Search Results - "Durst, Matthew"
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Effect of Emergency Department and ICU Occupancy on Admission Decisions and Outcomes for Critically Ill Patients
Published in Critical care medicine (01-05-2018)“…OBJECTIVES:ICU admission delays can negatively affect patient outcomes, but emergency department volume and boarding times may also affect these decisions and…”
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Journal Article -
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Identifying small molecule probes of ENTPD5 through high throughput screening
Published in PloS one (26-06-2019)“…Ectonucleoside Triphosphate Diphosphohydrolase 5 (ENTPD5) has been shown to be important in maintaining cellular function in cancer, and its expression is…”
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Journal Article -
3
Identification of a pH sensor in Influenza hemagglutinin using X-ray crystallography
Published in Journal of structural biology (01-01-2020)“…[Display omitted] •X-ray crystallography identifies a conserved histidine, HA1-H38, that changes side chain conformation at low pH.•We attribute the observed…”
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4
NMR-based metabolite studies with 15N amino acids
Published in Scientific reports (05-09-2019)“…15 N labeled amino acids are routinely used to label proteins or nucleic acids for study by NMR. However, NMR studies of 15 N labeled amino acids in metabolite…”
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Journal Article -
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Predictors of Delayed Recognition of Critical Illness in Emergency Department Patients and Its Effect on Morbidity and Mortality
Published in Journal of intensive care medicine (01-01-2022)“…Purpose: Timely recognition of critical illness is associated with improved outcomes, but is dependent on accurate triage, which is affected by system factors…”
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Metabolic Modifier Screen Reveals Secondary Targets of Protein Kinase Inhibitors within Nucleotide Metabolism
Published in Cell chemical biology (20-02-2020)“…Biosynthesis of the pyrimidine nucleotide uridine monophosphate (UMP) is essential for cell proliferation and is achieved by the activity of convergent de novo…”
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Structure of avian influenza hemagglutinin in complex with a small molecule entry inhibitor
Published in Life science alliance (01-08-2020)“…HA plays a critical role in influenza infection and, thus HA is a potential target for antivirals. Recently, our laboratories have described a novel fusion…”
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SEPTICEMIA FROM URINARY TRACT INFECTION WITH NEGATIVE URINARY CULTURE: AEROCCOCUS URINAE IN AN OLDER ADULT
Published in Chest (01-10-2019)Get full text
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Effect of Emergency Department and Intensive Care Unit occupancy on admission decisions and outcomes for critically ill patients
Published in Critical care medicine (01-05-2018)Get full text
Journal Article -
10
Probing the metastable state of influenza hemagglutinin
Published in The Journal of biological chemistry (29-12-2017)“…Viral entry into host cells is mediated by membrane proteins in a metastable state that transition to a more stable state upon a stimulus. For example, in the…”
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Drug Development Geared to Discover, Validate, and Potentiate Cancer Cell Vulnerabilities
Published 01-01-2021“…Cancers continue to have a large burden on individual health and our society at large. To achieve the constant growth, they have a unique set of metabolic…”
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Dissertation -
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NMR-based metabolite studies with 15 N amino acids
Published in Scientific reports (05-09-2019)“…N labeled amino acids are routinely used to label proteins or nucleic acids for study by NMR. However, NMR studies of N labeled amino acids in metabolite…”
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Journal Article