Search Results - "Duplan, Laure"
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Collapsin Response Mediator Protein 4a (CRMP4a) Is Upregulated in Motoneurons of Mutant SOD1 Mice and Can Trigger Motoneuron Axonal Degeneration and Cell Death
Published in The Journal of neuroscience (13-01-2010)“…Embryonic motoneurons from mutant SOD1 (mSOD1) mouse models of amyotrophic lateral sclerosis (ALS), but not wild-type motoneurons, can be triggered to die by…”
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Receptor protein tyrosine phosphatase sigma inhibits axon regrowth in the adult injured CNS
Published in Molecular and cellular neuroscience (01-04-2005)“…Recently, receptor protein tyrosine phosphatase-σ (RPTPσ) has been shown to inhibit axon regeneration in injured peripheral nerves. Unlike the peripheral…”
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Excitotoxic Death of Retinal Neurons In Vivo Occurs via a Non-Cell-Autonomous Mechanism
Published in The Journal of neuroscience (29-04-2009)“…The central hypothesis of excitotoxicity is that excessive stimulation of neuronal NMDA-sensitive glutamate receptors is harmful to neurons and contributes to…”
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Biophysical Characterization of Lithostathine
Published in The Journal of biological chemistry (06-08-1999)“…Lithostathine is a calcium carbonate crystal habit modifier. It is found precipitated under the form of fibrils in chronic calcifying pancreatitis or…”
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Three-dimensional structure of the lithostathine protofibril, a protein involved in Alzheimer's disease
Published in The EMBO journal (02-07-2001)“…Neurodegenerative diseases are characterized by the presence of filamentous aggregates of proteins. We previously established that lithostathine is a protein…”
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Lithostathine and pancreatitis-associated protein are involved in the very early stages of Alzheimer’s disease
Published in Neurobiology of aging (2001)“…According to one of the theories formulated to explain the etiology of Alzheimer’s disease (AD), amylosis may reflect a specific inflammatory response. Two…”
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Biophysical characterization of lithostathine. Evidences for a polymeric structure at physiological pH and a proteolysis mechanism leading to the formation of fibrils
Published in The Journal of biological chemistry (06-08-1999)“…Lithostathine is a calcium carbonate crystal habit modifier. It is found precipitated under the form of fibrils in chronic calcifying pancreatitis or…”
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Association of APOE promoter but not A2M polymorphisms with risk of developing Alzheimerʼs disease
Published in Neuroreport (09-11-2000)“…The APOE4 allele is widely accepted as a major risk factor for late-onset Alzheimerʼs disease (AD). Recently, it has been reported that polymorphisms in the…”
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