Search Results - "Duong, Duc M."

Posttranslational Modifications Mediate the Structural Diversity of Tauopathy Strains by Arakhamia, Tamta, Lee, Christina E., Carlomagno, Yari, Kumar, Mukesh, Duong, Duc M., Wesseling, Hendrik, Kundinger, Sean R., Wang, Kevin, Williams, Dewight, DeTure, Michael, Dickson, Dennis W., Cook, Casey N., Seyfried, Nicholas T., Petrucelli, Leonard, Steen, Judith A., Fitzpatrick, Anthony W.P.

“…Tau aggregation into insoluble filaments is the defining pathological hallmark of tauopathies. However, it is not known what controls the formation and…”
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Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer's disease by Rangaraju, Srikant, Dammer, Eric B, Raza, Syed Ali, Rathakrishnan, Priyadharshini, Xiao, Hailian, Gao, Tianwen, Duong, Duc M, Pennington, Michael W, Lah, James J, Seyfried, Nicholas T, Levey, Allan I

“…Disease-associated-microglia (DAM) represent transcriptionally-distinct and neurodegeneration-specific microglial profiles with unclear significance in…”
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Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer’s disease by Zhang, Zhentao, Song, Mingke, Liu, Xia, Su Kang, Seong, Duong, Duc M., Seyfried, Nicholas T., Cao, Xuebing, Cheng, Liming, Sun, Yi E., Ping Yu, Shan, Jia, Jianping, Levey, Allan I., Ye, Keqiang

“…The age-dependent deposition of amyloid-β peptides, derived from amyloid precursor protein (APP), is a neuropathological hallmark of Alzheimer’s disease (AD)…”
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Quantitative Proteomics Reveals the Function of Unconventional Ubiquitin Chains in Proteasomal Degradation by Xu, Ping, Duong, Duc M., Seyfried, Nicholas T., Cheng, Dongmei, Xie, Yang, Robert, Jessica, Rush, John, Hochstrasser, Mark, Finley, Daniel, Peng, Junmin

“…All seven lysine residues in ubiquitin contribute to the synthesis of polyubiquitin chains on protein substrates. Whereas K48-linked chains are well…”
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Large-scale proteomic analysis of human brain identifies proteins associated with cognitive trajectory in advanced age by Wingo, Aliza P., Dammer, Eric B., Breen, Michael S., Logsdon, Benjamin A., Duong, Duc M., Troncosco, Juan C., Thambisetty, Madhav, Beach, Thomas G., Serrano, Geidy E., Reiman, Eric M., Caselli, Richard J., Lah, James J., Seyfried, Nicholas T., Levey, Allan I., Wingo, Thomas S.

“…In advanced age, some individuals maintain a stable cognitive trajectory while others experience a rapid decline. Such variation in cognitive trajectory is…”
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Deep proteomic network analysis of Alzheimer's disease brain reveals alterations in RNA binding proteins and RNA splicing associated with disease by Johnson, Erik C B, Dammer, Eric B, Duong, Duc M, Yin, Luming, Thambisetty, Madhav, Troncoso, Juan C, Lah, James J, Levey, Allan I, Seyfried, Nicholas T

“…The complicated cellular and biochemical changes that occur in brain during Alzheimer's disease are poorly understood. In a previous study we used an unbiased…”
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Brain proteome-wide association study implicates novel proteins in depression pathogenesis by Wingo, Thomas S., Liu, Yue, Gerasimov, Ekaterina S., Gockley, Jake, Logsdon, Benjamin A., Duong, Duc M., Dammer, Eric B., Lori, Adriana, Kim, Paul J., Ressler, Kerry J., Beach, Thomas G., Reiman, Eric M., Epstein, Michael P., De Jager, Philip L., Lah, James J., Bennett, David A., Seyfried, Nicholas T., Levey, Allan I., Wingo, Aliza P.

“…Depression is a common condition, but current treatments are only effective in a subset of individuals. To identify new treatment targets, we integrated…”
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Systematical Optimization of Reverse-Phase Chromatography for Shotgun Proteomics by Xu, Ping, Duong, Duc M., Peng, Junmin

“…We report the optimization of a common LC−MS/MS platform to maximize the number of proteins identified from a complex biological sample. The platform uses…”
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Acetylation regulates ribonucleotide reductase activity and cancer cell growth by Chen, Guo, Luo, Yin, Warncke, Kurt, Sun, Youwei, Yu, David S., Fu, Haian, Behera, Madhusmita, Ramalingam, Suresh S., Doetsch, Paul W., Duong, Duc M., Lammers, Michael, Curran, Walter J., Deng, Xingming

“…Ribonucleotide reductase (RNR) catalyzes the de novo synthesis of deoxyribonucleoside diphosphates (dNDPs) to provide dNTP precursors for DNA synthesis. Here,…”
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Stress Induces p38 MAPK-Mediated Phosphorylation and Inhibition of Drosha-Dependent Cell Survival by Yang, Qian, Li, Wenming, She, Hua, Dou, Juan, Duong, Duc M., Du, Yuhong, Yang, Shao-Hua, Seyfried, Nicholas T., Fu, Haian, Gao, Guodong, Mao, Zixu

“…MicroRNAs (miRNAs) regulate the translational potential of their mRNA targets and control many cellular processes. The key step in canonical miRNA biogenesis…”
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A proteomic network approach across the ALS‐FTD disease spectrum resolves clinical phenotypes and genetic vulnerability in human brain by Umoh, Mfon E, Dammer, Eric B, Dai, Jingting, Duong, Duc M, Lah, James J, Levey, Allan I, Gearing, Marla, Glass, Jonathan D, Seyfried, Nicholas T

“…Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are neurodegenerative diseases with overlap in clinical presentation, neuropathology, and…”
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Global quantitative analysis of the human brain proteome in Alzheimer’s and Parkinson’s Disease by Ping, Lingyan, Duong, Duc M., Yin, Luming, Gearing, Marla, Lah, James J., Levey, Allan I., Seyfried, Nicholas T.

“…Patients with Alzheimer’s disease (AD) and Parkinson’s disease (PD) often have overlap in clinical presentation and brain neuropathology suggesting that these…”
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A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer's Disease by Seyfried, Nicholas T, Dammer, Eric B, Swarup, Vivek, Nandakumar, Divya, Duong, Duc M, Yin, Luming, Deng, Qiudong, Nguyen, Tram, Hales, Chadwick M, Wingo, Thomas, Glass, Jonathan, Gearing, Marla, Thambisetty, Madhav, Troncoso, Juan C, Geschwind, Daniel H, Lah, James J, Levey, Allan I

“…Here, we report proteomic analyses of 129 human cortical tissues to define changes associated with the asymptomatic and symptomatic stages of Alzheimer's…”
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Multi-platform proteomic analysis of Alzheimer's disease cerebrospinal fluid and plasma reveals network biomarkers associated with proteostasis and the matrisome by Dammer, Eric B, Ping, Lingyan, Duong, Duc M, Modeste, Erica S, Seyfried, Nicholas T, Lah, James J, Levey, Allan I, Johnson, Erik C B

“…Robust and accessible biomarkers that can capture the heterogeneity of Alzheimer's disease and its diverse pathological processes are urgently needed. Here, we…”
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Quantitative Analysis of the Brain Ubiquitylome in Alzheimer's Disease by Abreha, Measho H., Dammer, Eric B., Ping, Lingyan, Zhang, Tian, Duong, Duc M., Gearing, Marla, Lah, James J., Levey, Allan I., Seyfried, Nicholas T.

“…Several neurodegenerative diseases including Alzheimer's Disease (AD) are characterized by ubiquitin‐positive pathological protein aggregates. Here, an…”
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Cell type-specific biotin labeling in vivo resolves regional neuronal and astrocyte proteomic differences in mouse brain by Rayaprolu, Sruti, Bitarafan, Sara, Santiago, Juliet V., Betarbet, Ranjita, Sunna, Sydney, Cheng, Lihong, Xiao, Hailian, Nelson, Ruth S., Kumar, Prateek, Bagchi, Pritha, Duong, Duc M., Goettemoeller, Annie M., Oláh, Viktor János, Rowan, Matt, Levey, Allan I., Wood, Levi B., Seyfried, Nicholas T., Rangaraju, Srikant

“…Proteomic profiling of brain cell types using isolation-based strategies pose limitations in resolving cellular phenotypes representative of their native…”
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The Mount Sinai cohort of large-scale genomic, transcriptomic and proteomic data in Alzheimer's disease by Wang, Minghui, Beckmann, Noam D., Roussos, Panos, Wang, Erming, Zhou, Xianxiao, Wang, Qian, Ming, Chen, Neff, Ryan, Ma, Weiping, Fullard, John F., Hauberg, Mads E., Bendl, Jaroslav, Peters, Mette A., Logsdon, Ben, Wang, Pei, Mahajan, Milind, Mangravite, Lara M., Dammer, Eric B., Duong, Duc M., Lah, James J., Seyfried, Nicholas T., Levey, Allan I., Buxbaum, Joseph D., Ehrlich, Michelle, Gandy, Sam, Katsel, Pavel, Haroutunian, Vahram, Schadt, Eric, Zhang, Bin

“…Alzheimer’s disease (AD) affects half the US population over the age of 85 and is universally fatal following an average course of 10 years of progressive…”
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Genetic control of the human brain proteome by Robins, Chloe, Liu, Yue, Fan, Wen, Duong, Duc M., Meigs, Jacob, Harerimana, Nadia V., Gerasimov, Ekaterina S., Dammer, Eric B., Cutler, David J., Beach, Thomas G., Reiman, Eric M., De Jager, Philip L., Bennett, David A., Lah, James J., Wingo, Aliza P., Levey, Allan I., Seyfried, Nicholas T., Wingo, Thomas S.

“…We generated an online brain pQTL resource for 7,376 proteins through the analysis of genetic and proteomic data derived from post-mortem samples of the…”
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Hectd3 promotes pathogenic Th17 lineage through Stat3 activation and Malt1 signaling in neuroinflammation by Cho, Jonathan J., Xu, Zhiwei, Parthasarathy, Upasana, Drashansky, Theodore T., Helm, Eric Y., Zuniga, Ashley N., Lorentsen, Kyle J., Mansouri, Samira, Cho, Joshua Y., Edelmann, Mariola J., Duong, Duc M., Gehring, Torben, Seeholzer, Thomas, Krappmann, Daniel, Uddin, Mohammad N., Califano, Danielle, Wang, Rejean L., Jin, Lei, Li, Hongmin, Lv, Dongwen, Zhou, Daohong, Zhou, Liang, Avram, Dorina

“…Polyubiquitination promotes proteasomal degradation, or signaling and localization, of targeted proteins. Here we show that the E3 ubiquitin ligase Hectd3 is…”
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Quantitative proteomics of acutely-isolated mouse microglia identifies novel immune Alzheimer's disease-related proteins by Rangaraju, Srikant, Dammer, Eric B, Raza, Syed Ali, Gao, Tianwen, Xiao, Hailian, Betarbet, Ranjita, Duong, Duc M, Webster, James A, Hales, Chadwick M, Lah, James J, Levey, Allan I, Seyfried, Nicholas T

“…Microglia are innate immune cells of the brain that perform phagocytic and inflammatory functions in disease conditions. Transcriptomic studies of…”
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