Search Results - "Dunstan, Colin R"

Architectural Design of 3D Printed Scaffolds Controls the Volume and Functionality of Newly Formed Bone by Entezari, Ali, Roohani, Iman, Li, Guanglong, Dunstan, Colin R., Rognon, Pierre, Li, Qing, Jiang, Xinquan, Zreiqat, Hala

“…The successful regeneration of functional bone tissue in critical‐size defects remains a significant clinical challenge. To address this challenge, synthetic…”
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Zirconium ions up-regulate the BMP/SMAD signaling pathway and promote the proliferation and differentiation of human osteoblasts by Chen, Yongjuan, Roohani-Esfahani, Seyed-Iman, Lu, ZuFu, Zreiqat, Hala, Dunstan, Colin R

“…Zirconium (Zr) is an element commonly used in dental and orthopedic implants either as zirconia (ZrO2) or in metal alloys. It can also be incorporated into…”
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Osteoblasts Directly Control Lineage Commitment of Mesenchymal Progenitor Cells through Wnt Signaling by Zhou, Hong, Mak, Wendy, Zheng, Yu, Dunstan, Colin R., Seibel, Markus J.

“…Lineage commitment of mesenchymal progenitor cells is still poorly understood. Here we demonstrate that Wnt signaling by osteoblasts is essential for…”
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A Single‐Dose Placebo‐Controlled Study of AMG 162, a Fully Human Monoclonal Antibody to RANKL, in Postmenopausal Women by Bekker, Pirow J, Holloway, Donna L, Rasmussen, Amy S, Murphy, Robyn, Martin, Steven W, Leese, Philip T, Holmes, Gregory B, Dunstan, Colin R, DePaoli, Alex M

“…The safety and bone antiresorptive effect of a single subcutaneous dose of AMG 162, a human monoclonal antibody to RANKL, was investigated in 49 postmenopausal…”
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Follicle-stimulating hormone increases bone mass in female mice by Allan, Charles M., Kalak, Robert, Dunstan, Colin R., McTavish, Kirsten J., Zhou, Hong, Handelsman, David J., Seibel, Markus J., Potts, John T.

“…Elevated follicle-stimulating hormone (FSH) activity is proposed to directly cause bone loss independent of estradiol deficiency in aging women. Using…”
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Computational modeling of interactions between multiple myeloma and the bone microenvironment by Wang, Yan, Pivonka, Peter, Buenzli, Pascal R, Smith, David W, Dunstan, Colin R

“…Multiple Myeloma (MM) is a B-cell malignancy that is characterized by osteolytic bone lesions. It has been postulated that positive feedback loops in the…”
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Reprogramming of human fibroblasts into osteoblasts by insulin‐like growth factor‐binding protein 7 by Lu, ZuFu, Chiu, Joyce, Lee, Lucinda R., Schindeler, Aaron, Jackson, Miriam, Ramaswamy, Yogambha, Dunstan, Colin R., Hogg, Philip J., Zreiqat, Hala

“…The induced pluripotent stem cell (iPSC) is a promising cell source for tissue regeneration. However, the therapeutic value of iPSC technology is limited due…”
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Biphasic Glucocorticoid-Dependent Regulation of Wnt Expression and Its Inhibitors in Mature Osteoblastic Cells by Mak, Wendy, Shao, Xinyu, Dunstan, Colin R., Seibel, Markus J., Zhou, Hong

“…Glucocorticoids exert both anabolic and catabolic effects on bone. Previously, we reported that endogenous glucocorticoids control mesenchymal lineage…”
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Targeting IL-6 and RANKL signaling inhibits prostate cancer growth in bone by Zheng, Yu, Basel, Dennis, Chow, Shu-Oi, Fong-Yee, Colette, Kim, Sarah, Buttgereit, Frank, Dunstan, Colin R., Zhou, Hong, Seibel, Markus J.

“…In prostate cancer metastases to bone, cancer cell-derived cytokines stimulate RANKL expression by cells of the osteoblast lineage, which in turn activates…”
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Glucocorticoid-dependent Wnt signaling by mature osteoblasts is a key regulator of cranial skeletal development in mice by Zhou, Hong, Mak, Wendy, Kalak, Robert, Street, Janine, Fong-Yee, Colette, Zheng, Yu, Dunstan, Colin R, Seibel, Markus J

“…Glucocorticoids are important regulators of bone cell differentiation and mesenchymal lineage commitment. Using a cell-specific approach of osteoblast-targeted…”
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Calcification in Atherosclerosis: Bone Biology and Chronic Inflammation at the Arterial Crossroads by Doherty, Terence M., Asotra, Kamlesh, Fitzpatrick, Lorraine A., Qiao, Jian-Hua, Wilkin, Douglas J., Detrano, Robert C., Dunstan, Colin R., Shah, Prediman K., Rajavashisth, Tripathi B.

“…Dystrophic or ectopic mineral deposition occurs in many pathologic conditions, including atherosclerosis. Calcium mineral deposits that frequently accompany…”
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The Effect of a Single Dose of Osteoprotegerin in Postmenopausal Women by Bekker, Pirow J., Holloway, Donna, Nakanishi, Arline, Arrighi, Michael, Leese, Philip T., Dunstan, Colin R.

“…Osteoprotegerin (OPG), a tumor necrosis factor (TNF) receptor family member, is a critical regulator of bone resorption. It is an important inhibitor of the…”
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Functional Ultra-High Molecular Weight Polyethylene Composites for Ligament Reconstructions and Their Targeted Applications in the Restoration of the Anterior Cruciate Ligament by Wahed, Sonia B, Dunstan, Colin R, Boughton, Philip A, Ruys, Andrew J, Faisal, Shaikh N, Wahed, Tania B, Salahuddin, Bidita, Cheng, Xinying, Zhou, Yang, Wang, Chun H, Islam, Mohammad S, Aziz, Shazed

“…The selection of biomaterials as biomedical implants is a significant challenge. Ultra-high molecular weight polyethylene (UHMWPE) and composites of such kind…”
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OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis by Penninger, Josef M, Kong, Young-Yun, Yoshida, Hiroki, Sarosi, Ildiko, Tan, Hong-Lin, Timms, Emma, Capparelli, Casey, Morony, Sean, Oliveira-dos-Santos, Antonio J, Van, Gwyneth, Itie, Annick, Khoo, Wilson, Wakeham, Andrew, Dunstan, Colin R, Lacey, David L, Mak, Tak W, Boyle, William J

“…The tumour-necrosis-factor-family molecule osteoprotegerin ligand (OPGL; also known as TRANCE, RANKL and ODF) has been identified as a potential osteoclast…”
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The role of the bone microenvironment in skeletal metastasis by Zheng, Yu, Zhou, Hong, Dunstan, Colin R, Sutherland, Robert L, Seibel, Markus J

“…Abstract The bone microenvironment provides a fertile soil for cancer cells. It is therefore not surprising that the skeleton is a frequent site of cancer…”
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Nanoemulsion-Enabled Oral Delivery of Novel Anticancer ω-3 Fatty Acid Derivatives by Garrastazu Pereira, Gabriela, Rawling, Tristan, Pozzoli, Michele, Pazderka, Curtis, Chen, Yongjuan, Dunstan, Colin R, Murray, Michael, Sonvico, Fabio

“…Lipid-based drugs are emerging as an interesting class of novel anticancer drugs with the potential to target specific cancer cell metabolic pathways linked to…”
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Tumor Necrosis Factor Receptor Family Member RANK Mediates Osteoclast Differentiation and Activation Induced by Osteoprotegerin Ligand by Hsu, Hailing, Lacey, David L., Dunstan, Colin R., Solovyev, Irina, Colombero, Anne, Timms, Emma, Tan, Hong-Lin, Elliott, Gary, Kelley, Michael J., Sarosi, Ildiko, Wang, Ling, Xia, Xing-Zhong, Elliott, Robin, Chiu, Laura, Black, Tabitha, Scully, Sheila, Capparelli, Casey, Morony, Sean, Shimamoto, Grant, Bass, Michael B., Boyle, William J.

“…A receptor that mediates osteoprotegerin ligand (OPGL)-induced osteoclast differentiation and activation has been identified via genomic analysis of a primary…”
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Osteoprotegerin Reduces Osteoclast Numbers and Prevents Bone Erosion in Collagen-Induced Arthritis by Romas, Evan, Sims, Natalie A., Hards, Daphne K., Lindsay, Mandy, Quinn, Julian W.M., Ryan, Peter F.J., Dunstan, Colin R., Martin, T. John, Gillespie, Matthew T.

“…Rheumatoid arthritis is characterized by progressive synovial inflammation and joint destruction. While matrix metalloproteinases (MMPs) are implicated in the…”
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Mechanisms of Disease: roles of OPG, RANKL and RANK in the pathophysiology of skeletal metastasis by Blair, Julie M, Zhou, Hong, Seibel, Markus J, Dunstan, Colin R

“…The discovery of osteoprotegerin, receptor activator of nuclear factor kappa B (RANK) and RANK ligand as critical molecular determinants of osteoclastogenesis…”
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Personalized Baghdadite scaffolds: stereolithography, mechanics and in vivo testing by Mirkhalaf, Mohammad, Dao, Aiken, Schindeler, Aaron, Little, David G., Dunstan, Colin R., Zreiqat, Hala

“…An ongoing challenge in the field of orthopedics is to produce a clinically relevant synthetic ceramic scaffold for the treatment of ‘critical-sized’ bone…”
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