Search Results - "Dutta, Naibedya"

Hijacking Cellular Stress Responses to Promote Lifespan by Dutta, Naibedya, Garcia, Gilberto, Higuchi-Sanabria, Ryo

“…Organisms are constantly exposed to stress both from the external environment and internally within the cell. To maintain cellular homeostasis under different…”
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Unveiling a novel cellular stress response mechanism to photodamage by Dutta, Naibedya, Garcia, Gilberto, Higuchi‐Sanabria, Ryo

“…Ultraviolet (UV) radiation, a component of sunlight, holds both advantageous anddetrimental effects on human health. While shorter wavelengths of UV…”
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Investigating impacts of the mycothiazole chemotype as a chemical probe for the study of mitochondrial function and aging by Dutta, Naibedya, Gerke, Joe A., Odron, Sofia F., Morris, Joseph D., Hruby, Adam, Kim, Juri, Torres, Toni Castro, Shemtov, Sarah J., Clarke, Jacqueline G., Chang, Michelle C., Shaghasi, Hooriya, Ray, Marissa N., Averbukh, Maxim, Hoang, Sally, Oorloff, Maria, Alcala, Athena, Vega, Matthew, Mehta, Hemal H., Thorwald, Max A., Crews, Phillip, Vermulst, Marc, Garcia, Gilberto, Johnson, Tyler A., Higuchi-Sanabria, Ryo

“…Small molecule inhibitors of the mitochondrial electron transport chain (ETC) hold significant promise to provide valuable insights to the field of…”
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IL-13 and the hydroperoxy fatty acid 13(S)HpODE play crucial role in inducing an apoptotic pathway in cancer cells involving MAO-A/ROS/p53/p21 signaling axis by Biswas, Pritam, Swaroop, Surbhi, Dutta, Naibedya, Arya, Aditi, Ghosh, Suvranil, Dhabal, Sukhamoy, Das, Payel, Majumder, Chirantan, Pal, Mahadeb, Bhattacharjee, Ashish

“…This study depicted the effect of IL-13 and 13(S)HpODE (the endogenous product during IL-13 activation) in the process of cancer cell apoptosis. We examined…”
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S‐allyl cysteine inhibits TNF‐α‐induced inflammation in HaCaT keratinocytes by inhibition of NF‐ κB‐dependent gene expression via sustained ERK activation by Basu, Chitra, Chatterjee, Abhipriya, Bhattacharya, Sampurna, Dutta, Naibedya, Sur, Runa

“…Tumor necrosis factor‐α (TNF‐α)‐induced keratinocyte inflammation plays a key role in the pathogenesis of multiple inflammatory skin diseases. Here we…”
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Andrographolide upregulates protein quality control mechanisms in cell and mouse through upregulation of mTORC1 function by Dutta, Naibedya, Ghosh, Suvranil, Nelson, Vinod K., Sareng, Hossainoor R., Majumder, Chirantan, Mandal, Subhash C., Pal, Mahadeb

“…Heat shock response (HSR), a component of cellular protein quality control mechanisms, is defective in different neurodegenerative conditions such as…”
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Targeting cellular microtubule by phytochemical apocynin exhibits autophagy-mediated apoptosis to inhibit lung carcinoma progression and tumorigenesis by Paul, Santanu, Chakrabarty, Subhendu, Ghosh, Suvranil, Nag, Debasish, Das, Amlan, Dastidar, Debabrata Ghosh, Dasgupta, Moumita, Dutta, Naibedya, Kumari, Mandavi, Pal, Mahadeb, Chakrabarti, Gopal

“…•Tubulin binding and microtubule depolymerization by apocynin: a novel finding.•Apocynin, a natural compound inhibits lung carcinoma cells progression and…”
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Induction of monoamine oxidase A-mediated oxidative stress and impairment of NRF2-antioxidant defence response by polyphenol-rich fraction of Bergenia ligulata sensitizes prostate cancer cells in vitro and in vivo by Ghosh, Suvranil, Dutta, Naibedya, Banerjee, Pinaki, Gajbhiye, Rahul L., Sareng, Hossainoor Rahaman, Kapse, Prachi, Pal, Srabani, Burdelya, Lyudmila, Mandal, Narayan C., Ravichandiran, Velyutham, Bhattacharjee, Ashish, Kundu, Gopal C., Gudkov, Andrei V., Pal, Mahadeb

“…Prostate cancer (PCa) is a major cause of mortality and morbidity in men. Available therapies yield limited outcome. We explored anti-PCa activity in a…”
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Growth on stiffer substrates impacts animal health and longevity in C. elegans by Oorloff, Maria, Hruby, Adam, Averbukh, Maxim, Alcala, Athena, Dutta, Naibedya, Minor, Cray, Castro Torres, Toni, Moaddeli, Darius, Vega, Matthew, Kim, Juri, Bong, Andrew, Coakley, Aeowynn J, Hicks, Daniel, Wang, Jing, Wang, Tiffany, Hoang, Sally, Tharp, Kevin M, Garcia, Gilberto, Higuchi-Sanabria, Ryo

“…Mechanical stress is a measure of internal resistance exhibited by a body or material when external forces, such as compression, tension, bending, etc. are…”
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Alkaloid-rich fraction of Ervatamia coronaria sensitizes colorectal cancer through modulating AMPK and mTOR signalling pathways by Dutta, Naibedya, Pemmaraju, Deepak Bharadwaj, Ghosh, Suvranil, Ali, Asif, Mondal, Ayan, Majumder, Chirantan, Nelson, Vinod K., Mandal, Subhash C., Misra, Anup K., Rengan, Aravind K., Ravichandiran, Velyutham, Che, Chun-Tao, Gurova, Katerina V., Gudkov, Andrei V., Pal, Mahadeb

“…Ervatamia coronaria, a popular garden plant in India and some other parts of the world is known traditionally for its anti-inflammatory and anti-cancer…”
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Further Probing the Properties of a Unique Sponge-derived Alkaloid Through the Isolation of a New (−)-(5E)‑(8R)‑(14Z)‑Mycothiazole Analogue by Gerke, Joe A., Odron, Sofia F., Kim, Juri, Dutta, Naibedya, Clarke, Jacqueline G., Media, Joseph, Coppage, David A., Oorloff, Maria, Alcala, Athena, Garcia, Gilberto, Kang, Marissa E.F., Gerke, Cy L., Peterson, Jacob C., Morris, Joseph D., Higuchi-Sanabria, Ryo, Valeriote, Frederick A., Crews, Phillip, Johnson, Tyler A.

“…Scale-up isolation of (+)-(5Z)-(8S)-(14Z)-mycothiazole (1) from Vanuatu specimens of C. mycofijiensis to semisynthesize…”
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Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans by Castro Torres, Toni, Moaddeli, Darius, Averbukh, Maxim, Coakley, Aeowynn J, Dutta, Naibedya, Garcia, Gilberto, Higuchi-Sanabria, Ryo

“…The discovery and development of Caenorhabditis elegans as a model organism was influential in biology, particularly in the field of aging. Many historical and…”
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Large‐scale genetic screens identify BET‐1 as a cytoskeleton regulator promoting actin function and life span by Garcia, Gilberto, Bar‐Ziv, Raz, Averbukh, Maxim, Dasgupta, Nirmalya, Dutta, Naibedya, Zhang, Hanlin, Fan, Wudi, Moaddeli, Darius, Tsui, C. Kimberly, Castro Torres, Toni, Alcala, Athena, Moehle, Erica A., Hoang, Sally, Shalem, Ophir, Adams, Peter D., Thorwald, Max A., Higuchi‐Sanabria, Ryo

“…The actin cytoskeleton is a three‐dimensional scaffold of proteins that is a regulatory, energyconsuming network with dynamic properties to shape the structure…”
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Azadiradione ameliorates polyglutamine expansion disease in Drosophila by potentiating DNA binding activity of heat shock factor 1 by Nelson, Vinod K, Ali, Asif, Dutta, Naibedya, Ghosh, Suvranil, Jana, Manas, Ganguli, Arnab, Komarov, Andrei, Paul, Soumyadip, Dwivedi, Vibha, Chatterjee, Subhrangsu, Jana, Nihar R, Lakhotia, Subhash C, Chakrabarti, Gopal, Misra, Anup K, Mandal, Subhash C, Pal, Mahadeb

“…Aggregation of proteins with the expansion of polyglutamine tracts in the brain underlies progressive genetic neurodegenerative diseases (NDs) like…”
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Glial-derived mitochondrial signals affect neuronal proteostasis and aging by Bar-Ziv, Raz, Dutta, Naibedya, Hruby, Adam, Sukarto, Edward, Averbukh, Maxim, Alcala, Athena, Henderson, Hope R, Durieux, Jenni, Tronnes, Sarah U, Ahmad, Qazi, Bolas, Theodore, Perez, Joel, Dishart, Julian G, Vega, Matthew, Garcia, Gilberto, Higuchi-Sanabria, Ryo, Dillin, Andrew

“…The nervous system plays a critical role in maintaining whole-organism homeostasis; neurons experiencing mitochondrial stress can coordinate the induction of…”
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