Search Results - "Durieu, Véronique"

Synthesis and Evaluation of Bicyclic Hydroxypyridones as Inhibitors of Catechol O‑Methyltransferase by Ernst, Glen, Akuma, Daniel, Au, Vinh, Buchler, Ingrid P, Byers, Spencer, Carr, Gregory V, Defays, Sabine, de León, Pablo, Demaude, Thierry, DePasquale, Michael, Durieu, Véronique, Huang, Yifang, Jigorel, Emilie, Kimos, Martha, Kolobova, Anna, Montel, Florian, Moureau, Florence, Poslusney, Michael, Swinnen, Dominique, Vandergeten, Marie-Christine, Van houtvin, Nathalie, Wei, Huijun, White, Noelle, Wood, Martyn, Barrow, James C

“…A series of bicyclic pyridones were identified as potent inhibitors of catechol O-methyltransferase (COMT). Substituted benzyl groups attached to the basic…”
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Lead Optimization of Thiazolo[5,4-c]piperidines: 3-Cyclobutoxy Linker as a Key Spacer for H3R Inverse Agonists by Provins, Laurent, Denonne, Frédéric, Célanire, Sylvain, Christophe, Bernard, Defays, Sabine, Delaunoy, Christel, Delporte, Marie-Laure, Demaude, Thierry, Durieu, Véronique, Gillard, Michel, Hubert, Delphine, Lamberty, Yves, Lorent, Geneviève, Valade, Anne, Vanbellinghen, Alain, Van houtvin, Nathalie

“…The simpler, the better: H3 histamine receptor (H3R) are of interest as therapeutic targets in cognitive and somnolence disorders. Here, lead optimization of…”
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Acetamide Scanning around Bicyclic Thiazoles: SAR at the H 3 Receptor by Denonne , Frédéric, Célanire, Sylvain, Christophe, Bernard, Defays, Sabine, Delaunoy, Christel, Delporte, Marie‐Laure, Detrait, Eric, Durieu, Véronique, Gillard, Michel, Lamberty, Yves, Lorent, Geneviève, Nicolas, Jean‐Marie, Vanbellinghen, Alain, Van Houtvin, Nathalie, Provins, Laurent

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Phenyl‐oxazoles, a New Family of Inverse Agonists at the H 3 Histamine Receptor by Denonne, Frédéric, Atienzar, Franck, Célanire, Sylvain, Christophe, Bernard, Delannois, Frédérique, Delaunoy, Christel, Delporte, Marie‐Laure, Durieu, Véronique, Gillard, Michel, Lallemand, Bénédicte, Lamberty, Yves, Lorent, Geneviève, Vanbellinghen, Alain, Van houtvin, Nathalie, Verbois, Valérie, Provins, Laurent

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Discovery of a New Class of Non‐imidazole Oxazoline‐Based Histamine H 3 Receptor (H 3 R) Inverse Agonists by Célanire, Sylvain, Wijtmans, Maikel, Christophe, Bernard, Collart, Philippe, de Esch, Iwan, Dassesse, Donald, Delaunoy, Christel, Denonne, Frédéric, Durieu, Véronique, Gelens, Edith, Gillard, Michel, Lallemand, Bénédicte, Lamberty, Yves, Lebon, Florence, Nicolas, Jean‐Marie, Quéré, Luc, Snip, Erwin, Vanbellinghen, Alain, Van houtvin, Nathalie, Verbois, Valérie, Timmerman, Henk, Talaga, Patrice, Leurs, Rob, Provins, Laurent

“…H 3 R inverse agonists based on an aminopropoxy‐phenyloxazoline framework constitute highly valuable druglike lead compounds that display efficacy in a mouse…”
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First dual M3 antagonists-PDE4 inhibitors : Synthesis and SAR of 4,6-diaminopyrimidine derivatives by PROVINS, Laurent, CHRISTOPHE, Bernard, DANHAIVE, Pierre, DULIEU, Jacques, DURIEU, Véronique, GILLARD, Michel, LEBON, Florence, LENGELE, Sébastien, QUERE, Luc, VAN KEULEN, Berendjan

“…SAR around 4,6-diaminopyrimidine derivatives allowed the discovery of the first potent dual M(3) antagonists and PDE4 inhibitors. Various chemical modulations…”
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Lead Optimization of Thiazolo[5,4‐ c ]piperidines: 3‐Cyclobutoxy Linker as a Key Spacer for H 3 R Inverse Agonists by Provins, Laurent, Denonne, Frédéric, Célanire, Sylvain, Christophe, Bernard, Defays, Sabine, Delaunoy, Christel, Delporte, Marie‐Laure, Demaude, Thierry, Durieu, Véronique, Gillard, Michel, Hubert, Delphine, Lamberty, Yves, Lorent, Geneviève, Valade, Anne, Vanbellinghen, Alain, Van houtvin, Nathalie

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Phenyl-oxazoles, a New Family of Inverse Agonists at the H3 Histamine Receptor by Denonne, Frédéric, Atienzar, Franck, Célanire, Sylvain, Christophe, Bernard, Delannois, Frédérique, Delaunoy, Christel, Delporte, Marie-Laure, Durieu, Véronique, Gillard, Michel, Lallemand, Bénédicte, Lamberty, Yves, Lorent, Geneviève, Vanbellinghen, Alain, Van houtvin, Nathalie, Verbois, Valérie, Provins, Laurent

“…Drug design: Oxazoles and thiazoles were designed and synthesised based on previously reported ligands of the 3rd histamine receptor (H3R). The…”
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First dual M 3 antagonists-PDE4 inhibitors: Synthesis and SAR of 4,6-diaminopyrimidine derivatives by Provins, Laurent, Christophe, Bernard, Danhaive, Pierre, Dulieu, Jacques, Durieu, Véronique, Gillard, Michel, Lebon, Florence, Lengelé, Sébastien, Quéré, Luc, van Keulen, BerendJan

“…The synthesis and SAR around 4,6-diaminopyrimidine derivatives as dual M3 antagonists and PDE4 inhibitors are reported. SAR around 4,6-diaminopyrimidine…”
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Acetamide Scanning around Bicyclic Thiazoles: SAR at the H3 Receptor by Denonne , Frédéric, Célanire, Sylvain, Christophe, Bernard, Defays, Sabine, Delaunoy, Christel, Delporte, Marie-Laure, Detrait, Eric, Durieu, Véronique, Gillard, Michel, Lamberty, Yves, Lorent, Geneviève, Nicolas, Jean-Marie, Vanbellinghen, Alain, Van Houtvin, Nathalie, Provins, Laurent

“…A surprisingly homogeneous SAR against the H3 receptor was revealed for positional acetamide isomers of bicyclic thiazoles fused to various cyclic amines…”
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Lead optimization of thiazolo[5,4-c]piperidines: 3-cyclobutoxy linker as a key spacer for H(3)R inverse agonists by Provins, Laurent, Denonne, Frédéric, Célanire, Sylvain, Christophe, Bernard, Defays, Sabine, Delaunoy, Christel, Delporte, Marie-Laure, Demaude, Thierry, Durieu, Véronique, Gillard, Michel, Hubert, Delphine, Lamberty, Yves, Lorent, Geneviève, Valade, Anne, Vanbellinghen, Alain, Van Houtvin, Nathalie

“…The simpler, the better: H(3) histamine receptor (H(3)R) are of interest as therapeutic targets in cognitive and somnolence disorders. Here, lead optimization…”
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Discovery of a New Class of Non-imidazole Oxazoline-Based Histamine H3 Receptor (H3R) Inverse Agonists by Célanire, Sylvain, Wijtmans, Maikel, Christophe, Bernard, Collart, Philippe, de Esch, Iwan, Dassesse, Donald, Delaunoy, Christel, Denonne, Frédéric, Durieu, Véronique, Gelens, Edith, Gillard, Michel, Lallemand, Bénédicte, Lamberty, Yves, Lebon, Florence, Nicolas, Jean-Marie, Quéré, Luc, Snip, Erwin, Vanbellinghen, Alain, Van houtvin, Nathalie, Verbois, Valérie, Timmerman, Henk, Talaga, Patrice, Leurs, Rob, Provins, Laurent

“…H3R inverse agonists based on an aminopropoxy‐phenyloxazoline framework constitute highly valuable druglike lead compounds that display efficacy in a mouse…”
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Phenyl-oxazoles, a new family of inverse agonists at the H(3) histamine receptor by Denonne, Frédéric, Atienzar, Franck, Célanire, Sylvain, Christophe, Bernard, Delannois, Frédérique, Delaunoy, Christel, Delporte, Marie-Laure, Durieu, Véronique, Gillard, Michel, Lallemand, Bénédicte, Lamberty, Yves, Lorent, Geneviève, Vanbellinghen, Alain, Van Houtvin, Nathalie, Verbois, Valérie, Provins, Laurent

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Discovery of a new class of non-imidazole oxazoline-based histamine H(3) receptor (H(3)R) inverse agonists by Célanire, Sylvain, Wijtmans, Maikel, Christophe, Bernard, Collart, Philippe, de Esch, Iwan, Dassesse, Donald, Delaunoy, Christel, Denonne, Frédéric, Durieu, Véronique, Gelens, Edith, Gillard, Michel, Lallemand, Bénédicte, Lamberty, Yves, Lebon, Florence, Nicolas, Jean-Marie, Quéré, Luc, Snip, Erwin, Vanbellinghen, Alain, Van Houtvin, Nathalie, Verbois, Valérie, Timmerman, Henk, Talaga, Patrice, Leurs, Rob, Provins, Laurent

“…H(3)R inverse agonists based on an aminopropoxy-phenyloxazoline framework constitute highly valuable druglike lead compounds that display efficacy in a mouse…”
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First dual M sub(3) antagonists-PDE4 inhibitors: Synthesis and SAR of 4,6- diaminopyrimidine derivatives by Provins, Laurent, Christophe, Bernard, Danhaive, Pierre, Dulieu, Jacques, Durieu, Veronique, Gillard, Michel, Lebon, Florence, Lengele, Sebastien, Quere, Luc, Van Keulen, BerendJan

“…SAR around 4,6-diaminopyrimidine derivatives allowed the discovery of the first potent dual M sub(3) antagonists and PDE4 inhibitors. Various chemical…”
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