Abstract 5618: Multi-armed myxoma virus has therapeutic potential for treatment of multiple myeloma
Abstract Oncolytic viruses (OV) selectively replicate in and lyse tumor cells and provide stimulation to the immune system, representing a promising therapeutic option in development to treat cancers that do not respond well to treatment with immune checkpoint inhibitors. Myxoma virus (MYXV) is a me...
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| Published in: | Cancer research (Chicago, Ill.) Vol. 82; no. 12_Supplement; p. 5618 |
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| Main Authors: | , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
15-06-2022
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| Online Access: | Get full text |
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| Summary: | Abstract
Oncolytic viruses (OV) selectively replicate in and lyse tumor cells and provide stimulation to the immune system, representing a promising therapeutic option in development to treat cancers that do not respond well to treatment with immune checkpoint inhibitors. Myxoma virus (MYXV) is a member of the Pox family of double stranded DNA viruses and infects cancer cell lines of humans and other species. The genome of MYXV is relatively large and is amenable to engineering for expression of transgenic proteins, making it an excellent oncolytic virus for introduction of immunomodulatory proteins. We generated MYXV carrying IL-12 and decorin. IL-12 is an immune modulator that activates T- and NK-cells. Cellular responses to decorin include tumor cell intrinsic signaling effects, tumor matrix modulation, and inhibition of the TGF-beta pathway. We demonstrate the activity of multi-armed MYXV against human and mouse multiple myeloma (MM) cancer cell lines. Efficacy and mechanism of action of multi-armed myxoma virus was also demonstrated in vivo via syngeneic and xenograft models. Multi-armed MYXV represents a promising therapeutic option for MM patients that do not respond well to immunotherapy.
Citation Format: Ana L. de Matos, Rachel Dutcher, Lina S. Franco, Lino E. Torres-Dominguez, Heather Hrach, Mario Abrantes, Wazir Abdullahi, Zachary Tacner, Dillon McCrite, Nicole Grigiatis, Jack St. Peter, Leslie L. Sharp. Multi-armed myxoma virus has therapeutic potential for treatment of multiple myeloma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 5618. |
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| ISSN: | 1538-7445 1538-7445 |
| DOI: | 10.1158/1538-7445.AM2022-5618 |