Search Results - "Dunnick, J."

Environmental Chemical Exposure May Contribute to Uterine Cancer Development: Studies with Tetrabromobisphenol A by Dunnick, J. K., Sanders, J. M., Kissling, G. E., Johnson, C. L., Boyle, M. H., Elmore, S. A.

“…Tetrabromobisphenol A (TBBPA), a widely used flame retardant, caused uterine tumors in rats. In this study, TBBPA was administered to male and female Wistar…”
Get full text

Genetic pathways and mutation profiles of human cancers: site- and exposure-specific patterns by Lea, I.A., Jackson, M.A., Li, X., Bailey, S., Peddada, S.D., Dunnick, J.K.

“…Cancer is a complex disease that involves the accumulation of both genetic and epigenetic alterations of numerous genes. Data in the Genetic Alterations in…”
Get full text

PBDE-47 and PBDE mixture (DE-71) toxicities and liver transcriptomic changes at PND 22 after in utero/postnatal exposure in the rat by Dunnick, J. K., Shockley, K. R., Pandiri, A. R., Kissling, G. E., Gerrish, K. E., Ton, T. V., Wilson, R. E., Brar, S. S., Brix, A. E., Waidyanatha, S., Mutlu, E., Morgan, D. L.

“…Pentabromodiphenyl ethers (PBDE) are found in human tissue, in household dust, and in the environment, and a particular concern is the potential for the…”
Get full text

Characterization of Polybrominated Diphenyl Ether Toxicity in Wistar Han Rats and Use of Liver Microarray Data for Predicting Disease Susceptibilities by Dunnick, J. K., Brix, A., Cunny, H., Vallant, M., Shockley, K. R.

“…The toxicity of polybrominated diphenyl ethers (PBDEs), flame-retardant components, was characterized in offspring from Wistar Han dams exposed by gavage to a…”
Get full text

Tetrabromobisphenol A activates the hepatic interferon pathway in rats by Dunnick, J.K., Morgan, D.L., Elmore, S.A., Gerrish, K., Pandiri, A., Ton, T.V., Shockley, K.R., Merrick, B.A.

“…•Tetrabromobisphenol A (TBBPA) is a widely used flame retardant.•Oral administration of TBBPA to rats cause transcriptomic changes in the liver.•These…”
Get full text

Carcinogenicity of some nitrobenzenes and other industrial chemicals by Van den Berg, M, Cattley, R, Cherrie, J W, Dorman, D C, Dunnick, J K, Gohlke, J M, Jinot, J, Käfferlein, H U, Kopylev, L, Matsumoto, M, Nomiyama, T, Ogawa, K, Perbellini, L, Sone, H, Grosse, Y, Guyton, K Z, Schubauer-Berigan, M K, El Ghissassi, F, Bouvard, V, Benbrahim-Tallaa, L, Hall, A, Paul, A, Mattock, H, Straif, K

“…In rodent studies, drinking water exposure to ortho-phenylenediamine (tested as its dihydrochloride)2 increased the incidence of hepatocellular adenoma (HCA)…”
Get full text

Cardiotoxicity of Ma Huang/Caffeine or Ephedrine/Caffeine in a Rodent Model System by Dunnick, J. K., Kissling, G., Gerken, D. K., Vallant, M. A., Nyska, A.

“…Ma Huang (equivalent to 0, 12.5, 25, or 50 mg/kg ephedrine) or ephedrine (0, 6.25, 12.5, 25 mg/kg) were administered as one bolus oral dose to male F344 rats…”
Get full text

Carcinogenic activity of pentabrominated diphenyl ether mixture (DE-71) in rats and mice by Dunnick, J.K., Pandiri, A.R., Merrick, B.A., Kissling, G.E., Cunny, H., Mutlu, E., Waidyanatha, S., Sills, R., Hong, H.L., Ton, TV, Maynor, T., Recio, L., Phillips, S.L., Devito, M.J., Brix, A.

“…[Display omitted] •Pentabrominated diphenyl ether (PBDE) mixture was a multispecies carcinogen causing liver tumors in male and female rats and mice.•Hras or…”
Get full text

Toxicokinetics of bis(2-chloroethoxy)methane following intravenous administration and dermal application in male and female F344/N rats and B6C3F1 mice by Waidyanatha, S., Johnson, J.D., Hong, S.P., Godfrey-Robinson, V.D., Graves, S.W., Cristy, T., Dunnick, J.K., Smith, C.S.

“…► Bis(2-chloroethoxy)methane(CEM) was quickly absorbed and metabolized to thiodiglycolic acid (TDGA) in rats and mice following dermal application. ► Plasma…”
Get full text

Chemical-specific alterations in ras, p53, and β-catenin genes in hemangiosarcomas from B6C3F1 mice exposed to o-nitrotoluene or riddelliine for 2 years by Hong, H.L, Ton, T.V, Devereux, T.R, Moomaw, C, Clayton, N, Chan, P, Dunnick, J.K, Sills, R.C

“…The most prominent neoplastic lesions in mice in the 2-year studies of o-nitrotoluene and riddelliine were hemangiosarcomas. Fifteen o-nitrotoluene-induced…”
Get full text

Somatic mutation databases as tools for molecular epidemiology and molecular pathology of cancer: Proposed guidelines for improving data collection, distribution, and integration by Olivier, M, Petitjean, A, Teague, J, Forbes, S, Dunnick, J.K, den Dunnen, J.T, Langerød, A, Wilkinson, J.M, Vihinen, M, Cotton, R.G.H, Hainaut, P

“…There are currently less than 40 locus-specific databases (LSDBs) and one large general database that curate data on somatic mutations in human cancer genes…”
Get full text

Critical Pathways in Heart Function: Bis(2-chloroethoxy)methane-Induced Heart Gene Transcript Change in F344 Rats by Dunnick, J., Blackshear, P., Kissling, G., Cunningham, M., Parker, J., Nyska, A.

“…Gene transcript changes after exposure to the heart toxin, bis(2-chloroethoxy)methane (CEM), were analyzed to elucidate mechanisms in cardiotoxicity and…”
Get full text

Comparative carcinogenic effects of nickel subsulfide, nickel oxide, or nickel sulfate hexahydrate chronic exposures in the lung by DUNNICK, J. K, ELWELL, M. R, RADOVSKY, A. E, BENSON, J. M, HAHN, F. F, NIKULA, K. J, BARR, E. B, HOBBS, C. H

“…The relative toxicity and carcinogenicity of nickel sulfate hexahydrate (NiSO4.6H2O), nickel subsulfide (Ni3S2), and nickel oxide (NiO) were studied in F344/N…”
Get full text

Bis(2-chloroethoxy)methane-Induced Mitochondrial and Myofibrillar Damage: Short-Term Time-Course Study by Dunnick, June, Johnson, JoAnne, Horton, John, Nyska, Abraham

“…Cardiotoxicity induced by 2-, 3-, 5-, and 12-day dermal administration of 400 and 600 mg/kg/day of bis(2-chloroethoxy)methane to F344/N male and female rats…”
Get full text

Phenolphthalein exposure causes multiple carcinogenic effects in experimental model systems by DUNNICK, J. K, HAILEY, J. R

“…Phenolphthalein (a triphenylmethane derivative) has been commonly used as a laxative for most of the twentieth century, but little is known about its long-term…”
Get full text

Assessment of the carcinogenic potential of chlorinated water: experimental studies of chlorine, chloramine, and trihalomethanes by Dunnick, J K, Melnick, R L

“…Water chlorination has been one of the major disease prevention treatments of this century. While epidemiologic studies suggest an association between cancer…”
Get more information

o-Nitrotoluene-induced large intestinal tumors in B6C3F1 mice model human colon cancer in their molecular pathogenesis by Sills, R.C., Hong, H.L., Flake, G., Moomaw, C., Clayton, N., Boorman, G.A., Dunnick, J., Devereux, T.R.

“…In the previous 500 2-year chemical bioassays within the National Toxicology Program, large intestinal tumors (cecal carcinomas) related to chemical exposure…”
Get full text

Toxicokinetics of phenolphthalein in male and female rats and mice by COLLINS, B. J, GRIZZLE, T. B, DUNNICK, J. K

“…Phenolphthalein (PTH), which has been used as the active ingredient in a number of prescription and over-the-counter laxative products, is a rodent chemical…”
Get full text

Phenolphthalein induces thymic lymphomas accompanied by loss of the p53 wild type allele in heterozygous p53-deficient (+/-) mice by Dunnick, J K, Hardisty, J F, Herbert, R A, Seely, J C, Furedi-Machacek, E M, Foley, J F, Lacks, G D, Stasiewicz, S, French, J E

“…Epidemiology studies have indicated that many human cancers are influenced by environmental factors. Genetically altered mouse model systems offer us the…”
Get more information

Regenerative hyperplasia is not required for liver tumor induction in female B6C3F1 mice exposed to trihalomethanes by MELNICK, R. L, KOHN, M. C, DUNNICK, J. K, LEININGER, J. R

“…Chloroform (TCM), a water disinfection by-product, induced liver tumors in female mice when administered by gavage in corn oil but not when given in drinking…”
Get full text