Search Results - "Durgan, David J"

Examining the Role of the Microbiota-Gut-Brain Axis in Stroke by Durgan, David J, Lee, Juneyoung, McCullough, Louise D, Bryan, Robert M

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Gut Microbiota–Derived Short-Chain Fatty Acids Promote Poststroke Recovery in Aged Mice by Lee, Juneyoung, d’Aigle, John, Atadja, Louise, Quaicoe, Victoria, Honarpisheh, Pedram, Ganesh, Bhanu P., Hassan, Ahmad, Graf, Joerg, Petrosino, Joseph, Putluri, Nagireddy, Zhu, Liang, Durgan, David J., Bryan, Robert M., McCullough, Louise D., Venna, Venugopal Reddy

“…RATIONALE:The elderly experience profound systemic responses after stroke, which contribute to higher mortality and more severe long-term disability. Recent…”
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Age‐related changes in the gut microbiota influence systemic inflammation and stroke outcome by Spychala, Monica S., Venna, Venugopal Reddy, Jandzinski, Michal, Doran, Sarah J., Durgan, David J., Ganesh, Bhanu Priya, Ajami, Nadim J., Putluri, Nagireddy, Graf, Joerg, Bryan, Robert M., McCullough, Louise D.

“…Objective Chronic systemic inflammation contributes to the pathogenesis of many age‐related diseases. Although not well understood, alterations in the gut…”
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Alterations in the gut microbiota can elicit hypertension in rats by Adnan, Sareema, Nelson, James W, Ajami, Nadim J, Venna, Venugopal R, Petrosino, Joseph F, Bryan, Jr, Robert M, Durgan, David J

“…Gut dysbiosis has been linked to cardiovascular diseases including hypertension. We tested the hypothesis that hypertension could be induced in a normotensive…”
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Young versus aged microbiota transplants to germ-free mice: increased short-chain fatty acids and improved cognitive performance by Lee, Juneyoung, Venna, Venugopal R., Durgan, David J., Shi, Huanan, Hudobenko, Jacob, Putluri, Nagireddy, Petrosino, Joseph, McCullough, Louise D., Bryan, Robert M.

“…Aging is associated with cognitive decline and decreased concentrations of short-chain fatty acids (SCFAs) in the gut. SCFAs are significant in that they are…”
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Obstructive Sleep Apnea-Induced Hypertension Is Associated With Increased Gut and Neuroinflammation by Ayyaswamy, Sriram, Shi, Huanan, Zhang, Bojun, Bryan, Jr, Robert M, Durgan, David J

“…Background Obstructive sleep apnea (OSA) is an independent risk factor for the development of hypertension. We have demonstrated that OSA induces gut…”
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Alterations of the gut microbial community structure and function with aging in the spontaneously hypertensive stroke prone rat by Shi, Huanan, Nelson, James W., Phillips, Sharon, Petrosino, Joseph F., Bryan, Robert M., Durgan, David J.

“…Gut dysbiosis, a pathological imbalance of bacteria, has been shown to contribute to the development of hypertension (HT), systemic- and neuro-inflammation,…”
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O-GlcNAcylation, Novel Post-Translational Modification Linking Myocardial Metabolism and Cardiomyocyte Circadian Clock by Durgan, David J., Pat, Betty M., Laczy, Boglarka, Bradley, Jerry A., Tsai, Ju-Yun, Grenett, Maximiliano H., Ratcliffe, William F., Brewer, Rachel A., Nagendran, Jeevan, Villegas-Montoya, Carolina, Zou, Chenhang, Zou, Luyun, Johnson, Russell L., Dyck, Jason R.B., Bray, Molly S., Gamble, Karen L., Chatham, John C., Young, Martin E.

“…The cardiomyocyte circadian clock directly regulates multiple myocardial functions in a time-of-day-dependent manner, including gene expression, metabolism,…”
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Disruption of the circadian clock within the cardiomyocyte influences myocardial contractile function, metabolism, and gene expression by Bray, Molly S, Shaw, Chad A, Moore, Michael W S, Garcia, Rodrigo A P, Zanquetta, Melissa M, Durgan, David J, Jeong, William J, Tsai, Ju-Yun, Bugger, Heiko, Zhang, Dongfang, Rohrwasser, Andreas, Rennison, Julie H, Dyck, Jason R B, Litwin, Sheldon E, Hardin, Paul E, Chow, Chi-Wing, Chandler, Margaret P, Abel, E Dale, Young, Martin E

“…Virtually every mammalian cell, including cardiomyocytes, possesses an intrinsic circadian clock. The role of this transcriptionally based molecular mechanism…”
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Direct Regulation of Myocardial Triglyceride Metabolism by the Cardiomyocyte Circadian Clock by Tsai, Ju-Yun, Kienesberger, Petra C., Pulinilkunnil, Thomas, Sailors, Mary H., Durgan, David J., Villegas-Montoya, Carolina, Jahoor, Anil, Gonzalez, Raquel, Garvey, Merissa E., Boland, Brandon, Blasier, Zachary, McElfresh, Tracy A., Nannegari, Vijayalakshmi, Chow, Chi-Wing, Heird, William C., Chandler, Margaret P., Dyck, Jason R.B., Bray, Molly S., Young, Martin E.

“…Maintenance of circadian alignment between an organism and its environment is essential to ensure metabolic homeostasis. Synchrony is achieved by cell…”
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The intrinsic circadian clock within the cardiomyocyte by Durgan, David J, Hotze, Margaret A, Tomlin, Tara M, Egbejimi, Oluwaseun, Graveleau, Christophe, Abel, E Dale, Shaw, Chad A, Bray, Molly S, Hardin, Paul E, Young, Martin E

“…Circadian clocks are intracellular molecular mechanisms that allow the cell to anticipate the time of day. We have previously reported that the intact rat…”
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The Circadian Clock within the Cardiomyocyte Is Essential for Responsiveness of the Heart to Fatty Acids by Durgan, David J., Trexler, Nowice A., Egbejimi, Oluwaseun, McElfresh, Tracy A., Suk, Hee Yun, Petterson, Lauren E., Shaw, Chad A., Hardin, Paul E., Bray, Molly S., Chandler, Margaret P., Chow, Chi-Wing, Young, Martin E.

“…Cells/organs must respond both rapidly and appropriately to increased fatty acid availability; failure to do so is associated with the development of skeletal…”
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Combating hypertension beyond genome-wide association studies: Microbiome and artificial intelligence as opportunities for precision medicine by Aryal, Sachin, Manandhar, Ishan, Mei, Xue, Yeoh, Beng S, Tummala, Ramakumar, Saha, Piu, Osman, Islam, Zubcevic, Jasenka, Durgan, David J, Vijay-Kumar, Matam, Joe, Bina

“…The single largest contributor to human mortality is cardiovascular disease, the top risk factor for which is hypertension (HTN). The last two decades have…”
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Gut check: assessing the role of the gut microbiota in the adverse cardiovascular effects of obstructive sleep apnoea by Durgan, David J, Farré, Ramon

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Obstructive Sleep Apnea-Induced Hypertension: Role of the Gut Microbiota by Durgan, David J.

“…Purpose of Review Obstructive sleep apnea (OSA) is a significant risk factor for systemic hypertension and other cardiovascular diseases. While this…”
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Evidence for a gut‐immune‐vascular axis in the development of hypertension by Durgan, David J.

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The Cardiomyocyte Circadian Clock: Emerging Roles in Health and Disease by Durgan, David J, Young, Martin E

“…Circadian misalignment has been implicated in the development of obesity, diabetes mellitus, and cardiovascular disease. Time-of-day–dependent synchronization…”
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Role of the Gut Microbiome in Obstructive Sleep Apnea-Induced Hypertension by Durgan, David J, Ganesh, Bhanu P, Cope, Julia L, Ajami, Nadim J, Phillips, Sharon C, Petrosino, Joseph F, Hollister, Emily B, Bryan, Jr, Robert M

“…Individuals suffering from obstructive sleep apnea (OSA) are at increased risk for systemic hypertension. The importance of a healthy gut microbiota, and…”
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Distinct transcriptional regulation of long-chain acyl-CoA synthetase isoforms and cytosolic thioesterase 1 in the rodent heart by fatty acids and insulin by Durgan, David J, Smith, Justin K, Hotze, Margaret A, Egbejimi, Oluwaseun, Cuthbert, Karalyn D, Zaha, Vlad G, Dyck, Jason R B, Abel, E Dale, Young, Martin E

“…The molecular mechanism(s) responsible for channeling long-chain fatty acids (LCFAs) into oxidative versus nonoxidative pathways is (are) poorly understood in…”
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Prebiotics, Probiotics, and Acetate Supplementation Prevent Hypertension in a Model of Obstructive Sleep Apnea by Ganesh, Bhanu P, Nelson, James W, Eskew, Joshua R, Ganesan, Arunkumar, Ajami, Nadim J, Petrosino, Joseph F, Bryan, Robert M, Durgan, David J

“…Disruption of the gut microbiota, termed gut dysbiosis, has been described in animal models of hypertension and hypertensive patients. We have shown that gut…”
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