Search Results - "Duquette, Pierre"

Trial of Minocycline in a Clinically Isolated Syndrome of Multiple Sclerosis by Metz, Luanne M, Li, David K.B, Traboulsee, Anthony L, Duquette, Pierre, Eliasziw, Misha, Cerchiaro, Graziela, Greenfield, Jamie, Riddehough, Andrew, Yeung, Michael, Kremenchutzky, Marcelo, Vorobeychik, Galina, Freedman, Mark S, Bhan, Virender, Blevins, Gregg, Marriott, James J, Grand’Maison, Francois, Lee, Liesly, Thibault, Manon, Hill, Michael D, Yong, V. Wee

“…The risk of conversion from a first demyelinating event to MS was lower with minocycline than with placebo over 6 months but not over 24 months. Changes of…”
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Clinical insights on the spasticity-plus syndrome in multiple sclerosis by Alami Marrouni, Kanza, Duquette, Pierre

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Switch to natalizumab versus fingolimod in active relapsing-remitting multiple sclerosis by Kalincik, Tomas, Horakova, Dana, Spelman, Tim, Jokubaitis, Vilija, Trojano, Maria, Lugaresi, Alessandra, Izquierdo, Guillermo, Rozsa, Csilla, Grammond, Pierre, Alroughani, Raed, Duquette, Pierre, Girard, Marc, Pucci, Eugenio, Lechner-Scott, Jeannette, Slee, Mark, Fernandez-Bolanos, Ricardo, Grand'Maison, Francois, Hupperts, Raymond, Verheul, Freek, Hodgkinson, Suzanne, Oreja-Guevara, Celia, Spitaleri, Daniele, Barnett, Michael, Terzi, Murat, Bergamaschi, Roberto, McCombe, Pamela, Sanchez-Menoyo, Jose, Simo, Magdolna, Csepany, Tunde, Rum, Gabor, Boz, Cavit, Havrdova, Eva, Butzkueven, Helmut

“…Objective In patients suffering multiple sclerosis activity despite treatment with interferon β or glatiramer acetate, clinicians often switch therapy to…”
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A retrospective claims analysis: Compliance and discontinuation rates among Canadian patients with multiple sclerosis treated with disease-modifying therapies by Duquette, Pierre, Yeung, Michael, Mouallif, Soukaïna, Nakhaipour, Hamid Reza, Haddad, Paola, Schecter, Robyn

“…Compliance to disease modifying therapy (DMT) is associated with a reduced risk of relapse, lower healthcare resource utilization, and improved health-related…”
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The effects of aging and disease duration on cognition in multiple sclerosis by Tremblay, A., Charest, K., Brando, E., Roger, E., Duquette, P., Rouleau, I.

“…•Aging is a major factor that influences cognitive functions in MS.•A trend of disease duration influencing information processing speed is observed.•Results…”
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Discontinuing disease-modifying therapy in MS after a prolonged relapse-free period: a propensity score-matched study by Kister, Ilya, Spelman, Tim, Alroughani, Raed, Lechner-Scott, Jeannette, Duquette, Pierre, Grand'Maison, Francois, Slee, Mark, Lugaresi, Alessandra, Barnett, Michael, Grammond, Pierre, Iuliano, Gerardo, Hupperts, Raymond, Pucci, Eugenio, Trojano, Maria, Butzkueven, Helmut

“…BackgroundDiscontinuation of injectable disease-modifying therapy (DMT) for multiple sclerosis (MS) after a long period of relapse freedom is frequently…”
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Impact of aging on treatment considerations for multiple sclerosis patients by Macaron, Gabrielle, Larochelle, Catherine, Arbour, Nathalie, Galmard, Manon, Girard, Jean Marc, Prat, Alexandre, Duquette, Pierre

“…With a rapidly aging global population and improvement of outcomes with newer multiple sclerosis (MS)-specific disease-modifying therapies (DMTs), the…”
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CD70 defines a subset of proinflammatory and CNS-pathogenic TH1/TH17 lymphocytes and is overexpressed in multiple sclerosis by Dhaeze, Tessa, Tremblay, Laurence, Lachance, Catherine, Peelen, Evelyn, Zandee, Stephanie, Grasmuck, Camille, Bourbonnière, Lyne, Larouche, Sandra, Ayrignac, Xavier, Rébillard, Rose-Marie, Poirier, Josée, Lahav, Boaz, Duquette, Pierre, Girard, Marc, Moumdjian, Robert, Bouthillier, Alain, Larochelle, Catherine, Prat, Alexandre

“…CD70 is the unique ligand of CD27 and is expressed on immune cells only upon activation. Therefore, engagement of the costimulatory CD27/CD70 pathway is solely…”
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Cognitive reserve as a moderating factor between EDSS and cognition in multiple sclerosis by Tremblay, Alexandra, Charest, Kim, Brando, Estefania, Roger, Elaine, Duquette, Pierre, Rouleau, Isabelle

“…•Cognitive reserve represents the plasticity properties of the brain to resist damage caused by disease and/or aging.•The protective role of CR seems to target…”
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IL-27 shapes the immune properties of human astrocytes and their impact on encountered human T lymphocytes by Lemaître, Florent, Farzam-kia, Negar, Carmena Moratalla, Ana, Carpentier Solorio, Yves, Clenet, Marie-Laure, Tastet, Olivier, Cleret-Buhot, Aurélie, Guimond, Jean Victor, Haddad, Elie, Duquette, Pierre, Girard, J. Marc, Prat, Alexandre, Larochelle, Catherine, Arbour, Nathalie

“…Abstract Background Interleukin-27 (IL-27) can trigger both pro- and anti-inflammatory responses. This cytokine is elevated in the central nervous system (CNS)…”
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Perceptions and engagement of patients with chronic conditions on the use of medical cannabis: a scoping review by Pomey, Marie-Pascale, Jutras-Aswad, Didier, Paquette, Jesseca, Saadi, Kamilla, Taguemout, Mélissa, Ikene, Dina-Liza, Arbour, Nathalie, Zertal, Amel, Fréjeau, Nathalie, Morin, Danielle, Ouellette, Jean-Sylvain, Alami Marrouni, Kanza, Duquette, Pierre

“…Studies generally focus on one type of chronic condition and the effect of medical cannabis (MC) on symptoms; little is known about the perceptions and…”
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Efficacy of cannabinoids compared to the current standard treatments on symptom relief in persons with multiple sclerosis (CANSEP trial): study protocol for a randomized clinical trial by Zertal, Amel, Alami Marrouni, Kanza, Arbour, Nathalie, Jutras-Aswad, Didier, Pomey, Marie-Pascale, Rouleau, Isabelle, Prat, Alexandre, Larochelle, Catherine, Beaulieu, Pierre, Chamelian, Laury, Sylvestre, Marie-Pierre, Morin, Danielle, Ouellette, Jean-Sylvain, Fréjeau, Nathalie, Duquette, Pierre

“…Multiple sclerosis (MS) is an inflammatory and degenerative disease of the central nervous system. More than 90,000 Canadians are affected; a cure is yet to be…”
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Does pregnancy alter the long-term course of multiple sclerosis? by Karp, Igor, MD, MPH, PhD, Manganas, Alexandra, BCom, Sylvestre, Marie-Pierre, PhD, Ho, Annie, Roger, Elaine, Duquette, Pierre, MD

“…Abstract Purpose The purpose was to examine the impact of pregnancy on the rates of relapses, progression to irreversible disability, and transition to…”
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Multiple sclerosis susceptibility genes: associations with relapse severity and recovery by Mowry, Ellen M, Carey, Robert F, Blasco, Maria R, Pelletier, Jean, Duquette, Pierre, Villoslada, Pablo, Malikova, Irina, Roger, Elaine, Kinkel, R Phillip, McDonald, Jamie, Bacchetti, Peter, Waubant, Emmanuelle

“…Patients with early multiple sclerosis (MS) have stereotyped attack severity and recovery. We sought to determine if polymorphisms in MS susceptibility genes…”
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Statins reduce human blood-brain barrier permeability and restrict leukocyte migration: Relevance to multiple sclerosis by Ifergan, Igal, Wosik, Karolina, Cayrol, Romain, Kébir, Hania, Auger, Chantale, Bernard, Monique, Bouthillier, Alain, Moumdjian, Robert, Duquette, Pierre, Prat, Alexandre

“…Objective Dysregulation of the blood–brain barrier (BBB) and transendothelial migration of immune cells are among the earliest central nervous system changes…”
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Does pain in individuals with multiple sclerosis affect employment? A systematic review and meta-analysis by Shahrbanian, Shahnaz, Auais, Mohammad, Duquette, Pierre, Andersen, Katie, Anderson, Katie, Mayo, Nancy E

“…Individuals with multiple sclerosis (MS) experience some of the highest unemployment rates among all groups of chronic illnesses. Pain has been found to be a…”
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Impairment, disability and fatigue in multiple sclerosis by Shahrbanian, Shahnaz, Duquette, Pierre, E Mayo, Nancy

“…Identifying the predictors of pain is important for both health professionals and researchers, because pain has repeatedly been found to be a strong predictor…”
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Fingolimod after natalizumab and the risk of short-term relapse by JOKUBAITIS, Vilija G, LI, Vivien, BARNETT, Michael, GRAND'MAISON, Francois, TROJANO, Maria, SLEE, Mark, GIULIANI, Giorgio, SHAW, Cameron, BOZ, Cavit, SPITALERI, Daniele L. A, VERHEUL, Freek, HAARTSEN, Jodi, KALINCIK, Tomas, LIEW, Danny, BUTZKUEVEN, Helmut, IZQUIERDO, Guillermo, HODGKINSON, Suzanne, ALROUGHANI, Raed, LECHNER-SCOTT, Jeannette, LUGARESI, Alessandra, DUQUETTE, Pierre, GIRARD, Marc

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The IL‐27/IL‐27R axis is altered in CD4+ and CD8+ T lymphocytes from multiple sclerosis patients by Clénet, Marie‐Laure, Laurent, Cyril, Lemaitre, Florent, Farzam‐kia, Negar, Tastet, Olivier, Devergne, Odile, Lahav, Boaz, Girard, Marc, Duquette, Pierre, Prat, Alexandre, Larochelle, Catherine, Arbour, Nathalie

“…Objectives Pro‐ and anti‐inflammatory properties have been attributed to interleukin‐27 (IL‐27). Nevertheless, the impact of this cytokine on chronic…”
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Association of multiple sclerosis susceptibility variants and early attack location in the CNS by Mowry, Ellen M, Carey, Robert F, Blasco, Maria R, Pelletier, Jean, Duquette, Pierre, Villoslada, Pablo, Malikova, Irina, Roger, Elaine, Kinkel, R Phillip, McDonald, Jamie, Bacchetti, Peter, Waubant, Emmanuelle

“…The anatomic location of subsequent relapses in early multiple sclerosis (MS) appears to be predicted by the first attack location. We sought to determine if…”
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