Search Results - "Duplantier, J."
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The Human Cathelicidin Antimicrobial Peptide LL-37 as a Potential Treatment for Polymicrobial Infected Wounds
Published in Frontiers in immunology (01-01-2013)“…Diabetic patients often have ulcers on their lower-limbs that are infected by multiple biofilm-forming genera of bacteria, and the elimination of the biofilm…”
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Invasion genetics of a human commensal rodent: the black rat Rattus rattus in Madagascar
Published in Molecular ecology (01-08-2014)“…Studies focusing on geographical genetic patterns of commensal species and on human history complement each other and provide proxies to trace common…”
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AFLP genome scan in the black rat (Rattus rattus) from Madagascar: detecting genetic markers undergoing plague-mediated selection
Published in Molecular ecology (01-03-2011)“…The black rat (Rattus rattus) is the main reservoir of plague (Yersinia pestis infection) in Madagascar’s rural zones. Black rats are highly resistant to…”
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Mitigating the Impact of Antibacterial Drug Resistance through Host-Directed Therapies: Current Progress, Outlook, and Challenges
Published in mBio (30-01-2018)“…Increasing incidences of multidrug resistance in pathogenic bacteria threaten our ability to treat and manage bacterial infection. The development and FDA…”
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Searching for Therapeutics Against Botulinum Neurotoxins: A True Challenge for Drug Discovery
Published in Current topics in medicinal chemistry (01-09-2016)“…Botulinum neurotoxins (BoNTs), the most potent known toxins, cause severe muscle paralysis and death at nanogram exposures and are considered biothreat agents…”
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6
Urban population genetics of the invasive black rats in Franceville, Gabon
Published in Journal of zoology (1987) (01-07-2016)“…The invasive black rat Rattus rattus has established commensal populations in most cities of the world. Known as a reservoir of numerous zoonotic diseases,…”
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Beyond an AFLP genome scan towards the identification of immune genes involved in plague resistance in Rattus rattus from Madagascar
Published in Molecular ecology (01-01-2013)“…Genome scans using amplified fragment length polymorphism (AFLP) markers became popular in nonmodel species within the last 10 years, but few studies have…”
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Genetic structure and invasion history of the house mouse (Mus musculus domesticus) in Senegal, West Africa: a legacy of colonial and contemporary times
Published in Heredity (01-08-2017)“…Knowledge of the genetic make-up and demographic history of invasive populations is critical to understand invasion mechanisms. Commensal rodents are ideal…”
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Synthesis of [18F]Favipiravir and Biodistribution in C3H/HeN Mice as Assessed by Positron Emission Tomography
Published in Scientific reports (11-02-2019)“…Favipiravir (T705; 6-fluoro-3-hydroxypyrazine-2-carboxamide) is a pyrazine analog that has demonstrated potent antiviral activity against a broad spectrum of…”
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Vinyl Sulfone-Based Inhibitors of Nonstructural Protein 2 Block the Replication of Venezuelan Equine Encephalitis Virus
Published in ACS medicinal chemistry letters (12-11-2020)“…Emerging infectious diseases like those caused by arboviruses such as Venezuelan equine encephalitis virus (VEEV) pose a serious threat to public health…”
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Comparative population genetics of a parasitic nematode and its host community: The trichostrongylid Neoheligmonella granjoni and Mastomys rodents in southeastern Senegal
Published in International journal for parasitology (01-10-2011)“…[Display omitted] ► Population genetics of a nematode and of its two main rodent hosts were examined. ► Eleven microsatellites were used for the nematode, and…”
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Population genetic structure of two ecologically distinct multimammate rats: the commensal Mastomys natalensis and the wild Mastomys erythroleucus in southeastern Senegal
Published in Molecular ecology (01-07-2007)“…Using the same set of microsatellite markers, we compared the population genetic structure of two Mastomys species, one being exclusively commensal in…”
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Discovery, SAR, and Pharmacokinetics of a Novel 3-Hydroxyquinolin-2(1H)-one Series of Potent d-Amino Acid Oxidase (DAAO) Inhibitors
Published in Journal of medicinal chemistry (11-06-2009)“…3-Hydroxyquinolin-2(1H)-one (2) was discovered by high throughput screening in a functional assay to be a potent inhibitor of human DAAO, and its binding…”
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Susceptibility to Yersinia pestis Experimental Infection in Wild Rattus rattus, Reservoir of Plague in Madagascar
Published in EcoHealth (01-06-2010)“…In Madagascar, the black rat, Rattus rattus , is the main reservoir of plague ( Yersinia pestis infection), a disease still responsible for hundreds of cases…”
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15
Hemorrhagic transformation after stroke: inter‐ and intrarater agreement
Published in European journal of neurology (01-03-2019)“…Background and purpose Hemorrhagic transformation (HT) is a complication of stroke that can occur spontaneously or after treatment. We aimed to assess the…”
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Capacity for water conservation in invasive ( Gerbillus nigeriae) and declining rodents ( Taterillus pygargus and Taterillus gracilis) that exhibit climate-induced distribution changes in Senegal
Published in Journal of arid environments (01-11-2011)“…Following the southward shift of rainfall isolines in the Sahel at the end of the 1960s, Gerbillus nigeriae appeared in northern Senegal in the mid-1990s, and…”
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Gene expression profiling identifies sST2 as an effector of ErbB2-driven breast carcinoma cell motility, associated with metastasis
Published in Oncogene (26-07-2012)“…Overexpression of the ErbB2 receptor tyrosine kinase in breast cancer contributes to tumor development and is associated with poor prognosis. However, the…”
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Plio-Pleistocene history of West African Sudanian savanna and the phylogeography of the Praomys daltoni complex (Rodentia): the environment/geography/genetic interplay
Published in Molecular ecology (01-11-2010)“…Rodents of the Praomys daltoni complex are typical inhabitants of the Sudanian savanna ecosystem in western Africa and represent a suitable model for testing…”
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Discovery of 4-(5-Methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane (CP-810,123), a Novel α7 Nicotinic Acetylcholine Receptor Agonist for the Treatment of Cognitive Disorders in Schizophrenia: Synthesis, SAR Development, and in Vivo Efficacy in Cognition Models
Published in Journal of medicinal chemistry (11-02-2010)“…A novel α7 nAChR agonist, 4-(5-methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane (24, CP-810,123), has been identified as a potential treatment…”
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A role for thrombin in liver fibrosis
Published in Gut (01-11-2004)“…Background/Aim: Several lines of evidence incriminate the serine proteinase thrombin in liver fibrogenesis either through its procoagulant function or its…”
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