Search Results - "Dunn, Henry A."

Beyond the Ligand: Extracellular and Transcellular G Protein-Coupled Receptor Complexes in Physiology and Pharmacology by Dunn, Henry A, Orlandi, Cesare, Martemyanov, Kirill A

“…G protein-coupled receptors (GPCRs) remain one of the most successful targets of U.S. Food and Drug Administration-approved drugs. GPCR research has…”
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PDZ Protein Regulation of G Protein-Coupled Receptor Trafficking and Signaling Pathways by Dunn, Henry A, Ferguson, Stephen S G

“…G protein-coupled receptors (GPCRs) contribute to the regulation of every aspect of human physiology and are therapeutic targets for the treatment of numerous…”
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Interplay between cell-adhesion molecules governs synaptic wiring of cone photoreceptors by Cao, Yan, Wang, Yuchen, Dunn, Henry A., Orlandi, Cesare, Shultz, Nicole, Kamasawa, Naomi, Fitzpatrick, David, Li, Wei, Zeitz, Christina, Hauswirth, William, Martemyanov, Kirill A.

“…Establishment of functional synaptic connections in a selective manner is essential for nervous system operation. In mammalian retinas, rod and cone…”
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MAGI proteins can differentially regulate the signaling pathways of 5-HT 2A R by enhancing receptor trafficking and PLC recruitment by Hammad, Maha M, Dunn, Henry A, Ferguson, Stephen S G

“…MAGI proteins are Membrane-Associated Guanylate Kinase Inverted proteins that belong to the MAGUK family. They are scaffolding proteins that were shown to…”
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Role of Spinophilin in Group I Metabotropic Glutamate Receptor Endocytosis, Signaling, and Synaptic Plasticity by Di Sebastiano, Andrea R., Fahim, Sandra, Dunn, Henry A., Walther, Cornelia, Ribeiro, Fabiola M., Cregan, Sean P., Angers, Stephane, Schmid, Susanne, Ferguson, Stephen S.G.

“…Activation of Group I metabotropic glutamate receptors (mGluRs) activates signaling cascades, resulting in calcium release from intracellular stores, ERK1/2…”
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Role of SAP97 Protein in the Regulation of Corticotropin-releasing Factor Receptor 1 Endocytosis and Extracellular Signal-regulated Kinase 1/2 Signaling by Dunn, Henry A., Walther, Cornelia, Godin, Christina M., Hall, Randy A., Ferguson, Stephen S.G.

“…The corticotropin-releasing factor (CRF) receptor 1 (CRFR1) is a target for the treatment of psychiatric diseases such as depression, schizophrenia, anxiety…”
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Role of SAP97 in the regulation of 5-HT2AR endocytosis and signaling by Dunn, Henry A, Walther, Cornelia, Yuan, George Y, Caetano, Fabiana A, Godin, Christina M, Ferguson, Stephen S G

“…Serotonin (5-HT) interacts with a wide variety of 5-HT receptors (5-HTR) of which 5-HT2AR plays an important target for antidepressant and atypical…”
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Suppression of piriform cortex activity in rat by corticotropin-releasing factor 1 and serotonin 2A/C receptors by Narla, Chakravarthi, Dunn, Henry A, Ferguson, Stephen S G, Poulter, Michael O

“…The piriform cortex (PC) is richly innervated by corticotropin-releasing factor (CRF) and serotonin (5-HT) containing axons arising from central amygdala and…”
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ELFN2 is a postsynaptic cell adhesion molecule with essential roles in controlling group III mGluRs in the brain and neuropsychiatric behavior by Dunn, Henry A., Zucca, Stefano, Dao, Maria, Orlandi, Cesare, Martemyanov, Kirill A.

“…The functional characterization of the GPCR interactome has predominantly focused on intracellular binding partners; however, the recent emergence of…”
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Synaptic adhesion protein ELFN1 is a selective allosteric modulator of group III metabotropic glutamate receptors in trans by Dunn, Henry A., Patil, Dipak N., Cao, Yan, Orlandi, Cesare, Martemyanov, Kirill A.

“…Functional characterization of the GPCR interactome has been focused predominantly on intracellular interactions, yet GPCRs are increasingly found in complex…”
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Middle-Down Mass Spectrometry Reveals Activity-Modifying Phosphorylation Barcode in a Class C G Protein-Coupled Receptor by Ives, Ashley N., Dunn, Henry A., Afsari, Hamid Samareh, Seckler, Henrique dos Santos, Foroutan, Max J., Chavez, Erica, Melani, Rafael D., Fellers, Ryan T., LeDuc, Richard D., Thomas, Paul M., Martemyanov, Kirill A., Kelleher, Neil L., Vafabakhsh, Reza

“…G protein-coupled receptors (GPCRs) are the largest family of membrane receptors in humans. They mediate nearly all aspects of human physiology and thus are of…”
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Distinct Neuronal Expression Patterns of ELFN1 and ELFN2: Trans-synaptic Modulators of Group III mGluRs by Dunn, Henry A., Zucca, Stefano, Dao, Maria, Orlandi, Cesare, Martemyanov, Kirill A.

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Structural determinants governing β-arrestin2 interaction with PDZ proteins and recruitment to CRFR1 by Gupta, Sarah, Abd-Elrahman, Khaled S., Albaker, Awatif, Dunn, Henry A., Ferguson, Stephen S.G.

“…β-Arrestins are multifunctional adaptor proteins best know for their vital role in regulating G protein coupled receptor (GPCR) trafficking and signaling…”
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MAGI proteins can differentially regulate the signaling pathways of 5-HT2AR by enhancing receptor trafficking and PLC recruitment by Hammad, Maha M., Dunn, Henry A., Ferguson, Stephen S.G.

“…MAGI proteins are Membrane-Associated Guanylate Kinase Inverted proteins that belong to the MAGUK family. They are scaffolding proteins that were shown to…”
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PDZK1/NHERF3 Differentially Regulates Corticotropin-releasing Factor Receptor 1 and Serotonin 2A Receptor Signaling and Endocytosis by Walther, Cornelia, Caetano, Fabiana A., Dunn, Henry A., Ferguson, Stephen S.G.

“…The corticotropin-releasing factor receptor 1 (CRFR1) and serotonin 2A receptor (5-HT2AR) are linked to cellular mechanisms underlying stress anxiety and…”
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Role of cystic fibrosis transmembrane conductance regulator-associated ligand (CAL) in regulating the trafficking and signaling of corticotropin-releasing factor receptor 1 by Hammad, Maha M., Dunn, Henry A., Walther, Cornelia, Ferguson, Stephen S.G.

“…Corticotropin releasing factor (CRF) receptor1 (CRFR1) is associated with psychiatric illness and is a proposed target for the treatment of anxiety and…”
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PSD-95 regulates CRFR1 localization, trafficking and β-arrestin2 recruitment by Dunn, Henry A., Chahal, Harpreet S., Caetano, Fabiana A., Holmes, Kevin D., Yuan, George Y., Parikh, Ruchi, Heit, Bryan, Ferguson, Stephen S.G.

“…Corticotropin-releasing factor (CRF) is a neuropeptide commonly associated with the hypothalamic–pituitary adrenal axis stress response. Upon release, CRF…”
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MAGI Proteins Regulate the Trafficking and Signaling of Corticotropin-Releasing Factor Receptor 1 via a Compensatory Mechanism by Hammad, Maha M, Dunn, Henry A, Ferguson, Stephen S G

“…Corticotropin-releasing factor (CRF) receptor1 (CRFR1) is associated with psychiatric illness and is a proposed target for the treatment of anxiety and…”
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Trans‐synaptic regulation of group III mGluR pharmacology by endogenous allosteric modulators implicated in neuropsychiatric disease by Dunn, Henry A., Dao, Maria, Orlandi, Cesare, Zucca, Stefano, Martemyanov, Kirill A.

“…Functional characterization of the GPCR interactome has focused predominantly on intracellular interacting‐proteins, yet GPCRs are increasingly found in…”
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Regulation of CRFR1 and 5-HT2ar by Pdz Domain-Containing Proteins SAP97 and Psd-95 by Dunn, Henry A

“…Previous studies identified a crosstalk mechanism whereby CRFR1 sensitized 5- HT2AR-mediated signaling via interactions with PDZ domain-containing proteins: a…”
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