Search Results - "Dunn, Sandra E."

YB-1: oncoprotein, prognostic marker and therapeutic target? by Lasham, Annette, Print, Cristin G, Woolley, Adele G, Dunn, Sandra E, Braithwaite, Antony W

“…Hanahan and Weinberg have proposed the 'hallmarks of cancer' to cover the biological changes required for the development and persistence of tumours [Hanahan…”
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Concise Review: Bullseye: Targeting Cancer Stem Cells to Improve the Treatment of Gliomas by Repurposing Disulfiram by Triscott, Joanna, Rose Pambid, Mary, Dunn, Sandra E.

“…Cancer stem cells (CSCs) are thought to be at the root of cancer recurrence because they resist conventional therapies and subsequently reinitiate tumor cell…”
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Identification of ROCK1 kinase as a critical regulator of Beclin1-mediated autophagy during metabolic stress by Gurkar, Aditi U., Chu, Kiki, Raj, Lakshmi, Bouley, Richard, Lee, Seung-Hwan, Kim, Young-Bum, Dunn, Sandra E., Mandinova, Anna, Lee, Sam W.

“…The Ser/Thr Rho kinase 1 (ROCK1) is known to have major roles in a wide range of cellular activities, including those involved in tumour metastasis and…”
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Phosphorylated Insulin-Like Growth Factor-I/Insulin Receptor Is Present in All Breast Cancer Subtypes and Is Related to Poor Survival by LAW, Jennifer H, HABIBI, Golareh, NICHOLSON, Robert I, CARBONI, Joan, GOTTARDIS, Marco, POLLAK, Michael, DUNN, Sandra E, KAIJI HU, MASOUDI, Hamid, WANG, Michelle Y. C, STRATFORD, Anna L, PARK, Eugene, GEE, Julia M. W, FINLAY, Pauline, JONES, Helen E

“…Drugs that target the insulin-like growth factor-I receptor (IGF-IR) and/or insulin receptor (IR) are currently under investigation for a variety of…”
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YB-1 Expression and Phosphorylation Regulate Tumorigenicity and Invasiveness in Melanoma by Influencing EMT by Kosnopfel, Corinna, Sinnberg, Tobias, Sauer, Birgit, Busch, Christian, Niessner, Heike, Schmitt, Anja, Forchhammer, Stephan, Grimmel, Cornelia, Mertens, Peter R, Hailfinger, Stephan, Dunn, Sandra E, Garbe, Claus, Schittek, Birgit

“…Cutaneous melanoma represents one of the most aggressive human tumor entities possessing a high tendency to metastasize. Cancer cells frequently exploit a…”
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Inhibition of p90 ribosomal S6 kinases disrupts melanoma cell growth and immune evasion by Kosnopfel, Corinna, Wendlinger, Simone, Niessner, Heike, Siewert, Johannes, Sinnberg, Tobias, Hofmann, Angelika, Wohlfarth, Jonas, Schrama, David, Berthold, Marion, Siedel, Claudia, Sauer, Birgit, Jayanthan, Aarthi, Lenz, Georg, Dunn, Sandra E, Schilling, Bastian, Schittek, Birgit

“…The mitogen-activated protein kinase (MAPK) signaling pathway is frequently hyperactivated in malignant melanoma and its inhibition has proved to be an…”
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Y-Box Binding Protein-1 Induces the Expression of CD44 and CD49f Leading to Enhanced Self-Renewal, Mammosphere Growth, and Drug Resistance by TO, Karen, FOTOVATI, Abbas, RAOUF, Afshin, JOHNSON, Pauline, BERQUIN, Isabelle M, ROYER, Hans-Dieter, EAVES, Connie J, DUNN, Sandra E, REIPAS, Kristen M, LAW, Jennifer H, KAIJI HU, JING WANG, ASTANEHE, Arezoo, DAVIES, Alastair H, LEE, Lawrence, STRATFORD, Anna L

“…Y-box binding protein-1 (YB-1) is an oncogenic transcription/translation factor expressed in >40% of breast cancers, where it is associated with poor…”
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Targeting p90 Ribosomal S6 Kinase Eliminates Tumor-Initiating Cells by Inactivating Y-Box Binding Protein-1 in Triple-Negative Breast Cancers by Stratford, Anna L., Reipas, Kristen, Hu, Kaiji, Fotovati, Abbas, Brough, Rachel, Frankum, Jessica, Takhar, Mandeep, Watson, Peter, Ashworth, Alan, Lord, Christopher J., Lasham, Annette, Print, Cristin G., Dunn, Sandra E.

“…Y‐box binding protein‐1 (YB‐1) is the first reported oncogenic transcription factor to induce the tumor‐initiating cell (TIC) surface marker CD44 in…”
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Interplay between YB-1 and IL-6 promotes the metastatic phenotype in breast cancer cells by Castellana, Bàrbara, Aasen, Trond, Moreno-Bueno, Gema, Dunn, Sandra E, Ramón y Cajal, Santiago

“…Epithelial to mesenchymal transition (EMT) induces cell plasticity and promotes metastasis. The multifunctional oncoprotein Y-box binding protein-1 (YB-1) and…”
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YB‐1 Transforms Human Mammary Epithelial Cells Through Chromatin Remodeling Leading to the Development of Basal‐Like Breast Cancer by Davies, Alastair H., Reipas, Kristen M., Pambid, Mary Rose, Berns, Rachel, Stratford, Anna L., Fotovati, Abbas, Firmino, Natalie, Astanehe, Arezoo, Hu, Kaiji, Maxwell, Christopher, Mills, Gordon B., Dunn, Sandra E.

“…There is growing evidence that cancer‐initiation could result from epigenetic changes. Y‐box binding protein‐1 (YB‐1) is a transcription/translation factor…”
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Targeting YB-1 in HER-2 overexpressing breast cancer cells induces apoptosis via the mTOR/STAT3 pathway and suppresses tumor growth in mice by Lee, Cathy, Dhillon, Jaspreet, Wang, Michelle Y C, Gao, Yuanyuan, Hu, Kaiji, Park, Eugene, Astanehe, Arezoo, Hung, Mien-Chie, Eirew, Peter, Eaves, Connie J, Dunn, Sandra E

“…The Y-box binding protein-1 (YB-1) is a transcription/translation factor that is highly expressed in primary breast tumors where it is consistently associated…”
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Molecular Profiling Identifies Prognostic Subgroups of Pediatric Glioblastoma and Shows Increased YB-1 Expression in Tumors by FAURY, Damien, NANTEL, André, LOPEZ-AGUILAR, Enrique, VALERA, Elvis T, TONE, Luis G, CARRET, Anne-Sophie, DEL MAESTRO, Rolando F, GLEAVE, Martin, MONTES, Jose-Luis, PIETSCH, Torsten, ALBRECHT, Stephen, JABADO, Nada, DUNN, Sandra E, GUIOT, Marie-Christine, HAQUE, Takrima, HAUSER, Péter, GARAMI, Miklos, BOGNDR, Laszlo, HANZELY, Zoltan, LIBERSKI, Pawel P

“…Pediatric glioblastoma (pGBM) is a rare, but devastating brain tumor. In contrast to GBM in adults (aGBM), little is known about the mechanisms underlying its…”
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EZH2 expression is a prognostic factor in childhood intracranial ependymoma: A Canadian Pediatric Brain Tumor Consortium study by Li, Amanda M., Dunham, Christopher, Tabori, Uri, Carret, Anne‐Sophie, McNeely, P. Daniel, Johnston, Donna, Lafay‐Cousin, Lucie, Wilson, Beverly, Eisenstat, David D., Jabado, Nada, Zelcer, Shayna, Silva, Mariana, Scheinemann, Katrin, Fryer, Christopher, Hendson, Glenda, Fotovati, Abbas, Hawkins, Cynthia, Yip, Stephen, Dunn, Sandra E., Hukin, Juliette

“…BACKGROUND The cure rate for childhood intracranial ependymoma is approximately 70% in the setting of a gross total resection followed by radiation, but…”
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YB-1 Bridges Neural Stem Cells and Brain Tumor―Initiating Cells via Its Roles in Differentiation and Cell Growth by FOTOVATI, Abbas, ABU-ALI, Samah, UCHIUMI, Takeshi, KUWANO, Michihiko, LEAVITT, Blair R, SINGH, Sheila K, JURY, Alexa, JONES, Chris, WAKIMOTO, Hiroaki, REYNOLDS, Brent A, PALLEN, Catherine J, DUNN, Sandra E, WANG, Pei-Shan, DELEYROLLE, Loic P, LEE, Cathy, TRISCOTT, Joanna, CHEN, James Y, FRANCIOSI, Sonia, NAKAMURA, Yasuhiro, SUGITA, Yasuo

“…The Y-box binding protein 1 (YB-1) is upregulated in many human malignancies including glioblastoma (GBM). It is also essential for normal brain development,…”
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Redefining prognostic factors for breast cancer: YB-1 is a stronger predictor of relapse and disease-specific survival than estrogen receptor or HER-2 across all tumor subtypes by Habibi, Golareh, Leung, Samuel, Law, Jennifer H, Gelmon, Karen, Masoudi, Hamid, Turbin, Dmitry, Pollak, Michael, Nielsen, Torsten O, Huntsman, David, Dunn, Sandra E

“…Gene expression analysis is used to subtype breast cancers such that the most aggressive tumors are identified, but translating this into clinical practice can…”
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Molecular decoy to the Y-box binding protein-1 suppresses the growth of breast and prostate cancer cells whilst sparing normal cell viability by Law, Jennifer H, Li, Yvonne, To, Karen, Wang, Michelle, Astanehe, Arezoo, Lambie, Karen, Dhillon, Jaspreet, Jones, Steven J M, Gleave, Martin E, Eaves, Connie J, Dunn, Sandra E

“…The Y-box binding protein-1 (YB-1) is an oncogenic transcription/translation factor that is activated by phosphorylation at S102 whereby it induces the…”
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Akt phosphorylates the Y-box binding protein 1 at Ser102 located in the cold shock domain and affects the anchorage-independent growth of breast cancer cells by SUTHERLAND, Brent W, KUCAB, Jill, LEIGHTON GRIMES, H, MILLER, Kathy, BADVE, Sunil, HUNTSMAN, David, BLAKE-GILKS, C, MIN CHEN, PALLEN, Catherine J, DUNN, Sandra E, WU, Joyce, LEE, Cathy, CHEANG, Maggie C. U, YORIDA, Erika, TURBIN, Dmitry, DEDHAR, Shoukat, NELSON, Colleen, POLLAK, Michael

“…Akt/PKB is a serine/threonine kinase that promotes tumor cell growth by phosphorylating transcription factors and cell cycle proteins. There is particular…”
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Disruption of the Y-box binding protein-1 results in suppression of the epidermal growth factor receptor and HER-2 by WU, Joyce, LEE, Cathy, GILKS, C. Blake, DUNN, Sandra E, YOKOM, Daniel, JIANG, Helen, CHEANG, Maggie C. U, YORIDA, Erika, TURBIN, Dmitry, BERQUIN, Isabelle M, MERTENS, Peter R, IFTNER, Thomas

“…The overexpression of the epidermal growth factor receptor (EGFR) and HER-2 underpin the growth of aggressive breast cancer; still, it is unclear what governs…”
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Small interfering RNA library screen of human kinases and phosphatases identifies polo-like kinase 1 as a promising new target for the treatment of pediatric rhabdomyosarcomas by Hu, Kaiji, Lee, Cathy, Qiu, Dexin, Fotovati, Abbas, Davies, Alastair, Abu-Ali, Samah, Wai, Daniel, Lawlor, Elizabeth R, Triche, Timothy J, Pallen, Catherine J, Dunn, Sandra E

“…Rhabdomyosarcoma, consisting of alveolar (aRMS) and embryonal (eRMS) subtypes, is the most common type of sarcoma in children. Currently, there are no targeted…”
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Mechanisms underlying p53 regulation of PIK3CA transcription in ovarian surface epithelium and in ovarian cancer by Astanehe, Arezoo, Arenillas, David, Wasserman, Wyeth W, Leung, Peter C.K, Dunn, Sandra E, Davies, Barry R, Mills, Gordon B, Auersperg, Nelly

“…Inactivation of the transcription factor and tumor suppressor p53, and overexpression or mutational activation of PIK3CA, which encodes the p110α catalytic…”
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