Search Results - "Duronio, Gina N"

An Enhancer-Driven Stem Cell–Like Program Mediated by SOX9 Blocks Intestinal Differentiation in Colorectal Cancer by Liang, Xiaoyan, Duronio, Gina N., Yang, Yaying, Bala, Pratyusha, Hebbar, Prajna, Spisak, Sandor, Sahgal, Pranshu, Singh, Harshabad, Zhang, Yanxi, Xie, Yingtian, Cejas, Paloma, Long, Henry W., Bass, Adam J., Sethi, Nilay S.

“…Genomic alterations that encourage stem cell activity and hinder proper maturation are central to the development of colorectal cancer (CRC). Key molecular…”
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Early TP53 alterations engage environmental exposures to promote gastric premalignancy in an integrative mouse model by Sethi, Nilay S., Kikuchi, Osamu, Duronio, Gina N., Stachler, Matthew D., McFarland, James M., Ferrer-Luna, Ruben, Zhang, Yanxi, Bao, Chunyang, Bronson, Roderick, Patil, Deepa, Sanchez-Vega, Francisco, Liu, Jie-Bin, Sicinska, Ewa, Lazaro, Jean-Bernard, Ligon, Keith L., Beroukhim, Rameen, Bass, Adam J.

“…Somatic alterations in cancer genes are being detected in normal and premalignant tissue, thus placing greater emphasis on gene–environment interactions that…”
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YAP1 and PRDM14 converge to promote cell survival and tumorigenesis by Kim, Miju, Ly, Seav Huong, Xie, Yingtian, Duronio, Gina N., Ford-Roshon, Dane, Hwang, Justin H., Sulahian, Rita, Rennhack, Jonathan P., So, Jonathan, Gjoerup, Ole, Talamas, Jessica A., Grandclaudon, Maximilien, Long, Henry W., Doench, John G., Sethi, Nilay S., Giannakis, Marios, Hahn, William C.

“…The transcriptional co-activator YAP1 oncogene is the downstream effector of the Hippo pathway, which regulates tissue homeostasis, organ size, regeneration,…”
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Aberrant cell state plasticity mediated by developmental reprogramming precedes colorectal cancer initiation by Bala, Pratyusha, Rennhack, Jonathan P, Aitymbayev, Daulet, Morris, Clare, Moyer, Sydney M, Duronio, Gina N, Doan, Paul, Li, Zhixin, Liang, Xiaoyan, Hornick, Jason L, Yurgelun, Matthew B, Hahn, William C, Sethi, Nilay S

“…Cell state plasticity is carefully regulated in adult epithelia to prevent cancer. The aberrant expansion of the normally restricted capability for cell state…”
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Abstract 3119: Identification of genetic drivers in HER2enriched/HER2negative breast cancer by Recio, Susana Garcia, Fan, Cheng, Siegel, Marni, Parker, Joel S., Duronio, Gina N., Prat, Aleix, Perou, Charles M.

“…Abstract Background: The non-basal triple negative breast cancer (Non Basal-TNBC) tumors, also called the luminal androgen receptor (LAR) subtype, make up ~20%…”
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Abstract PR012: Aberrant cell state plasticity mediates colorectal cancer initiation by Bala, Pratyusha, Rennhack, Jonathan, Morris, Clare, Aitymbayev, Daulet, Moyer, Sydney M., Duronio, Gina N., Hahn, William, Sethi, Nilay S.

“…Abstract Cell state plasticity – the ability of cells to acquire new states via differentiation programs - is an important feature of embryogenesis, allowing…”
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