Search Results - "Dyer, Roy B"

Mutant Huntingtin Impairs Axonal Trafficking in Mammalian Neurons In Vivo and In Vitro by Trushina, Eugenia, Dyer, Roy B, Badger, 2nd, John D, Ure, Daren, Eide, Lars, Tran, David D, Vrieze, Brent T, Legendre-Guillemin, Valerie, McPherson, Peter S, Mandavilli, Bhaskar S, Van Houten, Bennett, Zeitlin, Scott, McNiven, Mark, Aebersold, Ruedi, Hayden, Michael, Parisi, Joseph E, Seeberg, Erling, Dragatsis, Ioannis, Doyle, Kelly, Bender, Anna, Chacko, Celin, McMurray, Cynthia T

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Protection conferred by myocardial ATP-sensitive K+ channels in pressure overload-induced congestive heart failure revealed in KCNJ11 Kir6.2-null mutant by Yamada, Satsuki, Kane, Garvan C., Behfar, Atta, Liu, Xiao‐Ke, Dyer, Roy B., Faustino, Randolph S., Miki, Takashi, Seino, Susumu, Terzic, Andre

“…Ventricular load can precipitate development of the heart failure syndrome, yet the molecular components that control the cardiac adaptive response to imposed…”
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Rhamnose Is Superior to Mannitol as a Monosaccharide in the Dual Sugar Absorption Test: A Prospective Randomized Study in Children With Treatment-Naïve Celiac Disease by Holtz, Lori R, Hoffmann, Julie, Linneman, Laura, He, Mai, Smyrk, Thomas C, Liu, Ta-Chiang, Shaikh, Nurmohammad, Rodriguez, Cynthia, Dyer, Roy B, Singh, Ravinder J, Faubion, William A

“…We sought to correlate two different measures of gut permeability [lactulose:mannitol (L:M) and lactulose:rhamnose (L:R)] to the severity of duodenal…”
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Development and Validation of Test for “Leaky Gut” Small Intestinal and Colonic Permeability Using Sugars in Healthy Adults by Khoshbin, Katayoun, Khanna, Lehar, Maselli, Daniel, Atieh, Jessica, Breen-Lyles, Margaret, Arndt, Kayla, Rhoten, Deborah, Dyer, Roy B., Singh, Ravinder J., Nayar, Sunita, Bjerkness, Sandra, Harmsen, William S., Busciglio, Irene, Camilleri, Michael

“…Oral monosaccharides and disaccharides are used to measure in vivo human gut permeability through urinary excretion. The aims were as follows: (1) to obtain…”
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Increased Bile Acid Biosynthesis Is Associated With Irritable Bowel Syndrome With Diarrhea by Wong, Banny S, Camilleri, Michael, Carlson, Paula, McKinzie, Sanna, Busciglio, Irene, Bondar, Olga, Dyer, Roy B, Lamsam, Jesse, Zinsmeister, Alan R

“…Background & Aims Variations in genes that regulate bile acid (BA) synthesis are associated with colonic transit in patients with irritable bowel syndrome…”
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Analysis of vitamin D3-sulfate and 25-hydroxyvitamin D3-sulfate in breastmilk by LC-MS/MS by Reynolds, Carmen J., Dyer, Roy B., Vizenor, Brady A., Koszewski, Nicholas J., Singh, Ravinder J., Thacher, Tom D.

“…•LC-MS/MS methods for vitamin D3-sulfate and 25OHD3-sulfate in breastmilk.•Vitamin D3-sulfate is more abundant in breastmilk than 25OHD3-sulfate.•Vitamin D…”
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Microtubule Destabilization and Nuclear Entry Are Sequential Steps Leading to Toxicity in Huntington's Disease by Trushina, Eugenia, Heldebrant, Michael P., Perez-Terzic, Carmen M., Bortolon, Ryan, Kovtun, Irina V., Badger, John D., Terzic, Andre, Estévez, Alvaro, Windebank, Anthony J., Dyer, Roy B., Yao, Janet, McMurray, Cynthia T.

“…There has been a longstanding debate regarding the role of proteolysis in Huntington's disease. The toxic peptide theory posits that N-terminal cleavage…”
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Sex differences in NSAID‐induced perturbation of human intestinal barrier function and microbiota by Edogawa, Shoko, Peters, Stephanie A., Jenkins, Gregory D., Gurunathan, Sakteesh V., Sundt, Wendy J., Johnson, Stephen, Lennon, Ryan J., Dyer, Roy B., Camilleri, Michael, Kashyap, Purna C., Farrugia, Gianrico, Chen, Jun, Singh, Ravinder J., Grover, Madhusudan

“…ABSTRACT Intestinal barrier function and microbiota are integrally related and play critical roles in maintenance of host physiology. Sex is a key biologic…”
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Detection of Alzheimer's disease amyloid beta 1‐42, p‐tau, and t‐tau assays by Harten, Argonde C., Wiste, Heather J., Weigand, Stephen D., Mielke, Michelle M., Kremers, Walter K., Eichenlaub, Udo, Dyer, Roy B., Algeciras‐Schimnich, Alicia, Knopman, David S., Jack, Clifford R., Petersen, Ronald C.

“…Introduction We aimed to provide cut points for the automated Elecsys Alzheimer's disease (AD) cerebrospinal fluid (CSF) biomarkers. Methods Cut points for…”
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Sulfated vitamin D metabolites represent prominent roles in serum and in breastmilk of lactating women by Reynolds, Carmen J., Dyer, Roy B., Oberhelman-Eaton, Sara S., Konwinski, Brianna L., Weatherly, Renee M., Singh, Ravinder J., Thacher, Tom D.

“…Concentrations of vitamin D (VitD) and 25-hydroxyvitamin D (25OHD) in breastmilk are low despite the essential role of VitD for normal infant bone development,…”
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CSF biomarkers in Olmsted County: Evidence of 2 subclasses and associations with demographics by Van Harten, Argonde C., Wiste, Heather J., Weigand, Stephen D., Mielke, Michelle M., Kremers, Walter K., Eichenlaub, Udo, Batrla-Utermann, Richard, Dyer, Roy B., Algeciras-Schimnich, Alicia, Knopman, David S., Jack, Clifford R., Petersen, Ronald C.

“…We studied interrelationships between CSF biomarkers and associations with ε4 genotype, demographic variables, vascular variables, and clinical diagnosis in…”
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Constipation-Predominant Irritable Bowel Syndrome Females Have Normal Colonic Barrier and Secretory Function by Peters, Stephanie A, Edogawa, Shoko, Sundt, Wendy J, Dyer, Roy B, Dalenberg, Daniel A, Mazzone, Amelia, Singh, Ravinder J, Moses, Natalie, Smyrk, Thomas C, Weber, Christopher, Linden, David R, MacNaughton, Wallace K, Turner, Jerrold R, Camilleri, Michael, Katzka, David A, Farrugia, Gianrico, Grover, Madhusudan

“…The objective of this study was to determine whether constipation-predominant irritable bowel syndrome (IBS-C) is associated with changes in intestinal barrier…”
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Measurement of gut permeability using fluorescent tracer agent technology by Dorshow, Richard B., Hall-Moore, Carla, Shaikh, Nurmohammad, Talcott, Michael R., Faubion, William A., Rogers, Thomas E., Shieh, Jeng Jong, Debreczeny, Martin P., Johnson, James R., Dyer, Roy B., Singh, Ravinder J., Tarr, Phillip I.

“…The healthy gut restricts macromolecular and bacterial movement across tight junctions, while increased intestinal permeability accompanies many intestinal…”
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Candidate Serum Biomarkers for Prostate Adenocarcinoma Identified by mRNA Differences in Prostate Tissue and Verified with Protein Measurements in Tissue and Blood by KLEE, Eric W, BONDAR, Olga P, GOODMANSON, Marcia K, DYER, Roy B, ERDOGAN, Sibel, BERGSTRALH, Eric J, BERGEN, H. Robert, SEBO, Thomas J, KLEE, George G

“…Improved tests are needed for detection and management of prostate cancer. We hypothesized that differential gene expression in prostate tissue could help…”
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Mutant huntingtin inhibits clathrin-independent endocytosis and causes accumulation of cholesterol in vitro and in vivo by Trushina, Eugenia, Singh, Raman Deep, Dyer, Roy B., Cao, Sheng, Shah, Vijay H., Parton, Robert G., Pagano, Richard E., McMurray, Cynthia T.

“…We show that the mutant Huntington's disease (HD) protein (mhtt) specifically inhibits endocytosis in primary striatal neurons. Unexpectedly, mhtt does not…”
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Measurement of Gut Permeability Using Fluorescent Tracer agent Technology by Dorshow, Richard, Hall-Moore, Carla, Shaikh, Nurmohammad, Talcott, Michael, Faubion, William, Rogers, Thomas E, Shieh, Jeng J, Debreczeny, Martin P, Johnson, James R, Dyer, Roy B, Singh, Ravinder J, Tarr, Phillip I

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Immunological and Mass Spectrometric Assays of SHBG: Consistent and Inconsistent Metabolic Associations in Healthy Men by Veldhuis, Johannes D, Bondar, Olga P, Dyer, Roy B, Trushin, Sergey A, Klee, Eric W, Singh, Ravinder J, Klee, George G

“…Context: SHBG concentrations correlate inconsistently with metabolic parameters. Hypothesis: SHBG assay platforms contribute to nonuniformities according to…”
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KCNJ11 gene knockout of the Kir6.2 KATP channel causes maladaptive remodeling and heart failure in hypertension by KANE, Garvan C, BEHFAR, Atta, DYER, Roy B, FEARGHAS O'COCHLAIN, D, LIU, Xiao-Ke, HODGSON, Denice M, REYES, Santiago, MIKI, Takashi, SEINO, Susumu, TERZIC, Andre

“…Heart failure is a growing epidemic, with systemic hypertension a major risk factor for development of disease. However, the molecular determinants that…”
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Interleukins 6 and 8 and abdominal fat depots are distinct correlates of lipid moieties in healthy pre- and postmenopausal women by Veldhuis, Johannes D., Dyer, Roy B., Trushin, Sergey A., Bondar, Olga P., Singh, Ravinder J., Klee, George G.

“…Available data associate lipids concentrations in men with body mass index, anabolic steroids, age, and certain cytokines. Data were less clear in women,…”
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KCNJ11 gene knockout of the Kir6.2 K ATP channel causes maladaptive remodeling and heart failure in hypertension by Kane, Garvan C., Behfar, Atta, Dyer, Roy B., O'Cochlain, D. Fearghas, Liu, Xiao-Ke, Hodgson, Denice M., Reyes, Santiago, Miki, Takashi, Seino, Susumu, Terzic, Andre

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