Changes in the Microbiome Profile in Different Parts of the Intestine in Piglets with Diarrhea

Determining the taxonomic composition of microbial consortia of the piglet intestine is of great importance for pig production. However, knowledge on the variety of the intestinal microbiome in newborn piglets is limited. Piglet diarrhea is a serious gastrointestinal disease with a high morbidity an...

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Bibliographic Details
Published in:	Animals (Basel) Vol. 12; no. 3; p. 320
Main Authors:	Gryaznova, Mariya V, Dvoretskaya, Yuliya D, Syromyatnikov, Mikhail Y, Shabunin, Sergey V, Parshin, Pavel A, Mikhaylov, Evgeniy V, Strelnikov, Nikolay A, Popov, Vasily N
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 28-01-2022 MDPI
Subjects:	16S rRNA Animals Bacteria Bacterial infections Bacteroides Coliforms Colon Commensals Composition Data analysis Diarrhea Digestive system Enterococcus Escherichia Feces Fusobacterium Gastrointestinal diseases Genera Hogs Ileum Infections Intestinal microflora Intestine intestines Laboratories Lactobacillus microbiome Microbiomes Microorganisms Morbidity Next-generation sequencing Pathogenesis piglet Rectum Relative abundance rRNA 16S sequencing Shigella Small intestine Software Swine Swine production Weaning United States > US 16S rRNA piglet intestines diarrhea microbiome sequencing
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Summary:	Determining the taxonomic composition of microbial consortia of the piglet intestine is of great importance for pig production. However, knowledge on the variety of the intestinal microbiome in newborn piglets is limited. Piglet diarrhea is a serious gastrointestinal disease with a high morbidity and mortality that causes great economic damage to the pig industry. In this study, we investigated the microbiome of various sections of the piglet intestine and compared the microbiome composition of healthy and diarrheal piglets using high-throughput sequencing of the 16S rRNA gene. The results showed that bacteria of the genus were the most common in the ileum, while and dominated in the rectum. Comparing the microbiome composition of healthy and diarrheal piglets revealed a reduced number of bacteria as a hallmark of diarrhea, as did an increased content of representatives of the genus and a reduced number of , which indicates the contribution of these bacteria to the development of diarrhea in piglets. The relative abundance of bacteria was higher in the diarrhea group. Although some bacteria of this genus are commensals, a small number of species may be associated with the development of diarrhea in piglets. Therefore, our results indicate that the gut microbiome may be an important factor in the development of diarrhea in piglets.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2076-2615 2076-2615
DOI:	10.3390/ani12030320