term repositories of cryopreserved peripheral blood mononuclear cells (PBMC), which are costly to maintain but are of…”
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An Ovine Model of Hemorrhagic Shock and Resuscitation, to Assess Recovery of Tissue Oxygen Delivery and Oxygen Debt, and Inform Patient Blood Management
Published in Shock (Augusta, Ga.) (01-12-2021)“…Aggressive fluid or blood component transfusion for severe hemorrhagic shock may restore macrocirculatory parameters, but not always improve microcirculatory…”
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3
HIV-1 evades virus-specific IgG2 and IgA responses by targeting systemic and intestinal B cells via long-range intercellular conduits
Published in Nature immunology (01-09-2009)“…Patients infected with human immunodeficiency virus (HIV) have profoundly dysfunctional T and B cell populations. Cerutti and colleagues show that HIV-infected…”
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Effect of flow change on brain injury during an experimental model of differential hypoxaemia in cardiogenic shock supported by extracorporeal membrane oxygenation
Published in Scientific reports (10-03-2023)“…Differential hypoxaemia (DH) is common in patients supported by femoral veno-arterial extracorporeal membrane oxygenation (V-A ECMO) and can cause cerebral…”
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Mapping the extent of heterogeneity of human CCR5+ CD4+ T cells in peripheral blood and lymph nodes
Published in AIDS (London) (01-05-2020)“…BACKGROUND:CD4 T cells that express the chemokine receptor, CCR5, are the most important target of HIV-1 infection, but their functions, phenotypes and…”
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High Levels of Human Antigen-Specific CD4+ T Cells in Peripheral Blood Revealed by Stimulated Coexpression of CD25 and CD134 (OX40)
Published in The Journal of immunology (1950) (15-08-2009)“…Ag-specific human CD4(+) memory T lymphocytes have mostly been studied using assays of proliferation in vitro. Intracellular cytokine and ELISPOT assays…”
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Genome-wide analysis of primary CD4+ and CD8+ T cell transcriptomes shows evidence for a network of enriched pathways associated with HIV disease
Published in Retrovirology (16-03-2011)“…HIV preferentially infects CD4+ T cells, and the functional impairment and numerical decline of CD4+ and CD8+ T cells characterize HIV disease. The numerical…”
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Fibrinogen Early In Severe Trauma studY (FEISTY): study protocol for a randomised controlled trial
Published in Current controlled trials in cardiovascular medicine (26-05-2017)“…Haemorrhage is a leading cause of death in severe trauma. Fibrinogen plays a critical role in maintaining haemostasis in traumatic haemorrhage. Early…”
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The Sydney Blood Bank Cohort: implications for viral fitness as a cause of elite control
Published in Current opinion in HIV & AIDS (01-05-2011)“…PURPOSE OF REVIEWThe Sydney Blood Bank Cohort comprised eight individuals who were infected with an attenuated, nef/LTR-deleted strain of HIV-1 from a single…”
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Fibrinogen early in severe trauma study (feisty): Results from an Australian multicentre randomised controlled pilot trial
Published in Critical care and resuscitation (01-03-2021)“…Background: Haemorrhage is a major cause of death in severe trauma. Fibrinogen plays a critical role in maintaining haemostasis in traumatic haemorrhage, and…”
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D‐immunized blood donors who are female and who possess at least one HLA‐DRB115 allele show a propensity for high serum RhIG production
Published in Transfusion (Philadelphia, Pa.) (01-05-2018)“…BACKGROUND D– individuals with previous D‐incompatible pregnancies and/or blood transfusions, as well as those who are actively immunized with small‐volume D+…”
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Mechanisms of HIV non-progression; robust and sustained CD4+ T-cell proliferative responses to p24 antigen correlate with control of viraemia and lack of disease progression after long-term transfusion-acquired HIV-1 infection
Published in Retrovirology (11-12-2008)“…Elite non-progressors (plasma viral load < 50 copies/ml while antiretroviral naive) constitute a tiny fraction of HIV-infected individuals. After 12 years…”
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Recovery of organ-specific tissue oxygen delivery at restrictive transfusion thresholds after fluid treatment in ovine haemorrhagic shock
Published in Intensive care medicine experimental (04-04-2022)“…Background Fluid resuscitation is the standard treatment to restore circulating blood volume and pressure after massive haemorrhage and shock. Packed red blood…”
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Identification of genetic polymorphisms that predict responder/non-responder profiles to the RhD antigen
Published in Molecular immunology (01-12-2015)“…•Anti-D donors exhibit a wide range of responder profiles to the RhD antigen.•Immunological and inflammatory SNPs are associated with responder profiles.•A…”
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Pathogenicity and immunogenicity of attenuated, nef-deleted HIV-1 strains in vivo
Published in Retrovirology (23-09-2007)“…In efforts to develop an effective vaccine, sterilizing immunity to primate lentiviruses has only been achieved by the use of live attenuated viruses carrying…”
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Possible clearance of transfusion-acquired nef/LTR-deleted attenuated HIV-1 infection by an elite controller with CCR5 Δ32 heterozygous and HLA-B57 genotype
Published in Journal of Virus Eradication (01-04-2019)“…Background: Subject C135 is one of the members of the Sydney Blood Bank Cohort, infected in 1981 through transfusion with attenuated nef/3′ long terminal…”
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Influence of HLA gene polymorphisms on susceptibility and outcome post infection with the SARS-CoV virus
Published in Virologica Sinica (01-04-2014)“…Dear Editor,Severe Acute Respiratory Syndrome (SARS) has been described as the first pandemic of the 21 st century and between November 2002 and July 2003,over…”
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Identification of circulating antigen-specific CD4+ T lymphocytes with a CCR5+, cytotoxic phenotype in an HIV-1 long-term nonprogressor and in CMV infection
Published in Blood (15-03-2004)“…Antigen-specific CD4+ effector T cells primarily provide help for B-cell antibody responses and CD8+ cytotoxic T-lymphocyte (CTL) responses. We have found an…”
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Longitudinal microarray analysis of cell surface antigens on peripheral blood mononuclear cells from HIV+ individuals on highly active antiretroviral therapy
Published in Retrovirology (04-03-2008)“…The efficacy of highly active antiretroviral therapy (HAART) determined by simultaneous monitoring over 100 cell-surface antigens overtime has not been…”
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Using Antibody Arrays to Detect Microparticles from Acute Coronary Syndrome Patients Based on Cluster of Differentiation (CD) Antigen Expression
Published in Molecular & cellular proteomics (01-04-2009)“…Microparticles circulate in plasma and have recently emerged as potential inflammatory markers in cardiovascular disease. They are fragments of cell membranes…”
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