Search Results - "Durante, Michael A."

Single-cell analysis reveals new evolutionary complexity in uveal melanoma by Durante, Michael A., Rodriguez, Daniel A., Kurtenbach, Stefan, Kuznetsov, Jeffim N., Sanchez, Margaret I., Decatur, Christina L., Snyder, Helen, Feun, Lynn G., Livingstone, Alan S., Harbour, J. William

“…Uveal melanoma (UM) is a highly metastatic cancer that, in contrast to cutaneous melanoma, is largely unresponsive to checkpoint immunotherapy. Here, we…”
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Single-cell analysis of olfactory neurogenesis and differentiation in adult humans by Durante, Michael A., Kurtenbach, Stefan, Sargi, Zoukaa B., Harbour, J. William, Choi, Rhea, Kurtenbach, Sarah, Goss, Garrett M., Matsunami, Hiroaki, Goldstein, Bradley J.

“…The presence of active neurogenic niches in adult humans is controversial. We focused attention to the human olfactory neuroepithelium, an extracranial site…”
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Punctuated evolution of canonical genomic aberrations in uveal melanoma by Field, Matthew G., Durante, Michael A., Anbunathan, Hima, Cai, Louis Z., Decatur, Christina L., Bowcock, Anne M., Kurtenbach, Stefan, Harbour, J. William

“…Cancer is thought to arise through the accumulation of genomic aberrations evolving under Darwinian selection. However, it remains unclear when the aberrations…”
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Gain of function of ASXL1 truncating protein in the pathogenesis of myeloid malignancies by Yang, Hui, Kurtenbach, Stefan, Guo, Ying, Lohse, Ines, Durante, Michael A., Li, Jianping, Li, Zhaomin, Al-Ali, Hassan, Li, Lingxiao, Chen, Zizhen, Field, Matthew G., Zhang, Peng, Chen, Shi, Yamamoto, Shohei, Li, Zhuo, Zhou, Yuan, Nimer, Stephen D., Harbour, J. William, Wahlestedt, Claes, Xu, Mingjiang, Yang, Feng-Chun

“…Additional Sex Combs-Like 1 (ASXL1) is mutated at a high frequency in all forms of myeloid malignancies associated with poor prognosis. We generated a Vav1…”
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Uphyloplot2: visualizing phylogenetic trees from single-cell RNA-seq data by Kurtenbach, Stefan, Cruz, Anthony M, Rodriguez, Daniel A, Durante, Michael A, Harbour, J William

“…Recent advances in single cell sequencing technologies allow for greater resolution in assessing tumor clonality using chromosome copy number variations…”
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Drug and disease signature integration identifies synergistic combinations in glioblastoma by Stathias, Vasileios, Jermakowicz, Anna M., Maloof, Marie E., Forlin, Michele, Walters, Winston, Suter, Robert K., Durante, Michael A., Williams, Sion L., Harbour, J. William, Volmar, Claude-Henry, Lyons, Nicholas J., Wahlestedt, Claes, Graham, Regina M., Ivan, Michael E., Komotar, Ricardo J., Sarkaria, Jann N., Subramanian, Aravind, Golub, Todd R., Schürer, Stephan C., Ayad, Nagi G.

“…Glioblastoma (GBM) is the most common primary adult brain tumor. Despite extensive efforts, the median survival for GBM patients is approximately 14 months…”
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On the in vivo origin of human nasal mesenchymal stem cell cultures by Choi, Rhea, Goncalves, Stefania, Durante, Michael A., Goldstein, Bradley J.

“…Objectives Mesenchymal stem cells (MSCs), classically expanded in culture from bone marrow, are of broad interest to the regenerative medicine community. Human…”
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Multiregional genetic evolution of metastatic uveal melanoma by Rodriguez, Daniel A., Yang, Jessica, Durante, Michael A., Shoushtari, Alexander N., Moschos, Stergios J., Wrzeszczynski, Kazimierz O., Harbour, J. William, Carvajal, Richard D.

“…Uveal melanoma (UM) is the most common primary intraocular malignancy in adults and leads to deadly metastases for which there is no approved treatment…”
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HDAC Inhibition Enhances the In Vivo Efficacy of MEK Inhibitor Therapy in Uveal Melanoma by Faião-Flores, Fernanda, Emmons, Michael F, Durante, Michael A, Kinose, Fumi, Saha, Biswarup, Fang, Bin, Koomen, John M, Chellappan, Srikumar P, Maria-Engler, Silvya Stuchi, Rix, Uwe, Licht, Jonathan D, Harbour, J William, Smalley, Keiran S M

“…The clinical use of MEK inhibitors in uveal melanoma is limited by the rapid acquisition of resistance. This study has used multiomics approaches and drug…”
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Impact of soluble BCMA and non-T-cell factors on refractoriness to BCMA-targeting T-cell engagers in multiple myeloma by Lee, Holly, Durante, Michael A, Skerget, Sheri, Vishwamitra, Deeksha, Benaoudia, Sacha, Ahn, Sungwoo, Poorebrahim, Mansour, Barakat, Elie, Jung, David, Leblay, Noémie, Ziccheddu, Bachisio, Diamond, Benjamin T, Papadimitriou, Marios, Cohen, Adam D, Landgren, Ola, Neri, Paola, Maura, Francesco, Bahlis, Nizar J

“…Adoptive T cell therapy is a promising therapy for multiple myeloma (MM), but its efficacy hinges on understanding relevant biological and predictive markers…”
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PRAME induces genomic instability in uveal melanoma by Kurtenbach, Stefan, Sanchez, Margaret I., Kuznetsoff, Jeffim, Rodriguez, Daniel A., Weich, Natalia, Dollar, James J., Cruz, Anthony, Kurtenbach, Sarah, Field, Matthew G., Durante, Michael A., Decatur, Christina, Sorouri, Mahsa, Lai, Fan, Yenisehirli, Gulum, Fang, Bin, Shiekhattar, Ramin, Pelaez, Daniel, Correa, Zelia M., Verdun, Ramiro E., Harbour, J. William

“…PRAME is a CUL2 ubiquitin ligase subunit that is normally expressed in the testis but becomes aberrantly overexpressed in many cancer types in association with…”
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Epigenetic reprogramming and aberrant expression of PRAME are associated with increased metastatic risk in Class 1 and Class 2 uveal melanomas by Field, Matthew G, Durante, Michael A, Decatur, Christina L, Tarlan, Bercin, Oelschlager, Kristen M, Stone, John F, Kuznetsov, Jeffim, Bowcock, Anne M, Kurtenbach, Stefan, Harbour, J William

“…We previously identified PRAME as a biomarker for metastatic risk in Class 1 uveal melanomas. In this study, we sought to define a threshold value for positive…”
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HDAC11 activity contributes to MEK inhibitor escape in uveal melanoma by Sriramareddy, Sathya Neelature, Faião-Flores, Fernanda, Emmons, Michael F., Saha, Biswarup, Chellappan, Srikumar, Wyatt, Clayton, Smalley, Inna, Licht, Jonathan D., Durante, Michael A., Harbour, J. William, Smalley, Keiran S. M.

“…We previously demonstrated that pan-HDAC inhibitors could limit escape from MEK inhibitor (MEKi) therapy in uveal melanoma (UM) through suppression of AKT and…”
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BAP1 regulates epigenetic switch from pluripotency to differentiation in developmental lineages giving rise to BAP1-mutant cancers by Kuznetsov, Jeffim N, Aguero, Tristan H, Owens, Dawn A, Kurtenbach, Stefan, Field, Matthew G, Durante, Michael A, Rodriguez, Daniel A, King, Mary Lou, Harbour, J William

“…The BAP1 tumor suppressor is mutated in many human cancers such as uveal melanoma, leading to poor patient outcome. It remains unclear how BAP1 functions in…”
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RB1 loss triggers dependence on ESRRG in retinoblastoma by Field, Matthew G, Kuznetsoff, Jeffim N, Zhang, Michelle G, Dollar, James J, Durante, Michael A, Sayegh, Yoseph, Decatur, Christina L, Kurtenbach, Stefan, Pelaez, Daniel, Harbour, J William

“…Retinoblastoma (Rb) is a deadly childhood eye cancer that is classically initiated by inactivation of the RB1 tumor suppressor. Clinical management continues…”
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A novel cardiomyogenic role for Isl1 + neural crest cells in the inflow tract by Hatzistergos, Konstantinos E, Durante, Michael A, Valasaki, Krystalenia, Wanschel, Amarylis C B A, Harbour, J William, Hare, Joshua M

“…The degree to which populations of cardiac progenitors (CPCs) persist in the postnatal heart remains a controversial issue in cardiobiology. To address this…”
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PieParty: visualizing cells from scRNA-seq data as pie charts by Kurtenbach, Stefan, Dollar, James J, Cruz, Anthony M, Durante, Michael A, Decatur, Christina L, Harbour, J William

“…Single-cell RNA sequencing (scRNA-seq) has been a transformative technology in many research fields. Dimensional reduction techniques such as UMAP and tSNE are…”
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Analytical Validation and Performance of a 7-Gene Next-Generation Sequencing Panel in Uveal Melanoma by Alsina, Katherina M., Sholl, Lauren M., Covington, Kyle R., Arnal, Suzzette M., Durante, Michael A., Decatur, Christina L., Stone, John F., Oelschlager, Kristen M., Harbour, J. William, Monzon, Federico A., Cook, Robert W., Borman, Sherri

“…Introduction: Gene expression profiling (GEP) is widely used for prognostication in patients with uveal melanoma (UM). Because biopsy tissue is limited, it is…”
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Genomic evolution of uveal melanoma arising in ocular melanocytosis by Durante, Michael A, Field, Matthew G, Sanchez, Margaret I, Covington, Kyle R, Decatur, Christina L, Dubovy, Sander R, Harbour, J William

“…Ocular melanocytosis is the most important predisposing condition for the eye cancer uveal melanoma (UM). Here, we present a patient who developed UM arising…”
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Abstract 2764: Mechanisms of genomic-microenvironmental interactions in uveal melanoma by Kaler, Christopher J., Dollar, James J., Kurtenbach, Stefan, Kuznetsov, Jeffim N., Durante, Michael A., Harbour, J. William

“…Abstract Uveal melanoma (UM) is the most common primary eye cancer and has a high rate of metastasis with liver tropism. UM can be stratified according to…”
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