Search Results - "Durham, Todd A"

How Did These Data Get Here? Recommendations for the Analysis of Data From ClinicalTrials.gov by Durham, Todd A

“…A paper by Drs Okada and Sengoku that appears in this issue of shows how data from Clinicaltrials.gov can be used for research on the pharmaceutical industry…”
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Integrated cardiac safety: assessment methodologies for noncardiac drugs in discovery, development, and postmarketing surveillance by Turner, J. Rick, Durham, Todd A

“…The serious nature of cardiovascular adverse drug reactions occurring in patients makes assessment of a drug's cardiac safety profile a high priority during…”
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Baseline Visual Field Findings in the RUSH2A Study: Associated Factors and Correlation With Other Measures of Disease Severity by Duncan, Jacque L., Liang, Wendi, Maguire, Maureen G., Audo, Isabelle, Ayala, Allison R., Birch, David G., Carroll, Joseph, Cheetham, Janet K., Esposti, Simona Degli, Durham, Todd A., Erker, Laura, Farsiu, Sina, Ferris, Frederick L., Heon, Elise, Hufnagel, Robert B., Iannaccone, Alessandro, Jaffe, Glenn J., Kay, Christine N., Michaelides, Michel, Pennesi, Mark E., Sahel, José-Alain

“…To report baseline visual fields in the Rate of Progression in USH2A-related Retinal Degeneration (RUSH2A) study. Cross-sectional study within a natural…”
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The RUSH2A Study: Dark-Adapted Visual Fields in Patients With Retinal Degeneration Associated With Biallelic Variants in the USH2A Gene by Birch, David G, Samarakoon, Lassana, Melia, Michele, Duncan, Jacque L, Ayala, Allison R, Audo, Isabelle, Cheetham, Janet K, Durham, Todd A, Iannaccone, Alessandro, Pennesi, Mark E, Stingl, Katarina

“…To measure visual fields using two-color dark-adapted chromatic perimetry in a subset of participants in the Rate of Progression of USH2A-related Retinal…”
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Functional Vision in Patients With Biallelic USH2A Variants by Heon, Elise, Melia, Michele, Bocchino, Laura E., Samarakoon, Lassana, Duncan, Jacque L., Ayala, Allison R., Audo, Isabelle, Bradley, Chris, Cheetham, Janet K., Dagnelie, Gislin, Durham, Todd A., Hoyng, Carel B., Jain, Nieraj, Jayasundera, Kanishka T., Pennesi, Mark E., Weng, Christina Y.

“…•ARRP and USH2 participants reported similar functional vision.•Overall FV score was moderately correlated with VA and visual field hill of vision.•The…”
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Baseline Microperimetry and OCT in the RUSH2A Study: Structure−Function Association and Correlation With Disease Severity by Lad, Eleonora M., Duncan, Jacque L., Liang, Wendi, Maguire, Maureen G., Ayala, Allison R., Audo, Isabelle, Birch, David G., Carroll, Joseph, Cheetham, Janet K., Durham, Todd A., Fahim, Abigail T., Loo, Jessica, Deng, Zengtian, Mukherjee, Dibyendu, Heon, Elise, Hufnagel, Robert B., Guan, Bin, Iannaccone, Alessandro, Jaffe, Glenn J., Kay, Christine N., Michaelides, Michel, Pennesi, Mark E., Vincent, Ajoy, Weng, Christina Y., Farsiu, Sina

“…•Baseline microperimetry and spectral domain OCT were analyzed in the RUSH2A study.•Better best corrected visual acuity and larger subfield thickness were…”
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Static Perimetry in the Rate of Progression in USH2A-related Retinal Degeneration (RUSH2A) Study: Assessment Through 2 Years by Duncan, Jacque L., Cheng, Peiyao, Maguire, Maureen G., Ayala, Allison A., Birch, David G., Cheetham, Janet K., Durham, Todd A., Fahim, Abigail T., Hoyng, Carel B., Ishikawa, Hiroshi, Michaelides, Michel, Pennesi, Mark E., Sahel, José-Alain, Stingl, Katarina, Weng, Christina Y.

“…•Static perimetry declined over 2 years in USH2A-related retinal degeneration.•Annual percentage rate of change was greater for peripheral than central…”
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Self-Reported Functional Vision in USH2A-Associated Retinal Degeneration as Measured by the Michigan Retinal Degeneration Questionnaire by Parekh, Bela, Duncan, Jacque L, Samarakoon, Lassana, Melia, Michele, Abalem, Maria Fernanda, Andrews, Chris A, Audo, Isabelle, Ayala, Allison R, Bradley, Chris, Cheetham, Janet K, Dagnelie, Gislin, Durham, Todd A, Huckfeldt, Rachel M, Lacy, Gabrielle D, Malbin, Brett, Michaelides, Michel, Musch, David C, Peck-Dimit, Nicholas, Stingl, Katarina, Weng, Christina Y, Zmejkoski, Alex Z, Jayasundera, K Thiran

“…The purpose of this study was to evaluate self-reported functional vision (FV) and the impact of vision loss in patients with USH2A-associated retinal…”
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Tissue‐specific genotype–phenotype correlations among USH2A‐related disorders in the RUSH2A study by Hufnagel, Robert B., Liang, Wendi, Duncan, Jacque L., Brewer, Carmen C., Audo, Isabelle, Ayala, Allison R., Branham, Kari, Cheetham, Janet K., Daiger, Stephen P., Durham, Todd A., Guan, Bin, Heon, Elise, Hoyng, Carel B., Iannaccone, Alessandro, Kay, Christine N., Michaelides, Michel, Pennesi, Mark E., Singh, Mandeep S., Ullah, Ehsan

“…We assessed genotype–phenotype correlations among the visual, auditory, and olfactory phenotypes of 127 participants with Usher syndrome (USH2) (n =80) or…”
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Utilization of Standard and Target-Specific Oral Anticoagulants Among Adults in the United Kingdom With Incident Atrial Fibrillation by Durham, Todd A., Hassmiller Lich, Kristen, Viera, Anthony J., Fine, Jason P., Mukherjee, Jayanti, Weinberger, Morris, Dusetzina, Stacie B.

“…New oral anticoagulants (OACs) and updated risk stratification have the potential to improve the quality of care for patients with atrial fibrillation (AF). To…”
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Auditory and olfactory findings in patients with USH2A‐related retinal degeneration—Findings at baseline from the rate of progression in USH2A‐related retinal degeneration natural history study (RUSH2A) by Iannaccone, Alessandro, Brewer, Carmen C., Cheng, Peiyao, Duncan, Jacque L., Maguire, Maureen G., Audo, Isabelle, Ayala, Allison R., Bernstein, Paul S., Bidelman, Gavin M., Cheetham, Janet K., Doty, Richard L., Durham, Todd A., Hufnagel, Robert B., Myers, Mark H., Stingl, Katarina, Zein, Wadih M.

“…Sensorineural hearing loss (SNHL) is characteristic of Usher syndrome type 2 (USH2), but less is known about SNHL in nonsyndromic autosomal recessive retinitis…”
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Meta‐Methodology: Conducting and Reporting Meta‐Analyses by Turner, J. Rick, Durham, Todd A.

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The RUSH2A Study: Best-Corrected Visual Acuity, Full-Field Electroretinography Amplitudes, and Full-Field Stimulus Thresholds at Baseline by Birch, David G, Cheng, Peiyao, Duncan, Jacque L, Ayala, Allison R, Maguire, Maureen G, Audo, Isabelle, Cheetham, Janet K, Durham, Todd A, Fahim, Abigail T, Ferris, 3rd, Frederick L, Heon, Elise, Huckfeldt, Rachel M, Iannaccone, Alessandro, Khan, Naheed W, Lad, Eleonora M, Michaelides, Michel, Pennesi, Mark E, Stingl, Katarina, Vincent, Ajoy, Weng, Christina Y

“…The purpose of this study was to evaluate baseline best corrected visual acuity (BCVA), full-field electroretinography (ERG), full-field stimulus thresholds…”
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Multicenter Study of a Novel Topical Interleukin-1 Receptor Inhibitor, Isunakinra, in Subjects With Moderate to Severe Dry Eye Disease by Goldstein, Michael H, Martel, Joseph R, Sall, Kenneth, Goldberg, Damien F, Abrams, Marc, Rubin, Jay, Sheppard, John, Tauber, Joseph, Korenfeld, Michael, Agahigian, Jennifer, Durham, Todd A, Furfine, Eric

“…OBJECTIVES:Isunakinra, formerly known as EBI-005, is a novel interleukin (IL)-1 receptor inhibitor developed for topical treatment of patients with dry eye…”
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Cost-Effectiveness Analysis of Four Simulated Colorectal Cancer Screening Interventions, North Carolina by Hassmiller Lich, Kristen, Cornejo, David A, Mayorga, Maria E, Pignone, Michael, Tangka, Florence K L, Richardson, Lisa C, Kuo, Tzy-Mey, Meyer, Anne-Marie, Hall, Ingrid J, Smith, Judith Lee, Durham, Todd A, Chall, Steven A, Crutchfield, Trisha M, Wheeler, Stephanie B

“…Colorectal cancer (CRC) screening rates are suboptimal, particularly among the uninsured and the under-insured and among rural and African American…”
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Must New Drugs Be Superior to Those Already Available? The Role of Noninferiority Clinical Trials by Turner, J. Rick, Durham, Todd A.

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Endpoints and Design for Clinical Trials in USH2A-Related Retinal Degeneration: Results and Recommendations From the RUSH2A Natural History Study by Maguire, Maureen G, Birch, David G, Duncan, Jacque L, Ayala, Allison R, Ayton, Lauren N, Cheetham, Janet K, Cheng, Peiyao, Durham, Todd A, Ferris, 3rd, Frederick L, Hoyng, Carel B, Huckfeldt, Rachel M, Jaffe, Glenn J, Kay, Christine, Lad, Eleonora M, Leroy, Bart P, Liang, Wendi, McDaniel, Lee S, Melia, Michele, Michaelides, Michel, Pennesi, Mark E, Sahel, José-Alain, Samarakoon, Lassana

“…To evaluate functional and structural assessments as endpoints for clinical trials for USH2A-related retinal degeneration. People with biallelic…”
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Tackling the Challenges of Product Development Through a Collaborative Rare Disease Network: The Foundation Fighting Blindness Consortium by Durham, Todd A, Duncan, Jacque L, Ayala, Allison R, Birch, David G, Cheetham, Janet K, Ferris, 3rd, Frederick L, Hoyng, Carel B, Pennesi, Mark E, Sahel, José-Alain

“…The Foundation Fighting Blindness, a 501(c)(3) nonprofit organization, established an international consortium of inherited retinal disease specialists in…”
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Assessing a Drug’s Proarrhythmic Liability: An Overview of Computer Simulation Modeling, Nonclinical Assays, and the Thorough QT/QTc Study by Satin, Lawrence Z., Durham, Todd A., Turner, J. Rick

“…The assessment of proarrhythmic liability has assumed considerable importance in drug development. Such liability is couched in terms of evaluating the degree…”
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Randomization-based nonparametric methods for the analysis of multicentre trials by LaVange, Lisa M, Durham, Todd A, Koch, Gary G

“…Multicentre trials offer several advantages over single centre trials in clinical research, including the ability to recruit patients at a faster rate over the…”
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