Search Results - "Duru, A. D."

P1456: EARLY SAFETY AND CLINICAL COURSE OF PATIENTS WITH ACUTE MYELOID LEUKEMIA AND MEASURABLE RESIDUAL DISEASE RECEIVING GTA002, AN OFF‐THE‐SHELF, EX VIVO‐CULTURED ALLOGENEIC NK CELL PREPARATION by Heuser, M., Fiedler, W., Block, A., Leeuw, D. C., Loosdrecht, A., Astrid Tschan‐Plessl, A., Passweg, J., Kloos, A., Schwarzer, A., Venturini, L., Duru, A. D., Pinkernell, K., Ganser, A.

Get full text

The use of novel drugs can effectively improve response, delay relapse and enhance overall survival in multiple myeloma patients with renal impairment by Uttervall, Katarina, Duru, Adil D, Lund, Johan, Liwing, Johan, Gahrton, Gösta, Holmberg, Erik, Aschan, Johan, Alici, Evren, Nahi, Hareth

“…Renal impairment is a common feature in multiple myeloma and is considered a poor prognostic factor. To determine the impact of novel drugs (i.e. bortezomib,…”
Get full text

Unexpected T‐cell recognition of an altered peptide ligand is driven by reversed thermodynamics by Allerbring, Eva B., Duru, Adil D., Uchtenhagen, Hannes, Madhurantakam, Chaithanya, Tomek, Markus B., Grimm, Sebastian, Mazumdar, Pooja A., Friemann, Rosmarie, Uhlin, Michael, Sandalova, Tatyana, Nygren, Per‐Åke, Achour, Adnane

“…The molecular basis underlying T‐cell recognition of MHC molecules presenting altered peptide ligands is still not well–established. A hierarchy of T‐cell…”
Get full text

The unexpected T-cell recognition of an altered peptide ligand is driven by reversed thermodynamics and an alternative structural hotspot by Allerbring, E. B., Duru, A. D., Uchtenhagen, H., Madhurantakam, C., Tomek, M. B., Grimm, Sebastian, Mazumdar, P. A., Friemann, R., Sandalova, T., Uhlin, M., Nygren, Per-Åke, Achour, A.

Get full text

Natural Killer Cell-Based Therapies Targeting Cancer: Possible Strategies to Gain and Sustain Anti-Tumor Activity by Dahlberg, Carin I M, Sarhan, Dhifaf, Chrobok, Michael, Duru, Adil D, Alici, Evren

“…Natural killer (NK) cells were discovered 40 years ago, by their ability to recognize and kill tumor cells without the requirement of prior antigen exposure…”
Get full text

Successive crystal structure snapshots suggest the basis for MHC class I peptide loading and editing by tapasin by Hafstrand, Ida, Sayitoglu, Ece Canan, Apavaloaei, Anca, Josey, Benjamin John, Sun, Renhua, Han, Xiao, Pellegrino, Sara, Ozkazanc, Didem, Potens, Renée, Janssen, Linda, Nilvebrant, Johan, Nygren, Per-Åke, Sandalova, Tatyana, Springer, Sebastian, Georgoudaki, Anna-Maria, Duru, Adil Doganay, Achour, Adnane

“…MHC-I epitope presentation to CD8+ T cells is directly dependent on peptide loading and selection during antigen processing. However, the exact molecular bases…”
Get full text

Engineering antigen‐specific NK cell lines against the melanoma‐associated antigen tyrosinase via TCR gene transfer by Parlar, Ayhan, Sayitoglu, Ece Canan, Ozkazanc, Didem, Georgoudaki, Anna‐Maria, Pamukcu, Cevriye, Aras, Mertkaya, Josey, Benjamin J., Chrobok, Michael, Branecki, Suzanne, Zahedimaram, Pegah, Ikromzoda, Lolai, Alici, Evren, Erman, Batu, Duru, Adil D., Sutlu, Tolga

“…Introduction of Chimeric Antigen Receptors to NK cells has so far been the main practical method for targeting NK cells to specific surface antigens. In…”
Get full text

Characterization of zika virus infection of human fetal cardiac mesenchymal stromal cells by Rossi, Fiorella, Josey, Benjamin, Sayitoglu, Ece Canan, Potens, Renee, Sultu, Tolga, Duru, Adil Doganay, Beljanski, Vladimir

“…Zika virus (ZIKV) is a single-stranded RNA virus belonging to the family Flaviviridae. ZIKV predominantly enters cells using the TAM-family protein tyrosine…”
Get full text

ALPL-1 is a target for chimeric antigen receptor therapy in osteosarcoma by Mensali, Nadia, Köksal, Hakan, Joaquina, Sandy, Wernhoff, Patrik, Casey, Nicholas P., Romecin, Paola, Panisello, Carla, Rodriguez, René, Vimeux, Lene, Juzeniene, Asta, Myhre, Marit R., Fåne, Anne, Ramírez, Carolina Castilla, Maggadottir, Solrun Melkorka, Duru, Adil Doganay, Georgoudaki, Anna-Maria, Grad, Iwona, Maturana, Andrés Daniel, Gaudernack, Gustav, Kvalheim, Gunnar, Carcaboso, Angel M., de Alava, Enrique, Donnadieu, Emmanuel, Bruland, Øyvind S., Menendez, Pablo, Inderberg, Else Marit, Wälchli, Sébastien

“…Osteosarcoma (OS) remains a dismal malignancy in children and young adults, with poor outcome for metastatic and recurrent disease. Immunotherapies in OS are…”
Get full text

Boosting Natural Killer Cell-Mediated Targeting of Sarcoma Through DNAM-1 and NKG2D by Sayitoglu, Ece Canan, Georgoudaki, Anna-Maria, Chrobok, Michael, Ozkazanc, Didem, Josey, Benjamin J, Arif, Muhammad, Kusser, Kim, Hartman, Michelle, Chinn, Tamara M, Potens, Renee, Pamukcu, Cevriye, Krueger, Robin, Zhang, Cheng, Mardinoglu, Adil, Alici, Evren, Temple, Harry Thomas, Sutlu, Tolga, Duru, Adil Doganay

“…Sarcomas are malignancies of mesenchymal origin that occur in bone and soft tissues. Many are chemo- and radiotherapy resistant, thus conventional treatments…”
Get full text

Re‐challenging with anti‐CD38 monotherapy in triple‐refractory multiple myeloma patients is a feasible and safe approach by Alici, Evren, Chrobok, Michael, Lund, Johan, Ahmadi, Tahamtan, Khan, Imran, Duru, Adil D., Nahi, Hareth

Get full text

Identification and strategic targeting of key anti-viral defense mechanisms in Natural Killer cells by Sayitoglu, Ece Canan, Ozkazanc, Didem, Sarac, Aydan, Parlar, Ayhan, Alici, Evren, Erman, Batu, Duru, Adil Doganay, Sutlu, Tolga

“…Abstract While genetic modification of lymphocytes proves to be an efficient approach in immunotherapy, commonly used lentiviral vectors are haunted by the…”
Get full text

Crystal structures of H-2D b in complex with the LCMV-derived peptides GP92 and GP392 explain pleiotropic effects of glycosylation on antigen presentation and immunogenicity by Hafstrand, I, Badia-Martinez, D, Josey, BJ, Norstrom, M, Buratto, J, Pellegrino, S, Duru, AD, Sandalova, T, Achour, A

Get full text

Tuning antiviral CD8 T-cell response via proline-altered peptide ligand vaccination by Duru, Adil Doganay, Sun, Renhua, Allerbring, Eva B, Chadderton, Jesseka, Kadri, Nadir, Han, Xiao, Peqini, Kaliroi, Uchtenhagen, Hannes, Madhurantakam, Chaithanya, Pellegrino, Sara, Sandalova, Tatyana, Nygren, Per-Åke, Turner, Stephen J, Achour, Adnane

“…Viral escape from CD8+ cytotoxic T lymphocyte responses correlates with disease progression and represents a significant challenge for vaccination. Here, we…”
Get full text

The Immunogenicity of a Proline-Substituted Altered Peptide Ligand toward the Cancer-Associated TEIPP Neoepitope Trh4 Is Unrelated to Complex Stability by Hafstrand, Ida, Doorduijn, Elien M, Sun, Renhua, Talyzina, Anna, Sluijter, Marjolein, Pellegrino, Sara, Sandalova, Tatyana, Duru, Adil Doganay, van Hall, Thorbald, Achour, Adnane

“…Human cancers frequently display defects in Ag processing and presentation allowing for immune evasion, and they therefore constitute a significant challenge…”
Get full text

Functional Assessment for Clinical Use of Serum-Free Adapted NK-92 Cells by Chrobok, Michael, Dahlberg, Carin I M, Sayitoglu, Ece Canan, Beljanski, Vladimir, Nahi, Hareth, Gilljam, Mari, Stellan, Birgitta, Sutlu, Tolga, Duru, Adil Doganay, Alici, Evren

“…Natural killer (NK) cells stand out as promising candidates for cellular immunotherapy due to their capacity to kill malignant cells. However, the therapeutic…”
Get full text

The MHC Class I Cancer-Associated Neoepitope Trh4 Linked with Impaired Peptide Processing Induces a Unique Noncanonical TCR Conformer by Hafstrand, Ida, Doorduijn, Elien M, Duru, Adil Doganay, Buratto, Jeremie, Oliveira, Claudia Cunha, Sandalova, Tatyana, van Hall, Thorbald, Achour, Adnane

“…MHC class I downregulation represents a significant challenge for successful T cell-based immunotherapy. T cell epitopes associated with impaired peptide…”
Get full text

Deletion of Chromosomal Region 8p21 Confers Resistance to Bortezomib and Is Associated with Upregulated Decoy TRAIL Receptor Expression in Patients with Multiple Myeloma by Duru, Adil Doganay, Sutlu, Tolga, Wallblom, Ann, Uttervall, Katarina, Lund, Johan, Stellan, Birgitta, Gahrton, Gösta, Nahi, Hareth, Alici, Evren

“…Loss of the chromosomal region 8p21 negatively effects survival in patients with multiple myeloma (MM) that undergo autologous stem cell transplantation…”
Get full text

Crystal structures of H-2Db in complex with the LCMV-derived peptides GP92 and GP392 explain pleiotropic effects of glycosylation on antigen presentation and immunogenicity by Hafstrand, Ida, Badia-Martinez, Daniel, Josey, Benjamin John, Norström, Melissa, Buratto, Jérémie, Pellegrino, Sara, Duru, Adil Doganay, Sandalova, Tatyana, Achour, Adnane

“…Post-translational modifications significantly broaden the epitope repertoire for major histocompatibility class I complexes (MHC-I) and may allow viruses to…”
Get full text

Inflammation-associated nitrotyrosination affects TCR recognition through reduced stability and alteration of the molecular surface of the MHC complex by Madhurantakam, Chaithanya, Duru, Adil D, Sandalova, Tatyana, Webb, John R, Achour, Adnane

“…Nitrotyrosination of proteins, a hallmark of inflammation, may result in the production of MHC-restricted neoantigens that can be recognized by T cells and…”
Get full text