Search Results - "Duschak, Vilma G"

Editorial: Chagas disease novel drug targets and treatments by Duschak, Vilma G, Paniz Mondolfi, Alberto E, Benaim, Gustavo

Get full text

Hallmarks of the relationship between host and Trypanosoma cruzi sulfated glycoconjugates along the course of Chagas disease by Soprano, Luciana L, Ferrero, Maximiliano R, Jacobs, Thomas, Couto, Alicia S, Duschak, Vilma G

“…American Trypanosomiasis or Chagas disease (ChD), a major problem that is still endemic in large areas of Latin America, is caused by . This agent holds a…”
Get full text

Cruzipain Sulfotopes-Specific Antibodies Generate Cardiac Tissue Abnormalities and Favor Trypanosoma cruzi Infection in the BALB/c Mice Model of Experimental Chagas Disease by Soprano, Luciana L, Ferrero, Maximiliano R, Landoni, Malena, García, Gabriela A, Esteva, Mónica I, Couto, Alicia S, Duschak, Vilma G

“…cruzipain (Cz) bears a C-terminal domain (C-T) that contains sulfated epitopes "sulfotopes" (GlcNAc6S) on its unique N-glycosylation site. The effects of…”
Get full text

Structural analysis of the N‐glycans of the major cysteine proteinase of Trypanosoma cruzi by Barboza, Mariana, Duschak, Vilma G., Fukuyama, Yuko, Nonami, Hiroshi, Erra‐Balsells, Rosa, Cazzulo, Juan J., Couto, Alicia S.

“…Trypanosoma cruzi, the parasitic protozoan that causes Chagas disease, contains a major cysteine proteinase, cruzipain. This lysosomal enzyme bears an unusual…”
Get full text

UV-MALDI Mass Spectrometry Analysis of NBD-Glycosphingolipids Without an External Matrix by Landoni, Malena, Duschak, Vilma G., Erra-Balsells, Rosa, Couto, Alicia S.

“…Each day, advances in the instrumentation and operating protocols bring new applications and insights into the molecular processes of ultra violet-matrix…”
Get full text

Tamoxifen acts on Trypanosoma cruzi sphingolipid pathway triggering an apoptotic death process by Landoni, Malena, Piñero, Tamara, Soprano, Luciana L., Garcia-Bournissen, Facundo, Fichera, Laura, Esteva, Monica I., Duschak, Vilma G., Couto, Alicia S.

“…This study shows the effects of tamoxifen, a known estrogen receptor antagonist used in the treatment of breast cancer, on the sphingolipid pathway of…”
Get full text

Cruzipain, the major cysteine protease of Trypanosoma cruzi: a sulfated glycoprotein antigen as relevant candidate for vaccine development and drug target. A review by Duschak, Vilma G, Couto, Alicia S

“…This review aims to present different aspects related to cruzipain, one of the most important proteins of the etiological agent of Chagas disease that has been…”
Get more information

Effect of tamoxifen on the sphingolipid biosynthetic pathway in the different intraerythrocytic stages of the apicomplexa Plasmodium falciparum by Piñero, Tamara A., Landoni, Malena, Duschak, Vilma G., Katzin, Alejandro M., Couto, Alicia S.

“…Parasites of the genus Plasmodium responsible for Malaria are obligate intracellular pathogens residing in mammalian red blood cells, hepatocytes, or mosquito…”
Get full text

Characterization of a novel Kazal-type serine proteinase inhibitor of Arabidopsis thaliana by Pariani, Sebastián, Contreras, Marisol, Rossi, Franco R., Sander, Valeria, Corigliano, Mariana G., Simón, Francisco, Busi, María V., Gomez-Casati, Diego F., Pieckenstain, Fernando L., Duschak, Vilma G., Clemente, Marina

“…Many different types of serine proteinase inhibitors have been involved in several kinds of plant physiological processes, including defense mechanisms against…”
Get full text

Trypanosoma cruzi serinecarboxipeptidase is a sulfated glycoprotein and a minor antigen in human Chagas disease infection by Soprano, Luciana L., Parente, Juliana E., Landoni, Malena, Couto, Alicia S., Duschak, Vilma G.

“…In this work, the presence of sulfated N -glycans was studied in a high-mannose-type glycoprotein of Trypanosoma cruzi with serinecarboxipeptidase ( Tc SCP)…”
Get full text

An anionic synthetic sugar containing 6‐SO3‐NAcGlc mimics the sulfated cruzipain epitope that plays a central role in immune recognition by Couto, Alicia S., Soprano, Luciana L., Landoni, Malena, Pourcelot, Marilyne, Acosta, Diana M., Bultel, Laurent, Parente, Juliana, Ferrero, Maximiliano R., Barbier, Maximilien, Dussouy, Christophe, Esteva, Mónica I., Kovensky, José, Duschak, Vilma G.

“…Cruzipain (Cz), the major cysteine proteinase of Trypanosoma cruzi, is a glycoprotein that contains sulfated high‐mannose‐type oligosaccharides. We have…”
Get full text

Involvement of sulfates from cruzipain, a major antigen of Trypanosoma cruzi, in the interaction with immunomodulatory molecule Siglec-E by Ferrero, Maximiliano R., Heins, Anja M., Soprano, Luciana L., Acosta, Diana M., Esteva, Mónica I., Jacobs, Thomas, Duschak, Vilma G.

“…In order to investigate the involvement of sulfated groups in the Trypanosoma cruzi host–parasite relationship, we studied the interaction between the major…”
Get full text

Effects of chlorate on the sulfation process of Trypanosoma cruzi glycoconjugates. Implication of parasite sulfates in cellular invasion by Ferrero, Maximiliano R., Soprano, Luciana L., Acosta, Diana M., García, Gabriela A., Esteva, Mónica I., Couto, Alicia S., Duschak, Vilma G.

“…•Our findings indicate that T. cruzi sulfation occurs via PAPS.•Presence of surface sulfated epitopes in trypomastigotes.•Cz sulfates are involved in the…”
Get full text

Structural analysis of the N-glycans of the major cysteine proteinase of Trypanosoma cruzi. Identification of sulfated high-mannose type oligosaccharides by Barboza, Mariana, Duschak, Vilma G, Fukuyama, Yuko, Nonami, Hiroshi, Erra-Balsells, Rosa, Cazzulo, Juan J, Couto, Alicia S

“…Trypanosoma cruzi, the parasitic protozoan that causes Chagas disease, contains a major cysteine proteinase, cruzipain. This lysosomal enzyme bears an unusual…”
Get full text

Plasmodium falciparum biosynthesizes sulfoglycosphingolipids by Landoni, Malena, Duschak, Vilma G., Peres, Valnice J., Nonami, Hiroshi, Erra-Balsells, Rosa, Katzin, Alejandro M., Couto, Alicia S.

“…Sulfated glycosphingolipids are present on the surface of a variety of cells. They are active participants in adhesion processes in many systems and appear to…”
Get full text

Antigenicity and immunocrossreactivity of orange tree pollen and orange fruit allergenic extracts by Irañeta, Silvia G, Seoane, Marta A, Laucella, Susana A, Apicella, Carolina, Alonso, Angel, Duschak, Vilma G

“…It is important to study the crossreactivity between orange tree pollen (OTPE) and orange fruit (OFE) due to the high incidence of pollen/food-related…”
Get full text

Identification and characterization of serine proteinase inhibitors from Neospora caninum by Bruno, S, Duschak, V.G, Ledesma, B, Ferella, M, Andersson, B, Guarnera, E.A, Angel, S.O

“…Two cDNA clones obtained from the Neospora caninum Expressed Sequence Tag project were selected by their homology with the Toxoplasma gondii serine proteinase…”
Get full text

Subcellular localization and post-secretory targeting of TgPI, a serine proteinase inhibitor from Toxoplasma gondii by Pszenny, Viviana, Ledesma, Bibiana E., Matrajt, Mariana, Duschak, Vilma G., Bontempi, Esteban J., Dubremetz, Jean-François, Angel, Sergio O.

Get full text

Humoral immune response to cruzipain and cardiac dysfunction in chronic Chagas disease by Duschak, Vilma G, Riarte, Adelina, Segura, Elsa L, Laucella, Susana A

“…The humoral immune response to epitopes expressed on cruzipain was evaluated in 31 Chagas disease patients (CDP) with different degrees of cardiac dysfunction…”
Get full text

Trypanosoma cruzi: partial characterization of minor cruzipain isoforms non-adsorbed to Concanavalin A–Sepharose by Duschak, Vilma G, Barboza, Mariana, Couto, Alicia S

“…The present paper reports the partial characterization of a subset of atypical cruzipain molecules which do not bind to Concanavalin A–Sepharose column. They…”
Get full text