Complex trait susceptibilities and population diversity in a sample of 4,145 Russians

The population of Russia consists of more than 150 local ethnicities. The ethnic diversity and geographic origins, which extend from eastern Europe to Asia, make the population uniquely positioned to investigate the shared properties of inherited disease risks between European and Asian ancestries....

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Published in:	Nature communications Vol. 15; no. 1; pp. 6212 - 10
Main Authors:	Usoltsev, Dmitrii, Kolosov, Nikita, Rotar, Oxana, Loboda, Alexander, Boyarinova, Maria, Moguchaya, Ekaterina, Kolesova, Ekaterina, Erina, Anastasia, Tolkunova, Kristina, Rezapova, Valeriia, Molotkov, Ivan, Melnik, Olesya, Freylikhman, Olga, Paskar, Nadezhda, Alieva, Asiiat, Baranova, Elena, Bazhenova, Elena, Beliaeva, Olga, Vasilyeva, Elena, Kibkalo, Sofia, Skitchenko, Rostislav, Babenko, Alina, Sergushichev, Alexey, Dushina, Alena, Lopina, Ekaterina, Basyrova, Irina, Libis, Roman, Duplyakov, Dmitrii, Cherepanova, Natalya, Donner, Kati, Laiho, Paivi, Kostareva, Anna, Konradi, Alexandra, Shlyakhto, Evgeny, Palotie, Aarno, Daly, Mark J., Artomov, Mykyta
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 23-07-2024 Nature Publishing Group Nature Portfolio
Subjects:	45/43 631/208/205/2138 631/208/457/649 692/499 Asian People - genetics Cluster analysis Cohort Studies Data analysis Eastern European People Ethnic factors Ethnicity - genetics Female Finland Gene Frequency Genetic analysis Genetic Predisposition to Disease Genetic Variation Genetics, Population Genome-Wide Association Study Health risks Hereditary diseases Humanities and Social Sciences Humans Male Metropolitan areas Multiculturalism & pluralism multidisciplinary Multifactorial Inheritance - genetics Phenotype Phenotypes Polymorphism, Single Nucleotide Population genetics Russia - epidemiology Science Science (multidisciplinary) White People - genetics Finland Russia
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Summary:	The population of Russia consists of more than 150 local ethnicities. The ethnic diversity and geographic origins, which extend from eastern Europe to Asia, make the population uniquely positioned to investigate the shared properties of inherited disease risks between European and Asian ancestries. We present the analysis of genetic and phenotypic data from a cohort of 4,145 individuals collected in three metro areas in western Russia. We show the presence of multiple admixed genetic ancestry clusters spanning from primarily European to Asian and high identity-by-descent sharing with the Finnish population. As a result, there was notable enrichment of Finnish-specific variants in Russia. We illustrate the utility of Russian-descent cohorts for discovery of novel population-specific genetic associations, as well as replication of previously identified associations that were thought to be population-specific in other cohorts. Finally, we provide access to a database of allele frequencies and GWAS results for 464 phenotypes. Here, the authors analyze genetic and phenotypic data from Biobank Russia and describe unique admixture of populations. They provide insights into shared properties of inherited disease risks between European and Asian ancestries along with GWAS results across 464 traits.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2041-1723 2041-1723
DOI:	10.1038/s41467-024-50304-1