Search Results - "Dunn, R. Scott"

Neurofibroma-associated macrophages play roles in tumor growth and response to pharmacological inhibition by Prada, Carlos E., Jousma, Edwin, Rizvi, Tilat A., Wu, Jianqiang, Dunn, R. Scott, Mayes, Debra A., Cancelas, Jose A., Dombi, Eva, Kim, Mi-Ok, West, Brian L., Bollag, Gideon, Ratner, Nancy

“…Neurofibromatosis type 1 (NF1) is a common genetic disease that predisposes 30–50 % of affected individuals to develop plexiform neurofibromas. We found that…”
Get full text

Impaired neural differentiation and glymphatic CSF flow in the Ccdc39 rat model of neonatal hydrocephalus: genetic interaction with L1cam by Emmert, A Scott, Iwasawa, Eri, Shula, Crystal, Schultz, Preston, Lindquist, Diana, Dunn, R Scott, Fugate, Elizabeth M, Hu, Yueh-Chiang, Mangano, Francesco T, Goto, June

“…Neonatal hydrocephalus affects about one child per 1000 births and is a major congenital brain abnormality. We previously discovered a gene mutation within the…”
Get full text

Synergy of combined tPA-edaravone therapy in experimental thrombotic stroke by Sun, Yu-Yo, Morozov, Yury M, Yang, Dianer, Li, Yikun, Dunn, R Scott, Rakic, Pasko, Chan, Pak H, Abe, Koji, Lindquist, Diana M, Kuan, Chia-Yi

“…Edaravone, a potent antioxidant, may improve thrombolytic therapy because it benefits ischemic stroke patients on its own and mitigates adverse effects of…”
Get full text

Preclincial testing of Sorafenib and RAD001 in the Nfflox/flox;DhhCre mouse model of plexiform neurofibroma using magnetic resonance imaging by Wu, Jianqiang, Dombi, Eva, Jousma, Edwin, Scott Dunn, R., Lindquist, Diana, Schnell, Beverly M., Kim, Mi-Ok, Kim, AeRang, Widemann, Brigitte C., Cripe, Timothy P., Ratner, Nancy

“…Background Neurofibromatosis type 1 (NF1) is an inherited disease predisposing affected patients to variable numbers of benign neurofibromas. To date there are…”
Get full text

Therapeutic Administration of Plasminogen Activator Inhibitor-1 Prevents Hypoxic-Ischemic Brain Injury in Newborns by Yang, Dianer, Nemkul, Niza, Shereen, Ahmed, Jone, Alice, Dunn, R. Scott, Lawrence, Daniel A, Lindquist, Diana, Kuan, Chia-Yi

“…Disruption of the integrity of the blood-brain barrier (BBB) is an important mechanism of cerebrovascular diseases, including neonatal cerebral…”
Get full text

CMV infection attenuates the disease course in a murine model of multiple sclerosis by Pirko, Istvan, Cardin, Rhonda, Chen, Yi, Lohrey, Anne K, Lindquist, Diana M, Dunn, R Scott, Zivadinov, Robert, Johnson, Aaron J

“…Recent evidence in multiple sclerosis (MS) suggests that active CMV infection may result in more benign clinical disease. The goal of this pilot study was to…”
Get full text

Practical Aspects of Conducting Large-Scale Functional Magnetic Resonance Imaging Studies in Children by Byars, Anna Weber, Holland, Scott K., Strawsburg, Richard H., Bommer, Wendy, Dunn, R. Scott, Schmithorst, Vince J., Plante, Elena

“…The potential benefits of functional magnetic resonance imaging (MRI) for the investigation of normal development have been limited by difficulties in its use…”
Get full text

Contrasting roles for CD4 vs. CD8 T-cells in a murine model of virally induced "T1 black hole" formation by Pirko, Istvan, Chen, Yi, Lohrey, Anne K, McDole, Jeremiah, Gamez, Jeffrey D, Allen, Kathleen S, Pavelko, Kevin D, Lindquist, Diana M, Dunn, R Scott, Macura, Slobodan I, Johnson, Aaron J

“…MRI is sensitive to tissue pathology in multiple sclerosis (MS); however, most lesional MRI findings have limited correlation with disability. Chronic T1…”
Get full text

Intranasal delivery of cell-penetrating anti-NF-κB peptides (Tat-NBD) alleviates infection-sensitized hypoxic–ischemic brain injury by Yang, Dianer, Sun, Yu-Yo, Lin, Xiaoyi, Baumann, Jessica M., Dunn, R. Scott, Lindquist, Diana M., Kuan, Chia-Yi

“…Perinatal infection aggravates neonatal hypoxic–ischemic (HI) brain injury and may interfere with therapeutic hypothermia. While the NF-κB signaling pathway…”
Get full text

Blocking lymphocyte trafficking with FTY720 prevents inflammation-sensitized hypoxic-ischemic brain injury in newborns by Yang, Dianer, Sun, Yu-Yo, Bhaumik, Siddhartha Kumar, Li, Yikun, Baumann, Jessica M, Lin, Xiaoyi, Zhang, Yujin, Lin, Shang-Hsuan, Dunn, R Scott, Liu, Chia-Yang, Shie, Feng-Shiun, Lee, Yi-Hsuan, Wills-Karp, Marsha, Chougnet, Claire A, Kallapur, Suhas G, Lewkowich, Ian P, Lindquist, Diana M, Murali-Krishna, Kaja, Kuan, Chia-Yi

“…Intrauterine infection (chorioamnionitis) aggravates neonatal hypoxic-ischemic (HI) brain injury, but the mechanisms linking systemic inflammation to the CNS…”
Get full text

Cerebral Ischemia-Hypoxia Induces Intravascular Coagulation and Autophagy by Adhami, Faisal, Liao, Guanghong, Morozov, Yury M., Schloemer, Aryn, Schmithorst, Vincent J., Lorenz, John N., Dunn, R. Scott, Vorhees, Charles V., Wills-Karp, Marsha, Degen, Jay L., Davis, Roger J., Mizushima, Noboru, Rakic, Pasko, Dardzinski, Bernard J., Holland, Scott K., Sharp, Frank R., Kuan, Chia-Yi

“…Hypoxia is a critical factor for cell death or survival in ischemic stroke, but the pathological consequences of combined ischemia-hypoxia are not fully…”
Get full text

Ex Vivo Diffusion Tensor Imaging and Neuropathological Correlation in a Murine Model of Hypoxia–Ischemia-Induced Thrombotic Stroke by Shereen, Ahmed, Nemkul, Niza, Yang, Dianer, Adhami, Faisal, Dunn, R Scott, Hazen, Missy L, Nakafuku, Masato, Ning, Gang, Lindquist, Diana M, Kuan, Chia-Yi

“…Diffusion tensor imaging (DTI) is a powerful method to visualize white matter, but its use in patients with acute stroke remains limited because of the lack of…”
Get full text

Magnetic resonance imaging of disease progression and resolution in a transgenic mouse model of pulmonary fibrosis by Cleveland, Zackary I, Zhou, Yu M, Akinyi, Teckla G, Dunn, R Scott, Davidson, Cynthia R, Guo, Jinbang, Woods, Jason C, Hardie, William D

“…Pulmonary fibrosis contributes to morbidity and mortality in a range of diseases, and there are no approved therapies for reversing its progression. To…”
Get more information

Plasminogen activator inhibitor-1 mitigates brain injury in a rat model of infection-sensitized neonatal hypoxia-ischemia by Yang, Dianer, Sun, Yu-Yo, Nemkul, Niza, Baumann, Jessica M, Shereen, Ahmed, Dunn, R Scott, Wills-Karp, Marsha, Lawrence, Daniel A, Lindquist, Diana M, Kuan, Chia-Yi

“…Intrauterine infection exacerbates neonatal hypoxic-ischemic (HI) brain injury and impairs the development of cerebral cortex. Here we used low-dose…”
Get full text

Preclincial testing of sorafenib and RAD001 in the Nf(flox/flox) ;DhhCre mouse model of plexiform neurofibroma using magnetic resonance imaging by Wu, Jianqiang, Dombi, Eva, Jousma, Edwin, Scott Dunn, R, Lindquist, Diana, Schnell, Beverly M, Kim, Mi-Ok, Kim, Aerang, Widemann, Brigitte C, Cripe, Timothy P, Ratner, Nancy

“…Neurofibromatosis type 1 (NF1) is an inherited disease predisposing affected patients to variable numbers of benign neurofibromas. To date there are no…”
Get full text

NMR relaxation times in the human brain at 3.0 tesla by Wansapura, Janaka P., Holland, Scott K., Dunn, R. Scott, Ball Jr, William S.

“…Relaxation time measurements at 3.0 T are reported for both gray and white matter in normal human brain. Measurements were made using a 3.0 T Bruker Biospec…”
Get full text

Brain atrophy correlates with functional outcome in a murine model of multiple sclerosis by Pirko, I., Johnson, A.J., Chen, Yi, Lindquist, D.M., Lohrey, A.K., Ying, J., Dunn, R. Scott

“…White matter (WM) lesions are the classic pathological hallmarks of multiple sclerosis (MS). However, MRI-based WM lesion load shows relatively poor…”
Get full text

Long term antipsychotic treatment does not alter metabolite concentrations in rat striatum: An in vivo magnetic resonance spectroscopy study by Lindquist, Diana M, Dunn, R. Scott, Cecil, Kim M

“…Abstract Proton magnetic resonance spectroscopy (MRS) studies of schizophrenic patients generally reveal reduced levels of N-acetyl aspartate (NAA) when…”
Get full text

Magnetic resonance imaging assessment of cardiac dysfunction in δ-sarcoglycan null mice by Wansapura, Janaka P, Millay, Douglas P, Dunn, R. Scott, Molkentin, Jeffery D, Benson, D. Woodrow

“…Abstract Delta-sarcoglycan (δ-sarcoglycan) null, Scgd−/− , mice develop cardiac and skeletal muscle histopathological alterations similar to those in humans…”
Get full text

Hypoglycemic Brain Injury: Potentiation From Respiratory Depression and Injury Aggravation From Hyperglycemic Treatment Overshoots by de Courten-Myers, Gabrielle M., Xi, Guohua, Hwang, Jong-Hee, Dunn, R. Scott, Mills, Ashley S., Holland, Scott K., Wagner, Kenneth R., Myers, Ronald E.

“…Hypoglycemia can cause brain dysfunction, brain injury, and death. The present study seeks to broaden current information regarding mechanisms of hypoglycemic…”
Get full text