Search Results - "Dwight, Timothy A"

Discovery of Brigatinib (AP26113), a Phosphine Oxide-Containing, Potent, Orally Active Inhibitor of Anaplastic Lymphoma Kinase by Huang, Wei-Sheng, Liu, Shuangying, Zou, Dong, Thomas, Mathew, Wang, Yihan, Zhou, Tianjun, Romero, Jan, Kohlmann, Anna, Li, Feng, Qi, Jiwei, Cai, Lisi, Dwight, Timothy A, Xu, Yongjin, Xu, Rongsong, Dodd, Rory, Toms, Angela, Parillon, Lois, Lu, Xiaohui, Anjum, Rana, Zhang, Sen, Wang, Frank, Keats, Jeffrey, Wardwell, Scott D, Ning, Yaoyu, Xu, Qihong, Moran, Lauren E, Mohemmad, Qurish K, Jang, Hyun Gyung, Clackson, Tim, Narasimhan, Narayana I, Rivera, Victor M, Zhu, Xiaotian, Dalgarno, David, Shakespeare, William C

“…In the treatment of echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase positive (ALK+) non-small-cell lung cancer (NSCLC),…”
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C−C Bond Formation via Double C−H Functionalization:  Aerobic Oxidative Coupling as a Method for Synthesizing Heterocoupled Biaryls by Dwight, Timothy A, Rue, Nicholas R, Charyk, Dagmara, Josselyn, Ryan, DeBoef, Brenton

“…The aerobic oxidative coupling of arenes such as benzofuran and N-substituted indoles with benzene and derivatives thereof is described. The reaction is shown…”
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Fluorinated Nucleotide Modifications Modulate Allele Selectivity of SNP-Targeting Antisense Oligonucleotides by Østergaard, Michael E., Nichols, Josh, Dwight, Timothy A., Lima, Walt, Jung, Michael E., Swayze, Eric E., Seth, Punit P.

“…Antisense oligonucleotides (ASOs) have the potential to discriminate between subtle RNA mismatches such as SNPs. Certain mismatches, however, allow ASOs to…”
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Remarkable and Unexpected Mechanism for (S)‑3-Amino-4-(difluoromethylenyl)cyclohex-1-ene-1-carboxylic Acid as a Selective Inactivator of Human Ornithine Aminotransferase by Zhu, Wei, Doubleday, Peter F, Butrin, Arseniy, Weerawarna, Pathum M, Melani, Rafael D, Catlin, Daniel S, Dwight, Timothy A, Liu, Dali, Kelleher, Neil L, Silverman, Richard B

“…Human ornithine aminotransferase (hOAT) is a pyridoxal 5′-phosphate (PLP)-dependent enzyme that was recently found to play an important role in the metabolic…”
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Oxidant-controlled regioselectivity in the oxidative arylation of N-acetylindoles by Potavathri, Shathaverdhan, Dumas, Ashley S., Dwight, Timothy A., Naumiec, Gregory R., Hammann, Jeffrey M., DeBoef, Brenton

“…N-Acetylindoles can be oxidatively coupled with arenes such as benzene or pentafluorobenzene in dioxane. The use of Cu(OAc) 2 as the stoichiometric oxidant…”
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Synthesis and Duplex-Stabilizing Properties of Fluorinated N-Methanocarbathymidine Analogues Locked in the C3′-endo Conformation by Jung, Michael E., Dwight, Timothy A., Vigant, Frederic, Østergaard, Michael E., Swayze, Eric E., Seth, Punit P.

“…The efficient synthesis, antiviral activity, and duplex‐stabilizing properties of both isomers of the 2′‐fluoro analogue of Northern methanocarbathymidine…”
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Synthesis of 2-Ethenylcyclopropyl Aryl Ketones via Intramolecular S N 2-like Displacement of an Ester by Jung, Michael E, Sun, Daniel L, Dwight, Timothy A, Yu, Peiyuan, Li, Wei, Houk, K N

“…The efficient synthesis of trans-2-ethenylcyclopropyl aryl ketones via an intramolecular S 2-like displacement of an allylic ester is reported. A novel…”
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Synthesis of 2‑Ethenylcyclopropyl Aryl Ketones via Intramolecular SN2‑like Displacement of an Ester by Jung, Michael E, Sun, Daniel L, Dwight, Timothy A, Yu, Peiyuan, Li, Wei, Houk, K. N

“…The efficient synthesis of trans-2-ethenylcyclopropyl aryl ketones via an intramolecular SN2-like displacement of an allylic ester is reported. A novel…”
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Synthesis and Duplex-Stabilizing Properties of Fluorinated N-Methanocarbathymidine Analogues Locked in the C3′-endo Conformation by Jung, Michael E., Dwight, Timothy A., Vigant, Frederic, Østergaard, Michael E., Swayze, Eric E., Seth, Punit P.

“…The efficient synthesis, antiviral activity, and duplex‐stabilizing properties of both isomers of the 2′‐fluoro analogue of Northern methanocarbathymidine…”
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C-C Bond Formation via Double C-H Functionalization: Aerobic Oxidative Coupling as a Method for Synthesizing Heterocoupled Bisarenes by Dwight, Timothy A., Rue, Nicholas R., Charyk, Dagmara, Josselyn, Ryan, DeBoef, Brenton

“…The aerobic oxidative coupling of arenes such as benzofuran and N -substituted indoles with benzene and derivatives thereof is described. The reaction is shown…”
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