Uptake of zinc by human placental microvillus border membranes and characterization of the effects of cadmium on this process

The uptake of Zinc (Zn) by microvillus border membrane vesicles formed from the trophoblast of term human placentae is markedly increased over brief periods of incubation with much slower increases persisting for up to 2 h of incubation. Zinc is both bound to membrane components and transported into...

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Bibliographic Details
Published in:	Placenta (Eastbourne) Vol. 13; no. 2; p. 151
Main Authors:	Page, K R, Abramovich, D R, Aggett, P J, Bain, M, Chipperfield, A R, Durdy, H, McLachlan, J, Smale, A
Format:	Journal Article
Language:	English
Published:	Netherlands 01-03-1992
Subjects:	Cadmium - pharmacology Female Humans Microvilli - metabolism Placenta - metabolism Placenta - ultrastructure Pregnancy Zinc - metabolism
Online Access:	Get more information
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Summary:	The uptake of Zinc (Zn) by microvillus border membrane vesicles formed from the trophoblast of term human placentae is markedly increased over brief periods of incubation with much slower increases persisting for up to 2 h of incubation. Zinc is both bound to membrane components and transported into intravesicular osmotically active space. Uptake is saturable, temperature dependent from 4 to 37 degrees C with a Q10 of 1.7, and is inhibited by the sulphydryl agent DTNB. About 20 per cent of the uptake is susceptible to inhibition by Cadmium (Cd) at concentrations from 5 to 50 microM, a significant part of the action of this metal being on the transmembrane component of Zn uptake.
ISSN:	0143-4004
DOI:	10.1016/0143-4004(92)90030-W