Search Results - "Duong, Francois H. T."

Interferon signaling and treatment outcome in chronic hepatitis C by Sarasin-Filipowicz, Magdalena, Oakeley, Edward J, Duong, Francois H.T, Christen, Verena, Terracciano, Luigi, Filipowicz, Witold, Heim, Markus H

“…Hepatitis C virus (HCV) infection is a major cause of chronic liver disease worldwide. The current standard therapy for chronic hepatitis C (CHC) consists of a…”
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Alpha Interferon Induces Long-Lasting Refractoriness of JAK-STAT Signaling in the Mouse Liver through Induction of USP18/UBP43 by Sarasin-Filipowicz, Magdalena, Wang, Xueya, Yan, Ming, Duong, Francois H. T., Poli, Valeria, Hilton, Douglas J., Zhang, Dong-Er, Heim, Markus H.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Vitamin D receptor and Jak-STAT signaling crosstalk results in calcitriol-mediated increase of hepatocellular response to IFN-α by Lange, Christian M, Gouttenoire, Jérôme, Duong, François H T, Morikawa, Kenichi, Heim, Markus H, Moradpour, Darius

“…Recent clinical research suggests a role for vitamin D in the response to IFN-α-based therapy of chronic hepatitis C. Therefore, we aimed to explore the…”
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Activation of endoplasmic reticulum stress response by hepatitis viruses up‐regulates protein phosphatase 2A by Christen, Verena, Treves, Susan, Duong, Francois H. T., Heim, Markus H.

“…The up‐regulation of protein phosphatase 2 A (PP2A) is an important factor leading to an inhibition of IFNα signaling caused by viral protein expression. Here,…”
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Hepatitis C virus–induced up‐regulation of protein phosphatase 2A inhibits histone modification and DNA damage repair by Duong, Francois H. T., Christen, Verena, Lin, Shanshan, Heim, Markus H.

“…The molecular mechanisms underlying hepatocarcinogenesis in chronic viral hepatitis are poorly understood. A potential tumorigenic pathway could involve…”
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S-adenosyl-methionine and betaine improve early virological response in chronic hepatitis C patients with previous nonresponse by Filipowicz, Magdalena, Bernsmeier, Christine, Terracciano, Luigi, Duong, Francois H T, Heim, Markus H

“…Treatment of chronic hepatitis C (CHC) with pegylated interferon α (pegIFNα) and ribavirin results in a sustained response in approximately half of patients…”
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miR-135a-5p-mediated downregulation of protein tyrosine phosphatase receptor delta is a candidate driver of HCV-associated hepatocarcinogenesis by Van Renne, Nicolaas, Roca Suarez, Armando Andres, Duong, Francois H T, Gondeau, Claire, Calabrese, Diego, Fontaine, Nelly, Ababsa, Amina, Bandiera, Simonetta, Croonenborghs, Tom, Pochet, Nathalie, De Blasi, Vito, Pessaux, Patrick, Piardi, Tullio, Sommacale, Daniele, Ono, Atsushi, Chayama, Kazuaki, Fujita, Masashi, Nakagawa, Hidewaki, Hoshida, Yujin, Zeisel, Mirjam B, Heim, Markus H, Baumert, Thomas F, Lupberger, Joachim

“…HCV infection is a leading risk factor of hepatocellular carcinoma (HCC). However, even after viral clearance, HCC risk remains elevated. HCV perturbs host…”
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Upregulation of Protein Phosphatase 2Ac by Hepatitis C Virus Modulates NS3 Helicase Activity through Inhibition of Protein Arginine Methyltransferase 1 by Duong, Francois H T, Christen, Verena, Berke, Jan Martin, Penna, Sabina Hernandez, Moradpour, Darius, Heim, Markus H

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IL28B expression depends on a novel TT/-G polymorphism which improves HCV clearance prediction by Bibert, Stéphanie, Roger, Thierry, Calandra, Thierry, Bochud, Murielle, Cerny, Andreas, Semmo, Nasser, Duong, François H T, Gerlach, Tilman, Malinverni, Raffaele, Moradpour, Darius, Negro, Francesco, Müllhaupt, Beat, Bochud, Pierre-Yves

“…Approximately 3% of the world population is chronically infected with the hepatitis C virus (HCV), with potential development of cirrhosis and hepatocellular…”
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Interferon‐β and interferon‐λ signaling is not affected by interferon‐induced refractoriness to interferon‐α in vivo by Makowska, Zuzanna, Duong, Francois H. T., Trincucci, Gaia, Tough, David F., Heim, Markus H.

“…Therapy of chronic hepatitis C with pegylated interferon α (pegIFN‐α) and ribavirin achieves sustained virological responses in approximately half of the…”
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Virus-induced over-expression of protein phosphatase 2A inhibits insulin signalling in chronic hepatitis C by Bernsmeier, Christine, Duong, Francois H.T, Christen, Verena, Pugnale, Paolo, Negro, Francesco, Terracciano, Luigi, Heim, Markus H

“…Background/Aims Hepatitis C virus (HCV) infection disturbs glucose and lipid metabolism contributing to the development of liver steatosis, insulin resistance…”
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PGC-1α and MEF2 Regulate the Transcription of the Carnitine Transporter OCTN2 Gene in C2C12 Cells and in Mouse Skeletal Muscle by Novakova, Katerina, Török, Michael, Panajatovic, Miljenko, Bouitbir, Jamal, Duong, François H. T., Handschin, Christoph, Krähenbühl, Stephan

“…OCTN2 (SLC22A5) is a carnitine transporter whose main function is the active transport of carnitine into cells. In skeletal muscle and other organs, the…”
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S-adenosylmethionine and betaine correct hepatitis C virus induced inhibition of interferon signaling in vitro by DUONG, Francois H. T, CHRISTEN, Verena, FILIPOWICZ, Magdalena, HEIM, Markus H

“…Hepatitis C virus (HCV) infection is an important cause of chronic liver disease. Standard therapy, pegylated interferon alpha (pegIFNalpha) combined with…”
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Protein phosphatase 2A promotes hepatocellular carcinogenesis in the diethylnitrosamine mouse model through inhibition of p53 by Duong, François H T, Dill, Michael T, Matter, Matthias S, Makowska, Zuzanna, Calabrese, Diego, Dietsche, Tanja, Ketterer, Sylvia, Terracciano, Luigi, Heim, Markus H

“…Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. Most HCCs develop in cirrhotic livers. Alcoholic liver disease, chronic hepatitis B…”
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SOCS1 is an inducible negative regulator of interferon λ (IFN-λ)–induced gene expression in vivo by Blumer, Tanja, Coto-Llerena, Mairene, Duong, Francois H.T., Heim, Markus H.

“…Type I (α and β) and type III (λ) IFNs are induced upon viral infection through host sensory pathways that activate IFN regulatory factors (IRFs) and nuclear…”
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HCV-Induced Epigenetic Changes Associated With Liver Cancer Risk Persist After Sustained Virologic Response by Hamdane, Nourdine, Jühling, Frank, Crouchet, Emilie, El Saghire, Houssein, Thumann, Christine, Oudot, Marine A., Bandiera, Simonetta, Saviano, Antonio, Ponsolles, Clara, Roca Suarez, Armando Andres, Li, Shen, Fujiwara, Naoto, Ono, Atsushi, Davidson, Irwin, Bardeesy, Nabeel, Schmidl, Christian, Bock, Christoph, Schuster, Catherine, Lupberger, Joachim, Habersetzer, François, Doffoël, Michel, Piardi, Tullio, Sommacale, Daniele, Imamura, Michio, Uchida, Takuro, Ohdan, Hideki, Aikata, Hiroshi, Chayama, Kazuaki, Boldanova, Tujana, Pessaux, Patrick, Fuchs, Bryan C., Hoshida, Yujin, Zeisel, Mirjam B., Duong, François H.T., Baumert, Thomas F.

“…Chronic hepatitis C virus (HCV) infection is an important risk factor for hepatocellular carcinoma (HCC). Despite effective antiviral therapies, the risk for…”
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Interferon-Induced Gene Expression Is a Stronger Predictor of Treatment Response Than IL28B Genotype in Patients With Hepatitis C by Dill, Michael T, Duong, Francois H.T, Vogt, Julia E, Bibert, Stéphanie, Bochud, Pierre–Yves, Terracciano, Luigi, Papassotiropoulos, Andreas, Roth, Volker, Heim, Markus H

“…Background & Aims The host immune response during the chronic phase of hepatitis C virus infection varies among individuals; some patients have a no interferon…”
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Reduced IFNλ4 activity is associated with improved HCV clearance and reduced expression of interferon-stimulated genes by Terczyńska-Dyla, Ewa, Bibert, Stephanie, Duong, Francois H. T., Krol, Ilona, Jørgensen, Sanne, Collinet, Emilie, Kutalik, Zoltán, Aubert, Vincent, Cerny, Andreas, Kaiser, Laurent, Malinverni, Raffaele, Mangia, Alessandra, Moradpour, Darius, Müllhaupt, Beat, Negro, Francesco, Santoro, Rosanna, Semela, David, Semmo, Nasser, Heim, Markus H., Bochud, Pierre-Yves, Hartmann, Rune

“…Hepatitis C virus (HCV) infections are the major cause of chronic liver disease, cirrhosis and hepatocellular carcinoma worldwide. Both spontaneous and…”
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Treatment of HCC with claudin-1-specific antibodies suppresses carcinogenic signaling and reprograms the tumor microenvironment by Roehlen, Natascha, Muller, Marion, Nehme, Zeina, Crouchet, Emilie, Jühling, Frank, Del Zompo, Fabio, Cherradi, Sara, Duong, Francois H.T., Almeida, Nuno, Saviano, Antonio, Fernández-Vaquero, Mirian, Riedl, Tobias, El Saghire, Houssein, Durand, Sarah C., Ponsolles, Clara, Oudot, Marine A., Martin, Romain, Brignon, Nicolas, Felli, Emanuele, Pessaux, Patrick, Lallement, Antonin, Davidson, Irwin, Bandiera, Simonetta, Thumann, Christine, Marchand, Patrice, Moll, Solange, Nicolay, Brandon, Bardeesy, Nabeel, Hoshida, Yujin, Heikenwälder, Mathias, Iacone, Roberto, Toso, Alberto, Meyer, Markus, Elson, Greg, Schweighoffer, Tamas, Teixeira, Geoffrey, Zeisel, Mirjam B., Laquerriere, Patrice, Lupberger, Joachim, Schuster, Catherine, Mailly, Laurent, Baumert, Thomas F.

“…Despite recent approvals, the response to treatment and prognosis of patients with advanced hepatocellular carcinoma (HCC) remain poor. Claudin-1 (CLDN1) is a…”
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A monoclonal antibody targeting nonjunctional claudin-1 inhibits fibrosis in patient-derived models by modulating cell plasticity by Roehlen, Natascha, Saviano, Antonio, El Saghire, Houssein, Crouchet, Emilie, Nehme, Zeina, Del Zompo, Fabio, Jühling, Frank, Oudot, Marine A, Durand, Sarah C, Duong, François H T, Cherradi, Sara, Gonzalez Motos, Victor, Almeida, Nuno, Ponsolles, Clara, Heydmann, Laura, Ostyn, Tessa, Lallement, Antonin, Pessaux, Patrick, Felli, Emanuele, Cavalli, Andrea, Sgrignani, Jacopo, Thumann, Christine, Koutsopoulos, Olga, Fuchs, Bryan C, Hoshida, Yujin, Hofmann, Maike, Vyberg, Mogens, Viuff, Birgitte Martine, Galsgaard, Elisabeth D, Elson, Greg, Toso, Alberto, Meyer, Markus, Iacone, Roberto, Schweighoffer, Tamas, Teixeira, Geoffrey, Moll, Solange, De Vito, Claudio, Roskams, Tania, Davidson, Irwin, Heide, Danijela, Heikenwälder, Mathias, Zeisel, Mirjam B, Lupberger, Joachim, Mailly, Laurent, Schuster, Catherine, Baumert, Thomas F

“…Tissue fibrosis is a key driver of end-stage organ failure and cancer, overall accounting for up to 45% of deaths in developed countries. There is a large…”
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