Search Results - "Duong, Connie"

Anti-PD-1 Antibody Therapy Potently Enhances the Eradication of Established Tumors By Gene-Modified T Cells by JOHN, Liza B, DEVAUD, Christel, DUONG, Connie P. M, YONG, Carmen S, BEAVIS, Paul A, HAYNES, Nicole M, CHOW, Melvyn T, SMYTH, Mark J, KERSHAW, Michael H, DARCY, Phillip K

“…To determine the antitumor efficacy and toxicity of a novel combination approach involving adoptive T-cell immunotherapy using chimeric antigen receptor (CAR)…”
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Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota by Vétizou, Marie, Pitt, Jonathan M., Daillère, Romain, Lepage, Patricia, Waldschmitt, Nadine, Flament, Caroline, Rusakiewicz, Sylvie, Routy, Bertrand, Roberti, Maria P., Duong, Connie P. M., Poirier-Colame, Vichnou, Roux, Antoine, Becharef, Sonia, Formenti, Silvia, Golden, Encouse, Cording, Sascha, Eberl, Gerard, Schlitzer, Andreas, Ginhoux, Florent, Mani, Sridhar, Yamazaki, Takahiro, Jacquelot, Nicolas, Enot, David P., Bérard, Marion, Nigou, Jérôme, Opolon, Paule, Eggermont, Alexander, Woerther, Paul-Louis, Chachaty, Elisabeth, Chaput, Nathalie, Robert, Caroline, Mateus, Christina, Kroemer, Guido, Raoult, Didier, Boneca, Ivo Gomperts, Carbonnel, Franck, Chamaillard, Mathias, Zitvogel, Laurence

“…Antibodies targeting CTLA-4 have been successfully used as cancer immunotherapy. We find that the antitumor effects of CTLA-4 blockade depend on distinct…”
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Enterococcus hirae and Barnesiella intestinihominis Facilitate Cyclophosphamide-Induced Therapeutic Immunomodulatory Effects by Daillère, Romain, Vétizou, Marie, Waldschmitt, Nadine, Yamazaki, Takahiro, Isnard, Christophe, Poirier-Colame, Vichnou, Duong, Connie P.M., Flament, Caroline, Lepage, Patricia, Roberti, Maria Paula, Routy, Bertrand, Jacquelot, Nicolas, Apetoh, Lionel, Becharef, Sonia, Rusakiewicz, Sylvie, Langella, Philippe, Sokol, Harry, Kroemer, Guido, Enot, David, Roux, Antoine, Eggermont, Alexander, Tartour, Eric, Johannes, Ludger, Woerther, Paul-Louis, Chachaty, Elisabeth, Soria, Jean-Charles, Golden, Encouse, Formenti, Silvia, Plebanski, Magdalena, Madondo, Mutsa, Rosenstiel, Philip, Raoult, Didier, Cattoir, Vincent, Boneca, Ivo Gomperts, Chamaillard, Mathias, Zitvogel, Laurence

“…The efficacy of the anti-cancer immunomodulatory agent cyclophosphamide (CTX) relies on intestinal bacteria. How and which relevant bacterial species are…”
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Chemotherapy-induced ileal crypt apoptosis and the ileal microbiome shape immunosurveillance and prognosis of proximal colon cancer by Roberti, Maria Paula, Yonekura, Satoru, Duong, Connie P. M., Picard, Marion, Ferrere, Gladys, Tidjani Alou, Maryam, Rauber, Conrad, Iebba, Valerio, Lehmann, Christian H. K., Amon, Lukas, Dudziak, Diana, Derosa, Lisa, Routy, Bertrand, Flament, Caroline, Richard, Corentin, Daillère, Romain, Fluckiger, Aurélie, Van Seuningen, Isabelle, Chamaillard, Mathias, Vincent, Audrey, Kourula, Stephanie, Opolon, Paule, Ly, Pierre, Pizzato, Eugénie, Becharef, Sonia, Paillet, Juliette, Klein, Christophe, Marliot, Florence, Pietrantonio, Filippo, Benoist, Stéphane, Scoazec, Jean-Yves, Dartigues, Peggy, Hollebecque, Antoine, Malka, David, Pagès, Franck, Galon, Jérôme, Gomperts Boneca, Ivo, Lepage, Patricia, Ryffel, Bernard, Raoult, Didier, Eggermont, Alexander, Vanden Berghe, Tom, Ghiringhelli, François, Vandenabeele, Peter, Kroemer, Guido, Zitvogel, Laurence

“…The prognosis of colon cancer (CC) is dictated by tumor-infiltrating lymphocytes, including follicular helper T (T FH ) cells and the efficacy of…”
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Targeting Chemokines and Chemokine Receptors in Melanoma and Other Cancers by Jacquelot, Nicolas, Duong, Connie P M, Belz, Gabrielle T, Zitvogel, Laurence

“…The tumor microenvironment is highly heterogeneous. It is composed of a diverse array of immune cells that are recruited continuously into lesions. They are…”
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Autoimmunity associated with immunotherapy of cancer by Amos, Sally M., Duong, Connie P.M., Westwood, Jennifer A., Ritchie, David S., Junghans, Richard P., Darcy, Phillip K., Kershaw, Michael H.

“…In this age of promise of new therapies for cancer, immunotherapy is emerging as an exciting treatment option for patients. Vaccines and cytokines are being…”
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Sustained Type I interferon signaling as a mechanism of resistance to PD-1 blockade by Jacquelot, Nicolas, Yamazaki, Takahiro, Roberti, Maria P., Duong, Connie P. M., Andrews, Miles C., Verlingue, Loic, Ferrere, Gladys, Becharef, Sonia, Vétizou, Marie, Daillère, Romain, Messaoudene, Meriem, Enot, David P., Stoll, Gautier, Ugel, Stefano, Marigo, Ilaria, Foong Ngiow, Shin, Marabelle, Aurélien, Prevost-Blondel, Armelle, Gaudreau, Pierre-Olivier, Gopalakrishnan, Vancheswaran, Eggermont, Alexander M., Opolon, Paule, Klein, Christophe, Madonna, Gabriele, Ascierto, Paolo A., Sucker, Antje, Schadendorf, Dirk, Smyth, Mark J., Soria, Jean-Charles, Kroemer, Guido, Bronte, Vincenzo, Wargo, Jennifer, Zitvogel, Laurence

“…PD-1 blockade represents a major therapeutic avenue in anticancer immunotherapy. Delineating mechanisms of secondary resistance to this strategy is…”
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Cancer immunotherapy utilizing gene-modified T cells: From the bench to the clinic by Duong, Connie P.M., Yong, Carmen S.M., Kershaw, Michael H., Slaney, Clare Y., Darcy, Phillip K.

“…•The presence of immune infiltrate in tumors has been correlated with a good prognosis following treatment.•Tumor-infiltrating lymphocytes have been utilized…”
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Cross-reactivity between tumor MHC class I–restricted antigens and an enterococcal bacteriophage by Fluckiger, Aurélie, Daillère, Romain, Sassi, Mohamed, Sixt, Barbara Susanne, Liu, Peng, Loos, Friedemann, Richard, Corentin, Rabu, Catherine, Alou, Maryam Tidjani, Goubet, Anne-Gaëlle, Lemaitre, Fabien, Ferrere, Gladys, Derosa, Lisa, Duong, Connie P. M., Messaoudene, Meriem, Gagné, Andréanne, Joubert, Philippe, De Sordi, Luisa, Debarbieux, Laurent, Simon, Sylvain, Scarlata, Clara-Maria, Ayyoub, Maha, Palermo, Belinda, Facciolo, Francesco, Boidot, Romain, Wheeler, Richard, Boneca, Ivo Gomperts, Sztupinszki, Zsofia, Papp, Krisztian, Csabai, Istvan, Pasolli, Edoardo, Segata, Nicola, Lopez-Otin, Carlos, Szallasi, Zoltan, Andre, Fabrice, Iebba, Valerio, Quiniou, Valentin, Klatzmann, David, Boukhalil, Jacques, Khelaifia, Saber, Raoult, Didier, Albiges, Laurence, Escudier, Bernard, Eggermont, Alexander, Mami-Chouaib, Fathia, Nistico, Paola, Ghiringhelli, François, Routy, Bertrand, Labarrière, Nathalie, Cattoir, Vincent, Kroemer, Guido, Zitvogel, Laurence

“…Phages and cancer immunity Gut bacteria are involved in the education of T cell immune responses, and the intestinal ecosystem influences anticancer immunity…”
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Gut Bacteria Composition Drives Primary Resistance to Cancer Immunotherapy in Renal Cell Carcinoma Patients by Derosa, Lisa, Routy, Bertrand, Fidelle, Marine, Iebba, Valerio, Alla, Laurie, Pasolli, Edoardo, Segata, Nicola, Desnoyer, Aude, Pietrantonio, Filippo, Ferrere, Gladys, Fahrner, Jean-Eudes, Le Chatellier, Emmanuelle, Pons, Nicolas, Galleron, Nathalie, Roume, Hugo, Duong, Connie P.M., Mondragón, Laura, Iribarren, Kristina, Bonvalet, Mélodie, Terrisse, Safae, Rauber, Conrad, Goubet, Anne-Gaëlle, Daillère, Romain, Lemaitre, Fabien, Reni, Anna, Casu, Beatrice, Alou, Maryam Tidjani, Alves Costa Silva, Carolina, Raoult, Didier, Fizazi, Karim, Escudier, Bernard, Kroemer, Guido, Albiges, Laurence, Zitvogel, Laurence

“…The development of immune checkpoint blockade (ICB) has revolutionized the clinical outcome of renal cell carcinoma (RCC). Nevertheless, improvement of…”
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Tissues in Different Anatomical Sites Can Sculpt and Vary the Tumor Microenvironment to Affect Responses to Therapy by Devaud, Christel, Westwood, Jennifer A, John, Liza B, Flynn, Jacqueline K, Paquet-Fifield, Sophie, Duong, Connie PM, Yong, Carmen SM, Pegram, Hollie J, Stacker, Steven A, Achen, Marc G, Stewart, Trina J, Snyder, Linda A, Teng, Michele WL, Smyth, Mark J, Darcy, Phillip K, Kershaw, Michael H

“…The tumor microenvironment can promote tumor growth and reduce treatment efficacy. Tumors can occur in many sites in the body, but how surrounding normal…”
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Engineering T cell function using chimeric antigen receptors identified using a DNA library approach by Duong, Connie P M, Westwood, Jennifer A, Yong, Carmen S M, Murphy, Amanda, Devaud, Christel, John, Liza B, Darcy, Phillip K, Kershaw, Michael H

“…Genetic engineering of cellular function holds much promise for the treatment of a variety of diseases including gene deficiencies and cancer. However,…”
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Cancer Induces a Stress Ileopathy Depending on β-Adrenergic Receptors and Promoting Dysbiosis that Contributes to Carcinogenesis by Yonekura, Satoru, Terrisse, Safae, Alves Costa Silva, Carolina, Lafarge, Antoine, Iebba, Valerio, Ferrere, Gladys, Goubet, Anne-Gaëlle, Fahrner, Jean-Eudes, Lahmar, Imran, Ueda, Kousuke, Mansouri, Gibrail, Pizzato, Eugénie, Ly, Pierre, Mazzenga, Marine, Thelemaque, Cassandra, Fidelle, Marine, Jaulin, Fanny, Cartry, Jérôme, Deloger, Marc, Aglave, Marine, Droin, Nathalie, Opolon, Paule, Puget, Angélique, Mann, Fanny, Neunlist, Michel, Bessard, Anne, Aymeric, Laetitia, Matysiak-Budnik, Tamara, Bosq, Jacques, Hofman, Paul, Duong, Connie P M, Ugolini, Sophie, Quiniou, Valentin, Berrard, Sylvie, Ryffel, Bernhard, Kepp, Oliver, Kroemer, Guido, Routy, Bertrand, Lordello, Leonardo, Bani, Mohamed-Amine, Segata, Nicola, Yengej, Fjodor Yousef, Clevers, Hans, Scoazec, Jean-Yves, Pasolli, Edoardo, Derosa, Lisa, Zitvogel, Laurence

“…Gut dysbiosis has been associated with intestinal and extraintestinal malignancies, but whether and how carcinogenesis drives compositional shifts of the…”
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Foxp3 expression in macrophages associated with RENCA tumors in mice by Devaud, Christel, Yong, Carmen S M, John, Liza B, Westwood, Jennifer A, Duong, Connie P M, House, Colin M, Denoyer, Delphine, Li, Jason, Darcy, Phillip K, Kershaw, Michael H

“…The transcription factor Foxp3 represents the most specific functional marker of CD4+ regulatory T cells (TRegs). However, previous reports have described…”
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TNFR2/BIRC3-TRAF1 signaling pathway as a novel NK cell immune checkpoint in cancer by Ivagnès, Alexandre, Messaoudene, Meriem, Stoll, Gautier, Routy, Bertrand, Fluckiger, Aurélie, Yamazaki, Takahiro, Iribarren, Kristina, Duong, Connie P. M., Fend, Laetitia, Caignard, Anne, Cremer, Isabelle, LeCesne, Axel, Adam, Julien, Honoré, Charles, Mir, Olivier, Chaigneau, Loïc, Berger, Anne, Validire, Pierre, Christidis, Christos, Brun-Ly, Valérie Le, Smyth, Mark J., Mariette, Xavier, Salomon, Benoît L., Kroemer, Guido, Rusakiewicz, Sylvie, Zitvogel, Laurence

“…Natural Killer (NK) cells control metastatic dissemination of murine tumors and are an important prognostic factor in several human malignancies. However,…”
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Future perspectives in melanoma research "Melanoma Bridge", Napoli, November 30th-3rd December 2016 by Ascierto, Paolo A, Agarwala, Sanjiv S, Ciliberto, Gennaro, Demaria, Sandra, Dummer, Reinhard, Duong, Connie P M, Ferrone, Soldano, Formenti, Silvia C, Garbe, Claus, Halaban, Ruth, Khleif, Samir, Luke, Jason J, Mir, Lluis M, Overwijk, Willem W, Postow, Michael, Puzanov, Igor, Sondel, Paul, Taube, Janis M, Thor Straten, Per, Stroncek, David F, Wargo, Jennifer A, Zarour, Hassane, Thurin, Magdalena

“…Major advances have been made in the treatment of cancer with targeted therapy and immunotherapy; several FDA-approved agents with associated improvement of…”
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Tumor Ablation by Gene-Modified T Cells in the Absence of Autoimmunity by WANG, Leanne X. J, WESTWOOD, Jennifer A, DARCY, Phillip K, MOELLER, Maria, DUONG, Connie P. M, WEI, Wei-Zen, MALATERRE, Jordane, TRAPANI, Joseph A, NEESON, Paul, SMYTH, Mark J, KERSHAW, Michael H

“…Adoptive immunotherapy involving genetic modification of T cells with antigen-specific, chimeric, single-chain receptors is a promising approach for the…”
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Combination anti-CD137 and anti-CD40 antibody therapy in murine myc-driven hematological cancers by Westwood, Jennifer A, Matthews, Geoffrey M, Shortt, Jake, Faulkner, David, Pegram, Hollie J, Duong, Connie P.M, Chesi, Marta, Bergsagel, P. Leif, Sharp, Leslie L, Huhn, Richard D, Darcy, Phillip K, Johnstone, Ricky W, Kershaw, Michael H

“…Highlights • Anti-CD40 plus anti-CD137 (BiMab) induced regression of subcutaneous MC38 tumors. • BiMab treatment of Eμ- Myc lymphoma led to significant…”
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Immune biomarkers for prognosis and prediction of responses to immune checkpoint blockade in cutaneous melanoma by Jacquelot, Nicolas, Pitt, Jonathan M., Enot, David P., Roberti, Maria Paula, Duong, Connie P. M., Rusakiewicz, Sylvie, Eggermont, Alexander M., Zitvogel, Laurence

“…Existing clinical, anatomopathological and molecular biomarkers fail to reliably predict the prognosis of cutaneous melanoma. Biomarkers for determining which…”
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Oncolytic Virus and Anti―4-1BB Combination Therapy Elicits Strong Antitumor Immunity against Established Cancer by JOHN, Liza B, HOWLAND, Linda J, SMYTH, Mark J, KERSHAW, Michael H, DARCY, Phillip K, FLYNN, Jacqueline K, WEST, Alison C, DEVAUD, Christel, DUONG, Connie P, STEWART, Trina J, WESTWOOD, Jenny A, SHENG GUO, Z, BARTLETT, David L

“…Oncolytic virotherapy using vaccinia virus (Vv) has shown some encouraging antitumor responses in mouse models and patients, but the breadth of efficacy in…”
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