Search Results - "Dutton, Richard W"

IL-10 Deficiency Unleashes an Influenza-Specific Th17 Response and Enhances Survival against High-Dose Challenge by McKinstry, K. Kai, Strutt, Tara M, Buck, Amanda, Curtis, Jonathan D, Dibble, John P, Huston, Gail, Tighe, Michael, Hamada, Hiromasa, Sell, Stewart, Dutton, Richard W, Swain, Susan L

“…We examined the expression and influence of IL-10 during influenza infection. We found that IL-10 does not impact sublethal infection, heterosubtypic immunity,…”
Get full text

Tc17 cells are capable of mediating immunity to vaccinia virus by acquisition of a cytotoxic phenotype by Yeh, Norman, Glosson, Nicole L, Wang, Nan, Guindon, Lynette, McKinley, Carl, Hamada, Hiromasa, Li, Qingsheng, Dutton, Richard W, Shrikant, Protul, Zhou, Baohua, Brutkiewicz, Randy R, Blum, Janice S, Kaplan, Mark H

“…CD8 T cells can acquire cytokine-secreting phenotypes paralleling cytokine production from Th cells. IL-17-secreting CD8 T cells, termed Tc17 cells, were shown…”
Get full text

Memory CD4+ T cells protect against influenza through multiple synergizing mechanisms by McKinstry, K Kai, Strutt, Tara M, Kuang, Yi, Brown, Deborah M, Sell, Stewert, Dutton, Richard W, Swain, Susan L

“…Memory CD4+ T cells combat viral infection and contribute to protective immune responses through multiple mechanisms, but how these pathways interact is…”
Get full text

Tc17, a Unique Subset of CD8 T Cells That Can Protect against Lethal Influenza Challenge by Hamada, Hiromasa, Garcia-Hernandez, Maria de la Luz, Reome, Joyce B, Misra, Sara K, Strutt, Tara M, McKinstry, Kai K, Cooper, Andrea M, Swain, Susan L, Dutton, Richard W

“…We show here that IL-17-secreting CD4 T (Th)17 and CD8 T (Tc)17 effector cells are found in the lung following primary challenge with influenza A and that…”
Get full text

Durable CD4 T-Cell Memory Generation Depends on Persistence of High Levels of Infection at an Effector Checkpoint that Determines Multiple Fates by Swain, Susan L, Jones, Michael C, Devarajan, Priyadharshini, Xia, Jingya, Dutton, Richard W, Strutt, Tara M, McKinstry, K Kai

“…We have discovered that the determination of CD4 effector and memory fates after infection is regulated not only by initial signals from antigen and pathogen…”
Get full text

Multipronged CD4+ T-cell effector and memory responses cooperate to provide potent immunity against respiratory virus by Strutt, Tara M., McKinstry, K. Kai, Marshall, Nikki B., Vong, Allen M., Dutton, Richard W., Swain, Susan L.

“…Summary Over the last decade, the known spectrum of CD4+ T‐cell effector subsets has become much broader, and it has become clear that there are multiple…”
Get full text

Memory CD4 + T cells induce innate responses independently of pathogen by Strutt, Tara M, Huston, Gail, Dibble, John P, Swain, Susan L, McKinstry, K Kai, Winchell, Caylin, Kuang, Yi, Curtis, Jonathan D, Dutton, Richard W

“…Innate immune responses markedly affect subsequent adaptive responses. Here the authors show that adaptive immunity in the form of memory CD4 + T cells can…”
Get full text

Multiple redundant effector mechanisms of CD8+ T cells protect against influenza infection by Hamada, Hiromasa, Bassity, Elizabeth, Flies, Amanda, Strutt, Tara M, Garcia-Hernandez, Maria de Luz, McKinstry, K Kai, Zou, Tie, Swain, Susan L, Dutton, Richard W

“…We have previously shown that mice challenged with a lethal dose of A/Puerto Rico/8/34-OVA(I) are protected by injection of 4-8 × 10(6) in vitro-generated Tc1…”
Get full text

Adoptive Transfer of Tumor-Specific Tc17 Effector T Cells Controls the Growth of B16 Melanoma in Mice by Garcia-Hernandez, Maria de la Luz, Hamada, Hiromasa, Reome, Joyce B, Misra, Sara K, Tighe, Michael P, Dutton, Richard W

“…In vitro generated OVA-specific IL-17-producing CD8 T effector cells (Tc17) from OT-1 mice, adoptively transferred into B16-OVA tumor-bearing mice, controlled…”
Get full text

Type 1 and type 2 tumor infiltrating effector cell subpopulations in progressive breast cancer by Reome, Joyce B, Hylind, James C, Dutton, Richard W, Dobrzanski, Mark J

“…Effector T cells fall into two subpopulations based on cytokine-secretion. Type 1 cells secrete IFN-γ, whereas type 2 cells secrete IL-4, IL-10, and GM-CSF…”
Get full text

Priming with Cold-Adapted Influenza A Does Not Prevent Infection but Elicits Long-Lived Protection against Supralethal Challenge with Heterosubtypic Virus by Powell, Timothy J, Strutt, Tara, Reome, Joyce, Hollenbaugh, Joseph A, Roberts, Alan D, Woodland, David L, Swain, Susan L, Dutton, Richard W

“…We show in this study several novel features of T cell-based heterosubtypic immunity against the influenza A virus in mice. First, T cell-mediated…”
Get full text

In vitro Studies of the Antibody Response: Antibodies of Different Specificity are Made in Different Populations of Cells by Dutton, Richard W

Get full text

IFN-gamma regulates donor CD8 T cell expansion, migration, and leads to apoptosis of cells of a solid tumor by Hollenbaugh, Joseph A, Dutton, Richard W

“…We previously reported that IFN-gamma secreted by donor cytotoxic T cell 1 (Tc1) cells was the most important factor in promoting EG7 (an OVA transfection the…”
Get full text

Heterogeneity of CD4 + and CD8 + T cells by Woodland, David L, Dutton, Richard W

“…There is extensive plasticity in the T-cell response to antigen. Helper CD4 + T cells, cytotoxic CD8 + T cells, the progression from naı̈ve to effector and…”
Get full text

Memory CD4 T Cell-Mediated Immunity against Influenza A Virus: More than a Little Helpful by Kai McKinstry, K., Dutton, Richard W., Swain, Susan L., Strutt, Tara M.

“…Recent observations have uncovered multiple pathways whereby CD4 T cells can contribute to protective immune responses against microbial threats. Incorporating…”
Get full text

Activated Antigen-Specific CD8+ T Cells Persist in the Lungs Following Recovery from Respiratory Virus Infections by Hogan, Robert J, Usherwood, Edward J, Zhong, Weimin, Roberts, Alan D, Dutton, Richard W, Harmsen, Allen G, Woodland, David L

“…The poor correlation between cellular immunity to respiratory virus infections and the numbers of memory CD8(+) T cells in the secondary lymphoid organs…”
Get full text

Intraepithelial T-cell cytotoxicity, induced bronchus-associated lymphoid tissue, and proliferation of pneumocytes in experimental mouse models of influenza by Sell, Stewart, Guest, Ian, McKinstry, K Kai, Strutt, Tara M, Kohlmeier, Jacob E, Brincks, Erik, Tighe, Mike, Blackman, Marcia A, Woodland, David L, Dutton, Richard W, Swain, Susan L

“…Immunopathologic examination of the lungs of mice with experimental influenza virus infection reveals three prominent findings. (i) There is rapidly developing…”
Get more information

Type 1 and Type 2: a fundamental dichotomy for all T-cell subsets by Carter, Laura L, Dutton, Richard W

“…Cytokine secretion is not confined to CD4 + T cells; rather, Type 1 and Type 2 populations of CD8 + and γδ T cells can also be generated in vitro and isolated…”
Get full text

Naive, Effector, and Memory CD8 T Cells in Protection Against Pulmonary Influenza Virus Infection: Homing Properties Rather Than Initial Frequencies Are Crucial by Cerwenka, Adelheid, Morgan, Tammy M, Dutton, Richard W

“…The goal of adoptive immunotherapy is to target a high number of persisting effector cells to the site of a virus infection or tumor. In this study, we…”
Get full text

Uneven distribution of MHC class II epitopes within the influenza virus by Crowe, Sherry R., Miller, Shannon C., Brown, Deborah M., Adams, Pamela S., Dutton, Richard W., Harmsen, Allen G., Lund, Frances E., Randall, Troy D., Swain, Susan L., Woodland, David L.

“…The identification of T cell epitopes is crucial for the understanding of the host immune response during infection. While much is known about the MHC class…”
Get full text