Search Results - "Dutia, Minu"

Optimization of 4-Phenylamino-3-quinolinecarbonitriles as Potent Inhibitors of Src Kinase Activity by Boschelli, Diane H, Ye, Fei, Wang, Yanong D, Dutia, Minu, Johnson, Steve L, Wu, Biqi, Miller, Karen, Powell, Dennis W, Yaczko, Deanna, Young, Mairead, Tischler, Mark, Arndt, Kim, Discafani, Carolyn, Etienne, Carlo, Gibbons, Jay, Grod, Janet, Lucas, Judy, Weber, Jennifer M, Boschelli, Frank

“…Subsequent to the discovery of 4-[(2,4-dichlorophenyl)amino]-6,7-dimethoxy-3-quinolinecarbonitrile (1a) as an inhibitor of Src kinase activity (IC50 = 30 nM),…”
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Synthesis and Src Kinase Inhibitory Activity of a Series of 4-Phenylamino-3-quinolinecarbonitriles by Boschelli, Diane H, Wang, Yanong D, Ye, Fei, Wu, Biqi, Zhang, Nan, Dutia, Minu, Powell, Dennis W, Wissner, Allan, Arndt, Kim, Weber, Jennifer M, Boschelli, Frank

“…Screening of a directed compound library in a yeast-based assay identified 4-[(2,4-dichlorophenyl)amino]-6,7-dimethoxy-3-quinolinecarbonitrile (2a) as a Src…”
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Indazolylpyrazolopyrimidine as Highly Potent B-Raf Inhibitors with in Vivo Activity by Wang, Xiaolun, Berger, Dan M, Salaski, Edward J, Torres, Nancy, Dutia, Minu, Hanna, Cilien, Hu, Yongbo, Levin, Jeremy I, Powell, Dennis, Wojciechowicz, Donald, Collins, Karen, Frommer, Eileen, Lucas, Judy

“…Novel indazolylpyrazolo[1,5-a]pyrimidine analogues have been prepared and found to be extremely potent type I B-Raf inhibitors. The lead compound shows good…”
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Lead identification to generate 3-cyanoquinoline inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment by Miller, Lori M., Mayer, Scott C., Berger, Dan M., Boschelli, Diane H., Boschelli, Frank, Di, Li, Du, Xuemei, Dutia, Minu, Floyd, Middleton B., Johnson, Mark, Kenny, Cynthia Hess, Krishnamurthy, Girija, Moy, Franklin, Petusky, Susan, Tkach, Diane, Torres, Nancy, Wu, Biqi, Xu, Weixin

“…The strategies, synthesis, and SAR behind novel cyanoquinoline IGFR inhibitors ( 1) are reported. Insulin-like growth factor receptor (IGF-1R) is a growth…”
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Disodium (R,R)-5-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylate (CL 316,243). A potent .beta.-adrenergic agonist virtually specific for .beta.3 receptors. A promising antidiabetic and antiobesity agent by Bloom, Jonathan D, Dutia, Minu D, Johnson, Bernard D, Wissner, Allan, Burns, Michael G, Largis, Elwood E, Dolan, Jo Alene, Claus, Thomas H

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Potential antiatherosclerotic agents. 6. Hypocholesterolemic trisubstituted urea analogs by DeVries, Vern G, Bloom, Jonathan D, Dutia, Minu D, Katocs, Andrew S, Largis, Elwood E

“…The discovery that a series of N,N-dialkyl-N'-arylureas were inhibitors of the ACAT enzyme has led to a structure-activity study involving the systematic…”
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Synthesis of 7-( E)-alkenyl-4-amino-3-quinolinecarbonitriles via Pd-mediated Heck, Stille, and Suzuki reactions by Wang, Yanong D., Dutia, Minu, Floyd, M. Brawner, Prashad, Amar S., Berger, Dan, Lin, Melissa

“…A regio- and stereoselective synthesis of 7-( E)-alkenyl-4-amino-3-quinolinecarbonitriles via Pd-mediated coupling reactions was developed. The comparison and…”
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Non-hinge-binding pyrazolo[1,5- a]pyrimidines as potent B-Raf kinase inhibitors by Berger, Dan M., Torres, Nancy, Dutia, Minu, Powell, Dennis, Ciszewski, Greg, Gopalsamy, Ariamala, Levin, Jeremy I., Kim, Kyung-Hee, Xu, Weixin, Wilhelm, James, Hu, YongBo, Collins, Karen, Feldberg, Larry, Kim, Steven, Frommer, Eileen, Wojciechowicz, Donald, Mallon, Robert

“…Optimization of initial lead compound 1 provided a series of pyrazolo[1,5- a]pyrimidines 2 as potent B-Raf kinase inhibitors. As part of our research effort to…”
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Novel pyrazolopyrimidines as highly potent B-Raf inhibitors by Di Grandi, Martin J., Berger, Dan M., Hopper, Darrin W., Zhang, Chunchun, Dutia, Minu, Dunnick, Alejandro L., Torres, Nancy, Levin, Jeremy I., Diamantidis, George, Zapf, Christoph W., Bloom, Jonathan D., Hu, YongBo, Powell, Dennis, Wojciechowicz, Donald, Collins, Karen, Frommer, Eileen

“…A novel series of pyrazolo[1,5-a]pyrimidines bearing a 3-hydroxyphenyl group at C(3) and substituted tropanes at C(7) have been identified as potent B-Raf…”
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Observation of differential reactivity of cyclic amines in SN2 and SNAr displacement reactions in the course of synthesizing C-6, C-7 substituted quinolinecarbonitrile MEK1 kinase inhibitors by Hopper, Darrin W., Dutia, Minu, Berger, Dan M., Powell, Dennis W.

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4-Anilino-7-alkenylquinoline-3-carbonitriles as potent MEK1 kinase inhibitors by Berger, Dan M., Dutia, Minu, Powell, Dennis, Floyd, Middleton B., Torres, Nancy, Mallon, Robert, Wojciechowicz, Donald, Kim, Steven, Feldberg, Larry, Collins, Karen, Chaudhary, Inder

“…A series of 7-alkenyl substituted 4-anilino-3-quinolinecarbonitriles were prepared and evaluated as MEK1 kinase inhibitors. One analog (R = H, NR 1R 2 =…”
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Observation of differential reactivity of cyclic amines in S N2 and S NAr displacement reactions in the course of synthesizing C-6, C-7 substituted quinolinecarbonitrile MEK1 kinase inhibitors by Hopper, Darrin W., Dutia, Minu, Berger, Dan M., Powell, Dennis W.

“…We have previously reported on a series of 4-anilino-6,7-dialkoxy-3-quinolinecarbonitriles as potent inhibitors of MEK1 kinase. Herein, we describe our…”
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Novel Multidrug Resistance Reversal Agents by Berger, Dan, Citarella, Ron, Dutia, Minu, Greenberger, Lee, Hallett, William, Paul, Rolf, Powell, Dennis

“…A series of 59 α-aryl-α-thioether-alkyl, -alkanenitrile, and -alkanecarboxylic acid methyl ester tetrahydroisoquinoline and isoindoline derivatives (15a−48)…”
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4-Anilino-7-alkenylquinoIine-3-carbonitriles as potent MEI1 kinase inhibitors by BERGER, Dan M, DUTIA, Minu, CHAUDHARY, Inder, POWELL, Dennis, FLOYD, Middleton B, TORRES, Nancy, MALLON, Robert, WOJCIECHOWICZ, Donald, KIM, Steven, FELDBERG, Larry, COLLINS, Karen

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4-Anilino-7,8-dialkoxybenzo[g]quinoline-3-carbonitriles as Potent Src Kinase Inhibitors by Berger, Dan M, Dutia, Minu, Birnberg, Gary, Powell, Dennis, Boschelli, Diane H, Wang, Yanong D, Ravi, Malini, Yaczko, Deanna, Golas, Jennifer, Lucas, Judy, Boschelli, Frank

“…It has been previously reported that appropriately substituted 4-anilinoquinoline-3-carbonitriles are potent inhibitors of Src kinase, with biological activity…”
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Potential antiatherosclerotic agents. 5. An acyl-coenzyme A:cholesterol O-acyltransferase inhibitor with hypocholesterolemic activity by DeVries, Vern G, Schaffer, Sheldon A, Largis, Elwood E, Dutia, Minu D, Wang, Ching Hua, Bloom, Jonathan D, Katocs, Andrew S

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Substituted 4-anilino-7-phenyl-3-quinolinecarbonitriles as Src kinase inhibitors by BERGER, Dan, DUTIA, Minu, POWELL, Dennis, WISSNER, Allan, DEMORIN, Frenel, RAIFELD, Yuri, WEBER, Jennifer, BOSCHELLI, Frank

“…A series of substituted 4-anilino-7-phenyl-3-quinolinecarbonitriles has been prepared as Src kinase inhibitors. Optimal activity is observed with compounds…”
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Disodium (R,R)-5[2-[[2-γ(3-chlorophenyl)-2-hydroxyethyl]-amino]propyl]-1,3-benzodioxole-2,2-dicarboxylate (CL 316,243). A potent β-adrenergic agonist virtually specific for β3 receptors. A promising antidiabetic and antiobesity agent by BLOOM, J. D, DUTIA, M. D, JOHNSON, B. D, WISSNER, A, BURNS, M. G, LARGIS, E. E, DOLAN, J. A, CLAUS, T. H

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Synthesis and evaluation of 4-Anilino-6,7-dialkoxy-3-quinolinecarbonitriles as inhibitors of kinases of the Ras-MAPK signaling cascade by Berger, Dan, Dutia, Minu, Powell, Dennis, Wu, Biqi, Wissner, Allan, Boschelli, Diane H., Floyd, M.Brawner, Zhang, Nan, Torres, Nancy, Levin, Jeremy, Du, Xuemei, Wojciechowicz, Donald, Discafani, Carolyn, Kohler, Constance, Kim, Steven C., Feldberg, Larry R., Collins, Karen, Mallon, Robert

“…4-[3-Chloro-4-(1-methyl-1H-imidazol-2-ylsulfanyl)]anilino-6,7-diethoxy-3-quinolinecarbonitrile ( 3) was identified as a MEK1 kinase inhibitor with exceptional…”
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8-Anilinoimidazo[4,5- g]quinoline-7-carbonitriles as Src Kinase Inhibitors by Berger, Dan, Dutia, Minu, Powell, Dennis, Wu, Biqi, Wissner, Allan, DeMorin, Frenel, Weber, Jennifer, Boschelli, Frank

“…A series of 8-anilinoimidazo[4,5- g]quinoline-7-carbonitriles was synthesized and evaluated as Src kinase inhibitors. Several aniline substituents were…”
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