Search Results - "Dwyer, Jennifer"

Hormonal Treatments for Major Depressive Disorder: State of the Art by Dwyer, Jennifer B, Aftab, Awais, Radhakrishnan, Rajiv, Widge, Alik, Rodriguez, Carolyn I, Carpenter, Linda L, Nemeroff, Charles B, McDonald, William M, Kalin, Ned H

“…Major depressive disorder is a common psychiatric disorder associated with marked suffering, morbidity, mortality, and cost. The World Health Organization…”
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Annual Research Review: Defining and treating pediatric treatment‐resistant depression by Dwyer, Jennifer B., Stringaris, Argyris, Brent, David A., Bloch, Michael H.

“…Background Adolescent major depressive disorder (MDD) is a significant health problem, associated with substantial morbidity, cost, and mortality. Depression…”
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The dynamic effects of nicotine on the developing brain by Dwyer, Jennifer B, McQuown, Susan C, Leslie, Frances M

“…Nicotinic acetylcholine receptors (nAChRs) regulate critical aspects of brain maturation during the prenatal, early postnatal, and adolescent periods. During…”
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A Developmental Perspective of Dopaminergic Dysfunction in Tourette Syndrome by Dwyer, Jennifer B.

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Adolescent Maturation of Dopamine D1 and D2 Receptor Function and Interactions in Rodents by Dwyer, Jennifer B, Leslie, Frances M

“…Adolescence is a developmental period characterized by heightened vulnerability to illicit drug use and the onset of neuropsychiatric disorders. These clinical…”
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An Integrated Neuroscience Perspective on Formulation and Treatment Planning for Posttraumatic Stress Disorder: An Educational Review by Ross, David A, Arbuckle, Melissa R, Travis, Michael J, Dwyer, Jennifer B, van Schalkwyk, Gerrit I, Ressler, Kerry J

“…Posttraumatic stress disorder (PTSD) is a common psychiatric illness, increasingly in the public spotlight in the United States due its prevalence in the…”
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Efficacy of Intravenous Ketamine in Adolescent Treatment-Resistant Depression: A Randomized Midazolam-Controlled Trial by Dwyer, Jennifer B, Landeros-Weisenberger, Angeli, Johnson, Jessica A, Londono Tobon, Amalia, Flores, José M, Nasir, Madeeha, Couloures, Kevin, Sanacora, Gerard, Bloch, Michael H

“…Objective:Adolescent depression is prevalent and is associated with significant morbidity and mortality. Although intravenous ketamine has shown efficacy in…”
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TRPC4/5 inhibitors: Phase I results and proof of concept studies by Grimm, Simone, Just, Stefan, Fuertig, Rene, Dwyer, Jennifer B, Sharma, Vikas M, Wunder, Andreas

“…Transient receptor potential canonical (TRPC) ion channels are expressed in areas of the brain responsible for processing emotion and mood and have been…”
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Human prostatic acid phosphatase: structure, function and regulation by Muniyan, Sakthivel, Chaturvedi, Nagendra K, Dwyer, Jennifer G, Lagrange, Chad A, Chaney, William G, Lin, Ming-Fong

“…Human prostatic acid phosphatase (PAcP) is a 100 kDa glycoprotein composed of two subunits. Recent advances demonstrate that cellular PAcP (cPAcP) functions as…”
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Glutamate Systems in DSM-5 Anxiety Disorders: Their Role and a Review of Glutamate and GABA Psychopharmacology by Nasir, Madeeha, Trujillo, Daniel, Levine, Jessica, Dwyer, Jennifer B, Rupp, Zachary W, Bloch, Michael H

“…Serotonin reuptake inhibitors and benzodiazepines are evidence-based pharmacological treatments for Anxiety Disorders targeting serotonin and GABAergic…”
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Lipin proteins and metabolic homeostasis by Reue, Karen, Dwyer, Jennifer R.

“…The lipin protein family, consisting of three members, was first identified early this century. In the last few years, the lipin proteins have been shown to…”
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Oxysterols Are Novel Activators of the Hedgehog Signaling Pathway in Pluripotent Mesenchymal Cells by Dwyer, Jennifer R., Sever, Navdar, Carlson, Marc, Nelson, Stanley F., Beachy, Philip A., Parhami, Farhad

“…Pluripotent mesenchymal cells form a population of precursors to a variety of cell types, including osteoblasts and adipocytes. Aging tilts the balance in…”
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Lipins, lipinopathies, and the modulation of cellular lipid storage and signaling by Csaki, Lauren S., Dwyer, Jennifer R., Fong, Loren G., Tontonoz, Peter, Young, Stephen G., Reue, Karen

“…Members of the lipin protein family are phosphatidate phosphatase (PAP) enzymes, which catalyze the dephosphorylation of phosphatidic acid to diacylglycerol,…”
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Ketamine as a Treatment for Adolescent Depression: A Case Report by Dwyer, Jennifer B., MD, PhD, Beyer, Chad, BA, Wilkinson, Samuel T., MD, Ostroff, Robert B., MD, Qayyum, Zheala, MD, Bloch, Michael H., MD, MS

“…Ketamine has been demonstrated to be an effective, rapidly acting treatment for adults with major depressive disorder (MDD) in multiple randomized, controlled…”
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Nfkbid Overexpression in Nonobese Diabetic Mice Elicits Complete Type 1 Diabetes Resistance in Part Associated with Enhanced Thymic Deletion of Pathogenic CD8 T Cells and Increased Numbers and Activity of Regulatory T Cells by Dwyer, Jennifer R, Racine, Jeremy J, Chapman, Harold D, Quinlan, Anna, Presa, Maximiliano, Stafford, Grace A, Schmitz, Ingo, Serreze, David V

“…Type 1 diabetes (T1D) in both humans and NOD mice is caused by T cell-mediated autoimmune destruction of pancreatic β cells. Increased frequency or activity of…”
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Nuclear pore protein NUP210 depletion suppresses metastasis through heterochromatin-mediated disruption of tumor cell mechanical response by Amin, Ruhul, Shukla, Anjali, Zhu, Jacqueline Jufen, Kim, Sohyoung, Wang, Ping, Tian, Simon Zhongyuan, Tran, Andy D., Paul, Debasish, Cappell, Steven D., Burkett, Sandra, Liu, Huaitian, Lee, Maxwell P., Kruhlak, Michael J., Dwyer, Jennifer E., Simpson, R. Mark, Hager, Gordon L., Ruan, Yijun, Hunter, Kent W.

“…Mechanical signals from the extracellular microenvironment have been implicated in tumor and metastatic progression. Here, we identify nucleoporin NUP210 as a…”
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Modern Microglia: Novel Targets in Psychiatric Neuroscience by Dwyer, Jennifer B, Ross, David A

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Nicotine and brain development by Dwyer, Jennifer B., Broide, Ron S., Leslie, Frances M.

“…Preclinical studies, using primarily rodent models, have shown acetylcholine to have a critical role in brain maturation via activation of nicotinic…”
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Profiling the cancer-prone microenvironment in a zebrafish model for MPNST by Cero, Cheryl, House, John S., Verdi, Vincenzo, Ferguson, Jordan L., Jima, Dereje D., Selmek, Aubrie A., Patania, Olivia M., Dwyer, Jennifer E., Wei, Bih-Rong, Lloyd, Dillon T., Shive, Heather R.

“…Abstract Microenvironmental contributions to soft tissue sarcoma progression are relatively undefined, particularly during sarcoma onset. Use of animal models…”
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Efficacy, Tolerability, and Pharmacokinetics of Combined Targeted MEK and Dual mTORC1/2 Inhibition in a Preclinical Model of Mucosal Melanoma by Wei, Bih-Rong, Hoover, Shelley B, Peer, Cody J, Dwyer, Jennifer E, Adissu, Hibret A, Shankarappa, Priya, Yang, Howard, Lee, Maxwell, Peat, Tyler J, Figg, William D, Simpson, R Mark

“…Melanomas arising in the mucous membranes are a rare and aggressive subtype. New treatment approaches are needed, yet accumulating sufficient evidence to…”
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