Search Results - "Dunnett, S.B"

The 6-OHDA mouse model of Parkinson's disease – Terminal striatal lesions provide a superior measure of neuronal loss and replacement than median forebrain bundle lesions by Bagga, V., Dunnett, S.B., Fricker, R.A.

“…•Generation of a reproducible mouse 6-hydroxydopamine lesion model.•Discovery that terminal striatal lesions produce reproducible motor asymmetry when mice are…”
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Recovery of functional deficits following early donor age ventral mesencephalic grafts in a rat model of Parkinson's disease by Torres, E.M, Dowd, E, Dunnett, S.B

“…Abstract It has previously been reported that dopaminergic grafts derived from early donor age, embryonic age 12-day-old (E12) rat embryos produced a fivefold…”
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Gene expression and behaviour in mouse models of HD by Bowles, K.R, Brooks, S.P, Dunnett, S.B, Jones, L

“…Highlights ► We review the current mouse models of Huntington's Disease. ► We examine the evidence for the relationship between gene expression and behaviour…”
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S10 CELLULAR REPAIR OF STRIATAL MOTOR AND COGNITIVE FUNCTIONS IN ANIMAL MODELS OF HUNTINGTON DISEASE by Dunnett, S.B

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Context-driven changes in l -DOPA-induced behaviours in the 6-OHDA lesioned rat by Lane, E.L, Daly, C.S, Smith, G.A, Dunnett, S.B

“…Abstract Both contralateral rotational behaviour and dyskinetic abnormal involuntary movements (AIMs) are induced by the administration of l -DOPA in the…”
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The lateral neostriatum is necessary for compensatory ingestive behaviour after intravascular dehydration in female rats by Lelos, M.J., Harrison, D.J., Rosser, A.E., Dunnett, S.B.

“…•We consider how the lateral neostriatum contributes to changes in water ingestion.•Rats with striatal lesions underwent physiological challenges inducing…”
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Operant-based instrumental learning for analysis of genetically modified models of Huntington's disease by Trueman, R.C, Dunnett, S.B, Brooks, S.P

“…Highlights ► Genetically modified models of Huntington's disease require behavioural phenotyping. ► Operant tests have been developed for behavioural analysis…”
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Early onset deficits on the delayed alternation task in the HdhQ92 knock-in mouse model of Huntington's disease by Trueman, R.C, Jones, L, Dunnett, S.B, Brooks, S.P

“…Highlights ► The delayed alternation task is sensitive to fronto-striatal dysfunction. ► 12 month old HdhQ92 mice have previously been tested and were severely…”
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Five choice serial reaction time performance in the HdhQ92 mouse model of Huntington's disease by Trueman, R.C, Dunnett, S.B, Jones, L, Brooks, S.P

“…Highlights ► Attention is affected in Huntington's disease patients. ► The 5-choice serial reaction time task assesses attention in rodents. ► The HdhQ92 mouse…”
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Improved survival of young donor age dopamine grafts in a rat model of Parkinson’s disease by Torres, E.M, Monville, C, Gates, M.A, Bagga, V, Dunnett, S.B

“…Abstract In an attempt to improve the survival of implanted dopamine cells, we have readdressed the optimal embryonic donor age for dopamine grafts. In a rat…”
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Training specificity, graft development and graft-mediated functional recovery in a rodent model of Huntington’s disease by Döbrössy, M.D., Dunnett, S.B.

“…Neuronal function and morphology are affected by the environment and the behavioral experience. Here we report on the effects of differential training…”
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Striatal Transplantation in a Transgenic Mouse Model of Huntington's Disease by Dunnett, S.B., Carter, R.J., Watts, C., Torres, E.M., Mahal, A., Mangiarini, L., Bates, G., Morton, A.J.

“…Striatal grafts have been proposed as a potential strategy for striatal repair in Huntington's disease, but it is unknown whether the diseased brain will…”
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The "staircase test": a measure of independent forelimb reaching and grasping abilities in rats by Montoya, C P, Campbell-Hope, L J, Pemberton, K D, Dunnett, S B

“…A novel reaching test for the rat has been developed to assess the independent use of forelimbs in skilled reaching and grasping tasks. The apparatus is a…”
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Differential expression of immediate early genes in the hippocampus and spinal cord by Wisden, W, Errington, M L, Williams, S, Dunnett, S B, Waters, C, Hitchcock, D, Evan, G, Bliss, T V, Hunt, S P

“…We have demonstrated that immediate early genes can be differentially activated within the central nervous system. We examined the effects of tetanic…”
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Porcine neural xenografts in the immunocompetent rat: immune response following grafting of expanded neural precursor cells by Armstrong, R.J.E, Harrower, T.P, Hurelbrink, C.B, McLaughin, M, Ratcliffe, E.L, Tyers, P, Richards, A, Dunnett, S.B, Rosser, A.E, Barker, R.A

“…Intracerebral neural xenografts elicit a host immune response that results in their rapid rejection. This forms a key barrier to the therapeutic use of…”
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Increased survival of rat EGF-generated CNS precursor cells using B27 supplemented medium by SVENDSEN, C. N, FAWCETT, J. W, BENTLAGE, C, DUNNETT, S. B

“…Previous studies suggest that a population of precursor cells from the developing and adult mouse striatum can be expanded in culture using serum-free,…”
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Targeting the subthalamic nucleus in the treatment of Parkinson’s disease by Henderson, J.M, Dunnett, S.B

“…As more is learnt about the functional implications of basal ganglia connectivity, the role of the subthalamic nucleus as a target site for stereotactic…”
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Effects of Surgical Anaesthesia on the Viability of Nigral Grafts in the Rat Striatum by S.B. Dunnett, E.M. Torres, H. Richards, R.A. Barker

“…Only a small proportion of dopamine neurons in nigral grafts typically survive transplantation into the adult striatum. Since many anaesthetics reduce blood…”
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Amelioration of non-motor dysfunctions after transplantation of human dopamine neurons in a model of Parkinson's disease by Lelos, M.J., Morgan, R.J., Kelly, C.M., Torres, E.M., Rosser, A.E., Dunnett, S.B.

“…Patients suffering from Parkinson's disease (PD) display cognitive and neuropsychiatric dysfunctions, especially with disease progression. Although these…”
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Technical factors that influence neural transplant safety in Huntington's disease by Freeman, T.B., Cicchetti, F., Bachoud-Lévi, A.C., Dunnett, S.B.

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