Search Results - "Durk, Matthew"

Optimized arylomycins are a new class of Gram-negative antibiotics by Smith, Peter A., Koehler, Michael F. T., Girgis, Hany S., Yan, Donghong, Chen, Yongsheng, Chen, Yuan, Crawford, James J., Durk, Matthew R., Higuchi, Robert I., Kang, Jing, Murray, Jeremy, Paraselli, Prasuna, Park, Summer, Phung, Wilson, Quinn, John G., Roberts, Tucker C., Rougé, Lionel, Schwarz, Jacob B., Skippington, Elizabeth, Wai, John, Xu, Min, Yu, Zhiyong, Zhang, Hua, Tan, Man-Wah, Heise, Christopher E.

“…Multidrug-resistant bacteria are spreading at alarming rates, and despite extensive efforts no new class of antibiotic with activity against Gram-negative…”
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Complex DDI by Fenebrutinib and the Use of Transporter Endogenous Biomarkers to Elucidate the Mechanism of DDI by Jones, Nicholas S., Yoshida, Kenta, Salphati, Laurent, Kenny, Jane R., Durk, Matthew R., Chinn, Leslie W.

“…Mechanistic understanding of complex clinical drug–drug interactions (DDIs) with potential involvement of multiple elimination pathways has been challenging,…”
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1α,25-Dihydroxyvitamin D3 reduces cerebral amyloid-β accumulation and improves cognition in mouse models of Alzheimer's disease by Durk, Matthew R, Han, Kyung, Chow, Edwin C Y, Ahrens, Rosemary, Henderson, Jeffrey T, Fraser, Paul E, Pang, K Sandy

“…We demonstrate a role of the vitamin D receptor (VDR) in reducing cerebral soluble and insoluble amyloid-β (Aβ) peptides. Short-term treatment of two human…”
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Design and Measurement of Drug Tissue Concentration Asymmetry and Tissue Exposure-Effect (Tissue PK-PD) Evaluation by Zang, Richard, Barth, Aline, Wong, Harvey, Marik, Jan, Shen, Jie, Lade, Julie, Grove, Kerri, Durk, Matthew R., Parrott, Neil, Rudewicz, Patrick J., Zhao, Sylvia, Wang, Tao, Yan, Zhengyin, Zhang, Donglu

“…The “free drug hypothesis” assumes that, in the absence of transporters, the steady state free plasma concentrations equal to that at the site of action that…”
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Elucidating a Potential Mechanism of Permeability Enhancer Sodium N-[8-(2-hydroxybenzoyl) amino] Caprylate in Rats: Evidence of Lymphatic Absorption of Cyanocobalamin using the Mesenteric Lymph Duct Cannulated Rat by Chiang, Po-Chang, Liu, Jia, Nagapudi, Karthik, Wu, Ricky, Dolton, Michael, Chen, Jacob, Plise, Emile, Liu, Liling, Durk, Matthew R

“…Oral administration is the most popular and convenient route for drug delivery, yet the success of oral drug delivery is dependent on the ADME properties of…”
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Inhaled JAK inhibitor GDC-0214 reduces exhaled nitric oxide in patients with mild asthma: A randomized, controlled, proof-of-activity trial by Braithwaite, Irene E., Cai, Fang, Tom, Jennifer A., Galanter, Joshua M., Owen, Ryan P., Zhu, Rui, Williams, Mathew, McGregor, Anna G., Eliahu, Avi, Durk, Matthew R., Dengler, Hart S., Zak, Mark, Kenny, Jane R., Wilson, Maria E., Beasley, Richard, Chen, Hubert

“…The Janus kinase (JAK) pathway mediates the activity of many asthma-relevant cytokines, including IL-4 and IL-13. GDC-0214 is a potent, inhaled, small-molecule…”
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Use of Subcutaneous and Intraperitoneal Administration Methods to Facilitate Cassette Dosing in Microdialysis Studies in Rats by Durk, Matthew R, Deshmukh, Gauri, Valle, Nicole, Ding, Xiao, Liederer, Bianca M, Liu, Xingrong

“…Microdialysis is a powerful technique allowing for real-time measurement of unbound drug concentrations in brain interstitial fluid (ISF) in conscious animals…”
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Design and Evaluation of Highly Selective Human Immunoproteasome Inhibitors Reveal a Compensatory Process That Preserves Immune Cell Viability by Ladi, Ena, Everett, Christine, Stivala, Craig E, Daniels, Blake E, Durk, Matthew R, Harris, Seth F, Huestis, Malcolm P, Purkey, Hans E, Staben, Steven T, Augustin, Martin, Blaesse, Michael, Steinbacher, Stefan, Eidenschenk, Celine, Pappu, Rajita, Siu, Michael

“…The pan-proteasome inhibitor bortezomib demonstrated clinical efficacy in off-label trials of Systemic Lupus Erythematosus. One potential mechanism of this…”
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Vitamin D Receptor Activation Down-regulates the Small Heterodimer Partner and Increases CYP7A1 to Lower Cholesterol by Chow, Edwin C.Y, Magomedova, Lilia, Quach, Holly P, Patel, Rucha, Durk, Matthew R, Fan, Jianghong, Maeng, Han-Joo, Irondi, Kamdi, Anakk, Sayeepriyadarshini, Moore, David D, Cummins, Carolyn L, Pang, K. Sandy

“…Background & Aims Little is known about the effects of the vitamin D receptor (VDR) on hepatic activity of human cholesterol 7α-hydroxylase (CYP7A1) and…”
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Targeting KRAS Mutant Cancers via Combination Treatment: Discovery of a 5‑Fluoro-4-(3H)‑quinazolinone Aryl Urea pan-RAF Kinase Inhibitor by Huestis, Malcolm P, Dela Cruz, Darlene, DiPasquale, Antonio G, Durk, Matthew R, Eigenbrot, Charles, Gibbons, Paul, Gobbi, Alberto, Hunsaker, Thomas L, La, Hank, Leung, Dennis H, Liu, Wendy, Malek, Shiva, Merchant, Mark, Moffat, John G, Muli, Christine S, Orr, Christine J, Parr, Brendan T, Shanahan, Frances, Sneeringer, Christopher J, Wang, Weiru, Yen, Ivana, Yin, Jianping, Siu, Michael, Rudolph, Joachim

“…Optimization of a series of aryl urea RAF inhibitors led to the identification of type II pan-RAF inhibitor GNE-0749 (7), which features a fluoroquinazolinone…”
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Understanding the Effect of Hydroxypropyl‐β‐Cyclodextrin on Fenebrutinib Absorption in an Itraconazole–Fenebrutinib Drug–Drug Interaction Study by Durk, Matthew R., Jones, Nicholas S., Liu, Jia, Nagapudi, Karthik, Mao, Chen, Plise, Emile G., Wong, Susan, Chen, Jacob Z., Chen, Yuan, Chinn, Leslie W., Chiang, Po‐Chang

“…Cyclodextrins are widely used pharmaceutical excipients, particularly for insoluble compounds dosed orally, such as the oral solution of itraconazole, which is…”
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1α,25-Dihydroxyvitamin D3-liganded vitamin D receptor increases expression and transport activity of P-glycoprotein in isolated rat brain capillaries and human and rat brain microvessel endothelial cells by Durk, Matthew R., Chan, Gary N.Y., Campos, Christopher R., Peart, John C., Chow, Edwin C. Y., Lee, Eason, Cannon, Ronald E., Bendayan, Reina, Miller, David S., Pang, K. Sandy

“…Induction of the multidrug resistance protein 1 (MDR1)/P‐glycoprotein (P‐gp) by the vitamin D receptor (VDR) was investigated in isolated rat brain capillaries…”
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Effects of inhaled JAK inhibitor GDC-4379 on exhaled nitric oxide and peripheral biomarkers of inflammation by Chen, Hubert, Kunder, Rebecca, Zou, Yixuan, Staton, Tracy, Zhu, Rui, Galanter, Joshua, Gugelmann, Hallam, Owen, Ryan, Grimbaldeston, Michele A., Chang, Joanna K., Durk, Matthew R., Eliahu, Avi, Wilson, Mark S., Choy, David F., Wilson, Maria, Black, Melissa, Doppen, Marjan, Kung, Stacey, Oldfield, Karen, Sparks, Jenny, Beasley, Richard, Braithwaite, Irene

“…Janus Kinases (JAKs) mediate activity of many asthma-relevant cytokines. GDC-0214, an inhaled small molecule JAK1 inhibitor, has previously been shown to…”
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Physiologically‐Based Pharmacokinetic Model‐Informed Drug Development for Fenebrutinib: Understanding Complex Drug‐Drug Interactions by Chen, Yuan, Ma, Fang, Jones, Nicholas S., Yoshida, Kenta, Chiang, Po‐Chang, Durk, Matthew R., Wright, Matthew R., Jin, Jin Yan, Chinn, Leslie W.

“…Fenebrutinib is a CYP3A substrate and time‐dependent inhibitor, as well as a BCRP and OATP1B transporter inhibitor in vitro. Physiologically‐based…”
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Phase I and scintigraphy studies to evaluate safety, tolerability, pharmacokinetics, and lung deposition of inhaled GDC‐0214 in healthy volunteers by Zhu, Rui, Chen, Hubert, Galanter, Joshua, She, Gaohong, Cai, Fang, Durk, Matthew R., Zou, Yixuan, Chen, Liuxi, Kenny, Jane R., Vadhavkar, Shweta, Warren, Simon, Taylor, Glyn, Hwang, Olivia, Eliahu, Avi, Wynne, Chris, Owen, Ryan

“…Several inflammatory cytokines that promote inflammation and pathogenesis in asthma signal through the Janus kinase 1 (JAK1) pathway. This phase I, randomized,…”
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Impact of age, hypercholesterolemia, and the vitamin D receptor on brain endogenous β‐amyloid peptide accumulation in mice by Peng, H. Benson, Bukuroshi, Paola, Durk, Matthew R., Grootendorst, Paul, Yan, Xiaoyu, Pan, Sophie R., Lannoy, Ines A. M., Pang, K. Sandy

“…Age, hypercholesterolemia, and vitamin D deficiency are risk factors that increase the brain accumulation of pathogenic β‐amyloid peptides (40 and 42),…”
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Lipid Tales: Optimizing Arylomycin Membrane Anchors by Koehler, Michael F. T., Chen, Yi-Chen, Chen, Yongsheng, Chen, Yuan, Crawford, James J., Durk, Matthew R., Garland, Keira, Hanan, Emily J., Higuchi, Robert I., Hu, Huiyong, Ly, Cuong Q., Paraselli, Prasuna G., Roberts, Tucker C., Schwarz, Jacob B., Smith, Peter A., Yu, Zhiyong, Heise, Christopher E.

“…Multidrug-resistant bacteria are spreading at alarming rates, and despite extensive efforts, no new antibiotic class with activity against Gram-negative…”
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Biorelevant Dissolution Models for a Weak Base To Facilitate Formulation Development and Overcome Reduced Bioavailability Caused by Hypochlordyria or Achlorhydria by Kou, Dawen, Dwaraknath, Sudharsan, Fischer, Yannick, Nguyen, Daniel, Kim, Myeonghui, Yiu, Hiuwing, Patel, Preeti, Ng, Tania, Mao, Chen, Durk, Matthew, Chinn, Leslie, Winter, Helen, Wigman, Larry, Yehl, Peter

“…In this study, two dissolution models were developed to achieve in vitro–in vivo relationship for immediate release formulations of Compound-A, a poorly…”
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Physiologically-based pharmacokinetic modeling for absorption, transport, metabolism and excretion by Pang, K. Sandy, Durk, Matthew R.

“…The seminal paper on the liver physiologically-based pharmacokinetic (PBPK) model by Rowland et al. (J Pharmacokinet Biopharm 1:123–136, 1973 ) that described…”
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Vitamin D Receptor Activation Induces P-Glycoprotein and Increases Brain Efflux of Quinidine:An Intracerebral Microdialysis Study in Conscious Rats by Durk, Matthew R., Fan, Jianghong, Sun, Huadong, Yang, Yingbo, Pang, Henrianna, Pang, K. Sandy, de Lannoy, Inés A. M.

“…Purpose Since the vitamin D receptor (VDR) was found to up-regulate cerebral P-glycoprotein expression in vitro and in mice, we extend our findings to rats by…”
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