Search Results - "Dutta, Pranabananda"

MCP-1 is overexpressed in triple-negative breast cancers and drives cancer invasiveness and metastasis by Dutta, Pranabananda, Sarkissyan, Marianna, Paico, Kimberly, Wu, Yanyuan, Vadgama, Jaydutt V.

“…Background Triple-negative breast cancer (TNBC) is the most aggressive type of breast cancer that lacks ER/PR and HER2 receptors. Hence, there is urgency in…”
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Utilization of NGS technologies to investigate transcriptomic and epigenomic mechanisms in trastuzumab resistance by Nava, Miguel, Dutta, Pranabananda, Farias-Eisner, Robin, Vadgama, Jaydutt V., Wu, Yanyuan

“…NGS (Next Generation Sequencing) technologies allows us to determine key gene expression signatures that correlate with resistance (and responsiveness) to…”
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The SERTAD protein Taranis plays a role in Polycomb-mediated gene repression by Dutta, Pranabananda, Li, Willis X

“…The Polycomb group (PcG) proteins have been implicated in epigenetic transcriptional repression in development, stem cell maintenance and in cancer. The…”
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Unphosphorylated STAT3 in heterochromatin formation and tumor suppression in lung cancer by Dutta, Pranabananda, Zhang, Lin, Zhang, Huijun, Peng, Qin, Montgrain, Phillippe R, Wang, Yingxiao, Song, Yuanlin, Li, Jinghong, Li, Willis X

“…Aberrant JAK/STAT activation has been detected in many types of human cancers. The role of JAK/STAT activation in cancer has been mostly attributed to direct…”
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Proinflammatory Cytokines IL-6 and TNF-α Increased Telomerase Activity through NF-κB/STAT1/STAT3 Activation, and Withaferin A Inhibited the Signaling in Colorectal Cancer Cells by Vadgama, Jaydutt, Clarke, Orette, Atefi, Mohammad, Adekoya, Debbie, Okobi, Quincy, Wu, Yong, Chung, Seyung S., Dutta, Pranabananda

“…There are increasing evidences of proinflammatory cytokine involvement in cancer development. Here, we found that two cytokines, IL-6 and TNF-α, activated…”
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Streptonigrin at low concentration promotes heterochromatin formation by Loyola, Andre C., Dao, Kevin, Shang, Robin, Zhang, Lin, Dutta, Pranabananda, Fowler, Cody, Li, Jinghong, Li, Willis X.

“…Heterochromatin is essential for regulating global gene transcription and protecting genome stability, and may play a role in tumor suppression. Drugs…”
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Comp34 displays potent preclinical antitumor efficacy in triple-negative breast cancer via inhibition of NUDT3-AS4, a novel oncogenic long noncoding RNA by Hao, Qiongyu, Wang, Piwen, Dutta, Pranabananda, Chung, Seyung, Li, Qun, Wang, Kun, Li, Jieqing, Cao, Wei, Deng, Wenhong, Geng, Qing, Schrode, Katrina, Shaheen, Magda, Wu, Ke, Zhu, Donghui, Chen, Qiao-Hong, Chen, Guanglin, Elshimali, Yahya, Vadgama, Jay, Wu, Yong

“…The abnormal PI3K/AKT/mTOR pathway is one of the most common genomic abnormalities in breast cancers including triple-negative breast cancer (TNBC), and…”
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Unphosphorylated STAT5A stabilizes heterochromatin and suppresses tumor growth by Hu, Xiaoyu, Dutta, Pranabananda, Tsurumi, Amy, Li, Jinghong, Wang, Jingtong, Land, Hartmut, Li, Willis X.

“…Tumor suppressors known to date impede cancer growth by arresting the cell cycle or promoting apoptosis. Here we show that unphosphorylated human STAT5A…”
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Drosophila STAT is required for directly maintaining HP1 localization and heterochromatin stability by Larson, Kimberly, Yan, Shian-Jang, Lim, Su Jun, Dutta, Pranabananda, Li, Willis X, Shi, Song, Guo, Dongdong

“…STAT (Signal transducer and activator of transcription) is a potent transcription factor and its aberrant activation by phosphorylation is associated with…”
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Transcriptomic and ChIP-sequence interrogation of EGFR signaling in HER2+ breast cancer cells reveals a dynamic chromatin landscape and S100 genes as targets by Nava, Miguel, Dutta, Pranabananda, Zemke, Nathan R, Farias-Eisner, Robin, Vadgama, Jaydutt V, Wu, Yanyuan

“…The Human Epidermal Growth Factor Receptor (EGFR/HER1) can be activated by several ligands including Transforming Growth Factor alpha (TGF-α) and Epidermal…”
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Unphosphorylated STAT and heterochromatin protect genome stability by Yan, Shian-Jang, Lim, Su Jun, Shi, Song, Dutta, Pranabananda, Li, Willis X

“…Heterochromatin is a form of highly compacted chromatin associated with epigenetic gene silencing and chromosome organization. We have previously shown that…”
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A novel copper complex induces ROS generation in doxorubicin resistant Ehrlich ascitis carcinoma cells and increases activity of antioxidant enzymes in vital organs in vivo by Mookerjee, Ananda, Basu, Jayati Mookerjee, Majumder, Surajit, Chatterjee, Shilpak, Panda, Gouri S, Dutta, Pranabananda, Pal, Smarajit, Mukherjee, Pratima, Efferth, Thomas, Roy, Syamal, Choudhuri, Soumitra K

“…In search of a suitable GSH-depleting agent, a novel copper complex viz., copper N-(2-hydroxyacetophenone) glycinate (CuNG) has been synthesized, which was…”
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Overcoming Drug-Resistant Cancer by a Newly Developed Copper Chelate through Host-Protective Cytokine-Mediated Apoptosis by MOOKERJEE, Ananda, BASU, Jayati Mookerjee, DAS, Tania, EFFERTH, Thomas, SA, Gourisankar, ROY, Shyamal, CHOUDHURI, Soumitra K, DUTTA, Pranabananda, MAJUMDER, Surajit, BHATTACHARYYA, Sankar, BISWAS, Jaydip, PAL, Smarajit, MUKHERJEE, Pratima, RAHA, Sanghamitra, BARAL, Rathindra N

“…Purpose: Previously, we have synthesized and characterized a novel Cu(II) complex, copper N -(2-hydroxy acetophenone) glycinate (CuNG). Herein, we have…”
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Tumour cell‐intrinsic CTLA4 regulates PD‐L1 expression in non‐small cell lung cancer by Zhang, Huijun, Dutta, Pranabananda, Liu, Jinguo, Sabri, Nafiseh, Song, Yuanlin, Li, Willis X., Li, Jinghong

“…Cytotoxic T lymphocyte antigen 4 (CTLA4) and programmed cell death protein 1 (PD‐1) are immune checkpoint proteins expressed in T cells. Although CTLA4…”
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Abstract A060: Breast cancer-associated leukocyte DNA methylation profile in obese African-American women by Dutta, Pranabananda, Wu, Yanyuan, Duta, Jaydutt V.

“…Abstract Background: DNA methylation (DNAme) is a stable epigenetic mark leading to reduced gene expression. However, genome-wide DNAme profile is susceptible…”
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Drosophila SERTAD domain protein Taranis is required in somatic cells for maintenance of male germline stem cells by Dutta, Pranabananda, Nath, Soma, Li, Jinghong, Li, Willis X.

“…Background Polycomb proteins are essential for maintaining stem cell identity across different stem cell niches. However, how they function to maintain stem…”
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Abstract B55: Tumor-derived MCP-1 regulates invasiveness in triple-negative breast cancer via the MAP kinase pathway by Dutta, Pranabananda, Paico, Kimberly, Wu, Yanyuan, Sarkissyan, Marianna, Vadgama, Jaydutt

“…Abstract Background: Triple-negative breast cancer (TNBC) is the most aggressive type of breast cancer compared to other breast cancer subtypes. The frequency…”
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Correction: Dutta et al. Transcriptional Regulation of CCL2 by PARP1 Is a Driver for Invasiveness in Breast Cancer. Cancers 2020, 12 , 1317 by Dutta, Pranabananda, Paico, Kimberly, Gomez, Gabriela, Wu, Yanyuan, Vadgama, Jaydutt V

“…In the original publication, there was a mistake in Figure 5D as published [...]…”
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Correction: Dutta et al. Transcriptional Regulation of CCL2 by PARP1 Is a Driver for Invasiveness in Breast Cancer. ICancers/I 2020, I12/I, 1317 by Dutta, Pranabananda, Paico, Kimberly, Gomez, Gabriela, Wu, Yanyuan, Vadgama, Jaydutt V

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Identification of methotrexate as a heterochromatin-promoting drug by Loyola, Andre C., Zhang, Lin, Shang, Robin, Dutta, Pranabananda, Li, Jinghong, Li, Willis X.

“…Heterochromatin is a tightly packed form of DNA involved in gene silencing, chromosome segregation, and protection of genome stability. Heterochromatin is…”
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