Search Results - "Durhan, Elizabeth J"

Propiconazole inhibits steroidogenesis and reproduction in the fathead minnow (Pimephales promelas) by Skolness, Sarah Y, Blanksma, Chad A, Cavallin, Jenna E, Churchill, Jessica J, Durhan, Elizabeth J, Jensen, Kathleen M, Johnson, Rodney D, Kahl, Michael D, Makynen, Elizabeth A, Villeneuve, Daniel L, Ankley, Gerald T

“…Conazoles are designed to inhibit cytochrome P450 (CYP) 14α-demethylase, an enzyme key to fungal cell wall formation. In vertebrates, conazoles may inhibit…”
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Effects of a glucocorticoid receptor agonist, dexamethasone, on fathead minnow reproduction, growth, and development by LaLone, Carlie A., Villeneuve, Daniel L., Olmstead, Allen W., Medlock, Elizabeth K., Kahl, Michael D., Jensen, Kathleen M., Durhan, Elizabeth J., Makynen, Elizabeth A., Blanksma, Chad A., Cavallin, Jenna E., Thomas, Linnea M., Seidl, Sara M., Skolness, Sarah Y., Wehmas, Leah C., Johnson, Rodney D., Ankley, Gerald T.

“…Synthetic glucocorticoids are pharmaceutical compounds prescribed in human and veterinary medicine as anti‐inflammatory agents and have the potential to…”
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Identification of metabolites of trenbolone acetate in androgenic runoff from a beef feedlot by Durhan, Elizabeth J, Lambright, Christy S, Makynen, Elizabeth A, Lazorchak, James, Hartig, Phillip C, Wilson, Vickie S, Gray, L Earl, Ankley, Gerald T

“…Little is known concerning the potential ecological effects of hormonally active substances associated with discharges from animal feeding operations…”
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Rapid effects of the aromatase inhibitor fadrozole on steroid production and gene expression in the ovary of female fathead minnows (Pimephales promelas) by Schroeder, Anthony L., Ankley, Gerald T., Habib, Tanwir, Garcia-Reyero, Natalia, Escalon, Barbara L., Jensen, Kathleen M., Kahl, Michael D., Durhan, Elizabeth J., Makynen, Elizabeth A., Cavallin, Jenna E., Martinovic-Weigelt, Dalma, Perkins, Edward J., Villeneuve, Daniel L.

“…•Estradiol concentrations were altered within hours of exposure to fadrozole.•Estradiol remained depressed over the first 24h of exposure.•Gene expression…”
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Effects of gemfibrozil on lipid metabolism, steroidogenesis, and reproduction in the fathead minnow (Pimephales promelas) by Skolness, Sarah Y., Durhan, Elizabeth J., Jensen, Kathleen M., Kahl, Michael D., Makynen, Elizabeth A., Villeneuve, Daniel L., Ankley, Gerald T.

“…Fibrates are a class of pharmaceuticals that indirectly modulate cholesterol biosynthesis through effects on peroxisome proliferator‐activated receptors…”
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Derivation and Evaluation of Putative Adverse Outcome Pathways for the Effects of Cyclooxygenase Inhibitors on Reproductive Processes in Female Fish by Martinovic-Weigelt, Dalma, Mehinto, Alvine C, Ankley, Gerald T, Berninger, Jason P, Collette, Timothy W, Davis, John M, Denslow, Nancy D, Durhan, Elizabeth J, Eid, Evan, Ekman, Drew R, Jensen, Kathleen M, Kahl, Michael D, LaLone, Carlie A, Teng, Quincy, Villeneuve, Daniel L

“…Cyclooxygenase (COX) inhibitors are ubiquitous in aquatic systems and have been detected in fish tissues. The exposure of fish to these pharmaceuticals is…”
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Effects of a short-term exposure to the fungicide prochloraz on endocrine function and gene expression in female fathead minnows ( Pimephales promelas) by Skolness, Sarah Y., Durhan, Elizabeth J., Garcia-Reyero, Natalia, Jensen, Kathleen M., Kahl, Michael D., Makynen, Elizabeth A., Martinovic-Weigelt, Dalma, Perkins, Edward, Villeneuve, Daniel L., Ankley, Gerald T.

“…Prochloraz is a fungicide known to cause endocrine disruption through effects on the hypothalamic–pituitary–gonadal (HPG) axis. To determine the short-term…”
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A time-course analysis of effects of the steroidogenesis inhibitor ketoconazole on components of the hypothalamic-pituitary-gonadal axis of fathead minnows by Ankley, Gerald T., Cavallin, Jenna E., Durhan, Elizabeth J., Jensen, Kathleen M., Kahl, Michael D., Makynen, Elizabeth A., Thomas, Linnea M., Wehmas, Leah C., Villeneuve, Daniel L.

“…► Fathead minnows (Pimephales promelas) were exposed to the fungicide ketoconazole in a time-course study. ► Ketoconazole caused rapid and persistent…”
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REPRODUCTIVE TOXICITY OF VINCLOZOLIN IN THE FATHEAD MINNOW: CONFIRMING AN ANTI-ANDROGENIC MODE OF ACTION by Martinovic, D, Blake, L.S, Durhan, E.J, Greene, K.J, Kahl, M.D, Jensen, K.M, Makynen, E.A, Villeneuve, D.L, Ankley, G.T

“…The objective of the present study was to characterize responses of the reproductive endocrine system of the fathead minnow (Pimephales promelas) to the…”
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Impacts of an Anti-Androgen and an Androgen/Anti-Androgen Mixture on the Metabolite Profile of Male Fathead Minnow Urine by Collette, Timothy W, Teng, Quincy, Jensen, Kathleen M, Kahl, Michael D, Makynen, Elizabeth A, Durhan, Elizabeth J, Villeneuve, Daniel L, Martinović-Weigelt, Dalma, Ankley, Gerald T, Ekman, Drew R

“…Male and female fathead minnows (Pimephales promelas, FHM) were exposed via water to 20 or 200 μg/L of cyproterone acetate (CA), a model androgen receptor (AR)…”
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Use of chemical mixtures to differentiate mechanisms of endocrine action in a small fish model by Ankley, Gerald T., Jensen, Kathleen M., Kahl, Michael D., Durhan, Elizabeth J., Makynen, Elizabeth A., Cavallin, Jenna E., Martinović, Dalma, Wehmas, Leah C., Mueller, Nathaniel D., Villeneuve, Daniel L.

“…Various assays with adult fish have been developed to identify potential endocrine-disrupting chemicals (EDCs) which may cause toxicity via alterations in the…”
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Ecotoxicogenomics to Support Ecological Risk Assessment: A Case Study with Bisphenol A in Fish by Villeneuve, Daniel L, Garcia-Reyero, Natàlia, Escalon, B. Lynn, Jensen, Kathleen M, Cavallin, Jenna E, Makynen, Elizabeth A, Durhan, Elizabeth J, Kahl, Michael D, Thomas, Linnea M, Perkins, Edward J, Ankley, Gerald T

“…Effects of bisphenol A (BPA) on ovarian transcript profiles as well as targeted end points with endocrine/reproductive relevance were examined in two fish…”
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Linkage of biochemical responses to population-level effects: A case study with vitellogenin in the fathead minnow (Pimephales promelas) by Miller, David H., Jensen, Kathleen M., Villeneuve, Daniel L., Kahl, Michael D., Makynen, Elizabeth A., Durhan, Elizabeth J., Ankley, Gerald T.

“…A challenge in the field of ecotoxicology is the linkage of alterations at molecular and biochemical levels of organization to adverse outcomes in individuals…”
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Effects of the antimicrobial contaminant triclocarban, and co-exposure with the androgen 17[beta]-trenbolone, on reproductive function and ovarian transcriptome of the fathead minnow (Pimephales promelas) by Villeneuve, Daniel L, Jensen, Kathleen M, Cavallin, Jenna E, Durhan, Elizabeth J, Garcia-Reyero, Natàlia, Kahl, Michael D, Leino, Richard L, Makynen, Elizabeth A, Wehmas, Leah C, Perkins, Edward J, Ankley, Gerald T

“…Triclocarban (TCC) is an antimicrobial agent routinely detected in surface waters that has been hypothesized to interact with the vertebrate endocrine system…”
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Effects of the antimicrobial contaminant triclocarban, and co‐exposure with the androgen 17β‐trenbolone, on reproductive function and ovarian transcriptome of the fathead minnow (Pimephales promelas) by Villeneuve, Daniel L., Jensen, Kathleen M., Cavallin, Jenna E., Durhan, Elizabeth J., Garcia‐Reyero, Natàlia, Kahl, Michael D., Leino, Richard L., Makynen, Elizabeth A., Wehmas, Leah C., Perkins, Edward J., Ankley, Gerald T.

“…Triclocarban (TCC) is an antimicrobial agent routinely detected in surface waters that has been hypothesized to interact with the vertebrate endocrine system…”
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Integrated assessment of runoff from livestock farming operations: Analytical chemistry, in vitro bioassays, and in vivo fish exposures by Cavallin, Jenna E, Durhan, Elizabeth J, Evans, Nicola, Jensen, Kathleen M, Kahl, Michael D, Kolpin, Dana W, Kolodziej, Edward P, Foreman, William T, LaLone, Carlie A, Makynen, Elizabeth A, Seidl, Sara M, Thomas, Linnea M, Villeneuve, Daniel L, Weberg, Matthew A, Wilson, Vickie S, Ankley, Gerald T

“…Animal waste from livestock farming operations can contain varying levels of natural and synthetic androgens and/or estrogens, which can contaminate…”
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inexpensive, temporally integrated system for monitoring occurrence and biological effects of aquatic contaminants in the field by Kahl, Michael D, Villeneuve, Daniel L, Stevens, Kyle, Schroeder, Anthony, Makynen, Elizabeth A, LaLone, Carlie A, Jensen, Kathleen M, Hughes, Meagan, Holmen, Bruce A, Eid, Evan, Durhan, Elizabeth J, Cavallin, Jenna E, Berninger, Jason, Ankley, Gerald T

“…Assessment of potential risks of complex contaminant mixtures in the environment requires integrated chemical and biological approaches. In support of the US…”
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Cross-species sensitivity to a novel androgen receptor agonist of potential environmental concern, spironolactone by LaLone, Carlie A., Villeneuve, Daniel L., Cavallin, Jenna E., Kahl, Michael D., Durhan, Elizabeth J., Makynen, Elizabeth A., Jensen, Kathleen M., Stevens, Kyle E., Severson, Megan N., Blanksma, Chad A., Flynn, Kevin M., Hartig, Philip C., Woodard, Jonne S., Berninger, Jason P., Norberg-King, Teresa J., Johnson, Rodney D., Ankley, Gerald T.

“…Spironolactone is a pharmaceutical that in humans is used to treat conditions like hirsutism, various dermatologic afflictions, and female‐pattern hair loss…”
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Direct Effects, Compensation, and Recovery in Female Fathead Minnows Exposed to a Model Aromatase Inhibitor by Villeneuve, Daniel L., Mueller, Nathaniel D., Martinović, Dalma, Makynen, Elizabeth A., Kahl, Michael D., Jensen, Kathleen M., Durhan, Elizabeth J., Cavallin, Jenna E., Bencic, David, Ankley, Gerald T.

“…Background: Several chemicals in the environment have the potential to inhibit aromatase, an enzyme critical to estrogen synthesis. Objectives: The objective…”
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A Graphical Systems Model to Facilitate Hypothesis-Driven Ecotoxicogenomics Research on the Teleost Brain−Pituitary−Gonadal Axis by Villeneuve, Daniel L, Larkin, Patrick, Knoebl, Iris, Miracle, Ann L, Kahl, Michael D, Jensen, Kathleen M, Makynen, Elizabeth A, Durhan, Elizabeth J, Carter, Barbara J, Denslow, Nancy D, Ankley, Gerald T

“…Graphical systems models are powerful tools that can help facilitate hypothesis-driven ecotoxicogenomic research and aid in mechanistic interpretation of…”
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