Search Results - "Dunn, Philip M."

P2X2 knockout mice and P2X2/P2X3 double knockout mice reveal a role for the P2X2 receptor subunit in mediating multiple sensory effects of ATP by Cockayne, Debra A., Dunn, Philip M., Zhong, Yu, Rong, Weifang, Hamilton, Sara G., Knight, Gillian E., Ruan, Huai‐Zhen, Ma, Bei, Yip, Ping, Nunn, Philip, McMahon, Stephen B., Burnstock, Geoffrey, Ford, Anthony P. D. W.

“…Extracellular ATP plays a role in nociceptive signalling and sensory regulation of visceral function through ionotropic receptors variably composed of P2X 2…”
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ATP regulates the differentiation of mammalian skeletal muscle by activation of a P2X5 receptor on satellite cells by Ryten, Mina, Dunn, Philip M, Neary, Joseph T, Burnstock, Geoffrey

“…ATP is well known for its role as an intracellular energy source. However, there is increasing awareness of its role as an extracellular messenger molecule…”
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Multiple P2X and P2Y receptor subtypes in mouse J774, spleen and peritoneal macrophages by Coutinho-Silva, Robson, Ojcius, David M., Górecki, Darek C., Persechini, Pedro M., Bisaggio, Rodrigo C., Mendes, Anderson N., Marks, Joanne, Burnstock, Geoffrey, Dunn, Philip M.

“…We investigated P2 receptor expression and function in macrophages from mouse, and in the J774 cell line, and revealed a larger spectrum of P2 receptor…”
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SK3 is an important component of K+ channels mediating the afterhyperpolarization in cultured rat SCG neurones by Hosseini, Ramine, Benton, David C. H., Dunn, Philip M., Jenkinson, Donald H., Moss, Guy W. J.

“…Our aim was to identify the small-conductance Ca 2+ -activated K + channel(s) (SK) underlying the apamin-sensitive afterhyperpolarization (AHP) in rat superior…”
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Synthesis, Molecular Modeling, and Pharmacological Testing of Bis-Quinolinium Cyclophanes:  Potent, Non-Peptidic Blockers of the Apamin-Sensitive Ca2+-Activated K+ Channel by Campos Rosa, Joaquin, Galanakis, Dimitrios, Piergentili, Alessandro, Bhandari, Kalpana, Ganellin, C. Robin, Dunn, Philip M, Jenkinson, Donald H

“…The synthesis and pharmacological testing of two series of novel bis-quinolinium cyclophanes as blockers of the apamin-sensitive Ca2+-activated K+ (SKCa)…”
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Differential expression of P2X receptors on neurons from different parasympathetic ganglia by Ma, Bei, Ruan, Huai-Zhen, Burnstock, Geoffrey, Dunn, Philip M.

“…Whole-cell patch clamp recording and immunohistochemistry were used to investigate the expression of P2X receptors on rat parasympathetic ganglion neurons of…”
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Guinea-pig sympathetic neurons express varying proportions of two distinct P2X receptors by Zhong, Yu, Dunn, Philip M., Burnstock, Geoffrey

“…Characterization of P2X receptors on neurons of guinea-pig superior cervical ganglion (SCG) has been carried out using a whole-cell voltage-clamp technique…”
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P2X receptors in peripheral neurons by Dunn, P M, Zhong, Y, Burnstock, G

“…P2X receptors are a family of ligand-gated ion channels, activated by extracellular ATP. The seven subunits cloned (P2X1-7) can assemble to form homomeric and…”
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Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient mice by COCKAYNE, Debra A, HAMILTON, Sara G, HEDLEY, Linda, LACHNIT, Wilhelm G, BURNSTOCK, Geoffrey, MCMAHON, Stephen B, FORD, Anthony P. D. W, ZHU, Quan-Ming, DUNN, Philip M, YU ZHONG, NOVAKOVIC, Sanja, MALMBERG, Annika B, CAIN, Gary, BERSON, Amy, KASSOTAKIS, Laura

“…Extracellular ATP is implicated in numerous sensory processes ranging from the response to pain to the regulation of motility in visceral organs. The ATP…”
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Purinoceptor expression in regenerating skeletal muscle in the mdx mouse model of muscular dystrophy and in satellite cell cultures by Ryten, Mina, Yang, Shi Yu, Dunn, Philip M., Goldspink, Geoffrey, Burnstock, Geoffrey

“…ATP is an important extracellular signaling molecule mediating its effects by activation of P2X and P2Y receptors. P2 receptors are expressed during muscle…”
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Synthesis and pharmacological testing of polyaminoquinolines as blockers of the apamin-sensitive Ca2+ activated K+ channel (SKCa) by FLETCHER, David I, GANELLIN, C. Robin, PIERGENTILI, Alessandro, DUNN, Philip M, JENKINSON, Donald H

“…The synthesis and pharmacological testing of a series of non-peptidic blockers of the SK(Ca) (SK-3) channel is described. Target compounds were designed to…”
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Changes in P2X receptor responses of sensory neurons from P2X3-deficient mice by Zhong, Yu, Dunn, Philip M., Bardini, Michelle, Ford, Anthony P. D. W., Cockayne, Debra A., Burnstock, Geoffrey

“…Dorsal root ganglion (DRG) neurons respond to ATP with transient, persistent or biphasic inward currents. In contrast, the ATP responses in nodose neurons are…”
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Bis-quinolinium cyclophanes: toward a pharmacophore model for the blockade of apamin-sensitive SKCa channels in sympathetic neurons by GALANAKIS, Dimitrios, GANELLIN, C. Robin, CHEN, Jian-Quing, GUNASEKERA, Diyan, DUNN, Philip M

“…The synthesis, pharmacological evaluation, and molecular modeling studies of unsymmetrical bis-alkylene bis-quinolinium cyclophanes and xylylene-alkylene…”
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Chicken DT40 cells stably transfected with the rat P2X7 receptor ion channel: a system suitable for the study of purine receptor-mediated cell death by HILLMAN, Kate A, HARADA, Hitoshi, CHAN, Choong M, TOWNSEND-NICHOLSON, Andrea, MOSS, Stephen E, MIYAMOTO, Kengo, SUKETA, Yasunobu, BURNSTOCK, Geoffrey, UNWIN, Robert J, DUNN, Philip M

“…We have generated and characterised a clone of chicken DT40 lymphocytes stably transfected with the rat P2X(7) receptor (rP2X(7)). Successful transfection was…”
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Fertility: Purinergic receptors and the male contraceptive pill by Dunn, Philip M

“…Knockout mice lacking the P2X1 receptor appear normal, but fail to breed. Analysis of these mutant mice clearly shows that purinergic co-transmission has a…”
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Pharmacological comparison of P2X receptors on rat coeliac, mouse coeliac and mouse pelvic ganglion neurons by Zhong, Yu, Dunn, Philip M, Burnstock, Geoffrey

“…Characteristics of P2X receptors on neurons of the rat coeliac, mouse coeliac and mouse pelvic ganglia have been studied using the whole cell voltage-clamp…”
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Pharmacological and molecular characterization of P2X receptors in rat pelvic ganglion neurons by Zhong, Yu, Dunn, Philip M, Xiang, Zhenghua, Bo, Xuenong, Burnstock, Geoffrey

“…1 The presence and characteristics of P2X receptors on neurons of the rat major pelvic ganglia (MPG) have been studied using whole cell voltage‐clamp, in situ…”
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Identification of P2X receptors in cultured mouse and rat parasympathetic otic ganglion neurones including P2X knockout studies by Ma, Bei, Ruan, Huai-Zhen, Cockayne, Debra A, Ford, Anthony P.D.W, Burnstock, Geoffrey, Dunn, Philip M

“…We have used patch-clamp recording from cultured neurones, immunohistochemistry and gene deletion techniques to characterize the P2X receptors present in mouse…”
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Dequalinium, a selective blocker of the slow afterhyperpolarization in rat sympathetic neurones in culture by Dunn, P M

“…The actions of dequalinium have been investigated in cultured rat sympathetic neurones. It produced a rapid and reversible inhibition of the slow…”
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Northern ring conformation of methanocarba-adenosine 5′-triphosphate required for activation of P2X receptors by Dunn, Philip M., Kim, Hak Sung, Jacobson, Kenneth A., Burnstock, Geoffrey

“…Replacement of the ribose moiety of adenosine 5′‐triphosphate (ATP) with a carbocyclic ring constrained in either the Northern (N) or Southern (S) conformation…”
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