An Unusual Giant Cell Tumor of the Thyroid: Case Report and Review of the Literature

Context: Bone giant cell tumors (GCTs) are among the most common benign bone tumors and affect mostly young patients. They represent a rare etiology of head and neck cancer. Objective: We report the case of a 38-yr-old male with a GCT of the thyroid cartilage, initially treated as a thyroid cancer....

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Bibliographic Details
Published in:	The journal of clinical endocrinology and metabolism Vol. 98; no. 1; pp. 1 - 6
Main Authors:	Derbel, O, Zrounba, P, Chassagne-Clément, C, Decouvelaere, A. V, Orlandini, F, Duplomb, S, Blay, J. Y, de la Fouchardiere, C
Format:	Journal Article
Language:	English
Published:	Bethesda, MD Endocrine Society 01-01-2013 Copyright by The Endocrine Society
Subjects:	Adult Antibodies, Monoclonal, Humanized - therapeutic use Antineoplastic Agents - therapeutic use Biological and medical sciences Combined Modality Therapy Denosumab Endocrinopathies Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology Giant Cell Tumors - diagnosis Giant Cell Tumors - drug therapy Giant Cell Tumors - pathology Giant Cell Tumors - surgery Humans Male Medical sciences Neoplasm, Residual Thyroid Neoplasms - diagnosis Thyroid Neoplasms - drug therapy Thyroid Neoplasms - pathology Thyroid Neoplasms - surgery Vertebrates: anatomy and physiology, studies on body, several organs or systems Vertebrates: endocrinology Case study Human Obesity Endocrine gland Nutrition Giant cell tumor Nutrition disorder Metabolic diseases Thyroid gland Endocrinology Nutritional status Bibliographic review
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Summary:	Context: Bone giant cell tumors (GCTs) are among the most common benign bone tumors and affect mostly young patients. They represent a rare etiology of head and neck cancer. Objective: We report the case of a 38-yr-old male with a GCT of the thyroid cartilage, initially treated as a thyroid cancer. Case Illustration: The patient had incomplete initial surgery, and a substantial tumor residue was observed at postoperative morphological evaluation. Given the potential risks associated with complete definitive surgery and recent data supporting the use of the receptor activator of nuclear factor κB ligand inhibitor, we proposed treatment with denosumab. Three months after initiating denosumab, computed tomography scan imaging showed a significant modification of the lesion with several calcifications. The patient underwent partial laryngectomy, and examination of the surgical specimen revealed a complete histological response. Results: A review of the literature was conducted to identify previous studies pertaining to GCTs, focusing on reports related to their management. Conclusion: Denosumab emerges as a new treatment for patients with GCTs. Additional clinical trial data are needed to establish the real efficacy and long-term safety of this treatment for the management of GCT.
Bibliography:	ObjectType-Case Study-3 SourceType-Scholarly Journals-1 content type line 23 ObjectType-Review-1 ObjectType-Feature-5 ObjectType-Report-2 ObjectType-Article-4
ISSN:	0021-972X 1945-7197
DOI:	10.1210/jc.2011-2306