Search Results - "Dunnen, Wilfred den"

Mesenchymal Differentiation Mediated by NF-κB Promotes Radiation Resistance in Glioblastoma by Bhat, Krishna P.L., Balasubramaniyan, Veerakumar, Vaillant, Brian, Ezhilarasan, Ravesanker, Hummelink, Karlijn, Hollingsworth, Faith, Wani, Khalida, Heathcock, Lindsey, James, Johanna D., Goodman, Lindsey D., Conroy, Siobhan, Long, Lihong, Lelic, Nina, Wang, Suzhen, Gumin, Joy, Raj, Divya, Kodama, Yoshinori, Raghunathan, Aditya, Olar, Adriana, Joshi, Kaushal, Pelloski, Christopher E., Heimberger, Amy, Kim, Se Hoon, Cahill, Daniel P., Rao, Ganesh, Den Dunnen, Wilfred F.A., Boddeke, Hendrikus W.G.M., Phillips, Heidi S., Nakano, Ichiro, Lang, Frederick F., Colman, Howard, Sulman, Erik P., Aldape, Kenneth

“…Despite extensive study, few therapeutic targets have been identified for glioblastoma (GBM). Here we show that patient-derived glioma sphere cultures (GSCs)…”
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Hypoxia enhances migration and invasion in glioblastoma by promoting a mesenchymal shift mediated by the HIF1α–ZEB1 axis by Joseph, Justin V, Conroy, Siobhan, Pavlov, Kirill, Sontakke, Pallavi, Tomar, Tushar, Eggens-Meijer, Ellie, Balasubramaniyan, Veerakumar, Wagemakers, Michiel, den Dunnen, Wilfred F.A, Kruyt, Frank A.E

“…Highlights • Hypoxia is a potent cell specific inducer of mesenchymal trans-differentiation in GBM cells in vitro and also appears to occur in patient…”
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Single-cell whole genome sequencing reveals no evidence for common aneuploidy in normal and Alzheimer's disease neurons by van den Bos, Hilda, Spierings, Diana C J, Taudt, Aaron S, Bakker, Bjorn, Porubský, David, Falconer, Ester, Novoa, Carolina, Halsema, Nancy, Kazemier, Hinke G, Hoekstra-Wakker, Karina, Guryev, Victor, den Dunnen, Wilfred F A, Foijer, Floris, Tatché, Maria Colomé, Boddeke, Hendrikus W G M, Lansdorp, Peter M

“…Alzheimer's disease (AD) is a neurodegenerative disease of the brain and the most common form of dementia in the elderly. Aneuploidy, a state in which cells…”
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VISTA expression by microglia decreases during inflammation and is differentially regulated in CNS diseases by Borggrewe, Malte, Grit, Corien, Den Dunnen, Wilfred F. A., Burm, Saskia M., Bajramovic, Jeffrey J., Noelle, Randolph J., Eggen, Bart J. L., Laman, Jon D.

“…V‐type immunoglobulin domain‐containing suppressor of T‐cell activation (VISTA) is a negative checkpoint regulator (NCR) involved in inhibition of T…”
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COVID‐19: immunopathology, pathophysiological mechanisms, and treatment options by Eijk, Larissa E, Binkhorst, Mathijs, Bourgonje, Arno R, Offringa, Annette K, Mulder, Douwe J, Bos, Eelke M, Kolundzic, Nikola, Abdulle, Amaal E, Voort, Peter HJ, Olde Rikkert, Marcel GM, Hoeven, Johannes G, Dunnen, Wilfred FA, Hillebrands, Jan‐Luuk, Goor, Harry

“…Coronavirus disease 2019 (COVID‐19), caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), continues to spread globally despite the worldwide…”
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Neurofibromatosis type 1 associated low grade gliomas: A comparison with sporadic low grade gliomas by Helfferich, Jelte, Nijmeijer, Ronald, Brouwer, Oebele F, Boon, Maartje, Fock, Annemarie, Hoving, Eelco W, Meijer, Lisethe, den Dunnen, Wilfred F.A, de Bont, Eveline S.J.M

“…Abstract Neurofibromatosis type 1 (NF1) is an autosomal dominant disorder, associated with a variable clinical phenotype including café-au-lait spots,…”
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CD146 increases stemness and aggressiveness in glioblastoma and activates YAP signaling by Liang, Yuanke, Voshart, Daniëlle, Paridaen, Judith T. M. L., Oosterhof, Nynke, Liang, Dong, Thiruvalluvan, Arun, Zuhorn, Inge S., den Dunnen, Wilfred F. A., Zhang, Guojun, Lin, Haoyu, Barazzuol, Lara, Kruyt, Frank A. E.

“…Glioblastoma (GBM), a highly malignant and lethal brain tumor, is characterized by diffuse invasion into the brain and chemo-radiotherapy resistance resulting…”
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Mutations in potassium channel kcnd3 cause spinocerebellar ataxia type 19 by Duarri, Anna, Jezierska, Justyna, Fokkens, Michiel, Meijer, Michel, Schelhaas, Helenius J., den Dunnen, Wilfred F. A., van Dijk, Freerk, Verschuuren-Bemelmans, Corien, Hageman, Gerard, van de Vlies, Pieter, Küsters, Benno, van de Warrenburg, Bart P., Kremer, Berry, Wijmenga, Cisca, Sinke, Richard J., Swertz, Morris A., Kampinga, Harm H., Boddeke, Erik, Verbeek, Dineke S.

“…Objective: To identify the causative gene for the neurodegenerative disorder spinocerebellar ataxia type 19 (SCA19) located on chromosomal region 1p21‐q21…”
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Frequency of nuclear mutant huntingtin inclusion formation in neurons and glia is cell‐type‐specific by Jansen, Anne H.P., van Hal, Maurik, op den Kelder, Ilse C., Meier, Romy T., de Ruiter, Anna‐Aster, Schut, Menno H., Smith, Donna L., Grit, Corien, Brouwer, Nieske, Kamphuis, Willem, Boddeke, H.W.G.M., den Dunnen, Wilfred F.A., van Roon, Willeke M.C., Bates, Gillian P., Hol, Elly M., Reits, Eric A.

“…Huntington's disease (HD) is an autosomal dominant inherited neurodegenerative disorder that is caused by a CAG expansion in the Huntingtin (HTT) gene, leading…”
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The Potential of Ferroptosis-Targeting Therapies for Alzheimer's Disease: From Mechanism to Transcriptomic Analysis by Majerníková, Nad'a, den Dunnen, Wilfred F A, Dolga, Amalia M

“…Alzheimer's disease (AD), the most common form of dementia, currently affects 40-50 million people worldwide. Despite the extensive research into amyloid β…”
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ER stress and UPR activation in glioblastoma: identification of a noncanonical PERK mechanism regulating GBM stem cells through SOX2 modulation by Peñaranda-Fajardo, Natalia M., Meijer, Coby, Liang, Yuanke, Dijkstra, Bianca M., Aguirre-Gamboa, Raul, den Dunnen, Wilfred F. A., Kruyt, Frank A. E.

“…Patients with aggressive brain tumors, named glioblastoma multiforme (GBM), have a poor prognoses. Here we explored if the ER stress/unfolded protein response…”
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Genotype―phenotype correlations in spastic paraplegia type 7: a study in a large Dutch cohort by VAN GASSEN, Koen L. I, VAN DER HEIJDEN, Charlotte D. C. C, VAN DE WARRENBURG, Bart P, DE BOT, Susanne T, DEN DUNNEN, Wilfred F. A, VAN DEN BERG, Leonard H, VERSCHUUREN-BEMELMANS, Corien C, KREMER, H. P. H, VELDINK, Jan H, KAMSTEEG, Erik-Jan, SCHEFFER, Hans

“…Spastic paraplegia type 7 is an autosomal recessive neurodegenerative disorder mainly characterized by progressive bilateral lower limb spasticity and referred…”
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Distinct amyloid-β and tau-associated microglia profiles in Alzheimer’s disease by Gerrits, Emma, Brouwer, Nieske, Kooistra, Susanne M., Woodbury, Maya E., Vermeiren, Yannick, Lambourne, Mirjam, Mulder, Jan, Kummer, Markus, Möller, Thomas, Biber, Knut, Dunnen, Wilfred F. A. den, De Deyn, Peter P., Eggen, Bart J. L., Boddeke, Erik W. G. M.

“…Alzheimer’s disease (AD) is the most prevalent form of dementia and is characterized by abnormal extracellular aggregates of amyloid-β and intraneuronal…”
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Glioblastoma and its treatment are associated with extensive accelerated brain aging by Ainslie, Anna P., Klaver, Myrthe, Voshart, Daniëlle C., Gerrits, Emma, Dunnen, Wilfred F. A., Eggen, Bart J. L., Bergink, Steven, Barazzuol, Lara

“…Progressive neurocognitive dysfunction is the leading cause of a reduced quality of life in patients with primary brain tumors. Understanding how the human…”
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MGMT-STP27 Methylation Status as Predictive Marker for Response to PCV in Anaplastic Oligodendrogliomas and Oligoastrocytomas. A Report from EORTC Study 26951 by VAN DEN BENT, Martin J, ERDEM-ERASLAN, Lale, KROS, Johan M, GORLIA, Thierry, FRENCH, Pim J, IDBAIH, Ahmed, DE ROOI, Johan, EILERS, Paul H. C, SPLIET, Wim G. M, DEN DUNNEN, Wilfred F. A, TIJSSEN, Cees, WESSELING, Pieter, SILLEVIS SMITT, Peter A. E

“…The long-term follow-up results from the EORTC-26951 trial showed that the addition of procarbazine, CCNU, and vincristine (PCV) after radiotherapy increases…”
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Feasibility of bevacizumab-IRDye800CW as a tracer for fluorescence-guided meningioma surgery by Dijkstra, Bianca M, Nonnekens, Julie, Nagengast, Wouter, Kruijff, Schelto, Meersma, Gert Jan, den Dunnen, Wilfred F A, Kruyt, Frank A E, Groen, Rob J M

“…Meningiomas are frequently occurring, often benign intracranial tumors. Molecular fluorescence can be used to intraoperatively identify residual meningioma…”
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Possible Obesogenic Effects of Bisphenols Accumulation in the Human Brain by Charisiadis, Pantelis, Andrianou, Xanthi D., van der Meer, Thomas P., den Dunnen, Wilfred F. A., Swaab, Dick F., Wolffenbuttel, Bruce H. R., Makris, Konstantinos C., van Vliet-Ostaptchouk, Jana V.

“…Evidence of bisphenols’ obesogenic effects on humans is mixed and inconsistent. We aimed to explore the presence of bisphenol A (BPA), bisphenol F (BPF) and…”
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Intrinsic Molecular Subtypes of Glioma Are Prognostic and Predict Benefit From Adjuvant Procarbazine, Lomustine, and Vincristine Chemotherapy in Combination With Other Prognostic Factors in Anaplastic Oligodendroglial Brain Tumors: A Report From EORTC Study 26951 by ERDEM-ERASLAN, Lale, GRAVENDEEL, Lonneke A, KROS, Johan M, GORLIA, Thierry, VAN DEN BENT, Martin J, FRENCH, Pim J, DE ROOI, Johan, EILERS, Paul H. C, IDBAIH, Ahmed, SPLIET, Wim G. M, DEN DUNNEN, Wilfred F. A, TEEPEN, Johannes L, WESSELING, Pieter, SILLEVIS SMITT, Peter A. E

“…Intrinsic glioma subtypes (IGSs) are molecularly similar tumors that can be identified based on unsupervised gene expression analysis. Here, we have evaluated…”
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Involvement of the cerebellum in Parkinson disease and dementia with Lewy bodies by Seidel, Kay, Bouzrou, Mohamed, Heidemann, Nina, Krüger, Rejko, Schöls, Ludger, den Dunnen, Wilfred F. A., Korf, Horst‐Werner, Rüb, Udo

“…Brains from patients with Parkinson disease or dementia with Lewy bodies show aggregation of alpha‐synuclein in precerebellar brainstem structures…”
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On the distribution of intranuclear and cytoplasmic aggregates in the brainstem of patients with spinocerebellar ataxia type 2 and 3 by Seidel, Kay, Siswanto, Sonny, Fredrich, Michaela, Bouzrou, Mohamed, den Dunnen, Wilfred F.A., Özerden, Inci, Korf, Horst‐Werner, Melegh, Bela, de Vries, Jeroen J., Brunt, Ewout R., Auburger, Georg, Rüb, Udo

“…The polyglutamine (polyQ) diseases are a group of genetically and clinically heterogeneous neurodegenerative diseases, characterized by the expansion of polyQ…”
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