Search Results - "Duong, Sophie L."
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Decreased Polycystin 2 Levels Result in Non-Renal Cardiac Dysfunction with Aging
Published in PloS one (15-04-2016)“…Mutations in the gene for polycystin 2 (Pkd2) lead to polycystic kidney disease, however the main cause of mortality in humans is cardiac related. We…”
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Molecular disease mechanisms of human antineuronal monoclonal autoantibodies
Published in Trends in molecular medicine (01-01-2023)“…Autoantibodies targeting brain antigens can mediate a wide range of neurological symptoms ranging from epileptic seizures to psychosis to dementia. Although…”
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Paraneoplastic Autoimmune Neurological Syndromes and the Role of Immune Checkpoint Inhibitors
Published in Neurotherapeutics (01-04-2022)“…The introduction of immune checkpoint inhibitors (ICIs) in oncologic therapies has led to a paradigm shift in cancer treatment. ICIs have increased the overall…”
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Neurotoxicities associated with immune checkpoint inhibitor therapy
Published in Journal of neuro-oncology (01-04-2021)“…Introduction Immune checkpoint inhibitors (ICIs) have emerged as a promising class of cancer immunotherapies. Neurotoxicities are uncommon, but often severe,…”
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Human cerebrospinal fluid monoclonal CASPR2 autoantibodies induce changes in electrophysiology, functional MRI, and behavior in rodent models
Published in Brain, behavior, and immunity (01-11-2024)“…•The isolated anti-CASPR2 antibodies all selectively bind the discoidin domain.•Monoclonal anti-CASPR2 antibodies block the interaction of CASPR2 with…”
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Spätfolgen nach Immuntherapie: Immunvermittelte Nebenwirkungen von Checkpointinhibitoren
Published in Der Onkologe (01-08-2021)“…Zusammenfassung Hintergrund Immuncheckpointinhibitoren (ICI) sind bei zahlreichen Tumorentitäten wirksam, können allerdings immunvermittelte Nebenwirkungen in…”
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