Search Results - "Durán, Pilar"
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Robust scoring of selective drug responses for patient-tailored therapy selection
Published in Nature protocols (2024)“…Most patients with advanced malignancies are treated with severely toxic, first-line chemotherapies. Personalized treatment strategies have led to improved…”
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Mcl‐1 and Bcl‐xL levels predict responsiveness to dual MEK/Bcl‐2 inhibition in B‐cell malignancies
Published in Molecular oncology (01-03-2022)“…Most patients with chronic lymphocytic leukemia (CLL) initially respond to targeted therapies, but eventually relapse and develop resistance. Novel treatment…”
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Tyrosine kinase inhibitors and interferon‐α increase tunneling nanotube (TNT) formation and cell adhesion in chronic myeloid leukemia (CML) cell lines
Published in The FASEB journal (01-03-2020)“…Chronic myeloid leukemia (CML) is a stem cell disease of the bone marrow where mechanisms of inter‐leukemic communication and cell‐to‐cell interactions are…”
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Maternal enrichment increases infantile spatial amnesia mediated by postnatal neurogenesis modulation
Published in Frontiers in behavioral neuroscience (25-08-2022)“…Infantile amnesia, the inability to form long-lasting episodic memories, is a phenomenon extensively known but with no clear understanding of its origins…”
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Olfactory neurogenesis and its role in fear memory modulation
Published in Frontiers in behavioral neuroscience (28-09-2023)“…Olfaction is a critical sense that allows animals to navigate and understand their environment. In mammals, the critical brain structure to receive and process…”
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Promising anti-proliferative indolic benzenesulfonamides alter mechanisms with sulfonamide nitrogen substituents
Published in European journal of medicinal chemistry (05-09-2024)“…Agents that cause apoptotic cell death by interfering with tubulin dynamics, such as vinblastine and paclitaxel, are an important class of chemotherapeutics…”
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Discovery of novel candidates for anti-liposarcoma therapies by medium-scale high-throughput drug screening
Published in PloS one (10-03-2021)“…Sarcomas are a heterogeneous group of mesenchymal orphan cancers and new treatment alternatives beyond traditional chemotherapeutic regimes are much needed. So…”
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Perinatal exposure to nicotine disrupts circadian locomotor and learning efficiency rhythms in juvenile mice
Published in Brain Structure and Function (01-09-2020)“…The increased rates of nicotine exposure by electronic nicotine delivery systems (vaping), ingestion, or patches during pregnancy as an alternative to the…”
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Standardized assays to monitor drug sensitivity in hematologic cancers
Published in Cell death discovery (01-12-2023)“…The principle of drug sensitivity testing is to expose cancer cells to a library of different drugs and measure its effects on cell viability. Recent…”
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Clinical forecasting of acute myeloid leukemia using ex vivo drug-sensitivity profiling
Published in Cell reports methods (18-12-2023)“…Current treatment selection for acute myeloid leukemia (AML) patients depends on risk stratification based on cytogenetic and genomic markers. However, the…”
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Rhabdomyolysis following Nuss Procedure: A Prospective Study in Children
Published in European journal of pediatric surgery (01-02-2023)“…Postoperative rhabdomyolysis (RML) has been documented after several surgical procedures in adults. Musculoskeletal remodeling after Nuss procedure for pectus…”
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GRP94 rewires and buffers the FLT3-ITD signaling network and promotes survival of acute myeloid leukemic stem cells
Published in Haematologica (Roma) (01-05-2019)Get full text
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13
Ketogenic Diet Provided During Three Months Increases KCC2 Expression but Not NKCC1 in the Rat Dentate Gyrus
Published in Frontiers in neuroscience (07-07-2020)“…Ketogenic diet, a high fat and low carbohydrate diet, has been used as a non-pharmacological treatment in refractory epilepsy since 1920. In recent years it…”
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Chronic lead exposure alters photic entrainment of locomotor activity rhythm and neuronal photoactivation in the suprachiasmatic nucleus of the adult rat
Published in Journal of chemical neuroanatomy (01-11-2021)“…•Rats were exposed to lead (Pb) from the beginning of gestation to adulthood.•Chronic exposure to Pb affects the entrainment of locomotor activity in adult…”
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Developmental Trends in Lexical Diversity
Published in Applied linguistics (01-06-2004)“…This article discusses issues in measuring lexical diversity, before outlining an approach based on mathematical modelling that produces a measure, D, designed…”
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Differences in electroencephalographic spectra during pre-sleep wakefulness, N1, and R sleep between comorbid insomnia and obstructive sleep apnea
Published in Sleep & breathing (01-03-2020)“…Purpose The neuropsychobiological effects of the comorbidity of insomnia and obstructive sleep apnea are not well studied. Our objective was to compare…”
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Fetal and Postnatal Nicotine Exposure Modifies Maturation of Gonocytes to Spermatogonia in Mice
Published in Analytical cellular pathology (Amsterdam) (2020)“…Studies in laboratory animals have shown that male offspring from dams, exposed to nicotine during pregnancy and postnatal periods, show alterations in…”
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Domain-specific mappings as conceptual categorisers for scientific and technical vocabularies
Published in Ibérica (Castellón de la Plana, Spain) (01-10-2017)“…The analysis of metaphorical lexical units in science and technology provides evidence for their existence either as separate cases or as part of a…”
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The CDK regulators Cdh1 and Sic1 promote efficient usage of DNA replication origins to prevent chromosomal instability at a chromosome arm
Published in Nucleic acids research (17-06-2014)“…Robustness and completion of DNA replication rely on redundant DNA replication origins. Reduced efficiency of origin licensing is proposed to contribute to…”
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Author Correction: Early response evaluation by single cell signaling profiling in acute myeloid leukemia
Published in Nature communications (30-03-2023)Get full text
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