Search Results - "Dvorozniak, Mark T"

Discovery of PiragliatinFirst Glucokinase Activator Studied in Type 2 Diabetic Patients by Sarabu, Ramakanth, Bizzarro, Fred T, Corbett, Wendy L, Dvorozniak, Mark T, Geng, Wanping, Grippo, Joseph F, Haynes, Nancy-Ellen, Hutchings, Stanley, Garofalo, Lisa, Guertin, Kevin R, Hilliard, Darryl W, Kabat, Marek, Kester, Robert F, Ka, Wang, Liang, Zhenmin, Mahaney, Paige E, Marcus, Linda, Matschinsky, Franz M, Moore, David, Racha, Jagdish, Radinov, Roumen, Ren, Yi, Qi, Lida, Pignatello, Michael, Spence, Cheryl L, Steele, Thomas, Tengi, John, Grimsby, Joseph

“…Glucokinase (GK) activation as a potential strategy to treat type 2 diabetes (T2D) is well recognized. Compound 1, a glucokinase activator (GKA) lead that we…”
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Allosteric Activators of Glucokinase: Potential Role in Diabetes Therapy by Grimsby, Joseph, Sarabu, Ramakanth, Corbett, Wendy L., Haynes, Nancy-Ellen, Bizzarro, Fred T., Coffey, John W., Guertin, Kevin R., Hilliard, Darryl W., Kester, Robert F., Mahaney, Paige E., Marcus, Linda, Qi, Lida, Spence, Cheryl L., Tengi, John, Magnuson, Mark A., Chu, Chang An, Dvorozniak, Mark T., Matschinsky, Franz M., Grippo, Joseph F.

“…Glucokinase (GK) plays a key role in whole-body glucose homeostasis by catalyzing the phosphorylation of glucose in cells that express this enzyme, such as…”
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Discovery, Structure−Activity Relationships, Pharmacokinetics, and Efficacy of Glucokinase Activator (2R)-3-Cyclopentyl-2-(4-methanesulfonylphenyl)-N-thiazol-2-yl-propionamide (RO0281675) by Haynes, Nancy-Ellen, Corbett, Wendy L, Bizzarro, Fred T, Guertin, Kevin R, Hilliard, Darryl W, Holland, George W, Kester, Robert F, Mahaney, Paige E, Qi, Lida, Spence, Cheryl L, Tengi, John, Dvorozniak, Mark T, Railkar, Aruna, Matschinsky, Franz M, Grippo, Joseph F, Grimsby, Joseph, Sarabu, Ramakanth

“…Glucokinase (GK) is a glucose sensor that couples glucose metabolism to insulin release. The important role of GK in maintaining glucose homeostasis is…”
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Identification of RO4597014, a Glucokinase Activator Studied in the Clinic for the Treatment of Type 2 Diabetes by Qian, Yimin, Corbett, Wendy L, Berthel, Steven J, Choi, Duk Soon, Dvorozniak, Mark T, Geng, Wanping, Gillespie, Paul, Guertin, Kevin R, Haynes, Nancy-Ellen, Kester, Robert F, Mennona, Francis A, Moore, David, Racha, Jagdish, Radinov, Roumen, Sarabu, Ramakanth, Scott, Nathan R, Grimsby, Joseph, Mallalieu, Navita L

“…To resolve the metabolite redox cycling associated with our earlier clinical compound 2, we carried out lead optimization of lead molecule 1. Compound 4 showed…”
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Characterization of Glucokinase Regulatory Protein-deficient Mice by Grimsby, Joseph, Coffey, John W., Dvorozniak, Mark T., Magram, Jeanne, Li, Guizhu, Matschinsky, Franz M., Shiota, Chiyo, Kaur, Satbir, Magnuson, Mark A., Grippo, Joseph F.

“…The glucokinase regulatory protein (GKRP) inhibits glucokinase competitively with respect to glucose by forming a protein-protein complex with this enzyme. The…”
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Characterization of Glucokinase Regulatory Protein Deficient Mice by GRIMSBY, JOSEPH, COFFEY, JOHN W, DVOROZNIAK, MARK T, LI, GUIZHU, MATSCHINSKY, FRANZ M, SHIOTA, CHIYO, MAGNUSON, MARK A, GRIPPO, JOSEPH F

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A second-generation enzyme immunoassay for detection of antibodies to IFN-alpha by Palleroni, A V, Specian, A, Aglione, A, Dvorozniak, M T, Raman, J

“…We have developed a solid-phase enzyme-linked immunoassay (EIA) for detecting antibodies to interferon-alpha2 (IFN-alpha2) in serum or plasma. In this assay,…”
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