Search Results - "Durek, Pawel"

Targeting CD38 with Daratumumab in Refractory Systemic Lupus Erythematosus by Ostendorf, Lennard, Burns, Marie, Durek, Pawel, Heinz, Gitta Anne, Heinrich, Frederik, Garantziotis, Panagiotis, Enghard, Philipp, Richter, Ulrich, Biesen, Robert, Schneider, Udo, Knebel, Fabian, Burmester, Gerd, Radbruch, Andreas, Mei, Henrik E, Mashreghi, Mir-Farzin, Hiepe, Falk, Alexander, Tobias

“…Long-lived plasma cells that express CD38 are thought to play a pathogenic role in systemic lupus erythematosus. The anti-CD38 antibody daratumumab was used to…”
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Peptide-specific recognition of human cytomegalovirus strains controls adaptive natural killer cells by Hammer, Quirin, Rückert, Timo, Borst, Eva Maria, Dunst, Josefine, Haubner, André, Durek, Pawel, Heinrich, Frederik, Gasparoni, Gilles, Babic, Marina, Tomic, Adriana, Pietra, Gabriella, Nienen, Mikalai, Blau, Igor Wolfgang, Hofmann, Jörg, Na, Il-Kang, Prinz, Immo, Koenecke, Christian, Hemmati, Philipp, Babel, Nina, Arnold, Renate, Walter, Jörn, Thurley, Kevin, Mashreghi, Mir-Farzin, Messerle, Martin, Romagnani, Chiara

“…Natural killer (NK) cells are innate lymphocytes that lack antigen-specific rearranged receptors, a hallmark of adaptive lymphocytes. In some people infected…”
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Discrete populations of isotype-switched memory B lymphocytes are maintained in murine spleen and bone marrow by Riedel, René, Addo, Richard, Ferreira-Gomes, Marta, Heinz, Gitta Anne, Heinrich, Frederik, Kummer, Jannis, Greiff, Victor, Schulz, Daniel, Klaeden, Cora, Cornelis, Rebecca, Menzel, Ulrike, Kröger, Stefan, Stervbo, Ulrik, Köhler, Ralf, Haftmann, Claudia, Kühnel, Silvia, Lehmann, Katrin, Maschmeyer, Patrick, McGrath, Mairi, Naundorf, Sandra, Hahne, Stefanie, Sercan-Alp, Özen, Siracusa, Francesco, Stefanowski, Jonathan, Weber, Melanie, Westendorf, Kerstin, Zimmermann, Jakob, Hauser, Anja E., Reddy, Sai T., Durek, Pawel, Chang, Hyun-Dong, Mashreghi, Mir-Farzin, Radbruch, Andreas

“…At present, it is not clear how memory B lymphocytes are maintained over time, and whether only as circulating cells or also residing in particular tissues…”
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PhosPhAt: the Arabidopsis thaliana phosphorylation site database. An update by Durek, Pawel, Schmidt, Robert, Heazlewood, Joshua L, Jones, Alexandra, MacLean, Daniel, Nagel, Axel, Kersten, Birgit, Schulze, Waltraud X

“…The PhosPhAt database of Arabidopsis phosphorylation sites was initially launched in August 2007. Since then, along with 10-fold increase in database entries,…”
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T-bet and RORα control lymph node formation by regulating embryonic innate lymphoid cell differentiation by Stehle, Christina, Rückert, Timo, Fiancette, Rémi, Gajdasik, Dominika W., Willis, Claire, Ulbricht, Carolin, Durek, Pawel, Mashreghi, Mir-Farzin, Finke, Daniela, Hauser, Anja Erika, Withers, David R., Chang, Hyun-Dong, Zimmermann, Jakob, Romagnani, Chiara

“…The generation of lymphoid tissues during embryogenesis relies on group 3 innate lymphoid cells (ILC3) displaying lymphoid tissue inducer (LTi) activity and…”
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The miR-221/222 cluster regulates hematopoietic stem cell quiescence and multipotency by suppressing both Fos/AP-1/IEG pathway activation and stress-like differentiation to granulocytes by Jani, Peter K, Petkau, Georg, Kawano, Yohei, Klemm, Uwe, Guerra, Gabriela Maria, Heinz, Gitta Anne, Heinrich, Frederik, Durek, Pawel, Mashreghi, Mir-Farzin, Melchers, Fritz

“…Throughout life, hematopoietic stem cells (HSCs), residing in bone marrow (BM), continuously regenerate erythroid/megakaryocytic, myeloid, and lymphoid cell…”
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The AP-1-BATF and -BATF3 module is essential for growth, survival and TH17/ILC3 skewing of anaplastic large cell lymphoma by Schleussner, Nikolai, Merkel, Olaf, Costanza, Mariantonia, Liang, Huan-Chang, Hummel, Franziska, Romagnani, Chiara, Durek, Pawel, Anagnostopoulos, Ioannis, Hummel, Michael, Jöhrens, Korinna, Niedobitek, Antonia, Griffin, Patrick R., Piva, Roberto, Sczakiel, Henrike L., Woessmann, Wilhelm, Damm-Welk, Christine, Hinze, Christian, Stoiber, Dagmar, Gillissen, Bernd, Turner, Suzanne D., Kaergel, Eva, von Hoff, Linda, Grau, Michael, Lenz, Georg, Dörken, Bernd, Scheidereit, Claus, Kenner, Lukas, Janz, Martin, Mathas, Stephan

“…Transcription factor AP-1 is constitutively activated and IRF4 drives growth and survival in ALK + and ALK – anaplastic large cell lymphoma (ALCL). Here we…”
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Simultaneous Presence of Non- and Highly Mutated Keyhole Limpet Hemocyanin (KLH)-Specific Plasmablasts Early after Primary KLH Immunization Suggests Cross-Reactive Memory B Cell Activation by Giesecke, Claudia, Meyer, Tim, Durek, Pawel, Maul, Jochen, Preiß, Jan, Jacobs, Joannes F M, Thiel, Andreas, Radbruch, Andreas, Ullrich, Reiner, Dörner, Thomas

“…There are currently limited insights into the progression of human primary humoral immunity despite numerous studies in experimental models. In this study, we…”
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Network quantification of EGFR signaling unveils potential for targeted combination therapy by Klinger, Bertram, Sieber, Anja, Fritsche‐Guenther, Raphaela, Witzel, Franziska, Berry, Leanne, Schumacher, Dirk, Yan, Yibing, Durek, Pawel, Merchant, Mark, Schäfer, Reinhold, Sers, Christine, Blüthgen, Nils

“…The epidermal growth factor receptor (EGFR) signaling network is activated in most solid tumors, and small‐molecule drugs targeting this network are…”
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Distinct tissue niches direct lung immunopathology via CCL18 and CCL21 in severe COVID-19 by Mothes, Ronja, Pascual-Reguant, Anna, Koehler, Ralf, Liebeskind, Juliane, Liebheit, Alina, Bauherr, Sandy, Philipsen, Lars, Dittmayer, Carsten, Laue, Michael, von Manitius, Regina, Elezkurtaj, Sefer, Durek, Pawel, Heinrich, Frederik, Heinz, Gitta A., Guerra, Gabriela M., Obermayer, Benedikt, Meinhardt, Jenny, Ihlow, Jana, Radke, Josefine, Heppner, Frank L., Enghard, Philipp, Stockmann, Helena, Aschman, Tom, Schneider, Julia, Corman, Victor M., Sander, Leif E., Mashreghi, Mir-Farzin, Conrad, Thomas, Hocke, Andreas C., Niesner, Raluca A., Radbruch, Helena, Hauser, Anja E.

“…Prolonged lung pathology has been associated with COVID-19, yet the cellular and molecular mechanisms behind this chronic inflammatory disease are poorly…”
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Questioning whether IgM Fc receptor (FcµR) is expressed by innate immune cells by Skopnik, Christopher M., Riedel, René, Addo, Richard K., Heinz, Gitta Anne, Heinrich, Frederik, Honjo, Kazuhito, Durek, Pawel, Enghard, Philipp, Mashreghi, Mir-Farzin, Radbruch, Andreas, Kubagawa, Hiromi

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Inhibition or Stimulation of Ochratoxin A Synthesis on Inoculated Barley Triggered by Diffuse Coplanar Surface Barrier Discharge Plasma by Durek, Julia, Schlüter, Oliver, Roscher, Anne, Durek, Pawel, Fröhling, Antje

“…Ochratoxin A (OTA) is one of the most abundant food-contaminating mycotoxins. Besides their high toxicity, mycotoxins are highly stable to physical, chemical…”
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DNA copy number changes define spatial patterns of heterogeneity in colorectal cancer by Mamlouk, Soulafa, Childs, Liam Harold, Aust, Daniela, Heim, Daniel, Melching, Friederike, Oliveira, Cristiano, Wolf, Thomas, Durek, Pawel, Schumacher, Dirk, Bläker, Hendrik, von Winterfeld, Moritz, Gastl, Bastian, Möhr, Kerstin, Menne, Andrea, Zeugner, Silke, Redmer, Torben, Lenze, Dido, Tierling, Sascha, Möbs, Markus, Weichert, Wilko, Folprecht, Gunnar, Blanc, Eric, Beule, Dieter, Schäfer, Reinhold, Morkel, Markus, Klauschen, Frederick, Leser, Ulf, Sers, Christine

“…Genetic heterogeneity between and within tumours is a major factor determining cancer progression and therapy response. Here we examined DNA sequence and DNA…”
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High‐resolution microbiota flow cytometry reveals dynamic colitis‐associated changes in fecal bacterial composition by Zimmermann, Jakob, Hübschmann, Thomas, Schattenberg, Florian, Schumann, Joachim, Durek, Pawel, Riedel, René, Friedrich, Marie, Glauben, Rainer, Siegmund, Britta, Radbruch, Andreas, Müller, Susann, Chang, Hyun‐Dong

“…Using high‐resolution flow cytometry of bacterial shape (forward scatter) and DNA content (DAPI staining), we detected dramatic differences in the fecal…”
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Stromal Cell-Contact Dependent PI3K and APRIL Induced NF-κB Signaling Prevent Mitochondrial- and ER Stress Induced Death of Memory Plasma Cells by Cornelis, Rebecca, Hahne, Stefanie, Taddeo, Adriano, Petkau, Georg, Malko, Darya, Durek, Pawel, Thiem, Manja, Heiberger, Lukas, Peter, Lena, Mohr, Elodie, Klaeden, Cora, Tokoyoda, Koji, Siracusa, Francesco, Hoyer, Bimba Franziska, Hiepe, Falk, Mashreghi, Mir-Farzin, Melchers, Fritz, Chang, Hyun-Dong, Radbruch, Andreas

“…The persistence of long-lived memory plasma cells in the bone marrow depends on survival factors available in the bone marrow, which are provided in niches…”
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Single‐cell transcriptomes of murine bone marrow stromal cells reveal niche‐associated heterogeneity by Addo, Richard K., Heinrich, Frederik, Heinz, Gitta Anne, Schulz, Daniel, Sercan‐Alp, Özen, Lehmann, Katrin, Tran, Cam Loan, Bardua, Markus, Matz, Mareen, Löhning, Max, Hauser, Anja E., Kruglov, Andrey, Chang, Hyun‐Dong, Durek, Pawel, Radbruch, Andreas, Mashreghi, Mir‐Farzin

“…Bone marrow (BM) stromal cells are important in the development and maintenance of cells of the immune system. Using single cell RNA sequencing, we here…”
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Deep Phenotyping of Urinary Leukocytes by Mass Cytometry Reveals a Leukocyte Signature for Early and Non-Invasive Prediction of Response to Treatment in Active Lupus Nephritis by Bertolo, Martina, Baumgart, Sabine, Durek, Pawel, Peddinghaus, Anette, Mei, Henrik, Rose, Thomas, Enghard, Philipp, Grützkau, Andreas

“…Non-invasive biomarkers are necessary for diagnosis and monitoring disease activity in lupus nephritis (LN) to circumvent risks and limitations of renal…”
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Recruitment of plasma cells from IL-21-dependent and IL-21-independent immune reactions to the bone marrow by Ferreira-Gomes, Marta, Chen, Yidan, Durek, Pawel, Rincon-Arevalo, Hector, Heinrich, Frederik, Bauer, Laura, Szelinski, Franziska, Guerra, Gabriela Maria, Stefanski, Ana-Luisa, Niedobitek, Antonia, Wiedemann, Annika, Bondareva, Marina, Ritter, Jacob, Lehmann, Katrin, Hardt, Sebastian, Hipfl, Christian, Hein, Sascha, Hildt, Eberhard, Matz, Mareen, Mei, Henrik E., Cheng, Qingyu, Dang, Van Duc, Witkowski, Mario, Lino, Andreia C., Kruglov, Andrey, Melchers, Fritz, Perka, Carsten, Schrezenmeier, Eva V., Hutloff, Andreas, Radbruch, Andreas, Dörner, Thomas, Mashreghi, Mir-Farzin

“…Bone marrow plasma cells (BMPC) are the correlate of humoral immunity, consistently releasing antibodies into the bloodstream. It remains unclear if BMPC…”
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MicroRNA regulation in blood cells of renal transplanted patients with interstitial fibrosis/tubular atrophy and antibody-mediated rejection by Matz, Mareen, Heinrich, Frederik, Lorkowski, Christine, Wu, Kaiyin, Klotsche, Jens, Zhang, Qiang, Lachmann, Nils, Durek, Pawel, Budde, Klemens, Mashreghi, Mir-Farzin

“…Interstitial fibrosis/tubular atrophy (IFTA) is associated with reduced allograft survival, whereas antibody-mediated rejection (ABMR) is the major cause for…”
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Detection and characterization of 3D-signature phosphorylation site motifs and their contribution towards improved phosphorylation site prediction in proteins by Durek, Pawel, Schudoma, Christian, Weckwerth, Wolfram, Selbig, Joachim, Walther, Dirk

“…Phosphorylation of proteins plays a crucial role in the regulation and activation of metabolic and signaling pathways and constitutes an important target for…”
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