Search Results - "Durum, S.K."

Cell Cycling through Cdc25A: Transducer of Cytokine Proliferative Signals by Kittipatarin, C., Li, WQ, Bulavin, D., Durum, S.K., Khaled, A.R.

“…A balance between survival and proliferative signals maintains a constant number of T lymphocytes that populate the mammalian immune system, a process termed…”
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Interferon-alpha suppresses the antiapoptotic effect of NF-kB and sensitizes renal cell carcinoma cells in vitro to chemotherapeutic drugs by Steiner, T, Junker, U, Henzgen, B, Nuske, K, Durum, S K, Schubert, J

“…Immunochemotherapy (ICT) with interleukin-2 (IL-2) and interferon-alpha (IFNalpha) with a secondary effector (5-fluorouracil, 5 FU) is the only promising…”
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Recombinant human growth hormone promotes human lymphocyte engraftment in immunodeficient mice and results in an increased incidence of human Epstein Barr virus-induced B-cell lymphoma by Murphy, W J, Durum, S K, Anver, M, Frazier, M, Longo, D L

“…Recombinant human growth hormone (rhGH) previously has been demonstrated to promote human or mouse T-cell engraftment in immunodeficient mice. We then wanted…”
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Interleukin-7: physiological roles and mechanisms of action by Hofmeister, R., Khaled, A.R., Benbernou, N., Rajnavolgyi, E., Muegge, K., Durum, S.K.

“…Interleukin-7 (IL-7), a product of stromal cells, provides critical signals to lymphoid cells at early stages in their development. Two types of cellular…”
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Characterization of Gene Expression, Genomic Structure, and Chromosomal Localization ofHells(Lsh) by Geiman, T.M., Durum, S.K., Muegge, K.

“…Hells(Lsh) is a lymphoid-specific presumptive helicase with highest expression in lymphoid precursor cells. Other members of the helicase family participate in…”
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Defective T-cell receptor γ gene rearrangement in interleukin-7 receptor knockout mice by Candéias, S, Peschon, J.J, Muegge, K, Durum, S.K

“…T-cell receptor (TCR) genes need to be rearranged by a site specific-VDJ recombinase before they are expressed. This process, initiated in CD44 +25 +…”
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p53-dependent apoptosis and transcription of p21 waf/ cip1/ sdi1 in SCID mice following γ-irradiation by Candéias, S.M., Durum, S.K., Muegge, K.

“…The recruitment and activation of DNA-repair mechanisms at the sites of DNA-damage after exposure of cells to genotoxic stress are poorly understood. The…”
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Defining Functional Domains of Ku80: DNA End Binding and Survival after Radiation by Osipovich, O., Duhe, R.J., Hasty, P., Durum, S.K., Muegge, K.

“…The Ku heterodimeric protein (Ku80/Ku70) is an essential component of the double-strand break DNA repair pathway in mammalian cells. We have recently defined a…”
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A novel putative helicase produced in early murine lymphocytes by Jarvis, C.D., Geiman, T., Vila-Storm, M.P., Osipovich, O., Akella, U., Candeias, S., Nathan, I., Durum, S.K., Muegge, K.

“…DNA helicases (Hel) play a role in a number of processes involving DNA strand separation, including replication, repair, recombination and transcription…”
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Interleukin-7: a cofactor for VJ rearrangement of the T cell receptor beta gene by Muegge, K, Vila, M.P, Durum, S.K

“…The diversity of the T cell receptor repertoire is generated by rearrangement of gene elements in immature thymocytes. To identify a thymic signal that induces…”
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Membrane IL-1: IL-1 alpha precursor binds to the plasma membrane via a lectin-like interaction by Brody, DT, Durum, SK

“…Although biologically active IL-1 associated with plasma membrane has been demonstrated in both mouse and man, a biochemical mechanism for membrane anchoring…”
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Defective TCRG gene rearrangement in interleukin-7 receptor knock out mice by Candéias, S., Peschon, J.J., Muegge, K., Durum, S.K.

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p53-dependent apoptosis and transcription of p21waf/cip1/sdi1 in SCID mice following gamma-irradiation by Candéias, S M, Durum, S K, Muegge, K

“…The recruitment and activation of DNA-repair mechanisms at the sites of DNA-damage after exposure of cells to genotoxic stress are poorly understood. The…”
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Accessory cells and T cell activation. The relationship between two components of macrophage accessory cell function: I-A and IL1 by Durum, S K, Higuchi, C, Ron, Y

“…Accessory cells are required for the activation of helper T cells. We have examined two characteristics of accessory cells, their expression of I-A, and their…”
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The comparative radiosensitivity of T and B lymphocytes by Durum, S K, Gengozian, N

“…This study deals with the comparative effects of gamma irradiation on T and B lymphocytes in mice. Quantitatively, splenic T cells appeared substantially more…”
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The onset of immune protection in acute experimental Chagas' disease in C3H(HE) mice by Kuhn, R E, Durum, S K

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IL-1 as a self-serving principle in T-cell clones by Durum, S K, Brody, D T, Tartakovsky, B

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