Search Results - "Duran, Jordi"

Role of Astrocytes in the Pathophysiology of Lafora Disease and Other Glycogen Storage Disorders by Duran, Jordi

“…Lafora disease is a rare disorder caused by loss of function mutations in either the EPM2A or NHLRC1 gene. The initial symptoms of this condition are most…”
Get full text

Suppression of glycogen synthesis as a treatment for Lafora disease: Establishing the window of opportunity by Varea, Olga, Duran, Jordi, Aguilera, Mònica, Prats, Neus, Guinovart, Joan J.

“…Lafora disease (LD) is a fatal adolescence-onset neurodegenerative condition. The hallmark of LD is the accumulation of aberrant glycogen aggregates called…”
Get full text

Astrocytes and neurons produce distinct types of polyglucosan bodies in Lafora disease by Augé, Elisabet, Pelegrí, Carme, Manich, Gemma, Cabezón, Itsaso, Guinovart, Joan J., Duran, Jordi, Vilaplana, Jordi

“…Lafora disease (LD), the most devastating adolescence‐onset epilepsy, is caused by mutations in the EPM2A or EPM2B genes, which encode the proteins laforin and…”
Get full text

Effects of hepatic glycogen on food intake and glucose homeostasis are mediated by the vagus nerve in mice by López-Soldado, Iliana, Fuentes-Romero, Rebeca, Duran, Jordi, Guinovart, Joan J.

“…Aims/hypothesis Liver glycogen plays a key role in regulating food intake and blood glucose. Mice that accumulate large amounts of this polysaccharide in the…”
Get full text

Active Glycogen Synthase in the Liver Prevents High-Fat Diet-Induced Glucose Intolerance, Decreases Food Intake, and Lowers Body Weight by López-Soldado, Iliana, Guinovart, Joan J, Duran, Jordi

“…Many lines of evidence demonstrate a correlation between liver glycogen content and food intake. We previously demonstrated that mice overexpressing protein…”
Get full text

Impairment in Long-Term Memory Formation and Learning-Dependent Synaptic Plasticity in Mice Lacking Glycogen Synthase in the Brain by Duran, Jordi, Saez, Isabel, Gruart, Agnes, Guinovart, Joan J, Delgado-García, José M

“…Glycogen is the only carbohydrate reserve of the brain, but its overall contribution to brain functions remains unclear. Although it has traditionally been…”
Get full text

Lack of Glycogenin Causes Glycogen Accumulation and Muscle Function Impairment by Testoni, Giorgia, Duran, Jordi, García-Rocha, Mar, Vilaplana, Francisco, Serrano, Antonio L., Sebastián, David, López-Soldado, Iliana, Sullivan, Mitchell A., Slebe, Felipe, Vilaseca, Marta, Muñoz-Cánoves, Pura, Guinovart, Joan J.

“…Glycogenin is considered essential for glycogen synthesis, as it acts as a primer for the initiation of the polysaccharide chain. Against expectations,…”
Get full text

Liver glycogen reduces food intake and attenuates obesity in a high-fat diet-fed mouse model by López-Soldado, Iliana, Zafra, Delia, Duran, Jordi, Adrover, Anna, Calbó, Joaquim, Guinovart, Joan J

“…We generated mice that overexpress protein targeting to glycogen (PTG) in the liver (PTG(OE)), which results in an increase in liver glycogen. When fed a…”
Get full text

Lack of Neuronal Glycogen Impairs Memory Formation and Learning-Dependent Synaptic Plasticity in Mice by Duran, Jordi, Gruart, Agnès, Varea, Olga, López-Soldado, Iliana, Delgado-García, José M, Guinovart, Joan J

“…Since brain glycogen is stored mainly in astrocytes, the role of this polysaccharide in neurons has been largely overlooked. To study the existence and…”
Get full text

Hepatic overexpression of protein targeting to glycogen attenuates obesity and improves hyperglycemia in db/db mice by López-Soldado, Iliana, Guinovart, Joan J., Duran, Jordi

“…Increased liver glycogen content has been shown to reduce food intake, attenuate obesity, and improve glucose tolerance in a mouse model of high-fat diet…”
Get full text

A Guideline to Univariate Statistical Analysis for LC/MS-Based Untargeted Metabolomics-Derived Data by Vinaixa, Maria, Samino, Sara, Saez, Isabel, Duran, Jordi, Guinovart, Joan J, Yanes, Oscar

“…Several metabolomic software programs provide methods for peak picking, retention time alignment and quantification of metabolite features in LC/MS-based…”
Get full text

Autophagy-regulating TP53INP2 mediates muscle wasting and is repressed in diabetes by Sala, David, Ivanova, Saška, Plana, Natàlia, Ribas, Vicent, Duran, Jordi, Bach, Daniel, Turkseven, Saadet, Laville, Martine, Vidal, Hubert, Karczewska-Kupczewska, Monika, Kowalska, Irina, Straczkowski, Marek, Testar, Xavier, Palacín, Manuel, Sandri, Marco, Serrano, Antonio L, Zorzano, Antonio

“…A precise balance between protein degradation and synthesis is essential to preserve skeletal muscle mass. Here, we found that TP53INP2, a homolog of the…”
Get full text

Mutant IDH regulates glycogen metabolism from early cartilage development to malignant chondrosarcoma formation by Pathmanapan, Sinthu, Poon, Raymond, De Renshaw, Tomasa Barrientos, Nadesan, Puviindran, Nakagawa, Makoto, Seesankar, Gireesh A., Loe, Adrian Kwan Ho, Zhang, Hongyuan H., Guinovart, Joan J., Duran, Jordi, Newgard, Christopher B., Wunder, Jay S., Alman, Benjamin A.

“…Chondrosarcomas are the most common malignancy of cartilage and are associated with somatic mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 genes…”
Get full text

Genetic models rule out a major role of beta cell glycogen in the control of glucose homeostasis by Mir-Coll, Joan, Duran, Jordi, Slebe, Felipe, García-Rocha, Mar, Gomis, Ramon, Gasa, Rosa, Guinovart, Joan J.

“…Aims/hypothesis Glycogen accumulation occurs in beta cells of diabetic patients and has been proposed to partly mediate glucotoxicity-induced beta cell…”
Get full text

Deleterious effects of neuronal accumulation of glycogen in flies and mice by Duran, Jordi, Tevy, María Florencia, Garcia‐Rocha, Mar, Calbó, Joaquim, Milán, Marco, Guinovart, Joan J.

“…Under physiological conditions, most neurons keep glycogen synthase (GS) in an inactive form and do not show detectable levels of glycogen. Nevertheless,…”
Get full text

DOR/Tp53inp2 and Tp53inp1 constitute a metazoan gene family encoding dual regulators of autophagy and transcription by Sancho, Ana, Duran, Jordi, García-España, Antonio, Mauvezin, Caroline, Alemu, Endalkachew A, Lamark, Trond, Macias, Maria J, DeSalle, Rob, Royo, Miriam, Sala, David, Chicote, Javier U, Palacín, Manuel, Johansen, Terje, Zorzano, Antonio

“…Human DOR/TP53INP2 displays a unique bifunctional role as a modulator of autophagy and gene transcription. However, the domains or regions of DOR that…”
Get full text

The nuclear cofactor DOR regulates autophagy in mammalian and Drosophila cells by Mauvezin, Caroline, Orpinell, Meritxell, Francis, Víctor A, Mansilla, Francisco, Duran, Jordi, Ribas, Vicent, Palacín, Manuel, Boya, Patricia, Teleman, Aurelio A, Zorzano, Antonio

“…The regulation of autophagy in metazoans is only partly understood, and there is a need to identify the proteins that control this process. The diabetes‐ and…”
Get full text

Arousal-induced cortical activity triggers lactate release from astrocytes by Zuend, Marc, Saab, Aiman S., Wyss, Matthias T., Ferrari, Kim David, Hösli, Ladina, Looser, Zoe J., Stobart, Jillian L., Duran, Jordi, Guinovart, Joan J., Barros, L. Felipe, Weber, Bruno

Get full text

Identification of a novel modulator of thyroid hormone receptor-mediated action by Baumgartner, Bernhard G, Orpinell, Meritxell, Duran, Jordi, Ribas, Vicent, Burghardt, Hans E, Bach, Daniel, Villar, Ana Victoria, Paz, José C, González, Meritxell, Camps, Marta, Oriola, Josep, Rivera, Francisca, Palacín, Manuel, Zorzano, Antonio

“…Diabetes is characterized by reduced thyroid function and altered myogenesis after muscle injury. Here we identify a novel component of thyroid hormone action…”
Get full text

Catalytic asymmetric defluorinative allylation of silyl enol ethers by Duran, Jordi, Mateos, Javier, Moyano, Albert, Companyó, Xavier

“…The stereocontrolled installation of alkyl fragments at the alpha position of ketones is a fundamental yet unresolved transformation in organic chemistry…”
Get full text