Search Results - "Duttaroy, Alokesh"

Muscarinic Stimulation of Pancreatic Insulin and Glucagon Release Is Abolished in M3 Muscarinic Acetylcholine Receptor–Deficient Mice by DUTTAROY, Alokesh, ZIMLIKI, Charles L, GAUTAM, Dinesh, YINGHONG CUI, MEARS, David, WESS, Jürgen

“…Muscarinic Stimulation of Pancreatic Insulin and Glucagon Release Is Abolished in M 3 Muscarinic Acetylcholine Receptor–Deficient Mice Alokesh Duttaroy 1 ,…”
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The DPP-4 inhibitor vildagliptin increases pancreatic beta cell mass in neonatal rats by Duttaroy, Alokesh, Voelker, Frank, Merriam, Kimberley, Zhang, Xia, Ren, Xianglin, Subramanian, Kala, Hughes, Thomas E., Burkey, Bryan F.

“…The present study addressed the effect of the dipeptidyl peptidase-4 (DPP-4) inhibitor vildagliptin ((1-[[(3-hydroxy-1-adamantyl) amino]…”
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Novel heterocyclic DPP-4 inhibitors for the treatment of type 2 diabetes by Sutton, Jon M., Clark, David E., Dunsdon, Stephen J., Fenton, Garry, Fillmore, Amanda, Harris, Neil V., Higgs, Chris, Hurley, Chris A., Krintel, Sussie L., MacKenzie, Robert E., Duttaroy, Alokesh, Gangl, Eric, Maniara, Wiesia, Sedrani, Richard, Namoto, Kenji, Ostermann, Nils, Gerhartz, Bernd, Sirockin, Finton, Trappe, Jörg, Hassiepen, Ulrich, Baeschlin, Daniel K.

“…Novel deazaxanthine-based DPP-4 inhibitors have been identified that are potent (IC50 <10nM) and highly selective versus other dipeptidyl peptidases. Their…”
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Deletion of the M5 muscarinic acetylcholine receptor attenuates morphine reinforcement and withdrawal but not morphine analgesia by Basile, Anthony S, Fedorova, Irina, Zapata, Agustin, Liu, Xiaoguang, Shippenberg, Toni, Duttaroy, Alokesh, Yamada, Masahisa, Wess, Jurgen

“…Little is known about the physiological roles of the M 5 muscarinic receptor, the last member of the muscarinic receptor family (M 1 –M 5 ) to be cloned. In…”
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Cholinergic dilation of cerebral blood vessels is abolished in M5 muscarinic acetylcholine receptor knockout mice by Yamada, Masahisa, Lamping, Kathryn G., Duttaroy, Alokesh, Zhang, Weilie, Cui, Yinghong, Bymaster, Frank P., McKinzie, David L., Felder, Christian C., Deng, Chu-Xia, Faraci, Frank M., Wess, Jürgen

“…The M 5 muscarinic receptor is the most recent member of the muscarinic acetylcholine receptor family (M 1 -M 5 ) to be cloned. At present, the physiological…”
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Muscarinic Induction of Hippocampal Gamma Oscillations Requires Coupling of the M1 Receptor to Two Mixed Cation Currents by Fisahn, André, Yamada, Masahisa, Duttaroy, Alokesh, Gan, Jai-Wei, Deng, Chu-Xia, McBain, Chris J, Wess, Jürgen

“…Oscillatory network activity at γ frequencies is assumed to be of major importance in cortical information processing. Whereas the synaptic mechanisms of γ…”
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Mice lacking the M3 muscarinic acetylcholine receptor are hypophagic and lean by Wess, Jürgen, Yamada, Masahisa, Miyakawa, Tsuyoshi, Duttaroy, Alokesh, Yamanaka, Akihiro, Moriguchi, Toru, Makita, Ryosuke, Ogawa, Masaharu, Chou, Chieh J, Xia, Bing, Crawley, Jacqueline N, Felder, Christian C, Deng, Chu-Xia

“…Members of the muscarinic acetylcholine receptor family (M1-M5) have central roles in the regulation of many fundamental physiological functions. Identifying…”
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Discovery of C-(1-aryl-cyclohexyl)-methylamines as selective, orally available inhibitors of dipeptidyl peptidase IV by Namoto, Kenji, Sirockin, Finton, Ostermann, Nils, Gessier, Francois, Flohr, Stefanie, Sedrani, Richard, Gerhartz, Bernd, Trappe, Jörg, Hassiepen, Ulrich, Duttaroy, Alokesh, Ferreira, Suzie, Sutton, Jon M., Clark, David E., Fenton, Garry, Beswick, Mandy, Baeschlin, Daniel K.

“…The successful launches of dipeptidyl peptidase IV (DPP IV) inhibitors as oral anti-diabetics warrant and spur the further quest for additional chemical…”
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Development of a Long-Acting Insulin Analog Using Albumin Fusion Technology by DUTTAROY, Alokesh, KANAKARAJ, Palanisamy, CROSSAN, Dan, BOCK, Jason, KAUFMAN, Thomas E, REAVEY, Peter, CAREY-BARBER, Melisa, KRISHNAN, Surekha R, GARCIA, Andy, MURPHY, Kelly, SISKIND, Jana K, MCLEAN, Malia A, OSBORN, Blaire L, CHENG, Susan, RUBEN, Steve, BIRSE, Charles E, BLONDEL, Olivier, SCHNEIDER, Helmut, PICKERAL, Oxana K, CHEN, Cecil, GUIYI ZHANG, KAITHAMANA, Shashi, SINGH, Mallika, SCHULINGKAMP, Robert

“…Development of a Long-Acting Insulin Analog Using Albumin Fusion Technology Alokesh Duttaroy , Palanisamy Kanakaraj , Blaire L. Osborn , Helmut Schneider ,…”
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An integrated functional genomics screening program reveals a role for BMP-9 in glucose homeostasis by Birse, Charles E, Chen, Cecil, Grzegorzewski, Krzysztof J, Barash, Steve, Zhao, Qinghai, Schneider, Helmut, Wang, Qi, Singh, Mallika, Pukac, Laurie, Bell, Adam C, Duan, Roxanne, Coleman, Tim, Duttaroy, Alokesh, Cheng, Susan, Hirsch, Jon, Zhang, Linyi, Lazard, Yanick, Fischer, Carrie, Barber, Melisa Carey, Ma, Zhi-Dong, Zhang, Ya-Qin, Reavey, Peter, Zhong, Lilin, Teng, Baiqin, Sanyal, Indra, Ruben, Steve M, Blondel, Olivier

“…A coordinated functional genomics program was implemented to identify secreted polypeptides with therapeutic applications in the treatment of diabetes…”
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Evaluation of muscarinic agonist-induced analgesia in muscarinic acetylcholine receptor knockout mice by Duttaroy, Alokesh, Gomeza, Jesus, Gan, Jai-Wei, Siddiqui, Nasir, Basile, Anthony S, Harman, W Dean, Smith, Philip L, Felder, Christian C, Levey, Allan I, Wess, Jürgen

“…Centrally active muscarinic agonists display pronounced analgesic effects. Identification of the specific muscarinic acetylcholine receptor (mAChR) subtype(s)…”
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Inhibition of Dipeptidyl Peptidase-4 by Vildagliptin During Glucagon-Like Peptide 1 Infusion Increases Liver Glucose Uptake in the Conscious Dog by EDGERTON, Dale S, JOHNSON, Kathryn M. S, NEAL, Doss W, SCOTT, Melanie, HOBBS, Charles H, XIA ZHANG, DUTTAROY, Alokesh, CHERRINGTON, Alan D

“…Inhibition of Dipeptidyl Peptidase-4 by Vildagliptin During Glucagon-Like Peptide 1 Infusion Increases Liver Glucose Uptake in the Conscious Dog Dale S…”
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GLP-1 signalling compensates for impaired insulin signalling in regulating beta cell proliferation in βIRKO mice by Kawamori, Dan, Shirakawa, Jun, Liew, Chong Wee, Hu, Jiang, Morioka, Tomoaki, Duttaroy, Alokesh, Burkey, Bryan, Kulkarni, Rohit N.

“…Aims/hypothesis We aimed to investigate potential interactions between insulin and glucagon-like peptide (GLP)-1 signalling pathways in the regulation of beta…”
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Supersensitivity to opioid analgesics following chronic opioid antagonist treatment: Relationship to receptor selectivity by Yoburn, Byron C, Shah, Sukrut, Chan, Kawa, Duttaroy, Alokesh, Davis, Trong

“…The effect of chronic opioid antagonist treatment on the analgesic potency of six opioid agonists was compared to changes in opioid receptor density and the…”
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Hyperactivity and Intact Hippocampus-Dependent Learning in Mice Lacking the M 1 Muscarinic Acetylcholine Receptor by Miyakawa, Tsuyoshi, Yamada, Masahisa, Duttaroy, Alokesh, Wess, Jürgen

“…Members of the muscarinic acetylcholine receptor family are thought to play key roles in the regulation of a large number of important functions of the CNS…”
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GLP-1 signalling compensates for impaired insulin signalling in regulating beta cell proliferation in [beta]IRKO mice by Kawamori, Dan, Shirakawa, Jun, Liew, Chong Wee, Hu, Jiang, Morioka, Tomoaki, Duttaroy, Alokesh, Burkey, Bryan, Kulkarni, Rohit N

“…Aims/hypothesis We aimed to investigate potential interactions between insulin and glucagon-like peptide (GLP)-1 signalling pathways in the regulation of beta…”
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Hyperactivity and Intact Hippocampus-Dependent Learning in Mice Lacking the M1 Muscarinic Acetylcholine Receptor by Miyakawa, Tsuyoshi, Yamada, Masahisa, Duttaroy, Alokesh, Wess, Jurgen

“…Members of the muscarinic acetylcholine receptor family are thought to play key roles in the regulation of a large number of important functions of the CNS…”
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The Effect of Cumulative Dosing on the Analgesic Potency of Morphine in Mice by Duttaroy, Alokesh, Kirtman, Randi, Farrell, Frank, Phillips, Mark, Philippe, Jacques, Monderson, Thesselon, Yoburn, Byron C

“…Opioid analgesic potency can be evaluated using cumulative dosing, in which subjects are repeatedly administered a drug and tested after each dose until a…”
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The Insulin Receptor Talks to Glucagon? by Gromada, Jesper, Duttaroy, Alokesh, Rorsman, Patrik

“…Type 2 diabetes (T2DM) is not only a disorder of impaired insulin secretion but also glucagon oversecretion. However, the link between the two remains unclear…”
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Generation and pharmacological analysis of M2 and M4 muscarinic receptor knockout mice by Gomeza, J, Zhang, L, Kostenis, E, Felder, C C, Bymaster, F P, Brodkin, J, Shannon, H, Xia, B, Duttaroy, A, Deng, C X, Wess, J

“…Muscarinic acetylcholine receptors (M1-M5) play important roles in the modulation of many key functions of the central and peripheral nervous system. To…”
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