Search Results - "Dupré, Elian"

Conformation and Affinity Modulations by Multiple Phosphorylation Occurring in the BIN1 SH3 Domain Binding Site of the Tau Protein Proline-Rich Region by Lasorsa, Alessia, Bera, Krishnendu, Malki, Idir, Dupré, Elian, Cantrelle, François-Xavier, Merzougui, Hamida, Sinnaeve, Davy, Hanoulle, Xavier, Hritz, Jozef, Landrieu, Isabelle

“…An increase in phosphorylation of the Tau protein is associated with Alzheimer’s disease (AD) progression through unclear molecular mechanisms. In general,…”
Get full text

Inhibition of Tau seeding by targeting Tau nucleation core within neurons with a single domain antibody fragment by Danis, Clément, Dupré, Elian, Zejneli, Orgeta, Caillierez, Raphaëlle, Arrial, Alexis, Bégard, Séverine, Mortelecque, Justine, Eddarkaoui, Sabiha, Loyens, Anne, Cantrelle, François-Xavier, Hanoulle, Xavier, Rain, Jean-Christophe, Colin, Morvane, Buée, Luc, Landrieu, Isabelle

“…Tau proteins aggregate into filaments in brain cells in Alzheimer's disease and related disorders referred to as tauopathies. Here, we used fragments of…”
Get full text

Translocation path of a substrate protein through its Omp85 transporter by Baud, Catherine, Guérin, Jérémy, Petit, Emmanuelle, Lesne, Elodie, Dupré, Elian, Locht, Camille, Jacob-Dubuisson, Françoise

“…TpsB proteins are Omp85 superfamily members that mediate protein translocation across the outer membrane of Gram-negative bacteria. Omp85 transporters are…”
Get full text

Aggregate-selective removal of pathological tau by clustering-activated degraders by Benn, Jonathan, Cheng, Shi, Keeling, Sophie, Smith, Annabel E, Vaysburd, Marina J, Böken, Dorothea, Miller, Lauren V C, Katsinelos, Taxiarchis, Franco, Catarina, Dupré, Elian, Danis, Clément, Landrieu, Isabelle, Buée, Luc, Klenerman, David, James, Leo C, McEwan, William A

“…Selective degradation of pathological protein aggregates while sparing monomeric forms is of major therapeutic interest. The E3 ligase tripartite…”
Get full text

Magnetic resonance investigation of conformational responses of tau protein to specific phosphorylation by Lasorsa, Alessia, Merzougui, Hamida, Cantrelle, François-Xavier, Sicoli, Giuseppe, Dupré, Elian, Hanoulle, Xavier, Belle, Valérie, Smet-Nocca, Caroline, Landrieu, Isabelle

“…Intrinsically disordered proteins (IDPs) are known to adopt many rapidly interconverting structures, making it difficult to pinpoint the specific…”
Get full text

Novel dithiocarbamates selectively inhibit 3CL protease of SARS-CoV-2 and other coronaviruses by Brier, Lucile, Hassan, Haitham, Hanoulle, Xavier, Landry, Valerie, Moschidi, Danai, Desmarets, Lowiese, Rouillé, Yves, Dumont, Julie, Herledan, Adrien, Warenghem, Sandrine, Piveteau, Catherine, Carré, Paul, Ikherbane, Sarah, Cantrelle, François-Xavier, Dupré, Elian, Dubuisson, Jean, Belouzard, Sandrine, Leroux, Florence, Deprez, Benoit, Charton, Julie

“…Since end of 2019, the global and unprecedented outbreak caused by the coronavirus SARS-CoV-2 led to dramatic numbers of infections and deaths worldwide…”
Get full text

A selection and optimization strategy for single-domain antibodies targeting the PHF6 linear peptide within the tau intrinsically disordered protein by Mortelecque, Justine, Zejneli, Orgeta, Bégard, Séverine, Simões, Margarida C., ElHajjar, Lea, Nguyen, Marine, Cantrelle, François-Xavier, Hanoulle, Xavier, Rain, Jean-Christophe, Colin, Morvane, Gomes, Cláudio M., Buée, Luc, Landrieu, Isabelle, Danis, Clément, Dupré, Elian

“…The use of variable domain of the heavy-chain of the heavy-chain-only antibodies (VHHs) as disease-modifying biomolecules in neurodegenerative disorders holds…”
Get full text

Virulence regulation with Venus flytrap domains: structure and function of the periplasmic moiety of the sensor-kinase BvgS by Dupré, Elian, Herrou, Julien, Lensink, Marc F, Wintjens, René, Vagin, Alexey, Lebedev, Andrey, Crosson, Sean, Villeret, Vincent, Locht, Camille, Antoine, Rudy, Jacob-Dubuisson, Françoise

“…Two-component systems (TCS) represent major signal-transduction pathways for adaptation to environmental conditions, and regulate many aspects of bacterial…”
Get full text

Coiled-Coil Antagonism Regulates Activity of Venus Flytrap-Domain-Containing Sensor Kinases of the BvgS Family by Lesne, Elodie, Dupré, Elian, Lensink, Marc F, Locht, Camille, Antoine, Rudy, Jacob-Dubuisson, Françoise

“…controls the expression of its virulence regulon through the two-component system BvgAS. BvgS is a prototype for a family of multidomain sensor kinases. In…”
Get full text

Single Domain Antibody Fragments as New Tools for the Detection of Neuronal Tau Protein in Cells and in Mice Studies by Dupré, Elian, Danis, Clément, Arrial, Alexis, Hanoulle, Xavier, Homa, Mégane, Cantrelle, François-Xavier, Merzougui, Hamida, Colin, Morvane, Rain, Jean-Christophe, Buée, Luc, Landrieu, Isabelle

“…Tau is a neuronal protein linked to pathologies called tauopathies, including Alzheimer’s disease. In Alzheimer’s disease, tau aggregates into filaments,…”
Get full text

Deciphering the Structure and Formation of Amyloids in Neurodegenerative Diseases With Chemical Biology Tools by Landrieu, Isabelle, Dupré, Elian, Sinnaeve, Davy, El Hajjar, Léa, Smet-Nocca, Caroline

“…Protein aggregation into highly ordered, regularly repeated cross-β sheet structures called amyloid fibrils is closely associated to human disorders such as…”
Get full text

Signal Transduction by BvgS Sensor Kinase: BINDING OF MODULATOR NICOTINATE AFFECTS THE CONFORMATION AND DYNAMICS OF THE ENTIRE PERIPLASMIC MOIETY by Dupré, Elian, Lesne, Elodie, Guérin, Jérémy, Lensink, Marc F, Verger, Alexis, de Ruyck, Jérôme, Brysbaert, Guillaume, Vezin, Hervé, Locht, Camille, Antoine, Rudy, Jacob-Dubuisson, Françoise

“…The two-component sensory transduction system BvgAS controls the virulence regulon of the whooping-cough agent Bordetella pertussis. The periplasmic moiety of…”
Get full text

Periplasmic domain of the sensor-kinase BvgS reveals a new paradigm for the Venus flytrap mechanism by Herrou, Julien, Bompard, Coralie, Wintjens, René, Dupré, Elian, Willery, Eve, Villeret, Vincent, Locht, Camille, Antoine, Rudy, Jacob-Dubuisson, Françoise

“…Two-component sensory transduction systems control important bacterial programs. In Bordetella pertussis, expression of the virulence regulon is controlled by…”
Get full text

Characterization of the PAS domain in the sensor-kinase BvgS: mechanical role in signal transmission by Dupré, Elian, Wohlkonig, Alexandre, Herrou, Julien, Locht, Camille, Jacob-Dubuisson, Françoise, Antoine, Rudy

“…In bacteria, signal-transduction two-component systems are major players for adaptation to environmental stimuli. The perception of a chemical or physical…”
Get full text

Signal transduction by BvgS sensor kinase. BINDING OF MODULATOR NICOTINATE AFFECTS THE CONFORMATION AND DYNAMICS OF THE ENTIRE PERIPLASMIC MOIETY by Dupré, Elian, Lesne, Elodie, Guérin, Jérémy, Lensink, Marc F., Verger, Alexis, de Ruyck, Jérôme, Brysbaert, Guillaume, Vezin, Hervé, Locht, Camille, Antoine, Rudy, Jacob-Dubuisson, Françoise

Get full text

Structural Insight into the Role of the PAS Domain for Signal Transduction in Sensor Kinase BvgS by Dupré, Elian, Clantin, Bernard, Yuan, Youhua, Lecher, Sophie, Lesne, Elodie, Antoine, Rudy, Villeret, Vincent, Jacob-Dubuisson, Françoise

“…The two-component system BvgAS controls the virulence regulon in Bordetella pertussis. BvgS is the prototype of a family of sensor histidine kinases harboring…”
Get full text

Conformational Changes of an Interdomain Linker Mediate Mechanical Signal Transmission in Sensor Kinase BvgS by Lesne, Elodie, Dupré, Elian, Locht, Camille, Antoine, Rudy, Jacob-Dubuisson, Françoise

“…The whooping cough agent, , controls the expression of its large virulence regulon in a coordinated manner through the two-component system BvgAS. BvgS is a…”
Get full text

Recombinant Production and Characterization of VHHs/Nanobodies Targeting Tau to Block Fibrillar Assembly by Mortelecque, Justine, Danis, Clément, Landrieu, Isabelle, Dupré, Elian

“…Tau protein was extensively studied using nuclear magnetic resonance spectroscopy, providing a powerful way to determine interaction sites between Tau and…”
Get more information

Nuclear Magnetic Resonance Spectroscopy Insights into Tau Structure in Solution: Impact of Post-translational Modifications by Danis, Clément, Dupré, Elian, Hanoulle, Xavier, Landrieu, Isabelle, Lasorsa, Alessia, Neves, João Filipe, Schneider, Robert, Smet-Nocca, Caroline

“…Although Tau is an intrinsically disordered protein, some level of structure can still be defined, corresponding to short stretches of dynamic secondary…”
Get more information

Structural insight into the role of the PAS domainfor signal transduction in sensor-kinase BvgS by Dupré, Elian, Clantin, Bernard, Yuan, Youhua, Lecher, Sophie, Lesne, Elodie, Antoine, Rudy, Villeret, Vincent, Jacob-Dubuisson, Françoise

“…The two-component system BvgAS controls the virulence regulon in BvgS is the prototype of a family of sensor histidine-kinases harboring periplasmic Venus…”
Get full text