Search Results - "Duyster, Justus"

Anti-Angiogenics: Current Situation and Future Perspectives by Zirlik, Katja, Duyster, Justus

“…Angiogenesis, the process leading to the formation of new blood vessels, is one of the hallmarks of cancer. Extensive studies established that i) vascular…”
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HIF-1α and HIF-2α differently regulate tumour development and inflammation of clear cell renal cell carcinoma in mice by Hoefflin, Rouven, Harlander, Sabine, Schäfer, Silvia, Metzger, Patrick, Kuo, Fengshen, Schönenberger, Désirée, Adlesic, Mojca, Peighambari, Asin, Seidel, Philipp, Chen, Chia-yi, Consenza-Contreras, Miguel, Jud, Andreas, Lahrmann, Bernd, Grabe, Niels, Heide, Danijela, Uhl, Franziska M., Chan, Timothy A., Duyster, Justus, Zeiser, Robert, Schell, Christoph, Heikenwalder, Mathias, Schilling, Oliver, Hakimi, A. Ari, Boerries, Melanie, Frew, Ian J.

“…Mutational inactivation of VHL is the earliest genetic event in the majority of clear cell renal cell carcinomas (ccRCC), leading to accumulation of the HIF-1α…”
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Demethylating therapy increases anti-CD123 CAR T cell cytotoxicity against acute myeloid leukemia by El Khawanky, Nadia, Hughes, Amy, Yu, Wenbo, Myburgh, Renier, Matschulla, Tony, Taromi, Sanaz, Aumann, Konrad, Clarson, Jade, Vinnakota, Janaki Manoja, Shoumariyeh, Khalid, Miething, Cornelius, Lopez, Angel F., Brown, Michael P., Duyster, Justus, Hein, Lutz, Manz, Markus G., Hughes, Timothy P., White, Deborah L., Yong, Agnes S. M., Zeiser, Robert

“…Successful treatment of acute myeloid leukemia (AML) with chimeric antigen receptor (CAR) T cells is hampered by toxicity on normal hematopoietic progenitor…”
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Combination of Lenvatinib and Pembrolizumab Is an Effective Treatment Option for Anaplastic and Poorly Differentiated Thyroid Carcinoma by Dierks, Christine, Seufert, Jochen, Aumann, Konrad, Ruf, Juri, Klein, Claudius, Kiefer, Selina, Rassner, Michael, Boerries, Melanie, Zielke, Andreas, la Rosee, Paul, Meyer, Philipp Tobias, Kroiss, Matthias, Weißenberger, Christian, Schumacher, Tilmann, Metzger, Patrick, Weiss, Harald, Smaxwil, Constantin, Laubner, Katharina, Duyster, Justus, von Bubnoff, Nikolas, Miething, Cornelius, Thomusch, Oliver

“…Anaplastic thyroid carcinoma (ATC) and metastatic poorly differentiated thyroid carcinomas (PDTCs) are rare aggressive malignancies with poor overall survival…”
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Activity of therapeutic JAK 1/2 blockade in graft-versus-host disease by Spoerl, Silvia, Mathew, Nimitha R., Bscheider, Michael, Schmitt-Graeff, Annette, Chen, Sophia, Mueller, Tony, Verbeek, Mareike, Fischer, Julius, Otten, Vera, Schmickl, Martina, Maas-Bauer, Kristina, Finke, Jürgen, Peschel, Christian, Duyster, Justus, Poeck, Hendrik, Zeiser, Robert, von Bubnoff, Nikolas

“…Graft-versus-host-disease (GVHD) is a severe complication of allogeneic hematopoietic cell transplantation (allo-HCT) characterized by the production of high…”
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Activating JAK-mutations confer resistance to FLT3 kinase inhibitors in FLT3-ITD positive AML in vitro and in vivo by Rummelt, Christoph, Gorantla, Sivahari P., Meggendorfer, Manja, Charlet, Anne, Endres, Cornelia, Döhner, Konstanze, Heidel, Florian H., Fischer, Thomas, Haferlach, Torsten, Duyster, Justus, von Bubnoff, Nikolas

“…An important limitation of FLT3 tyrosine kinase inhibitors (TKIs) in FLT3-ITD positive AML is the development of resistance. To better understand resistance to…”
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Functional Analysis of Epidermal Growth Factor Receptor (EGFR) Mutations and Potential Implications for EGFR Targeted Therapy by KANCHA, Rama Krishna, VON BUBNOFF, Nikolas, PESCHEL, Christian, DUYSTER, Justus

“…Purpose: Epidermal growth factor receptor (EGFR) mutations in non–small cell lung cancer (NSCLC) might be predictive for clinical response to EGFR inhibitor…”
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Allogeneic transplantation of multiple myeloma patients may allow long-term survival in carefully selected patients with acceptable toxicity and preserved quality of life by Greil, Christine, Engelhardt, Monika, Ihorst, Gabriele, Schoeller, Katja, Bertz, Hartmut, Marks, Reinhard, Zeiser, Robert, Duyster, Justus, Einsele, Hermann, Finke, Jürgen, Wäsch, Ralph

“…Despite significantly improved survival and response rates in patients diagnosed with multiple myeloma, it still remains an incurable disease with a poor…”
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Sorafenib in Combination With Intensive Chemotherapy in Elderly Patients With Acute Myeloid Leukemia: Results From a Randomized, Placebo-Controlled Trial by SERVE, Hubert, KRUG, Utz, FISCHER, Thomas, GIAGOUNIDIS, Aristoteles, NEUBAUER, Andreas, REICHLE, Albrecht, AULITZKY, Walter, NOPPENEY, Richard, BLAU, Igor, KUNZMANN, Volker, STUHLMANN, Reingard, KRÄMER, Alwin, WAGNER, Ruth, KREUZER, Karl-Anton, BRANDTS, Christian, STEFFEN, Björn, THIEDE, Christian, MÜLLER-TIDOW, Carsten, EHNINGER, Gerhard, BERDEL, Wolfgang E, SAUERLAND, M. Cristina, HEINECKE, Achim, BRUNNBERG, Uta, SCHAICH, Markus, OTTMANN, Oliver, DUYSTER, Justus, WANDT, Hannes

“…The prognosis of elderly patients with acute myeloid leukemia (AML) is still dismal even with intensive chemotherapy. In this trial, we compared the…”
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Neutrophil granulocytes recruited upon translocation of intestinal bacteria enhance graft-versus-host disease via tissue damage by Schwab, Lukas, Goroncy, Luise, Palaniyandi, Senthilnathan, Gautam, Sanjivan, Triantafyllopoulou, Antigoni, Mocsai, Attila, Reichardt, Wilfried, Karlsson, Fridrik J, Radhakrishnan, Sabarinath V, Hanke, Kathrin, Schmitt-Graeff, Annette, Freudenberg, Marina, von Loewenich, Friederike D, Wolf, Philipp, Leonhardt, Franziska, Baxan, Nicoleta, Pfeifer, Dietmar, Schmah, Oliver, Schönle, Anne, Martin, Stefan F, Mertelsmann, Roland, Duyster, Justus, Finke, Jürgen, Prinz, Marco, Henneke, Philipp, Häcker, Hans, Hildebrandt, Gerhard C, Häcker, Georg, Zeiser, Robert

“…Although neutrophils have crucial functions in microbial killing, they can also trigger tissue damage via the release of reactive oxygen species and…”
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MicroRNA-155–deficient dendritic cells cause less severe GVHD through reduced migration and defective inflammasome activation by Chen, Sophia, Smith, Benjamin A.H., Iype, Joseena, Prestipino, Alessandro, Pfeifer, Dietmar, Grundmann, Sebastian, Schmitt-Graeff, Annette, Idzko, Marco, Beck, Yvonne, Prinz, Gabriele, Finke, Jürgen, Duyster, Justus, Zeiser, Robert

“…The successful treatment of acute leukemias with allogeneic hematopoietic cell transplantation (allo-HCT) is limited by acute graft-versus-host disease (GVHD)…”
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Ruxolitinib in GvHD (RIG) study: a multicenter, randomized phase 2 trial to determine the response rate of Ruxolitinib and best available treatment (BAT) versus BAT in steroid-refractory acute graft-versus-host disease (aGvHD) (NCT02396628) by von Bubnoff, Nikolas, Ihorst, Gabriele, Grishina, Olga, Röthling, Nadine, Bertz, Hartmut, Duyster, Justus, Finke, Jürgen, Zeiser, Robert

“…Graft-versus-Host Disease (GvHD) causes significant morbidity and mortality in patients after allogeneic stem cell transplantation. Donor T-cells cause…”
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The IL-3, IL-5, and GM-CSF common receptor beta chain mediates oncogenic activity of FLT3-ITD-positive AML by Charlet, Anne, Kappenstein, Max, Keye, Philip, Kläsener, Kathrin, Endres, Cornelia, Poggio, Teresa, Gorantla, Sivahari P., Kreutmair, Stefanie, Sänger, Jana, Illert, Anna L., Miething, Cornelius, Reth, Michael, Duyster, Justus, Rummelt, Christoph, von Bubnoff, Nikolas

“…FLT3-ITD is the most predominant mutation in AML being expressed in about one-third of AML patients and is associated with a poor prognosis. Efforts to better…”
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Donor lymphocyte infusions after first allogeneic hematopoietic stem-cell transplantation in adults with acute myeloid leukemia: a single-center landmark analysis by Rettig, Andrés R., Ihorst, Gabriele, Bertz, Hartmut, Lübbert, Michael, Marks, Reinhard, Waterhouse, Miguel, Wäsch, Ralph, Zeiser, Robert, Duyster, Justus, Finke, Jürgen

“…Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is potentially curative for acute myeloid leukemia (AML). The inherent graft-versus-leukemia…”
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The Nlrp3 inflammasome regulates acute graft-versus-host disease by Jankovic, Dragana, Ganesan, Jayanthi, Bscheider, Michael, Stickel, Natalie, Weber, Felix C, Guarda, Greta, Follo, Marie, Pfeifer, Dietmar, Tardivel, Aubry, Ludigs, Kristina, Bouazzaoui, Abdellatif, Kerl, Katrin, Fischer, Julius C, Haas, Tobias, Schmitt-Gräff, Annette, Manoharan, Anand, Müller, Leonard, Finke, Jürgen, Martin, Stefan F, Gorka, Oliver, Peschel, Christian, Ruland, Jürgen, Idzko, Marco, Duyster, Justus, Holler, Ernst, French, Lars E, Poeck, Hendrik, Contassot, Emmanuel, Zeiser, Robert

“…The success of allogeneic hematopoietic cell transplantation is limited by acute graft-versus-host disease (GvHD), a severe complication accompanied by high…”
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Graft-versus-host disease of the CNS is mediated by TNF upregulation in microglia by Mathew, Nimitha R, Vinnakota, Janaki M, Apostolova, Petya, Erny, Daniel, Hamarsheh, Shaimaa, Andrieux, Geoffroy, Kim, Jung-Seok, Hanke, Kathrin, Goldmann, Tobias, Chappell-Maor, Louise, El-Khawanky, Nadia, Ihorst, Gabriele, Schmidt, Dominik, Duyster, Justus, Finke, Jürgen, Blank, Thomas, Boerries, Melanie, Blazar, Bruce R, Jung, Steffen, Prinz, Marco, Zeiser, Robert

“…Acute graft-versus-host disease (GVHD) can affect the central nervous system (CNS). The role of microglia in CNS-GVHD remains undefined. In agreement with…”
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Bile acids regulate intestinal antigen presentation and reduce graft-versus-host disease without impairing the graft-versus-leukemia effect by Haring, Eileen, Uhl, Franziska M, Andrieux, Geoffroy, Proietti, Michele, Bulashevska, Alla, Sauer, Barbara, Braun, Lukas M, de Vega Gomez, Enrique, Esser, Philipp R, Martin, Stefan F, Pfeifer, Dietmar, Follo, Marie, Schmitt-Graeff, Annette, Buescher, Joerg, Duyster, Justus, Grimbacher, Bodo, Boerries, Melanie, Pearce, Erika L, Zeiser, Robert, Apostolova, Petya

“…Acute graft-versus-host disease causes significant mortality in patients undergoing allogeneic hematopoietic cell transplantation. Immunosuppressive treatment…”
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Differential sensitivity of ERBB2 kinase domain mutations towards lapatinib by Kancha, Rama Krishna, von Bubnoff, Nikolas, Bartosch, Natalie, Peschel, Christian, Engh, Richard A, Duyster, Justus

“…Overexpression of the ERBB2 kinase is observed in about one-third of breast cancer patients and the dual ERBB1/ERBB2 kinase inhibitor lapatinib was recently…”
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A newly identified 45‐kDa JAK2 variant with an altered kinase domain structure represents a novel mode of JAK2 kinase inhibitor resistance by Gorantla, Sivahari Prasad, Mueller, Tony Andreas, Albers‐Leischner, Corinna, Rudelius, Martina, Bubnoff, Nikolas, Duyster, Justus

“…Tyrosine‐protein kinase (janus kinase; JAK)–signal transducer and activator of transcription (STAT) signaling plays a pivotal role in the development of…”
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Early assessment of circulating tumor DNA after curative‐intent resection predicts tumor recurrence in early‐stage and locally advanced non‐small‐cell lung cancer by Waldeck, Silvia, Mitschke, Jan, Wiesemann, Sebastian, Rassner, Michael, Andrieux, Geoffroy, Deuter, Max, Mutter, Jurik, Lüchtenborg, Anne‐Marie, Kottmann, Daniel, Titze, Laurin, Zeisel, Christoph, Jolic, Martina, Philipp, Ulrike, Lassmann, Silke, Bronsert, Peter, Greil, Christine, Rawluk, Justyna, Becker, Heiko, Isbell, Lisa, Müller, Alexandra, Doostkam, Soroush, Passlick, Bernward, Börries, Melanie, Duyster, Justus, Wehrle, Julius, Scherer, Florian, von Bubnoff, Nikolas

“…Circulating tumor DNA (ctDNA) has demonstrated great potential as a noninvasive biomarker to assess minimal residual disease (MRD) and profile tumor genotypes…”
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