Search Results - "Duran, Jason"

Natriuretic Peptides in Heart Failure: Atrial and B-type Natriuretic Peptides by Maisel, Alan S, Duran, Jason M, Wettersten, Nicholas

“…The natriuretic peptides play a vital role in normal physiology and as counter-regulatory hormones in heart failure (HF). Clinical assessment of their levels…”
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Bone-Derived Stem Cells Repair the Heart After Myocardial Infarction Through Transdifferentiation and Paracrine Signaling Mechanisms by Duran, Jason M., Makarewich, Catherine A., Sharp, Thomas E., Starosta, Timothy, Zhu, Fang, Hoffman, Nicholas E., Chiba, Yumi, Madesh, Muniswamy, Berretta, Remus M., Kubo, Hajime, Houser, Steven R.

“…RATIONALE:Autologous bone marrow–derived or cardiac-derived stem cell therapy for heart disease has demonstrated safety and efficacy in clinical trials, but…”
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Mitochondria are secreted in extracellular vesicles when lysosomal function is impaired by Liang, Wenjing, Sagar, Shakti, Ravindran, Rishith, Najor, Rita H., Quiles, Justin M., Chi, Liguo, Diao, Rachel Y., Woodall, Benjamin P., Leon, Leonardo J., Zumaya, Erika, Duran, Jason, Cauvi, David M., De Maio, Antonio, Adler, Eric D., Gustafsson, Åsa B.

“…Mitochondrial quality control is critical for cardiac homeostasis as these organelles are responsible for generating most of the energy needed to sustain…”
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Increased Peripheral Blood Neutrophil Activation Phenotypes and Neutrophil Extracellular Trap Formation in Critically Ill Coronavirus Disease 2019 (COVID-19) Patients: A Case Series and Review of the Literature by Masso-Silva, Jorge A, Moshensky, Alexander, Lam, Michael T Y, Odish, Mazen F, Patel, Arjun, Xu, Le, Hansen, Emily, Trescott, Samantha, Nguyen, Celina, Kim, Roy, Perofsky, Katherine, Perera, Samantha, Ma, Lauren, Pham, Josephine, Rolfsen, Mark, Olay, Jarod, Shin, John, Dan, Jennifer M, Abbott, Robert K, Ramirez, Sydney, Alexander, Thomas H, Lin, Grace Y, Fuentes, Ana Lucia, Advani, Ira, Gunge, Deepti, Pretorius, Victor, Malhotra, Atul, Sun, Xin, Duran, Jason, Hepokoski, Mark, Crotty, Shane, Coufal, Nicole G, Meier, Angela, Crotty Alexander, Laura E

“…Abstract Background Increased inflammation has been well defined in coronavirus disease 2019 (COVID-19), while definitive pathways driving severe forms of this…”
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Excess neuropeptides in lung signal through endothelial cells to impair gas exchange by Xu, Jinhao, Xu, Le, Sui, Pengfei, Chen, Jiyuan, Moya, Esteban A., Hume, Patrick, Janssen, William J., Duran, Jason M., Thistlethwaite, Patricia, Carlin, Aaron, Gulleman, Peter, Banaschewski, Brandon, Goldy, Mary Kate, Yuan, Jason X.-J., Malhotra, Atul, Pryhuber, Gloria, Crotty-Alexander, Laura, Deutsch, Gail, Young, Lisa R., Sun, Xin

“…Although increased neuropeptides are often detected in lungs that exhibit respiratory distress, whether they contribute to the condition is unknown. Here, we…”
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Cardiovascular Manifestations of Mitochondrial Disease by Duran, Jason, Martinez, Armando, Adler, Eric

“…Genetic mitochondrial cardiomyopathies are uncommon causes of heart failure that may not be seen by most physicians. However, the prevalence of mitochondrial…”
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Modeling Nonischemic Genetic Cardiomyopathies Using Induced Pluripotent Stem Cells by Khedro, Tarek, Duran, Jason M., Adler, Eric D.

“…Purpose of Review The advent of induced pluripotent stem cells (iPSC) has paved the way for new in vitro models of human cardiomyopathy. Herein, we will review…”
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Adult stem cell-derived complete lung organoid models emulate lung disease in COVID-19 by Tindle, Courtney, Fuller, MacKenzie, Fonseca, Ayden, Taheri, Sahar, Ibeawuchi, Stella-Rita, Beutler, Nathan, Katkar, Gajanan Dattatray, Claire, Amanraj, Castillo, Vanessa, Hernandez, Moises, Russo, Hana, Duran, Jason, Crotty Alexander, Laura E, Tipps, Ann, Lin, Grace, Thistlethwaite, Patricia A, Chattopadhyay, Ranajoy, Rogers, Thomas F, Sahoo, Debashis, Ghosh, Pradipta, Das, Soumita

“…SARS-CoV-2, the virus responsible for COVID-19, causes widespread damage in the lungs in the setting of an overzealous immune response whose origin remains…”
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The DNA glycosylase NEIL2 is protective during SARS-CoV-2 infection by Tapryal, Nisha, Chakraborty, Anirban, Saha, Kaushik, Islam, Azharul, Pan, Lang, Hosoki, Koa, Sayed, Ibrahim M., Duran, Jason M., Alcantara, Joshua, Castillo, Vanessa, Tindle, Courtney, Sarker, Altaf H., Wakamiya, Maki, Cardenas, Victor J., Sharma, Gulshan, Crotty Alexander, Laura E., Sur, Sanjiv, Sahoo, Debashis, Ghosh, Gourisankar, Das, Soumita, Ghosh, Pradipta, Boldogh, Istvan, Hazra, Tapas K.

“…SARS-CoV-2 infection-induced aggravation of host innate immune response not only causes tissue damage and multiorgan failure in COVID-19 patients but also…”
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Thin filament cardiomyopathies: A review of genetics, disease mechanisms, and emerging therapeutics by Keyt, Lucas K., Duran, Jason M., Bui, Quan M., Chen, Chao, Miyamoto, Michael I., Silva Enciso, Jorge, Tardiff, Jil C., Adler, Eric D.

“…All muscle contraction occurs due to the cyclical interaction between sarcomeric thin and thick filament proteins within the myocyte. The thin filament…”
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Effect of Eplontersen on Cardiac Structure and Function in Patients With Hereditary Transthyretin Amyloidosis by Masri, Ahmad, Maurer, Mathew S., Claggett, Brian L., Kulac, Ian, Waddington Cruz, Marcia, Conceição, Isabel, Weiler, Markus, Berk, John L., Gertz, Morie, Gillmore, Julian D., Rush, Stephen, Chen, Jersey, Zhou, Wunan, Kwoh, Jesse, Duran, Jason M., Tsimikas, Sotirios, Solomon, Scott D.

“…Hereditary transthyretin amyloidosis (ATTRv) is associated with polyneuropathy, cardiomyopathy, or both. The effects of eplontersen on cardiac structure and…”
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Hyperphosphorylation of the Cardiac Ryanodine Receptor at Serine 2808 Is Not Involved in Cardiac Dysfunction After Myocardial Infarction by Zhang, Hongyu, Makarewich, Catherine A, Kubo, Hajime, Wang, Wei, Duran, Jason M, Li, Ying, Berretta, Remus M, Koch, Walter J, Chen, Xiongwen, Gao, Erhe, Valdivia, Héctor H, Houser, Steven R

“…RATIONALE:Abnormal behavior of the cardiac ryanodine receptor (RyR2) has been linked to cardiac arrhythmias and heart failure (HF) after myocardial infarction…”
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Sorafenib Cardiotoxicity Increases Mortality After Myocardial Infarction by Duran, Jason M, Makarewich, Catherine A, Trappanese, Danielle, Gross, Polina, Husain, Sharmeen, Dunn, Jonathan, Lal, Hind, Sharp, Thomas E, Starosta, Timothy, Vagnozzi, Ronald J, Berretta, Remus M, Barbe, Mary, Yu, Daohai, Gao, Erhe, Kubo, Hajime, Force, Thomas, Houser, Steven R

“…RATIONALE:Sorafenib is an effective treatment for renal cell carcinoma, but recent clinical reports have documented its cardiotoxicity through an unknown…”
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Acute Catecholamine Exposure Causes Reversible Myocyte Injury Without Cardiac Regeneration by Wallner, Markus, Duran, Jason M, Mohsin, Sadia, Troupes, Constantine D, Vanhoutte, Davy, Borghetti, Giulia, Vagnozzi, Ronald J, Gross, Polina, Yu, Daohai, Trappanese, Danielle M, Kubo, Hajime, Toib, Amir, Sharp, Thomas E, Harper, Shavonn C, Volkert, Michael A, Starosta, Timothy, Feldsott, Eric A, Berretta, Remus M, Wang, Tao, Barbe, Mary F, Molkentin, Jeffrey D, Houser, Steven R

“…RATIONALE:Catecholamines increase cardiac contractility, but exposure to high concentrations or prolonged exposures can cause cardiac injury. A recent study…”
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Unique Features of Cortical Bone Stem Cells Associated With Repair of the Injured Heart by Mohsin, Sadia, Troupes, Constantine D, Starosta, Timothy, Sharp, Thomas E, Agra, Elorm J, Smith, Shavonn, Duran, Jason M, Zalavadia, Neil, Zhou, Yan, Kubo, Hajime, Berretta, Remus M, Houser, Steven R

“…RATIONALE:Adoptive transfer of multiple stem cell types has only had modest effects on the structure and function of failing human hearts. Despite increasing…”
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Low mortality in SARS‐CoV‐2 infected heart transplant recipients at a single center by Duran, Jason M., Barat, Masihullah, Lin, Andrew Y., King, Kevin R., Greenberg, Barry, Adler, Eric D., Aslam, Saima

“…Immunosuppressed heart transplant (HT) recipients are thought to be at higher risk of infection and mortality from SARS‐CoV‐2 infection coronavirus disease…”
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PI3Kγ inhibition circumvents inflammation and vascular leak in SARS-CoV-2 and other infections by Shepard, Ryan M, Ghebremedhin, Anghesom, Pratumchai, Isaraphorn, Robinson, Sally R, Betts, Courtney, Hu, Jingjing, Sasik, Roman, Fisch, Kathleen M, Zak, Jaroslav, Chen, Hui, Paradise, Marc, Rivera, Jason, Amjad, Mohammad, Uchiyama, Satoshi, Seo, Hideya, Campos, Alejandro D, Dayao, Denise Ann, Tzipori, Saul, Piedra-Mora, Cesar, Das, Soumita, Hasteh, Farnaz, Russo, Hana, Sun, Xin, Xu, Le, E Alexander, Laura Crotty, Duran, Jason M, Odish, Mazen, Pretorius, Victor, Kirchberger, Nell C, Chin, Shao-Ming, Von Schalscha, Tami, Cheresh, David, Morrey, John D, Alargova, Rossitza, O'Connell, Brenda, Martinot, Theodore A, Patel, Sandip P, Nizet, Victor, Martinot, Amanda J, Coussens, Lisa M, Teijaro, John R, Varner, Judith A

“…Virulent infectious agents such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and methicillin-resistant (MRSA) induce tissue damage that…”
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Mineralocorticoid receptor antagonist use following heart failure hospitalization by Duran, Jason M., Gad, Shady, Brann, Alison, Greenberg, Barry

“…Aims Patients hospitalized for heart failure (HF) are at increased risk for events post‐discharge. Mineralocorticoid receptor antagonists (MRAs) improve the…”
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Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death programs correlates with COVID-19 severity by Inde, Zintis, Croker, Ben A, Yapp, Clarence, Joshi, Gaurav N, Spetz, Johan, Fraser, Cameron, Qin, Xingping, Xu, Le, Deskin, Brian, Ghelfi, Elisa, Webb, Gabrielle, Carlin, Aaron F, Zhu, Yanfang Peipei, Leibel, Sandra L, Garretson, Aaron F, Clark, Alex E, Duran, Jason M, Pretorius, Victor, Crotty-Alexander, Laura E, Li, Chendi, Lee, Jamie Casey, Sodhi, Chhinder, Hackam, David J, Sun, Xin, Hata, Aaron N, Kobzik, Lester, Miller, Jeffrey, Park, Jin-Ah, Brownfield, Douglas, Jia, Hongpeng, Sarosiek, Kristopher A

“…Novel coronavirus disease 2019 (COVID-19) severity is highly variable, with pediatric patients typically experiencing less severe infection than adults and…”
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AI-guided discovery of the invariant host response to viral pandemics by Sahoo, Debashis, Katkar, Gajanan D., Khandelwal, Soni, Behroozikhah, Mahdi, Claire, Amanraj, Castillo, Vanessa, Tindle, Courtney, Fuller, MacKenzie, Taheri, Sahar, Rogers, Thomas F., Beutler, Nathan, Ramirez, Sydney I., Rawlings, Stephen A., Pretorius, Victor, Smith, Davey M., Burton, Dennis R., Alexander, Laura E. Crotty, Duran, Jason, Crotty, Shane, Dan, Jennifer M., Das, Soumita, Ghosh, Pradipta

“…Coronavirus Disease 2019 (Covid-19) continues to challenge the limits of our knowledge and our healthcare system. Here we sought to define the host immune…”
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