Search Results - "Durante, Cristina"
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In Ovarian Cancer Multicellular Spheroids, Platelet Releasate Promotes Growth, Expansion of ALDH+ and CD133+ Cancer Stem Cells, and Protection against the Cytotoxic Effects of Cisplatin, Carboplatin and Paclitaxel
Published in International journal of molecular sciences (16-03-2021)“…A high platelet count is associated with a poor prognosis in ovarian cancer (OvCa). Despite good clinical responses with platinating agents in combination with…”
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Ex vivo expansion in a clinical grade medium, containing growth factors from human platelets, enhances migration capacity of adipose stem cells
Published in Frontiers in immunology (14-05-2024)“…Adipose tissue mesenchymal stem/stromal cells (ASC) can be used as advanced therapy medicinal product in regenerative and cancer medicine. We previously…”
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Identification and Characterization of Approved Drugs and Drug-Like Compounds as Covalent Escherichia coli ClpP Inhibitors
Published in International journal of molecular sciences (31-05-2019)“…The serine protease Caseinolytic protease subunit P (ClpP) plays an important role for protein homeostasis in bacteria and contributes to various developmental…”
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Improved GMP compliant approach to manipulate lipoaspirates, to cryopreserve stromal vascular fraction, and to expand adipose stem cells in xeno-free media
Published in Stem cell research & therapy (11-05-2018)“…The stromal vascular fraction (SVF) derived from adipose tissue contains adipose-derived stromal/stem cells (ASC) and can be used for regenerative…”
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Standardization of platelet releasate products for clinical applications in cell therapy: a mathematical approach
Published in Journal of translational medicine (19-05-2017)“…Standardized animal-free components are required for manufacturing cell-based medicinal products. Human platelet concentrates are sources of growth factors for…”
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The production method affects the efficacy of platelet derivatives to expand mesenchymal stromal cells in vitro
Published in Journal of translational medicine (01-05-2017)“…The use of fetal bovine serum (FBS) as a media supplement for the ex vivo expansion of bone-marrow derived mesenchymal stromal cells (BM-MSC) has been…”
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Nucleofection of Adipose Mesenchymal Stem/Stromal Cells: Improved Transfection Efficiency for GMP Grade Applications
Published in Cells (Basel, Switzerland) (03-12-2021)“…Nucleofection (NF) is a safe, non-viral transfection method, compatible with Good Manufacturing Practice guidelines. Such a technique is useful to improve…”
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IRE1a-Induced FilaminA Phosphorylation Enhances Migration of Mesenchymal Stem Cells Derived from Multiple Myeloma Patients
Published in Cells (Basel, Switzerland) (26-07-2023)“…Multiple myeloma (MM) is an aggressive malignancy that shapes, during its progression, a pro-tumor microenvironment characterized by altered protein secretion…”
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New N-phenylpyrrolamide DNA gyrase B inhibitors: Optimization of efficacy and antibacterial activity
Published in European journal of medicinal chemistry (25-06-2018)“…The ATP binding site located on the subunit B of DNA gyrase is an attractive target for the development of new antibacterial agents. In recent decades, several…”
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ADAM9 silencing inhibits breast tumor cell invasion in vitro
Published in Biochimie (01-07-2013)“…ADAM9 (A Disintegrin And Metalloproteinase 9) is a member of the ADAM protein family which contains a disintegrin domain. This protein family plays key roles…”
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Pheno- and genotypic characterization of Listeria monocytogenes clinical isolates from the southwestern region of the State of São Paulo, Brazil
Published in Brazilian journal of microbiology (01-06-2007)“…Considering the lack of information available in Brazil concerning listeriosis, the present study aimed to analyze phenotypic and genotypically Listeria…”
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A New Shear-Stress-Based Point-of-Care Technology for Evaluation of the Hemostatic Pattern in Whole Blood
Published in Biosensors (Basel) (22-10-2024)“…The currently available point-of-care hemostasis tests are burdened by criticisms concerning the use of different activators and inhibitors and the lack of…”
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Modified mesenchymal stem cells in cancer therapy: A smart weapon requiring upgrades for wider clinical applications
Published in World journal of stem cells (26-01-2022)“…Mesenchymal stem stromal cells (MSC) are characterized by the intriguing capacity to home toward cancer cells after systemic administration. Thus, MSC can be…”
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Exploring the Chemical Space of Benzothiazole-Based DNA Gyrase B Inhibitors
Published in ACS medicinal chemistry letters (10-12-2020)“…We designed and synthesized a series of inhibitors of the bacterial enzymes DNA gyrase and DNA topoisomerase IV, based on our recently published…”
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miR-335-laden B Cell-Derived Extracellular Vesicles Promote SOX4-Dependent Apoptosis in Human Multiple Myeloma Cells
Published in Journal of personalized medicine (23-11-2021)“…Multiple myeloma (MM) is characterized by the accumulation of malignant plasma cells in the bone marrow. Despite novel therapies, MM still remains an incurable…”
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Postautologous stem cell transplantation long-term outcomes in 26 HIV-positive patients affected by relapsed/refractory lymphoma
Published in AIDS (London) (01-11-2015)“…To describe survival data, CD4 T-cell long-term dynamics and the correlation between dynamics and events occurrence in 26 HIV-positive patients with refractory…”
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Adipose mesenchymal stromal/stem cells expanded by a GMP compatible protocol displayed improved adhesion on cancer cells in flow conditions
Published in Annals of translational medicine (01-04-2020)“…Adipose tissue derived mesenchymal stromal/stem cells (ASC) can be expanded using supernatant rich in growth factors (SRGF) as Good Manufacturing Practice…”
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Ações educativas em um Programa de Agentes Comunitários de Saúde
Published in Revista Brasileira de Enfermagem (01-06-2012)“…Este estudo teve por objetivo identificar e analisar as ações educativas realizadas por um Programa de Agentes Comunitários de Saúde de uma cidade do interior…”
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Post-transplantation long-term events in a cohort of HIV-positive patients affected by relapsed/refractory lymphoma
Published in Journal of clinical oncology (20-05-2015)“…Abstract only…”
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Post-transplantation long-term outcomes in 43 HIV-positive patients affected by high-risk or relapsed lymphoma
Published in Journal of clinical oncology (10-02-2017)“…Abstract only 121 Background: The advent of highly active antiretroviral therapy (HAART) allowed to extend autologous stem cell transplantation (ASCT) to…”
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