Search Results - "Durandt, Chrisna"

An In Vitro and In Vivo Comparison of Osteogenic Differentiation of Human Mesenchymal Stromal/Stem Cells by Mollentze, Jamie, Durandt, Chrisna, Pepper, Michael S.

“…The use of stem cells in regenerative medicine, including tissue engineering and transplantation, has generated a great deal of enthusiasm. Mesenchymal…”
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Consequences of HIV infection in the bone marrow niche by Herd, Candice Lee, Mellet, Juanita, Mashingaidze, Tsungai, Durandt, Chrisna, Pepper, Michael Sean

“…Dysregulation of the bone marrow niche resulting from the direct and indirect effects of HIV infection contributes to haematological abnormalities observed in…”
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The Role of Pref-1 during Adipogenic Differentiation: An Overview of Suggested Mechanisms by da Silva, Carina, Durandt, Chrisna, Kallmeyer, Karlien, Ambele, Melvin A, Pepper, Michael S

“…Obesity contributes significantly to the global health burden. A better understanding of adipogenesis, the process of fat formation, may lead to the discovery…”
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Comparison of human platelet lysate alternatives using expired and freshly isolated platelet concentrates for adipose-derived stromal cell expansion by Dessels, Carla, Durandt, Chrisna, Pepper, Michael S

“…Pooled human platelet lysate (pHPL) has been used to expand adipose-derived stromal cells (ASCs) and can be formulated using fresh or expired buffy coats (BCs)…”
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Extensive immunophenotypic sub-population analysis of StemRegenin1 expanded haematopoietic stem/progenitor cells by Mellet, Juanita, Hendricks, Candice L, Stivaktas, Voula, Durandt, Chrisna, Ambele, Melvin A, Pepper, Michael S

“…Ex vivo haematopoietic stem/progenitor cell (HSPCs) expansion constitutes an important area of research, and has the potential to improve access to umbilical…”
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Considerations for enhanced mesenchymal stromal/stem cell myogenic commitment in vitro by Grobbelaar, Simone, Mercier, Anne E., Bout, Iman, Durandt, Chrisna, Pepper, Michael S.

“…The generation of tissue from stem cells is an alluring concept as it holds a number of potential applications in clinical therapeutics and regenerative…”
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The c-Myc/TBX3 Axis Promotes Cellular Transformation of Sarcoma-Initiating Cells by Damerell, Victoria, Ambele, Melvin Anyasi, Salisbury, Shanel, Neumann-Mufweba, Alexis, Durandt, Chrisna, Pepper, Michael Sean, Prince, Sharon

“…Sarcomas are highly aggressive cancers of mesenchymal origin whose clinical management is highly complex. This is partly due to a lack of understanding of the…”
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Evaluation of [ 68 Ga]Ga-DOTA-AeK as a Potential Imaging Tool for PET Imaging of Cell Wall Synthesis in Bacterial Infections by Koatale, Palesa C, Welling, Mick M, Mdanda, Sipho, Mdlophane, Amanda, Takyi-Williams, John, Durandt, Chrisna, van den Bout, Iman, Cleeren, Frederik, Sathekge, Mike M, Ebenhan, Thomas

“…The ability of bacteria to recycle exogenous amino acid-based peptides and amino sugars for peptidoglycan biosynthesis was extensively investigated using…”
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Single-Cell Transcriptome Analysis of Human Adipose-Derived Stromal Cells Identifies a Contractile Cell Subpopulation by Wolmarans, Elize, Mellet, Juanita, Durandt, Chrisna, Joubert, Fourie, Pepper, Michael S.

“…The potential for human adipose-derived stromal cells (hASCs) to be used as a therapeutic product is being assessed in multiple clinical trials. However, much…”
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Genome-wide analysis of gene expression during adipogenesis in human adipose-derived stromal cells reveals novel patterns of gene expression during adipocyte differentiation by Ambele, Melvin Anyasi, Dessels, Carla, Durandt, Chrisna, Pepper, Michael Sean

“…We have undertaken an in-depth transcriptome analysis of adipogenesis in human adipose-derived stromal cells (ASCs) induced to differentiate into adipocytes in…”
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Novel flow cytometric approach for the detection of adipocyte subpopulations during adipogenesis[S] by Durandt, Chrisna, van Vollenstee, Fiona A., Dessels, Carla, Kallmeyer, Karlien, de Villiers, Danielle, Murdoch, Candice, Potgieter, Marnie, Pepper, Michael S.

“…The ability of mesenchymal stromal cells (MSCs) to differentiate into adipocytes provides a cellular model of human origin to study adipogenesis in vitro. One…”
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Immunosuppressive Signaling Pathways as Targeted Cancer Therapies by Setlai, Botle Precious, Hull, Rodney, Bida, Meshack, Durandt, Chrisna, Mulaudzi, Thanyani Victor, Chatziioannou, Aristotelis, Dlamini, Zodwa

“…Immune response has been shown to play an important role in defining patient prognosis and response to cancer treatment. Tumor-induced immunosuppression…”
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Effect of 2‐methoxyestradiol on mammary tumor initiation and progression by Peta, Kimberly T., Durandt, Chrisna, Heerden, Marlene B., Joubert, Anna M., Pepper, Michael S., Ambele, Melvin A.

“…Background The anti‐cancer agent 2‐methoxyestradiol (2‐ME) has been shown to have anti‐proliferative and anti‐angiogenic properties. Previously, the effect of…”
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Clofazimine, but Not Isoniazid or Rifampicin, Augments Platelet Activation in vitro by Anderson, Ronald, Theron, Annette J, Nel, Jan G, Durandt, Chrisna, Cholo, Moloko C, Feldman, Charles, Tintinger, Gregory R

“…Although the inclusion of the cationic amphiphilic, anti-mycobacterial agent, clofazimine, in the chemotherapeutic regimens of patients with…”
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Side Population: Its Use in the Study of Cellular Heterogeneity and as a Potential Enrichment Tool for Rare Cell Populations by Mellet, Juanita, Durandt, Chrisna, Nel, Sulette, Wolmarans, Elize, Pepper, Michael S.

“…There is still much to learn about the cells used for cell- and gene-based therapies in the clinical setting. Stem cells are found in virtually all tissues in…”
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Targeting the aryl hydrocarbon receptor nuclear translocator complex with DMOG and Stemregenin 1 improves primitive hematopoietic stem cell expansion by Jackson, Carlo Stephan, Durandt, Chrisna, Janse van Rensburg, Ilse, Praloran, Vincent, Brunet de la Grange, Philippe, Pepper, Michael Sean

“…Culture conditions used for the expansion of hematopoietic stem and progenitor cells (HSCs and HPCs, collectively HSPCs) should ideally favor the self renewal…”
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Neutrophil extracellular traps and their role in health and disease by Nel, Jan G, Theron, Annette J, Pool, Roger, Durandt, Chrisna, Tintinger, Gregory R, Anderson, Ronald

“…The human innate immune system is indispensable for protection against potentially invasive microbial and viral pathogens, either neutralising them or…”
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Does in utero HIV exposure and the early nutritional environment influence infant development and immune outcomes? Findings from a pilot study in Pretoria, South Africa by White, Marina, Feucht, Ute D, Duffley, Eleanor, Molokoane, Felicia, Durandt, Chrisna, Cassol, Edana, Rossouw, Theresa, Connor, Kristin L

“…As mother-to-child transmission of HIV decreases, and the population of infants who are born HIV-exposed, but uninfected (HEU) continues to rise, there is a…”
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The Beta-2-Adrenoreceptor Agonists, Formoterol and Indacaterol, but Not Salbutamol, Effectively Suppress the Reactivity of Human Neutrophils In Vitro by Tintinger, G. R., Durandt, Chrisna, Steel, Helen C., Theron, A. J., Anderson, Ronald, Feldman, Charles

“…The clinical relevance of the anti-inflammatory properties of beta-2 agonists remains contentious possibly due to differences in their molecular structures and…”
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Introduction of the AmpliChip CYP450 Test to a South African cohort: a platform comparative prospective cohort study by Dodgen, Tyren M, Hochfeld, Warren E, Fickl, Heidi, Asfaha, Sahle M, Durandt, Chrisna, Rheeder, Paul, Drögemöller, Britt I, Wright, Galen E B, Warnich, Louise, Labuschagne, Christiaan D J, van Schalkwyk, Antoinette, Gaedigk, Andrea, Pepper, Michael S

“…Adverse drug reactions and lack of therapeutic efficacy associated with currently prescribed pharmacotherapeutics may be attributed, in part, to…”
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