Search Results - "Dustin, Lynn B."

Innate and Adaptive Immune Responses in Chronic HCV Infection by Dustin, Lynn B

“…Hepatitis C virus (HCV) remains a public health problem of global importance, even in the era of potent directly-acting antiviral drugs. In this chapter, I…”
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Lessons from a large-scale COVID-19 vaccine trial by Mahla, Ranjeet Singh, Dustin, Lynn B

“…Global vaccination coverage remains indispensable in combatting the ongoing SARS-CoV-2 pandemic. Safety, efficacy, and durability of immune protection are the…”
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Searching for escape-resistant anti-SARS-CoV-2 neutralizing antibodies by Mahla, Ranjeet Singh, Dustin, Lynn B

“…A major goal of SARS-CoV-2 vaccination is the induction of neutralizing antibodies (nAbs) capable of blocking infection by preventing interaction of the…”
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TRIM21/Ro52 - Roles in Innate Immunity and Autoimmune Disease by Jones, Esther L, Laidlaw, Stephen M, Dustin, Lynn B

“…TRIM21 (Ro52/SSA1) is an E3 ubiquitin ligase with key roles in immune host defence, signal transduction, and possibly cell cycle regulation. It is also an…”
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Flying under the radar: the immunobiology of hepatitis C by Dustin, Lynn B, Rice, Charles M

“…The hepatitis C virus (HCV) is a remarkably successful pathogen, establishing persistent infection in more than two-thirds of those who contract it. Its…”
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Ro60-Roles in RNA Processing, Inflammation, and Rheumatic Autoimmune Diseases by Mahla, Ranjeet Singh, Jones, Esther L, Dustin, Lynn B

“…The Ro60/SSA2 autoantigen is an RNA-binding protein and a core component of nucleocytoplasmic ribonucleoprotein (RNP) complexes. Ro60 is essential in RNA…”
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Immunotherapy of chronic hepatitis C virus infection with antibodies against programmed cell death-1 (PD-1) by Fuller, Michael J., Callendret, Benoit, Zhu, Baogong, Freeman, Gordon J., Hasselschwert, Dana L., Satterfield, William, Sharpe, Arlene H., Dustin, Lynn B., Rice, Charles M., Grakoui, Arash, Ahmed, Rafi, Walker, Christopher M.

“…Hepatitis C virus (HCV) persistence is facilitated by exhaustion of CD8+ T cells that express the inhibitory receptor programmed cell death 1 (PD-1). Blockade…”
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Beyond bNAbs: Uses, Risks, and Opportunities for Therapeutic Application of Non-Neutralising Antibodies in Viral Infection by Mader, Kahlio, Dustin, Lynn B

“…The vast majority of antibodies generated against a virus will be non-neutralising. However, this does not denote an absence of protective capacity. Yet,…”
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Efficient Replication of Genotype 3a and 4a Hepatitis C Virus Replicons in Human Hepatoma Cells by SAEED, Mohsan, SCHEEL, Troels K. H, GOTTWEIN, Judith M, MARUKIAN, Svetlana, DUSTIN, Lynn B, BUKH, Jens, RICE, Charles M

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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The Humoral Immune Response to HCV: Understanding is Key to Vaccine Development by Cashman, Siobhán B, Marsden, Brian D, Dustin, Lynn B

“…Hepatitis C virus (HCV) remains a global problem, despite advances in treatment. The low cost and high benefit of vaccines have made them the backbone of…”
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Interferon (IFN)–γ–Inducible Protein–10: Association with Histological Results, Viral Kinetics, and Outcome during Treatment with Pegylated IFN-α2a and Ribavirin for Chronic Hepatitis C Virus Infection by Romero, Ana I., Lagging, Martin, Westin, Johan, Dhillon, Amar P., Dustin, Lynn B., Pawlotsky, Jean-Michel, Neumann, Avidan U., Ferrari, Carlo, Missale, Gabriele, Haagmans, Bart L., Schalm, Solko W., Zeuzem, Stefan, Negro, Francesco, Verheij-Hart, Elke

“…BackgroundWe investigated associations between interferon (IFN)–γ–inducible protein (IP)–10 and liver histological results, viral kinetic response, and…”
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Somatic Hypermutations Confer Rheumatoid Factor Activity in Hepatitis C Virus–Associated Mixed Cryoglobulinemia by Charles, Edgar D., Orloff, Michael I. M., Nishiuchi, Eiko, Marukian, Svetlana, Rice, Charles M., Dustin, Lynn B.

“…Objective Hepatitis C virus (HCV) is the most frequent cause of mixed cryoglobulinemia (MC), which is characterized by endothelial deposition of rheumatoid…”
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Interferon lambda: opportunities, risks, and uncertainties in the fight against HCV by Laidlaw, Stephen M, Dustin, Lynn B

“…Innate immunity is key to the fight against the daily onslaught from viruses that our bodies are subjected to. Essential to this response are the interferons…”
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Expression of paramyxovirus V proteins promotes replication and spread of hepatitis C virus in cultures of primary human fetal liver cells by Andrus, Linda, Marukian, Svetlana, Jones, Christopher T., Catanese, Maria Teresa, Sheahan, Timothy P., Schoggins, John W., Barry, Walter T., Dustin, Lynn B., Trehan, Kartik, Ploss, Alexander, Bhatia, Sangeeta N., Rice, Charles M.

“…Here we demonstrate that primary cultures of human fetal liver cells (HFLC) reliably support infection with laboratory strains of hepatitis C virus (HCV),…”
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Clonal expansion of immunoglobulin M+CD27+ B cells in HCV-associated mixed cryoglobulinemia by Charles, Edgar D., Green, Rashidah M., Marukian, Svetlana, Talal, Andrew H., Lake-Bakaar, Gerond V., Jacobson, Ira M., Rice, Charles M., Dustin, Lynn B.

“…Hepatitis C virus (HCV) is associated with B-cell lymphoproliferative disorders such as mixed cryoglobulinemia (MC) and B-cell non-Hodgkin lymphoma (B-NHL)…”
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Comparison of different methods for isolating CD8+ T lymphocyte‐derived extracellular vesicles and supramolecular attack particles by Jainarayanan, Ashwin K., Capera, Jesusa, Céspedes, Pablo F., Conceição, Mariana, Elanchezhian, Mirudula, Thomas, Tom, Bonner, Scott, Valvo, Salvatore, Kurz, Elke, Mahla, Ranjeet Singh, Berridge, Georgina, Hester, Svenja, Fischer, Roman, Dustin, Lynn B., Wood, Matthew J. A., Dustin, Michael L.

“…CD8+ T lymphocytes play vital roles in killing infected or deranged host cells, recruiting innate immune cells, and regulating other aspects of immune…”
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Selection of apoptotic cell specific human antibodies from adult bone marrow by Grönwall, Caroline, Charles, Edgar D, Dustin, Lynn B, Rader, Christoph, Silverman, Gregg J

“…Autoreactive antibodies that recognize neo-determinants on apoptotic cells in mice have been proposed to have protective, homeostatic and immunoregulatory…”
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COVID‐19 vaccination and autoimmunity: Do we need more evidence? by Mahla, Ranjeet Singh, Dustin, Lynn B.

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Primary, post-primary and non-specific immunoglobulin M responses in HCV infection by Dustin, Lynn B, Charles, Edgar D

“…Delayed and variable antibody responses to HCV make it difficult to diagnose acute HCV infection reliably. Immunoglobulin (Ig)M and IgG anti-HCV may be…”
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MAIT cells are activated during human viral infections by van Wilgenburg, Bonnie, Scherwitzl, Iris, Hutchinson, Edward C., Leng, Tianqi, Kurioka, Ayako, Kulicke, Corinna, de Lara, Catherine, Cole, Suzanne, Vasanawathana, Sirijitt, Limpitikul, Wannee, Malasit, Prida, Young, Duncan, Denney, Laura, Moore, Michael D., Fabris, Paolo, Giordani, Maria Teresa, Oo, Ye Htun, Laidlaw, Stephen M., Dustin, Lynn B., Ho, Ling-Pei, Thompson, Fiona M., Ramamurthy, Narayan, Mongkolsapaya, Juthathip, Willberg, Christian B., Screaton, Gavin R., Klenerman, Paul

“…Mucosal-associated invariant T (MAIT) cells are abundant in humans and recognize bacterial ligands. Here, we demonstrate that MAIT cells are also activated…”
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